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Interleukin-1 [IL-1] & Receptors / Related Products
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ALX-350-371 Revised 03-Dec-08
Harmine
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SYNONYMS Leucoharmine
Banisterine
Telepathine
Yageine
7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-371-M250   250 mg 22.00 USD Add To Cart
Product Specification
FORMULA: C13H12N2O
MW: 212.3
CAS NUMBER: 442-51-3
MERCK INDEX: 14: 4616
RTECS: UV0175000
SOURCE/HOST: Originally isolated from Peganum harmala.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: 1.5mg/ml soluble in DMSO, dimethyl formamide or 100% ethanol; slightly soluble in PBS, pH 7.2 (0.25mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: We do not recommend storing aqueous solutions for more than one day.
HAZARD: HARMFUL.

Product Description
Alkaloid of the β-carboline family. Regulates PPARγ expression. Inhibits the Wnt signalling pathway in a cell-specific manner. Down-regulates inflammatory gene expression (TNF-α, IL-1β, iNOS). Reversibly inhibits monoamine oxidase inhibitor A (MAO-A), but has no effect on MAO-B.
Product Specific Literature References
The chemotherapy of derivatives of harmine and harmaline. I: C.E. Coulthard, et al.; Biochee. J. 27, 727 (1933) Abstract; Full Text
The chemotherapy of derivatives of harmine and harmaline. II: C.E. Coulthard; Biochem. J. 28, 264 (1934) Abstract; Full Text
Interrelationships between amphetamine and harmala alkaloids: H. Schmitt; Nature 203, 877 (1964) Abstract
Effect of moclobemide on rat brain monoamine oxidase A and B: comparison with harmaline and clorgyline: J. Gerardy; Prog. Neuropsychopharmacol. Biol. Psychiatry 18, 793 (1994) Abstract
Hypothermic effect of harmala alkaloid in rats: involvement of serotonergic mechanism: A.F. Abdel-Fattah, et al.; Pharmacol. Biochem. Behav. 52, 421 (1995) Abstract
The mode of action of thiazolidinediones: H. Hauner; Diabet. Metab. Res. Rev. 18, S10 (2002) Abstract
Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis: Q. Chen, et al.; Int. J. Cancer 114, 675 (2005) Abstract
The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression: H. Waki, et al.; Cell Metab. 5, 357 (2007) Abstract
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products • Wnt Signalling Pathway Other Products • NOS Regulation • Antidiabetic Agents / Related Products • Interleukin-1 [IL-1] & Receptors / Related Products • Alkaloids • Natural Products - Other Signal Transduction Pathway Modulators
 
 
ALX-520-001 Revised 01-Oct-08
IL-1β (human) (recombinant) (cell culture grade)
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SYNONYMS Interleukin-1β (human) (recombinant) (cell culture grade)
IL-1F2 (human) (recombinant) (cell culture grade)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
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ALX-520-001-C010   10 µg 297.00 USD Add To Cart
Product Specification
MW: ~17kDa.
CAS NUMBER: 97599-21-8
MERCK INDEX: 14: 4993
SOURCE/HOST: Produced in E. coli.
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Lyophilized. Salt-free.
ENDOTOXIN CONTENT: <1EU/µg protein.
RECONSTITUTION: Reconstitute with water, PBS or aqueous buffer to a concentration of 100µg/ml. For further dilution carrier protein (~1%) should be added to avoid loss of bioactivity.
BIOLOGICAL ACTIVITY: Exerts in vitro biological activity in the range of 0.1-10ng/ml.
SPECIFIC ACTIVITY: ≥1x107U/mg protein. Determined by proliferation assay using human TF-1 (T. Kitamura, et al.; Int. Immunol. 3, 571 (1991)). The ED50 for this effect is typically 0.2-2ng/ml. Results were compared with the international IL-1 reference standard preparation (WHO 86/680, NIBSC).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Potent immunomodulator. Mediates a wide range of immune and inflammatory responses including the activation of B and T cells.
Further Categories Containing This Product:
Interleukin-1 [IL-1] & Receptors / Related Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-056 Revised 18-Sep-07
IL-1β, Soluble (human) (recombinant)
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SYNONYMS Interleukin-1β, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
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ALX-522-056-C010   10 µg 200.00 USD Add To Cart
ALX-522-056-3010 SuperPack 3x10 µg 410.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: Produced in E. coli. Human IL-1β (interleukin-1β) (aa 117-270) is fused to a linker peptide (10 aa) and an N-terminal FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water.
SPECIFICITY: Binds to human IL-1R (interleukin-1 receptor).
BIOLOGICAL ACTIVITY: Activates the NF-κB pathway.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
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Product Specific Literature References
Insulin-secreting beta-cell dysfunction induced by human lipoproteins: M.E. Roehrich, et al.; J. Biol. Chem. 278, 18368 (2003) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P01584: Interleukin-1β (human) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Human interleukin 1: I. Gery & J.A. Schmidt; Meth. Enzymol. 116, 456 (1985) Abstract
Interleukin 1: an immunological perspective: S.K. Durum, et al.; Annu. Rev. Immunol. 3, 263 (1985) Abstract
The in vivo effects of interleukin 1. I. Bone marrow cells are induced to cycle after administration of interleukin 1: R. Neta, et al.; J. Immunol. 139, 1861 (1987) Abstract
Interleukin 1 or tumor necrosis factor-alpha: which is the real target in rheumatoid arthritis?: J.M. Dayer; J. Rheumatol. Suppl. 65, 10 (2002) Abstract
Further Categories Containing This Product:
Interleukin-1 [IL-1] & Receptors / Related Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-850-209 Revised 10-Apr-08
IL-1β (human) ELISA Kit
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SYNONYMS Interleukin-1β (human) ELISA Kit
IL-1F2 (human) ELISA Kit
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Kits & Sets
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ALX-850-209-KI01   1 Kit 619.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.32pg/ml (range 3.9 to 250pg/ml)
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of human IL-1β in cell culture supernatants, serum and other body fluids.
SHIPPING: SHIPPED ON BLUE ICE
HANDLING: Store controls at -20°C. Store rest of the kit at +4°C.
General Information
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
Interleukin-1 [IL-1] & Receptors / Related Products • ELISA & EIA Kits
 
