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ALX-210-335
Revised 29-Aug-06
Polyclonal Antibody to TNF-α
SYNONYMS
anti-Tumor Necrosis Factor-α PAb
anti-TNFSF 2 PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
TNF-alpha
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-335-C100
100 µg
259.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY:
≥99% (SDS-PAGE).
FORMULATION:
Liquid. In PBS.
ENDOTOXIN CONTENT:
≤0.0005EU/µg protein.
IMMUNOGEN:
Recombinant rat TNF-α (tumor necrosis factor-α).
SPECIFICITY:
Recognizes human, mouse and rat TNF-α.
APPLICATION:
ELISA
Western Blot
: 10ng recombinant rat TNF-α by 40-60µg/ml Prod. No. ALX-210-335.
Functional Application
: Neutralizes cytotoxic activity of recombinant rat TNF-α (Neutralizing activity: >2x10
5
U/mg. One unit is defined as the amount of antibody sufficient for neutralizing the cytotoxic activity of 1 unit recombinant rat TNF-α).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-345
Revised 12-Jan-05
Polyclonal Antibody to Adiponectin (mouse)
SYNONYMS
anti-ACRP30 (mouse) PAb
anti-Adipocyte Complement Related Protein of 30kDa (mouse) PAb
anti-AdipoQ (mouse) PAb
anti-apM1 (mouse) PAb
anti-GBP28 (mouse) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-345-C200
200 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. Protein A purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 18-32 and 187-200 of mouse adiponectin.
SPECIFICITY:
Recognizes mouse adiponectin. Detects a band of ~30kDa by Western blot.
APPLICATION:
Immunoprecipitation
Western Blot (4-8µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-352
Revised 30-Oct-06
Polyclonal Antibody to MDA5 (mouse) (AL180)
SYNONYMS
anti-Melanoma Differentiation-associated Gene 5 (mouse) PAb (AL180)
anti-Helicard (mouse) PAb (AL180)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
RNA Helicases / Related Products
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
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ALX-210-352-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Contains 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse MDA5 (melanoma differentiation-associated gene 5) (aa 2-208).
SPECIFICITY:
Recognizes mouse MDA5.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored as recommended.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Overexpression of Helicard, a CARD-Containing Helicase Cleaved during Apoptosis, Accelerates DNA Degradation:
M. Kovacsovics, et al.; Curr. Biol.
12
, 838 (2002)
Abstract
General Information
MDA5 is a highly conserved helicase whose ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. The helicase domain, once freed from the CARD domains, then translocates from the cytoplasm to the nucleus where it acts on chromatin architecture. This could allow a more easy access of CAD, thereby accelerating the degradation of genomic DNA.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties
:
D.C. Kang, et al.; PNAS
99
, 637 (2002)
Abstract
Further Categories Containing This Product:
NF-kB Pathway Other Products
•
Polyclonal Antibodies
•
Antiviral Signalling / Related Products
•
Interferons & Interferon Receptors Other Products
•
Caspase Recruitment Domain [CARD] Proteins / Related Products
ALX-210-354
Revised 30-Oct-06
Polyclonal Antibody to Resistin (human)
SYNONYMS
anti-ADSF (human) PAb
anti-FIZZ3 (human) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Resistin & Resistin-like Molecules [RELMs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-354-C100
100 µg
399.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml after reconstitution.
FORMULATION:
Lyophilized from sterile filtered solution of affinity purified antibody in 0.1M phosphate buffer, pH 7.2, containing 0.1M sodium chloride.
RECONSTITUTION:
Reconstitute with 100µl of distilled water and let the lyophilized pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect the activity of the antibody. In this case clarify the solution by centrifugation.
IMMUNOGEN:
Recombinant human resistin.
SPECIFICITY:
Recognizes human resistin.
APPLICATION:
ELISA
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Reconstituted antibody can be stored at +4°C for two weeks.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-357
Revised 02-Feb-06
Polyclonal Antibody to Resistin (mouse)
SYNONYMS
anti-ADSF (mouse) PAb
anti-FIZZ3 (mouse) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Resistin & Resistin-like Molecules [RELMs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-357-C200
200 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 21-39 (S
21
SMPLCPIDEAIDKKIKQD
39
) of mouse resistin.
SPECIFICITY:
Recognizes mouse resistin. Detects a band of ~14kDa by Western blot.
APPLICATION:
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-166-009
.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-358
Revised 30-Jul-07
Polyclonal Antibody to Perilipin A (mouse)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Perilipins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
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ALX-210-358-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Purified IgG.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 502-517 (E
502
PILGRTQYSQLRKKS
517
) of rat perilipin A. This sequence is 93% conserved in human perilipin A.
SPECIFICITY:
Recognizes mouse perilipin A. Detects a band of ~62kDa by Western blot.
APPLICATION:
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-053
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysisv
:
D.L. Brasaemle, et al.; J. Biol. Chem.
275
, 38486 (2000)
Abstract
;
Full Text
Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes
:
G.M. Clifford, et al.; J. Biol. Chem.
