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Chemokines & Cytokines
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ALX-201-308 Revised 31-Aug-06
GITRL, Soluble (mouse) (recombinant) (His)
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SYNONYMS TNFSF 18, Soluble (mouse) (recombinant) (His)
Glucocorticoid-induced TNF Receptor Ligand, Soluble (mouse) (recombinant) (His)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY GITR & GITRL
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-308-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The extracellular domain of mouse GITRL (aa 45-173) is fused at the C-terminus to a His-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 10mM glycin, pH 10.0.
ENDOTOXIN CONTENT: <1EU/mg protein (LAL test; Bio Whittaker).
SPECIFICITY: Binds to mouse GITR.
APPLICATION: rmsGITRL can be used for GITR-mediated NF-κB activation.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Specific Literature References
Soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) stimulates osteoclast differentiation in response to receptor activator of NF-kappaB ligand (RANKL) in osteoclast cells: H.H. Shin, et al.; Bone 36, 832 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q7TS55: GITR Ligand (mouse)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-327 Revised 04-Sep-08
GITRL (human) (recombinant) (His)
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SYNONYMS Glucocorticoid-induced TNF Receptor Ligand (human) (recombinant) (His)
AITRL (human) (recombinant) (His)
Activation-inducible TNF-related Ligand (human) (recombinant) (His)
TNFSF 18 (human) (recombinant) (His)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY GITR & GITRL
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ALX-201-327-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The extracellular domain of human GITRL (AITRL) is fused at the N-terminus to a His-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 55mM TRIS, pH 8.2 containing 150 mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL test).
ACTIVITY: Binds to human GITR (AITR).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9UNG2: Tumor necrosis factor ligand superfamily member 18 (human)
MANUFACTURER Manufactured by Adipogen, Inc.
General Literature References
Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand: B. Kwon, et al.; J. Biol. Chem. 274, 6056 (1999) Abstract; Full Text
Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR: A.L. Gurney, et al.; Curr. Biol. 9, 215 (1999) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-350-371 Revised 10-Mar-08
Harmine
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SYNONYMS Leucoharmine
Banisterine
Telepathine
Yageine
7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-371-M250   250 mg 22.00 USD Add To Cart
Product Specification
FORMULA: C13H12N2O
MW: 212.3
CAS NUMBER: 442-51-3
MERCK INDEX: 14: 4616
RTECS: UV0175000
SOURCE/HOST: Originally isolated from Peganum harmala.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Alkaloid of the β-carboline family. Regulates PPARγ expression. Inhibits the Wnt signalling pathway in a cell-specific manner. Down-regulates inflammatory gene expression (TNF-α, IL-1β, iNOS). Reversibly inhibits monoamine oxidase inhibitor A (MAO-A), but has no effect on MAO-B.
Product Specific Literature References
The chemotherapy of derivatives of harmine and harmaline. I: C.E. Coulthard, et al.; Biochee. J. 27, 727 (1933) Abstract; Full Text
The chemotherapy of derivatives of harmine and harmaline. II: C.E. Coulthard; Biochem. J. 28, 264 (1934) Abstract; Full Text
Interrelationships between amphetamine and harmala alkaloids: H. Schmitt; Nature 203, 877 (1964) Abstract
Effect of moclobemide on rat brain monoamine oxidase A and B: comparison with harmaline and clorgyline: J. Gerardy; Prog. Neuropsychopharmacol. Biol. Psychiatry 18, 793 (1994) Abstract
Hypothermic effect of harmala alkaloid in rats: involvement of serotonergic mechanism: A.F. Abdel-Fattah, et al.; Pharmacol. Biochem. Behav. 52, 421 (1995) Abstract
The mode of action of thiazolidinediones: H. Hauner; Diabet. Metab. Res. Rev. 18, S10 (2002) Abstract
Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis: Q. Chen, et al.; Int. J. Cancer 114, 675 (2005) Abstract
The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression: H. Waki, et al.; Cell Metab. 5, 357 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Other Signal Transduction Pathway Modulators • Interleukin-1 [IL-1] & Receptors / Related Products • TNF-alpha & TNF Receptors Other Products • Wnt Signalling Pathway Other Products • NOS Regulation • Antidiabetic Agents / Related Products • Alkaloids
 
 
ALX-522-017 Revised 24-Mar-05
HVEM (human):Fc (human) (recombinant)
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SYNONYMS Herpesvirus Entry Mediator A (human):Fc (human) (recombinant)
ATAR (human):Fc (human) (recombinant)
LIGHT-R (human):Fc (human) (recombinant)
TR2 (human):Fc (human) (recombinant)
TNFRSF 14 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY HVEM & LIGHT / LT-betaR / DcR3 / Related Products
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ALX-522-017-C050   50 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~58kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human HVEM (aa 39-200) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml, after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds human and mouse LIGHT. 
