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APO-54N-032
Revised 18-Jun-08
ILEI (human) Detection Set [For ELISA Application]
SYNONYMS
Interleukin-like EMT Inducer (human) Detection Set [For ELISA Application]
FAM3C (human) Detection Set [For ELISA Application]
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Chemokines & Cytokines Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
APO-54N-032-KI01
1 Set
630.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY:
200 pg/ml (range 0 to 20 ng/ml).
QUANTITY:
For 5x96 wells.
KIT/SET CONTAINS:
1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION:
For the quantitative determination of human ILEI from biological fluids (serum, plasma and cell culture supernatant).
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
General Information
In 2006, T. Waerner, et al. characterized ILEI as a key player in both epithelial to mesenchymal transition and late-stage carcinoma progression. EMT is a process that involves changes in gene expression, cytoskeleton organization, cell adhesion, and extracellular matrix composition. This process is important during tissue formation and organogenesis, but also during cancer progression, metastasis and chronic inflammation. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer.
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q92520:
FAM3C (human)
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Cloning, expression, and initial characterization of a novel cytokine-like gene family:
Y. Zhu, et al.; Genomics
80
, 144 (2002)
Abstract
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells:
T. Waerner, et al.; Cancer Cell
10
, 227 (2006)
Abstract
Further Categories Containing This Product:
Transforming Growth Factor beta [TGFbeta] & Receptors/Related Products
•
Cancer Other Products
•
ELISA Sets
ALX-522-137
Revised 18-Jun-08
ILEI (human) (recombinant)
SYNONYMS
Interleukin-like EMT Inducer (human) (recombinant)
FAM3C (human) (recombinant)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Chemokines & Cytokines Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-522-137-C010
10 µg
360.00 USD
Product Specification
MW:
~25kDa
SOURCE/HOST:
Produced in CHO cells. Human ILEI (interleukin-like EMT inducer) (aa 25-227) is fused at the C-terminus to a FLAG
®
-tag
CONCENTRATION:
0.1mg/ml after reconstitution.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:
Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
In 2006, T. Waerner, et al. characterized ILEI as a key player in both epithelial to mesenchymal transition and late-stage carcinoma progression. EMT is a process that involves changes in gene expression, cytoskeleton organization, cell adhesion, and extracellular matrix composition. This process is important during tissue formation and organogenesis, but also during cancer progression, metastasis and chronic inflammation. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer.
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q92520:
FAM3C (human)
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Cloning, expression, and initial characterization of a novel cytokine-like gene family:
Y. Zhu, et al.; Genomics
80
, 144 (2002)
Abstract
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells:
T. Waerner, et al.; Cancer Cell
10
, 227 (2006)
Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
•
Cancer Other Products
•
Transforming Growth Factor beta [TGFbeta] & Receptors/Related Products
ALX-522-119
Revised 18-Jun-08
ILEI (mouse) (recombinant)
SYNONYMS
Interleukin-like EMT Inducer (mouse) (recombinant)
FAM3C (mouse) (recombinant)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Chemokines & Cytokines Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-522-119-C010
10 µg
360.00 USD
Product Specification
MW:
~25kDa
SOURCE/HOST:
Produced in HEK 293 cells. Mouse ILEI (interleukin-like EMT inducer) (aa 25-227) is fused at the C-terminus to a FLAG
®
-tag
CONCENTRATION:
0.1mg/ml after reconstitution.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:
Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
In 2006, T. Waerner, et al. characterized ILEI as a key player in both epithelial to mesenchymal transition and late-stage carcinoma progression. EMT is a process that involves changes in gene expression, cytoskeleton organization, cell adhesion, and extracellular matrix composition. This process is important during tissue formation and organogenesis, but also during cancer progression, metastasis and chronic inflammation. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer.
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q91VU0:
FAM3C (mouse)
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Cloning, expression, and initial characterization of a novel cytokine-like gene family:
Y. Zhu, et al.; Genomics
80
, 144 (2002)
Abstract
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells:
T. Waerner, et al.; Cancer Cell
10
, 227 (2006)
Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
•
Cancer Other Products
•
Transforming Growth Factor beta [TGFbeta] & Receptors/Related Products
ALX-270-236
Revised 04-Feb-05
JM 34
SYNONYMS
N-(4,6-Dimethylpyridin-2-yl)furane-2-carboxamide
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
TNF-alpha & TNF Receptors Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-236-M010
10 mg
60.00 USD
Product Specification
FORMULA:
C
12
H
12
N
2
O
2
MW:
216.2
PURITY:
≥99%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
For biological studies, solubilize as a maleate salt just before use.
HANDLING:
Keep under inert gas. Protect from light.
Product Description
Anti-inflammatory pyridinylamide that inhibits TNF-α production, probably by interacting with a protein kinase C (PKC)-dependent pathway of ERK2 phosphorylation. No inhibition of PKC activity
in vitro
. May serve as an alternative to classical cyclooxygenase (COX) inhibitors in TNF-α pathogenesis.
