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Items 11 of 11
ALX-210-801
Revised 30-Oct-06
Polyclonal Antibody to Troy
SYNONYMS
anti-TAJ PAb
anti-TNFRSF 19 PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
EDA & EDAR, Troy / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-801-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptides corresponding to aa 29-44, 204-219 and 409-421 of human Troy (TAJ).
SPECIFICITY:
Recognizes human and mouse Troy. Detects a band of ~46kDa by Western blot.
APPLICATION:
Western Blot (0.5-2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
TAJ/TROY, an Orphan TNF Receptor Family Member, Binds Nogo-66 Receptor 1 and Regulates Axonal Regeneration
:
Z. Shao, et al.; Neuron
45
, 353 (2005)
Abstract
General Information
Analysis of EST clones and use of a signal sequence trap screening of the mouse brain have lead to identification of a new member of the tumor necrosis factor receptor superfamily designated as TAJ and Troy, respectively [3,2]. Troy is a membrane protein of 416 amino acids with characteristic cystene-rich motifs in the extracellular domain and a tumor necrosis factor receptor-associated factor (TRAF) 2 binding sequence in the cytoplasmic domain. Human Troy has 78% identity at the amino acid level with mouse Troy. The extracellular domain of Troy has significant homology with that of EDAR (another newly identified receptor belonging to TNF receptor family) that specifies hair follicle fate [1]. The cytoplasmic domain of Troy is different than other TNF receptor family members. Although its cytoplasmic domain does not contain death domain, Troy induced cell death is probably mediated through a caspase-independent pathway. Troy-induced JNK activation was not blocked by dominant-negative inhibitors of TRAF2, TRAF5, or ASK I, which have been previously implicated in JNK activation via TNF-R1 and CD40. However, coimmunoprecipitation assays revealed that Troy is capable of binding a number of different TRAF family members, and it is possible that Troy induced JNK activation is mediated by an as yet untested TRAF homolog, such as TRAF6. Troy mRNA is highly expressed in brain, prostate and embryo and moderately expressed in the heart, lung, liver.
General Literature References
[1]
Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia
:
A.W. Monreal, et al.; Nat. Genet.
22
, 366 (1999)
Abstract
[2]
TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles
:
T. Kojima, et al.; J. Biol. Chem.
275
, 20742 (2000)
Abstract
;
Full Text
[3]
TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death
:
M.T. Eby, et al.; J. Biol. Chem.
275
, 15336 (2000)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-931
Revised 31-Oct-06
Polyclonal Antibody to XEDAR (human) (AT108)
SYNONYMS
anti-X-linked Ectodysplasin-A2 Receptor (human) PAb (AT108)
anti-EDA-A2 Receptor (human) PAb (AT108)
anti-EDA2R (human) PAb (AT108)
anti-TNFRSF27 (human) PAb (AT108)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
EDA & EDAR, Troy / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-931-C050
50 µg
180.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human XEDAR (X-linked ectodysplasin-A2 receptor) (aa 1-133) (Prod. No.
ALX-522-049
).
SPECIFICITY:
Recognizes human XEDAR.
APPLICATION:
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
POSITIVE CONTROL:
XEDAR (human):Fc (human) (recombinant) (Prod. No.
ALX-522-049
).
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products
•
Polyclonal Antibodies
ALX-522-037
Revised 24-Oct-06
EDAR (human):Fc (human) (recombinant)
SYNONYMS
Anhidrotic Ectodysplasin-A1 Receptor (human):Fc (human) (recombinant)
EDA-A1 Receptor (human):Fc (human) (recombinant)
TNFRSF EDAR (human):Fc (human) (recombinant)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
EDA & EDAR, Troy / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-522-037-C050
50 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
Produced in
E. coli
. The cysteine-rich region of human EDAR (ectodysplasin-A receptor) (aa 1-183) is fused to the Fc portion of human IgG1.
CONCENTRATION:
1mg/ml after reconstitution.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:
Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY:
Binds human EDA-A1 (ectodysplasin-A1).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C.
Product Specific Literature References
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A:
P. Schneider, et al.; J. Biol. Chem.
276
, 18819 (2001)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q9UNE0:
EDAR (human) (precursor)
MANUFACTURER
Manufactured by Apotech Corporation.
Related Products
ALX-203-004
Control:Fc Fusion Protein (human) (recombinant)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-522-038
Revised 27-Mar-08
EDA-A1, Soluble (human) (recombinant)
SYNONYMS
Ectodysplasin-A1, Soluble (human) (recombinant)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
EDA & EDAR, Troy / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-522-038-C010
10 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW:
~20kDa (SDS-PAGE).
SOURCE/HOST:
Produced in
E. coli
. The extracellular domain of human EDA-A1 (ectodysplasin-A1) (aa 245-391) is fused at the N-terminus to a linker peptide (9 aa) and a FLAG
®
-tag.
CONCENTRATION:
0.1mg/ml after reconstitution.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:
Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY:
Binds to human EDAR (ectodysplasin-A1 receptor).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C.
Product Specific Literature References
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A:
P. Schneider, et al.; J. Biol. Chem.
276
, 18819 (2001)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q92838:
EDA-A1 (human)
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products
•
Recombinant Proteins / Fusion Proteins
ALX-522-045
Revised 24-Mar-05
Troy (human):Fc (human) (recombinant)
SYNONYMS
TAJ (human):Fc (human) (recombinant)
TNFRSF 19 (human):Fc (human) (recombinant)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
EDA & EDAR, Troy / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-522-045-C050
50 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW:
~48kDa (under reducing conditions).
SOURCE/HOST:
Produced in HEK 293 cells. The cysteine-rich domain of human Troy (TAJ) (aa 1-168) is fused to the Fc portion of human IgG1.