 
ALX-522-057 Revised 01-Oct-08
IL-1 Receptor Type I (human):Fc (human) (recombinant)
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SYNONYMS IL-1RI (human):Fc (human) (recombinant)
Interleukin-1 Receptor Type I (human):Fc (human) (recombinant)
CD121a (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Receptors
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ALX-522-057-C050   50 µg 365.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~83kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. Human IL-1RI (interleukin-1 receptor type I) (aa 21-336) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water.
SPECIFICITY: Binds to human IL-1 (interleukin-1).
BIOLOGICAL ACTIVITY: Blocks IL-1 activity.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
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General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Cytokine receptors and signal transduction: A. Miyajima, et al.; Annu. Rev. Immunol. 10, 295 (1992) Abstract
cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily: J.E. Sims, et al.; Science 241, 585 (1988) Abstract
The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense: L.A. O'Neill; Sci. STKE 2000, RE1 (2000) Abstract
IL-1 and IL-18 receptors, and their extended family: J.E. Sims, et al.; Curr. Opin. Immunol. 14, 117 (2002) Abstract
Related Products
Further Categories Containing This Product:
CD Proteins • Interleukin-1 [IL-1] & Receptors / Related Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-143 Revised 24-Nov-08 New product
IL-1RAcP (human):Fc (human) (recombinant)
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SYNONYMS Interleukin-1 Receptor Accessory Protein (human):Fc (human) (recombinant)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Interleukin-1 [IL-1] & Receptors / Related Products
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ALX-522-143-C050   50 µg 390.00 USD Add To Cart
Product Specification
MW: ~80kDa
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human IL-1RAcP (aa 21-356) is fused at the C-terminus to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Lonza).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9NPH3: IL-1RAcP (human)
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
NF-kB Pathway Other Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-804-461 Revised 08-Dec-08
Monoclonal Antibody to IL-1 Receptor Type II (human) (MNC2)
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SYNONYMS anti-IL-1RII (human) MAb (MNC2)
anti-CD121b (human) MAb (MNC2)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Receptor Antibodies
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ALX-804-461-C100   100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MNC2
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Purified antibody in PBS containing 0.1% sodium azide.
IMMUNOGEN: Recombinant human IL-1RII (interleukin-1 receptor type II; CD121b).
SPECIFICITY: Recognizes human IL-1RII.
APPLICATION: ELISA (capture)
Flow Cytometry
Immunocytochemistry (see [3])
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Role of metalloproteases in the release of the IL-1 type II decoy receptor: S. Orlando, et al.; J. Biol. Chem. 272, 31764 (1997) Abstract; Full Text
High circulating levels of the IL-1 type II decoy receptor in critically ill patients with sepsis: association of high decoy receptor levels with glucocorticoid administration: B. Müller, et al.; J. Leukoc. Biol. 72, 643 (2002) Abstract; Full Text
IL-1 beta scavenging by the type II IL-1 decoy receptor in human neutrophils: E. Bourke, et al.; J. Immunol. 170, 5999 (2003) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Clone MNC2 is also called 8-5, 8/5 or 8.5 in the literature.
Further Categories Containing This Product:
Interleukin-1 [IL-1] & Receptors / Related Products • Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-338 Revised 28-Nov-07
Monoclonal Antibody to IL-1F1 (mouse) (Flo1)
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SYNONYMS anti-Interleukin-1 Family Member 1 (mouse) MAb (Flo1)
anti-IL-1α (mouse) MAb (Flo1)
anti-Interleukin-1α (mouse) MAb (Flo1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Antibodies
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ALX-804-338-C100   100 µg 259.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: Flo1
ISOTYPE: Mouse IgG1
IMMUNOGEN: Mouse IL-1F1 (IL-1α).
SPECIFICITY: Recognizes mouse IL-1F1.
APPLICATION: ELISA
Functional Application (neutralizing)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Specific Literature References
Functional discrimination between interleukin 6 and interleukin 1: M. Helle, et al.; Eur. J. Immunol. 18, 1535 (1988) Abstract
Further Categories Containing This Product:
Interleukin-1 [IL-1] & Receptors / Related Products • Monoclonal Antibodies
 