Product Specific Literature References
New antiinflammatory compounds that inhibit tumor necrosis factor production: probable interaction with protein kinase C activation:
F. Lang, et al.; J. Pharmacol. Exp. Ther.
275
, 171 (1995)
Abstract
An anti-inflammatory benzamide derivative inhibits the protein kinase C (PKC)-dependent pathway of ERK2 phosphorylation in murine macrophages:
L. Vernhet, et al.; J. Pharmacol. Exp. Ther.
283
, 358 (1997)
Abstract
;
Full Text
ALX-270-235
Revised 04-Feb-05
JM 42
SYNONYMS
N-(4,6-Dimethylpyridin-2-yl)-5-bromofurane-2-carboxamide
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
TNF-alpha & TNF Receptors Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-235-M005
5 mg
80.00 USD
Product Specification
FORMULA:
C
12
H
11
BrN
2
O
2
MW:
295.1
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
For biological studies, solubilize as a maleate salt just before use.
HANDLING:
Keep under inert gas. Protect from light.
Product Description
Anti-inflammatory pyridinylamide that inhibits TNF-α production, probably by interacting with a protein kinase C (PKC)-dependent pathway. May serve as an alternative to classical cyclooxygenase (COX) inhibitors in TNF-α involved pathogenesis.
Product Specific Literature References
New antiinflammatory compounds that inhibit tumor necrosis factor production: probable interaction with protein kinase C activation
:
F. Lang, et al.; J. Pharmacol. Exp. Ther.
275
, 171 (1995)
Abstract
ALX-350-223
Revised 07-Apr-08
Kahweol
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Chemopreventive Agents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-223-M010
10 mg
90.00 USD
Product Specification
FORMULA:
C
20
H
26
O
3
MW:
314.2
CAS NUMBER:
6894-43-5
SOURCE/HOST:
Natural product isolated from the unsaponifiable fraction of petroleum ether extract of coffee beans.
PURITY:
≥98% (HPLC)
APPEARANCE:
Off-white to yellow solid.
SOLUBILITY:
Soluble in ethyl acetate, acetone or DMSO; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Induces glutathione S-transferase. Has anti-cancer, chemoprotective, anti-inflammatory and anti-atherosclerotic properties.
Product Specific Literature References
R.O. Bengis & R.J. Anderson; J. Biol. Chem.
47
, 99 (1932)
Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse:
L.K. Lam, et al.; Cancer Res.
42
, 1193 (1982)
Abstract
Effects of derivatives of kahweol and cafestol on the activity of glutathione S-transferase in mice:
L.K. Lam, et al.; J. Med. Chem.
30
, 1399 (1987)
Abstract
Placental glutathione S-transferase (GST-P) induction as a potential mechanism for the anti-carcinogenic effect of the coffee-specific components cafestol and kahweol:
B. Schilter, et al.; Carcinogenesis
17
, 2377 (1996)
Abstract
Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat:
W.W. Huber, et al.; Mutat. Res.
376
, 115 (1997)
Abstract
The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism:
C. Cavin, et al.; Carcinogenesis
19
, 1369 (1998)
Abstract
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity:
C. Cavin, et al.; Food Chem. Toxicol.
40
, 1155 (2002)
Abstract
The coffee diterpene kahweol inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells:
H.G. Kim, et al.; Toxicol. Appl. Pharmacol.
217
, 332 (2006)
Abstract
Further Categories Containing This Product:
Glutathione S-Transferase
•
Antitumor Agents (Enzyme Activators & Inducers)
•
TNF-alpha & TNF Receptors Other Products
•
CD11a, CD18 [LFA-1] & CD54 [ICAM-1], CD102 [ICAM-2], CD50 [ICAM-3]/Related Products
•
Natural Products - Anti-inflammatory Agents
•
Active Substances from Fruit and Vegetables
ALX-201-123
Revised 06-Jun-08
KillerTRAIL™, Soluble (human) (recombinant) (BULK)
SYNONYMS
Apo-2L, Soluble (human) (recombinant)
TNFSF 10, Soluble (human) (recombinant)
CD253, Soluble (human) (recombinant)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
TRAIL [Apo-2L]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-123-C500
500 µg
1'400.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
Produced in
E. coli
. The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide.
CONCENTRATION:
0.5mg/ml.
PURITY:
≥99% (SDS-PAGE)
PURITY DETAIL:
Affinity purified.
FORMULATION:
Liquid. In 20mM HEPES, pH 7.9, containing 120mM sodium chloride, 0.01% Tween 20, 1% sucrose, 1mM DTT.
ENDOTOXIN CONTENT:
<0.2EU/µg protein (LAL test; Bio Whittaker).
RECONSTITUTION:
For a special storage and dilution buffer see
Killer
TRAIL™ Storage and Dilution Buffer (Prod. No.
ALX-505-005
).
SPECIFICITY:
Binds to human and mouse TRAIL receptors and osteoprotegerin (OPG).
BIOLOGICAL ACTIVITY:
Induces apoptosis in a concentration range of 10-100ng/ml.
Note:
This protein does not require a cross-linking enhancer for its potent biological activity. For cell lines that require extensive cross-linking of the TRAIL-Rs for killing (e.g. Jurkat) use Super
Killer
TRAIL™ (Prod. No.
ALX-201-115
).