BIOLOGICAL ACTIVITY: Inhibits LIGHT-mediated effects such as the cytotoxic effect on HT29 target cells. Prevents Herpes Simplex Virus-1 infection of T-cells.
APPLICATION: Detection of membrane-bound human and mouse LIGHT (HVEML) in combination with PAb to human IgG1.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
HVEM (TR2, ATAR, HVEA) is a 36 kDa type I transmembrane protein belonging to the TNF receptor family. HVEM contains 3 cysteine-rich repeats in the extracellular portion which is typical of TNFR family members. HVEM mediates Herpes Simplex Virus-1 infection of T cells. Ligation of HVEM by its cellular trimeric ligand LIGHT (Prod. No. ALX-522-018) induces recruitment to the cytoplasmic domain of the signaling molecules TRAF2 and 5. Activation in vitro of HVEM leads to induction of nuclear factors NFκB and AP-1. The outcome of HVEM activation on T cells is still controversial. A second ligand for HVEM is soluble LTα.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q92956: HVEM (human) (precursor)
AfCS Signalling Gateway link A001150: HVEM (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-850-208 Revised 10-Apr-08
IFN-ω (human) ELISA Kit
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PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interferon Kits & Sets
Ordering Information
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ALX-850-208-KI01   1 Kit 619.00 USD Add To Cart
Product Specification
SENSITIVITY: 1.51pg/ml (range 4.7 to 300pg/ml)
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of human IFN-ω in cell culture supernatants, serum and other body fluids.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-201-374 Revised 18-Mar-08
IL-17A (human):Fc (human) (recombinant)
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SYNONYMS Interleukin-17A (human):Fc (human) (recombinant)
CTLA-8 (human):Fc (human) (recombinant)
Cytotoxic T-lymphocyte-associated Antigen 8 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
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ALX-201-374-C010   10 µg 140.00 USD Add To Cart
ALX-201-374-C050   50 µg 380.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The signal peptide and the sequence of human IL-17A (interleukin-17A) (aa 1-155) are fused at the C-terminus to the Fc portion of human IgG1.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q16552: Interleukin-17A (human) [Precursor]
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-520-001 Revised 01-Oct-08
IL-1β (human) (recombinant) (cell culture grade)
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SYNONYMS Interleukin-1β (human) (recombinant) (cell culture grade)
IL-1F2 (human) (recombinant) (cell culture grade)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
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ALX-520-001-C010   10 µg 297.00 USD Add To Cart
Product Specification
MW: ~17kDa.
CAS NUMBER: 97599-21-8
MERCK INDEX: 14: 4993
SOURCE/HOST: Produced in E. coli.
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Lyophilized. Salt-free.
ENDOTOXIN CONTENT: <1EU/µg protein.
RECONSTITUTION: Reconstitute with water, PBS or aqueous buffer to a concentration of 100µg/ml. For further dilution carrier protein (~1%) should be added to avoid loss of bioactivity.
