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Growth Factors / Related Products
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ALX-521-007 Revised 13-Mar-08
Nerve Growth Factor 2.5S (mouse) Grade II
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SYNONYMS NGF 2.5S (mouse) Grade II
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Nerve Growth Factors [NGF] & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-521-007-C025   25 µg 180.00 USD Add To Cart
ALX-521-007-C100   100 µg 420.00 USD Add To Cart
Product Specification
MW: ~26kDa; homodimer.
CAS NUMBER: 93828-24-6
SOURCE/HOST: Isolated from mouse submaxillary glands by a modification of the procedure described by T. Darling, et al.; Cell Culture Meth. Mol. Cell Biol. 4, 79 (1984).
QUANTITY: Concentration is estimated spectroscopically from its extinction coefficient and amino acid analysis.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized.
RECONSTITUTION: Dilute in sterile water or DMEM to a concentration of at least 10µg/ml and store at -80°C before use.
BIOLOGICAL ACTIVITY: Neurotrophic activity was bioassayed using rat pheochromocytoma cell PC12 cultures over a period of 7-14 days. Activity is in the range of 0.5-50ng/ml. Recommended concentration to be used in vitro for maintenance of sympathetic and sensory nerve cultures is 50ng/ml medium [1].
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 2-3 weeks when stored at room temperature. After reconstitution, stable for up to 1 week when stored at +4°C and for 4-6 weeks at -80°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C. Do not reuse medium containing mNGF.
Product Specific Literature References
[1] Nerve growth factor: R.A. Bradshaw; Annu. Rev. Biochem. 47, 191 (1978) Abstract
[2] The changing scene of neurotrophic factors: H. Thoenen; TINS 14, 165 (1991), (Review) Abstract
[3] Towards a comprehensive understanding of the trophic support of motoneurons: H. Thoenen, et al.; C. R. Acad. Sci. III 316, 1158 (1993), (Review) Abstract
[4] The neurotrophins and their receptors: structure, function, and neuropathology: L.M. Maness, et al.; Neurosci. & Biobehav. Rev. 18, 143 (1994), (Review) Abstract
[5] Neurotrophic factors enter the clinic: M. Barinaga; Science 264, 772 (1994), (Review) Abstract
[6] Neurobiology. Tracking neurotrophin function: A.M. Davies; Nature 368, 193 (1994), (Review) Abstract
[7] Role of neurotrophins in mouse neuronal development: R. Klein; FASEB J. 8, 738 (1994), (Review) Abstract
[8] Neurotrophic factors: two are better than one: R. Nishi; Science 265, 1052 (1994), (Review) Abstract
 
 
ALX-521-008 Revised 17-Oct-06
Nerve Growth Factor 7S (mouse)
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SYNONYMS NGF 7S (mouse)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Nerve Growth Factors [NGF] & Receptors / Related Products
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ALX-521-008-C100   100 µg 245.00 USD Add To Cart
Product Specification
MW: ~130kDa.
SOURCE/HOST: Isolated from mouse submaxillary glands by a modification of the procedure described by T. Darling, et al.; Cell Culture Meth. Mol. Cell Biol. 4, 79 (1984).
QUANTITY: Determined by Lowry and Pierce method.
PURITY: ≥97% (SDS-PAGE)
FORMULATION: Lyophilized.
RECONSTITUTION: Dilute in sterile water or DMEM to a concentration of at least 10µg/ml and store at -80°C before use. Medium containing NGF cannot be reused due to NGF degradation.
BIOLOGICAL ACTIVITY: Bioassayed for neurotrophic activity using the rat pheochromocytoma cell PC12 cultures over a period of 7-14 days. Neurotrophic activity is in the range of 0.5-50ng/ml. Recommended concentration to be used in vitro for maintenance of sympathetic and immature sensory nerve cells is 50-100ng/ml medium (See [2]).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 2-3 weeks when stored at room temperature. After reconstitution, store for up to one week at +4°C and for 4-6 weeks at -80°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Product Specific Literature References
[1] O.H. Lowry, et al.; J. Biol. Chem. 193, 265 (1951)
[2] The isolation of the mouse nerve growth factor protein in a high molecular weight form: S. Varon, et al.; Biochemistry 6, 2202 (1967) Abstract
[3] The changing scene of neurotrophic factors: H. Thoenen; TINS 14, 165 (1991), (Review) Abstract
[4] Towards a comprehensive understanding of the trophic support of motoneurons: H. Thoenen, et al.; C. R. Acad. Sci. III 316, 1158 (1993), (Review) Abstract
[5] Neurotrophic factors enter the clinic: M. Barinaga; Science 264, 772 (1994), (Review) Abstract
[6] Neurobiology. Tracking neurotrophin function: A.M. Davies; Nature 368, 193 (1994), (Review) Abstract
[7] Role of neurotrophins in mouse neuronal development: R. Klein; FASEB J. 8, 738 (1994), (Review) Abstract
[8] The neurotrophins and their receptors: structure, function, and neuropathology: L.M. Maness, et al.; Neurosci. & Biobehav. Rev. 18, 143 (1994), (Review) Abstract
[9] Neurotrophic factors: two are better than one: R. Nishi; Science 265, 1052 (1994), (Review) Abstract
 
