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Chemokines & Chemokine Receptors/Related Products
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ALX-210-819 Revised 25-Jan-07
Polyclonal Antibody to CXCR4 (mouse)
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SYNONYMS anti-CXC Chemokine Receptor 4 (mouse) PAb
anti-CD184 (mouse) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CXC Chemokines & Receptors/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-819-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 14-40 (Y14SEEVGSGDYDS
NKEPCFRDENVHFNR40) of the N-terminal extracellular domain of mouse CXCR4 (CXC chemokine receptor 4).
SPECIFICITY: Recognizes mouse CXCR4.
APPLICATION: Immunocytochemistry (1:300)
Immunohistochemistry (paraffin sections (1:200))
Western Blot (1:1’000)
QUALITY CONTROL: Immunocytochemistry on mouse spleen cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-034.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-270-478 Revised 30-Jul-08
SB 225002
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SYNONYMS N-(2-Bromophenyl)-N’-(2-hydroxy-4-nitrophenyl)urea
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CXC Chemokines & Receptors/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-478-M001   1 mg 30.00 USD Add To Cart
ALX-270-478-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C13H10BrN3O4
MW: 352.1
CAS NUMBER: 182498-32-4
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO (40mg/ml), 100% ethanol or methanol (15mg/ml); slightly soluble in acetonitrile (2mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by MS, 1H-NMR and 13C-NMR.

Product Description
Potent and selective antagonist of CXCR2 chemokine receptor (IC50=22nM). >150-fold more selective over CXCR1 receptor. Inhibits IL-8- (IC50=8nM) and GROα-mediated (IC50=10nM) calcium mobilisation. Prevents IL-8-induced neutrophil migration. Inhibits HIV replication in lymphocytes and macrophages.
Product Specific Literature References
Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration: J.R. White, et al.; J. Biol. Chem. 273, 10095 (1998) Abstract; Full Text
Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen alpha (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2: J. Catusse, et al.; Biochem. Pharmacol. 65, 813 (2003) Abstract
A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer: B. Wang, et al.; Cancer Res. 66, 3071 (2006) Abstract; Full Text
Further Categories Containing This Product:
Interleukins Other Products • HIV/AIDS/Related Products
 
 
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