CONCENTRATION:
1mg/ml after reconstitution.
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:
Reconstitute in 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C. Once reconstituted, it is recommended to prepare appropriate aliquots and to store them at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Description
General Information
Troy, or TAJ, is a member of the tumor necrosis factor receptor (TNFR) family. Troy plays a role in axonal regeneration by forming a functional receptor complex with Nog-66 receptor 1 and LINGO-1. This receptor complex binds myelin inhibitors (Nogo-A, myelin.associated glycoprotein (MAG), oligodendrocyte myelin glycoprotein (OMgp) and signals myelin inhibition by activating RhoA. Troy also interacts with TRAF proteins and activates JNK.
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q9NS68:
Troy (human) (precursor)
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
A TNF Receptor Family Member, TROY, Is a Coreceptor with Nogo Receptor in Mediating the Inhibitory Activity of Myelin Inhibitors
:
J.B. Park, et al.; Neuron
45
, 345 (2005)
Abstract
TAJ/TROY, an Orphan TNF Receptor Family Member, Binds Nogo-66 Receptor 1 and Regulates Axonal Regeneration
:
Z. Shao, et al.; Neuron
45
, 353 (2005)
Abstract
Related Products
ALX-203-004
Control:Fc Fusion Protein (human) (recombinant)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
•
JNK [SAPK1] / Related Products
ALX-522-048
Revised 24-Oct-06
EDA-A2, Soluble (human) (recombinant)
SYNONYMS
Ectodysplasin-A2, Soluble (human) (recombinant)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
EDA & EDAR, Troy / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-522-048-C010
10 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW:
~28kDa (SDS-PAGE).
SOURCE/HOST:
Produced in HEK 293 cells. The extracellular domain of human EDA-A2 (ectodysplasin-A2) (aa 245-391) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG
®
-tag.
CONCENTRATION:
0.1mg/ml after reconstitution.
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:
Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY:
Binds to human XEDAR (X-linked ectodysplasin-A2 receptor).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C.
Product Specific Literature References
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A:
P. Schneider, et al.; J. Biol. Chem.
276
, 18819 (2001)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products
•
Recombinant Proteins / Fusion Proteins
ALX-522-049
Revised 18-Jul-06
XEDAR (human):Fc (human) (recombinant)
SYNONYMS
X-linked Ectodysplasin-A2 Receptor (human):Fc (human) (recombinant)
EDA-A2 Receptor (human):Fc (human) (recombinant)
EDA2R (human):Fc (human) (recombinant)
TNFRSF27 (human):Fc (human) (recombinant)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
EDA & EDAR, Troy / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-522-049-C050
50 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW:
~47kDa (SDS-PAGE).
SOURCE/HOST:
Produced in HEK 293 cells. The cysteine-rich domain of human XEDAR (X-linked ectodysplasin-A2 receptor) (aa 1-133) is fused to the Fc portion of human IgG1.
CONCENTRATION:
1mg/ml after reconstitution
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:
Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY:
Binds human EDA-A2 (ectodysplasin-A2).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C.
Product Specific Literature References
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A
:
P. Schneider, et al.; J. Biol. Chem.
276
, 18819 (2001)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q9HAV5:
XEDAR (human)
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors
:
M. Yan, et al.; Science
290
, 523 (2000)
Abstract
Related Products
ALX-203-004
Control:Fc Fusion Protein (human) (recombinant)
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products
•
Recombinant Proteins / Fusion Proteins
ALX-804-146
Revised 31-Oct-06
Monoclonal Antibody to Troy (human) (Giu.Li)
SYNONYMS
anti-TAJ (human) MAb (Giu.Li)
anti-TNFRSF 19 (human) MAb (Giu.Li)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
EDA & EDAR, Troy / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-146-C050
50 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
Giu.Li
ISOTYPE:
Rat IgG
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
0.3mg/ml
PURITY:
95% (SDS-PAGE)
FORMULATION:
Liquid. Antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human Troy cysteine-rich domain (aa 1-168) (Prod. No.
ALX-522-045
).
SPECIFICITY:
Recognizes human Troy.
APPLICATION:
Flow Cytometry
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored as recommended.
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles
:
T. Kojima, et al.; J. Biol. Chem.
275
, 20742 (2000)
Abstract
;
Full Text
TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death
:
M.T. Eby, et al.; J. Biol. Chem.
275
, 15336 (2000)
Abstract
;
Full Text
TRAF6-deficient mice display hypohidrotic ectodermal dysplasia
:
A. Naito, et al.; PNAS
99
, 8766 (2002)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-839
Revised 03-May-07
Monoclonal Antibody to EDA-A1 (Renzo-2)
SYNONYMS
anti-Ectodysplasin-A1 MAb (Renzo-2)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
EDA & EDAR, Troy / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-839-C100
100 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE:
Renzo-2
ISOTYPE:
Mouse IgG1
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human EDA-A1 (ectodysplasin-A1) extracellular domain (aa 245-391) (Prod. No
ALX-522-038
).
SPECIFICITY:
Recognizes human and mouse EDA-A1 and EDA-A2.
CROSSREACTIVITY PROTEINS:
EDA-A2
APPLICATION:
ELISA
Immunoprecipitation (1:100)
Flow Cytometry
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
POSITIVE CONTROL:
Prod. No.
ALX-522-038
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A:
P. Schneider, et al.; J. Biol. Chem.
276
, 18819 (2001)
Abstract
Related Products
ALX-522-038
EDA-A1, Soluble (human) (recombinant)
ALX-522-048
EDA-A2, Soluble (human) (recombinant)
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products
•
Monoclonal Antibodies
ALX-804-843
Revised 16-Aug-07
Monoclonal Antibody to EDA-A1 (Renzo-1)