 
ALX-201-208 Revised 12-Feb-08
β-Nerve Growth Factor (human) (recombinant)
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SYNONYMS β-NGF (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Nerve Growth Factors [NGF] & Receptors / Related Products
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ALX-201-208-C020   20 µg 190.00 USD Add To Cart
Product Specification
MW: ~26.5kDa.
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: ~0.65mg/ml.
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Liquid. In 50mM sodium phosphate, pH 7.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <0.05EU/µg protein.
BIOLOGICAL ACTIVITY: Stimulates the proliferation of TF1 cells (EC50=10.9±2.7pM).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for up to 5 weeks after receipt when stored at +4°C and for at least 1 year when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P01138: β-Nerve Growth Factor (human)
MANUFACTURER Manufactured by Scil Proteins GmbH.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-521-005 Revised 08-Jan-07
β-Nerve Growth Factor (human) (recombinant)
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SYNONYMS β-NGF (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Nerve Growth Factors [NGF] & Receptors / Related Products
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ALX-521-005-C005   5 µg 140.00 USD Add To Cart
Product Specification
MW: ~27kDa (dimer).
CAS NUMBER: 86923-98-0
SOURCE/HOST: Produced in E. coli. Dimer of two identical subunits (119 aa) linked together by very strong hydrophobic interactions.
QUANTITY: 5µg (determined by amino acid analysis).
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Lyophilized. No additives.
BIOLOGICAL ACTIVITY: ED50: 2ng/ml (determined by the dose-dependent induction of neuronal outgrowth in PC12 cells).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Lyophilized protein is stable for 2-3 weeks when stored at room temperature and for 6-9 months when stored at -20°C.
Reconstituted protein is stable for up to 1 week when stored at +4°C and for 4-6 weeks when stored at 80°C.
HANDLING: Avoid freeze/thaw cycles.
Product Images
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General Information
Human β-NGF is responsible for survival, differentiation and maturation of sympathetic and sensory neurons.
General Literature References
The changing scene of neurotrophic factors : H. Thoenen; TINS 14, 165 (1991), (Review) Abstract
Towards a comprehensive understanding of the trophic support of motoneurons: H. Thoenen, et al.; C.R. Acad. Sci. III 316, 1158 (1193), (Review) Abstract
Neurotrophic factors enter the clinic: M. Barinaga; Science 264, 772 (1994), (Review) Abstract
Neurobiology. Tracking neurotrophin function: A.M. Davies; Nature 368, 193 (1994), (Review) Abstract
Role of neurotrophins in mouse neuronal development: R. Klein; FASEB J. 8, 738 (1994), (Review) Abstract
The neurotrophins and their receptors: structure, function, and neuropathology: L.M. Maness, et al.; Neurosci. & Biobehav. Rev. 18, 143 (1994), (Review) Abstract
Neurotrophic factors: two are better than one  : R. Nishi; Science 265, 1052 (1994), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-207 Revised 14-Oct-08
pro-β-Nerve Growth Factor (human) (recombinant)
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SYNONYMS pro-β-NGF (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Nerve Growth Factors [NGF] & Receptors / Related Products
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ALX-201-207-C020   20 µg 490.00 USD Add To Cart
Product Specification
MW: ~49.7kDa.
SOURCE/HOST: Produced in E. coli.
CONCENTRATION:  
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Liquid. In 50mM sodium phosphate, pH 7.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <0.05EU/µg protein.
BIOLOGICAL ACTIVITY: Stimulates the proliferation of TF1 cells (EC50=130±30pM).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for up to 5 weeks after receipt when stored at +4°C and for at least 1 year when stored at -20°C.
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
MANUFACTURER Manufactured by Scil Proteins GmbH.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-044 Revised 25-Oct-05
Nerve Growth Factor Receptor (human):Fc (human) (recombinant)
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SYNONYMS NGFR (human):Fc (human) (recombinant)
TNFRSF 16 (human):Fc (human) (recombinant)
p75NTR (human):Fc (human) (recombinant)
p75 Neurotrophin Receptor (human):Fc (human) (recombinant)
CD271 (human):Fc (human) (recombinant)
Low-affinity Nerve Growth Factor Receptor (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Nerve Growth Factors [NGF] & Receptors / Related Products
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ALX-522-044-C050   50 µg 360.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
MW: ~80kDa (under reducing conditions).
SOURCE/HOST: Produced in HEK 293 cells. The cysteine-rich domain of human NGFR (nerve growth factor receptor; p75NTR) (aa 1-264) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute in 50µl sterile water. Further dilutions can be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds human, mouse and rat NGF (nerve growth factor).
BIOLOGICAL ACTIVITY: Inhibits rat NGF-mediated activation of rat PC12 cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C. After reconstitution, it is recommended to make appropriate aliquots and to store them at -20°C.
HANDLING: Avoid freeze/thaw cycles.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P08138: NGFR (human) (precursor)
AfCS Signalling Gateway link A001650: NGFR (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Neurotrophins in cell survival/death decisions: P. Casaccia-Bonnefil, et al.; Adv. Exp. Med. Biol. 468, 275 (1999) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-270-319 Revised 04-Mar-05
PD 156,273
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SYNONYMS 6-Amino-4-[(3-bromophenyl)amino]-7-(methylamino)quinazoline
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGFR Kinase Inhibitors
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ALX-270-319-M001   1 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C15H14BrN5
MW: 344.2
PURITY: ≥98%
APPEARANCE: Off white to yellow powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep under inert gas. Protect from light.