SPECIFIC ACTIVITY:
ED
50
: 20ng/ml (BJAB cells)
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
The cytokines tumor necrosis factor-alpha (TNF-alpha ) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papillomavirus-16 E7 oncoprotein J.R. Basile, et al.; J. Biol. Chem.
276
, 22522 (2001)
Abstract
;
Full Text
The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines
:
Q. Liao, et al.; FEBS Lett.
503
, 151 (2001)
Abstract
;
Full Text
TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors
:
M. Plasilova, et al.; Leukemia
16
, 67 (2002)
Abstract
TRAIL and its receptors in the colonic epithelium: a putative role in the defense of viral infections
:
J. Sträter, et al.; Gastroenterology
122
, 659 (2002)
Abstract
Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1:
M. MacFarlane, et al.; Cell Death Differ.
12
, 773 (2005)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P50591:
TRAIL (human)
AfCS Signalling Gateway link A002862:
TRAIL (mouse)
Related Products
ALX-505-005
Killer
TRAIL™ Storage and Dilution Buffer
ALX-804-296
Monoclonal Antibody to TRAIL (human) (2E5)
ALX-201-115
Super
Killer
TRAIL™, Soluble (human) (recombinant)
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
ALX-505-005
Revised 23-Jul-08
KillerTRAIL™ Storage and Dilution Buffer
PRODUCT LINE
Molecular Biology
PRODUCT CATEGORY
Buffers/Detergents/Solutions
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-505-005-R500
500 µl
60.00 USD
Product Specification
PURITY DETAIL:
Sterile filtered.
FORMULATION:
Liquid. 20mM HEPES, pH 7.4, containing 300mM NaCl, 0.01% Tween 20, 1% sucrose and 1mM DTT.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Description
Storage and dilution buffer for use with the following products:
Killer
TRAIL™, Soluble (human) (recombinant) (Prod. No.
ALX-201-073
)
Super
Killer
TRAIL™, Soluble (human) (recombinant) (Prod. No.
ALX-201-115
)
Super
Killer
TRAIL™, Soluble (mouse) (recombinant) (Prod. No.
ALX-201-130
)
Useful for prediluting the above mentioned products before preparing aliquots or performing experiments. Predilution with
Killer
TRAIL™ Storage and Dilution Buffer allows for easier handling of small working concentrations (sometimes only 0.1µl of the
Killer
TRAIL™ or Super
Killer
TRAIL™ stock solution is necessary because of their high activity). Predilution with
Killer
TRAIL™ Storage and Dilution Buffer instead of medium or PBS prevents loss of biological activity. Can also be used as negative control.
General Information
BACKGROUND/TECHNICAL INFORMATION
Prepare a 1:10 dilution of
Killer
TRAIL™ or Super
Killer
TRAIL™ with
Killer
TRAIL™ Storage and Dilution Buffer. For immediate use, keep prediluted
Killer
TRAIL™ or Super
Killer
TRAIL™ on ice until adding to cells. For storage, prepare aliquots and freeze at -80°C.
Related Products
ALX-201-115
Super
Killer
TRAIL™, Soluble (human) (recombinant)
ALX-201-073
Killer
TRAIL™, Soluble (human) (recombinant)
ALX-201-130
Super
Killer
TRAIL™, Soluble (mouse) (recombinant)
Further Categories Containing This Product:
TRAIL [Apo-2L]
ALX-201-073
Revised 05-May-08
KillerTRAIL™, Soluble (human) (recombinant)
SYNONYMS
Apo-2L, Soluble (human) (recombinant)
TNFSF 10, Soluble (human) (recombinant)
CD253, Soluble (human) (recombinant)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
TRAIL [Apo-2L]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-073-C020
20 µg
360.00 USD
ALX-201-073-3020
SuperPack
3x20 µg
720.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
Produced in
E. coli
. The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide.
CONCENTRATION:
0.5mg/ml
PURITY:
≥99% (SDS-PAGE)
PURITY DETAIL:
Affinity purified. Sterile filtered.
FORMULATION:
Liquid. In 20mM HEPES, pH 7.4, 300mM sodium chloride, 1% sucrose, 0.01% Tween 20 and 1mM DTT.
ENDOTOXIN CONTENT:
≤0.004EU/μg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:
For a special storage and dilution buffer see
Killer
TRAIL™ Storage and Dilution Buffer (Prod. No.
ALX-505-005
).
SPECIFICITY:
Binds to human and mouse TRAIL receptors and osteoprotegerin (OPG).
BIOLOGICAL ACTIVITY:
Induces apoptosis in a concentration range of 10-100ng/ml.
Note:
Does not require a cross-linking enhancer for its potent biological activity. For cell lines that require extensive cross-linking of the TRAIL-Rs for killing (e.g. Jurkat) use Super
Killer
TRAIL™ (Prod. No.
ALX-201-115
).
SPECIFIC ACTIVITY:
ED
50
: 20ng/ml (BJAB cells)
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
HANDLING:
After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
The cytokines tumor necrosis factor-α (TNF-α) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papilloma:
J.R. Basile, et al.; J. Biol. Chem.
276
, 22522 (2001)