275
, 5011 (2000)
Abstract
;
Full Text
Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis
:
P.J. Havel; Exp. Biol. Med. (Maywood)
226
, 963 (2001)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-359
Revised 06-Jun-06
Polyclonal Antibody to Perilipin A/B (mouse)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Perilipins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-359-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
Purified IgG.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-17 (M
1
SMNKGPTLLDGDLPEQ
17
) of rat perilipin A and B. This sequence is 82% conserved in human perilipin.
SPECIFICITY:
Recognizes mouse perilipin A and B. Detects bands of ~62kDa (perilipin A) and ~46kDa (perilipin B) by Western blot.
APPLICATION:
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-054
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis
:
D.L. Brasaemle, et al.; J. Biol. Chem.
275
, 38486 (2000)
Abstract
;
Full Text
Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes
:
G.M. Clifford, et al.; J. Biol. Chem.
275
, 5011 (2000)
Abstract
;
Full Text
Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis
:
P.J. Havel; Exp. Biol. Med. (Maywood)
226
, 963 (2001)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-360
Revised 29-Sep-05
Polyclonal Antibody to ANGPTL4 (rat)
SYNONYMS
anti-Angiopoietin-like Protein 4 (rat) PAb
anti-FIAF (rat) PAb
anti-Fasting-induced Adipose Factor (rat) PAb
anti-HFARP (rat) PAb
anti-Hepatic Fibrinogen/Angiopoietin-related Protein (rat) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-360-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 80-94 (C
80
QGPKGKDAPFKDSE
94
) of mouse ANGPTL4 (angiopoietin-like protein 4).
SPECIFICITY:
Recognizes rat ANGPTL4. Detects a band of ~50kDa by Western blot.
APPLICATION:
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-156-004
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene
:
S. Kersten, et al.; J. Biol. Chem.
275
, 28488 (2000)
Abstract
;
Full Text
General Information
Adipose tissue is an energy reserve in animals and, in nondomestic species, is strictly regulated. Adipose cells produce and secrete numerous physiologically important proteins that help regulate whole body metabolism, such as leptin and adiponectin. Fasting causes significant changes in nutrient metabolism and many of these changes are controlled by transcription factors that regulate rate-limiting enzymes. An important transcription factor that mediates metabolic processes induced by fasting is peroxisome proliferator-activated receptor α (PPARα). PPARα has been reported to target a gene encoding the secreted protein ANGPTL4 (angiopoietin-like protein 4; FIAF; fasting-induced adipose factor). ANGPTL4 is expressed predominantly in adipose tissue and is strongly upregulated in white adipose tissue and the liver under fasting conditions. Initial studies suggest that ANGPTL4 represents an endocrine signal helping to regulate metabolism, especially under fasting conditions.
Related Products
ALX-156-004
Blocking Peptide for PAb to ANGPTL4 (Prod. No.
ALX-210-360
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-374
Revised 30-Oct-06
Polyclonal Antibody to GITR (mouse)
SYNONYMS
anti-TNFRSF 18 (mouse) PAb
anti-Glucocorticoid-induced TNFR-related Protein (mouse) PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
GITR & GITRL Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-374-C100
100 µg
290.00 USD
ALX-210-374B-C050
Biotin
50 µg
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rat.
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant mouse GITR.
SPECIFICITY:
Recognizes both natural and recombinant mouse GITR. Does not cross-react with human GITR (AITR).
APPLICATION:
ELISA
(direct and indirect: 1:5'000-1:10'000).
Flow Cytometry
(1:1'000).
Western Blot
(1:2'000-1:5'000 using ECL. Suggested blocking and dilution buffer is TBST with 0.05% Tween 20 with 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells
:
K.Y. Yu, et al.; BBRC
310
, 433 (2003)
Abstract
The soluble glucocorticoid-induced tumor necrosis factor receptor causes cell cycle arrest and apoptosis in murine macrophages
:
H.H. Shin, et al.; BBRC
316
, 24 (2004)
Abstract
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-375
Revised 30-Oct-06
Polyclonal Antibody to GITRL (mouse)
SYNONYMS
anti-TNFSF 18 (mouse) PAb
anti-Glucocorticoid-induced TNF Receptor Ligand (mouse) PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
GITR & GITRL Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-375-C100
100 µg
290.00 USD
ALX-210-375B-C050
Biotin
50 µg
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant mouse GITRL.
SPECIFICITY:
Recognizes both natural and recombinant mouse GITRL. Does not cross-react with human GITRL (AITRL).
APPLICATION:
ELISA
(direct and indirect: 1:5’000-1:10’000)
Flow Cytometry
(1:1’000)
Western Blot
(1:2’000-1:5’000 using ECL; suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5 % skim milk; suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells
:
K.Y. Yu, et al.; BBRC
310
, 433 (2003)
Abstract
The soluble glucocorticoid-induced tumor necrosis factor receptor causes cell cycle arrest and apoptosis in murine macrophages
:
H.H. Shin, et al.; BBRC
316
, 24 (2004)
Abstract
Soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) stimulates osteoclast differentiation in response to receptor activator of NF-kappaB ligand (RANKL) in osteoclast cells:
H.H. Shin, et al.; Bone
36
, 832 (2005)
Abstract
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-377
Revised 26-Jul-05
Polyclonal Antibody to Adiponectin (human)