Product Description
Potent inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) (IC50=690pM). Inhibits the growth of primary human tumor cell cultures.
Product Specific Literature References
Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor: A.J. Bridges, et al.; J. Med. Chem. 39, 267 (1996) Abstract; Full Text
Inhibition of growth of primary human tumour cell cultures by a 4-anilinoquinazoline inhibitor of the epidermal growth factor receptor family of tyrosine kinases: B.C. Baguley, et al.; Eur. J. Cancer 34, 1086 (1998) Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
 
 
ALX-270-322 Revised 04-Mar-05
PD 168,393
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SYNONYMS 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGFR Kinase Inhibitors
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ALX-270-322-M001   1 mg 156.00 USD Add To Cart
Product Specification
FORMULA: C17H13BrN4O
MW: 369.2
PURITY: ≥95%
APPEARANCE: Yellow to orange solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas.

Product Description
Potent, cell permeable, irreversible, and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50=700pM). Antitumor agent in vivo.
Product Specific Literature References
Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor: D.W. Fry, et al.; PNAS 95, 12022 (1998) Abstract; Full Text
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • Antitumor Agents (Enzyme Inhibitors)
 
 
ALX-270-323 Revised 04-Mar-05
PD 174,265
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SYNONYMS 4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGFR Kinase Inhibitors
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ALX-270-323-M001   1 mg 130.00 USD Add To Cart
Product Specification
FORMULA: C17H15BrN4O
MW: 371.2
PURITY: ≥98%
APPEARANCE: Off white to yellow powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep under inert gas. Protect from light.

Product Description
Potent, cell permeable, reversible, and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50=450pM).
Product Specific Literature References
Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor: D.W. Fry, et al.; PNAS 95, 12022 (1998) Abstract; Full Text
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
 
 
ALX-165-019 Revised 24-Feb-05
PDGF Fragment (phosphorylated) (cyclic)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY SH2 & SH3 Domains
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ALX-165-019-MC01   0.1 mg 50.00 USD Add To Cart
ALX-165-019-M001   1 mg 250.00 USD Add To Cart
Product Specification
SEQUENCE: cyclo(Gly-Tyr(PO3H2)-Val-Pro-Met-Leu)
FORMULA: C32H49N6O10PS
MW: 740.8
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Cyclic hexapeptide inhibitor of SH2 interactions. The peptide sequence represents the autophosphorylation region around Tyr751 of the PDGF β-receptor.
Product Specific Literature References
Synthesis of phosphonomethyl-phenylalanine and phosphotryrosine containing cyclic peptides as inhibitors of protein kinase/SN2 interactions: M. Nomizu, et al.; Tetrahedron 50, 2691 (1994)
Further Categories Containing This Product:
Platelet-derived Growth Factors [PDGFs] & Receptors / Related Products • Peptides
 
 
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ALX-165-005