BIOLOGICAL ACTIVITY: Exerts in vitro biological activity in the range of 0.1-10ng/ml.
SPECIFIC ACTIVITY: ≥1x107U/mg protein. Determined by proliferation assay using human TF-1 (T. Kitamura, et al.; Int. Immunol. 3, 571 (1991)). The ED50 for this effect is typically 0.2-2ng/ml. Results were compared with the international IL-1 reference standard preparation (WHO 86/680, NIBSC).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Potent immunomodulator. Mediates a wide range of immune and inflammatory responses including the activation of B and T cells.
Further Categories Containing This Product:
Interleukin-1 [IL-1] & Receptors / Related Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-056 Revised 18-Sep-07
IL-1β, Soluble (human) (recombinant)
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SYNONYMS Interleukin-1β, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
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ALX-522-056-C010   10 µg 200.00 USD Add To Cart
ALX-522-056-3010 SuperPack 3x10 µg 410.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: Produced in E. coli. Human IL-1β (interleukin-1β) (aa 117-270) is fused to a linker peptide (10 aa) and an N-terminal FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water.
SPECIFICITY: Binds to human IL-1R (interleukin-1 receptor).
BIOLOGICAL ACTIVITY: Activates the NF-κB pathway.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Images
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Product Specific Literature References
Insulin-secreting beta-cell dysfunction induced by human lipoproteins: M.E. Roehrich, et al.; J. Biol. Chem. 278, 18368 (2003) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P01584: Interleukin-1β (human) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Human interleukin 1: I. Gery & J.A. Schmidt; Meth. Enzymol. 116, 456 (1985) Abstract
Interleukin 1: an immunological perspective: S.K. Durum, et al.; Annu. Rev. Immunol. 3, 263 (1985) Abstract
The in vivo effects of interleukin 1. I. Bone marrow cells are induced to cycle after administration of interleukin 1: R. Neta, et al.; J. Immunol. 139, 1861 (1987) Abstract
Interleukin 1 or tumor necrosis factor-alpha: which is the real target in rheumatoid arthritis?: J.M. Dayer; J. Rheumatol. Suppl. 65, 10 (2002) Abstract
Further Categories Containing This Product:
Interleukin-1 [IL-1] & Receptors / Related Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-850-209 Revised 10-Apr-08
IL-1β (human) ELISA Kit
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SYNONYMS Interleukin-1β (human) ELISA Kit
IL-1F2 (human) ELISA Kit
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Kits & Sets
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-209-KI01   1 Kit 619.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.32pg/ml (range 3.9 to 250pg/ml)
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of human IL-1β in cell culture supernatants, serum and other body fluids.
SHIPPING: SHIPPED ON BLUE ICE
HANDLING: Store controls at -20°C. Store rest of the kit at +4°C.
General Information
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
Interleukin-1 [IL-1] & Receptors / Related Products • ELISA & EIA Kits
 
 
ALX-522-127 Revised 27-Mar-08
IL-1F5 (human) (recombinant)
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SYNONYMS Interleukin-1 Family Member 5 (human) (recombinant)
IL-1δ (human) (recombinant)
Interleukin-1δ (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
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ALX-522-127-C050   50 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~16kDa (SDS-PAGE)
SOURCE/HOST: Produced in E. coli (aa 1-155).
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
IL-1F5, F6, F8 and F9 are new members of the family of IL-1 (IL-1α/β, IL-18, IL-33). IL-1F6, IL-1F8 and IL-1F9 activate the NF-κB and MAPK pathways through the IL-Rrp2 and IL-1RAcP receptor complex leading to the production of IL-6 and IL-8. Agonistic activation of the IL-1F6, F8 and F9 is counterbalanced by the inhibitory activity of IL-1F5. These interleukins are mainly expressed in skin keratinocytes and internal epithelial tissues exposed to pathogenic bacteria suggesting a role in immune signalling and inflammation. IL-F5, F6 and F9 as well as the rec