 
ALX-804-462 Revised 02-Mar-06
Monoclonal Antibody to IL-1ra3 (human) (MND1)
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SYNONYMS anti-icIL-1raII (human) MAb (MND1)
anti-IL-1 Receptor Agonist Type II (intracellular isoform) (human) MAb (MND1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin & Interleukin Receptors Other Products
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ALX-804-462-C100   100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MND1
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Purified antibody in PBS containing 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to a partial sequence (ADLYEEGGGGGGEGEDNADSK) of human IL-1ra3.
SPECIFICITY: Recognizes human IL-1ra3.
APPLICATION: Immunohistochemistry
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Characterization of type II intracellular IL-1 receptor antagonist (IL-1ra3): a depot IL-1ra: M. Muzio, et al.; Eur. J. Immunol. 29, 781 (1999) Abstract
Further Categories Containing This Product:
Interleukin-1 [IL-1] & Receptors / Related Products • Monoclonal Antibodies
 
 
ALX-215-010 Revised 27-Feb-07
Polyclonal Antibody to SIGIRR
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SYNONYMS anti-Single Ig IL-1R-related Molecule PAb
anti-TIR8 PAb
anti-Toll/Interleukin-1 Receptor 8 PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY Interleukin-1 [IL-1] & Receptors / Related Products
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ALX-215-010-C100   100 µg 287.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 334-358 (L334RGRVPEGRALDSEVDPDPEGDLGV358) of human SIGIRR (single Ig IL-1R-related molecule).
SPECIFICITY: Recognizes human and mouse SIGIRR.
APPLICATION: Western Blot (0.5µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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Further Categories Containing This Product:
Polyclonal Antibodies • Proteasome / Related Products
 
 
ALX-210-371 Revised 27-Feb-07
Polyclonal Antibody to SIGIRR (human)
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SYNONYMS anti-Single Ig IL-1R-related Molecule (human) PAb
anti-TIR8 (human) PAb
anti-Toll/Interleukin-1 Receptor 8 (human) PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY Interleukin-1 [IL-1] & Receptors / Related Products
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ALX-210-371-R200   200 µl 267.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide and 0.1mg/ml BSA.
IMMUNOGEN: Synthetic peptides corresponding to aa 309-323 and 380-393 of human SIGIRR (single Ig IL-1R-related molecule).
SPECIFICITY: Recognizes human SIGIRR.
APPLICATION: Western Blot (1:500-1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months when stored at +4°C.
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General Literature References
Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily: E. Thomassen, et al.; Cytokine 11, 389 (1999) Abstract
Three novel mammalian toll-like receptors: gene structure, expression, and evolution: X. Du, et al.; Eur. Cytokine Netw. 11, 362 (2000) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies • Proteasome / Related Products
 
 
ALX-201-402 Revised 27-Mar-08
SIGIRR (human):Fc (human) (recombinant)
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SYNONYMS Single Ig IL-1R-related Molecule (human):Fc (human) (recombinant)
TIR8 (human):Fc (human) (recombinant)
Toll/Interleukin-1 Receptor 8 (human):Fc (human) (recombinant)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Interleukin-1 [IL-1] & Receptors / Related Products
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ALX-201-402-C010   10 µg 260.00 USD Add To Cart
ALX-201-402-C050   50 µg 560.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG.