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Chemokines & Cytokines
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ALX-201-231 Revised 18-Mar-08
Leptin (rat) (recombinant)
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SYNONYMS OB Gene Product (rat) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
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ALX-201-231-M001   1 mg 190.00 USD Add To Cart
Product Specification
MW: ~16kDa.
MERCK INDEX: 14: 5443
SOURCE/HOST: Produced in E. coli. Homologous to rat serum leptin.
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Lyophilized from 0.0045mM sodium bicarbonate.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein.
RECONSTITUTION: Reconstitute with sterile water or 0.4% sodium bicarbonate, pH 8-9. Do not reconstitute to less than 0.1mg/ml. Further dilutions should be made with medium containing a carrier protein.
BIOLOGICAL ACTIVITY: Induces proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted protein is stable for 4 weeks when stored at +4°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
Leptin, the product of the ob (obese) gene, is a 16kDa protein consisting of 146 amino acid residues. Leptin is produced in the adipose tissue, and is considered to play an important role in appetite control, fat metabolism and regulation of body weight. It targets the central nervous system, particularly hypothalamus, affecting food intake. Leptin levels are high in most obese individuals. Studies have shown that it may also influence reproductive function.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P50596: Leptin (rat) (precursor)
General Literature References
Leptin and the regulation of body weight in mammals: J.M. Friedman and J.L. Halaas; Nature 395, 763 (1998), review Abstract
Mutation screening and identification of a sequence variation in the human ob gene coding region: R.V. Considine, et al.; BBRC 220, 735 (1996) Abstract
Serum immunoreactive leptin concentrations in normal-weight and obese humans  : R.V. Considine, et al. ; New Engl. J. Med. 334, 292 (1996) Abstract
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects  : M. Maffei, et al.; Nature Medicine 1, 1155 (1995) Abstract
Effects of the obese gene product on body weight regulation in ob/ob mice  : M.A. Pelleymounter, et al. ; Science 269, 540 (1995) Abstract
Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity  : R.V. Considine, et al. ; J. Clin. Invest 95, 2986 (1995) Abstract
Overexpression of the obese (ob) gene in adipose tissue of the human subjects  : F. Lönnqvist, et al. ; Nature Medicine 1, 950 (1995) Abstract
Positional cloning of the mouse obese gene and its human homologue  : Y. Zhang, et al.; Nature 372, 425 (1994) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-303 Revised 10-Jul-08
Adiponectin (rat) (recombinant)
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SYNONYMS ACRP30 (rat) (recombinant)
Adipocyte Complement Related Protein of 30kDa (rat) (recombinant)
AdipoQ (rat) (recombinant)
apM1 (rat) (recombinant)
GBP28 (rat) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
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ALX-201-303-C050   50 µg 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Rat adiponectin (aa 16-244) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION:

PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 30mM TRIS-HCl, pH 8.5.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; Bio Whittaker).
BIOLOGICAL ACTIVITY: Induces the phosphorylation of acetyl-CoA carboxylase (ACC) in C2C12 cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism: A.H. Berg, et al.; Trends Endocrinol. Metab. 13, 84 (2002), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-304 Revised 12-Nov-08
Adiponectin (Globular Domain) (human) (recombinant) (His)
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SYNONYMS ACRP30 (Globular Domain) (human) (recombinant) (His)
Adipocyte Complement Related Protein of 30kDa (Globular Domain) (human) (recombinant) (His)
AdipoQ (Globular Domain) (human) (recombinant) (His)
apM1 (Globular Domain) (human) (recombinant) (His)
GBP28 (Globular Domain) (human) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
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ALX-201-304-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The globular domain of human adiponectin (aa 104-244) is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 30mM TRIS-Cl, pH 8.5.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL test; Bio Whittaker).
BIOLOGICAL ACTIVITY: Effect on phosphorylation of acetyl-CoA carboxylase (ACC) in C2C12 cells (see Fig. 2).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q15848: Adiponectin (human) (precursor)
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism: A.H. Berg, et al.; Trends Endocrinol. Metab. 13, 84 (2002), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-305 Revised 08-Dec-06
Adiponectin (Globular Domain) (human) (recombinant)
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SYNONYMS ACRP30 (Globular Domain) (human) (recombinant)
Adipocyte Complement Related Protein of 30kDa (Globular Domain) (human) (recombinant)
AdipoQ (Globular Domain) (human) (recombinant)
apM1 (Globular Domain) (human) (recombinant)
GBP28 (Globular Domain) (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-305-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The globular domain of human adiponectin (aa 104-244) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION:   
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 30mM TRIS, pH 8.5.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; Bio Whittaker).
BIOLOGICAL ACTIVITY: Induces the phosphorylation of acetyl-CoA carboxylase (ACC) in C2C12 cells. Activates AMPK in HUVEC cells in a PI(3)K-independent way.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q15848: Adiponectin (human) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism: A.H. Berg, et al.; Trends Endocrinol. Metab. 13, 84 (2002), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-306 Revised 28-Nov-07
Adiponectin (Globular Domain) (mouse) (recombinant) (His)
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SYNONYMS ACRP30 (Globular Domain) (mouse) (recombinant) (His)
Adipocyte Complement Related Protein of 30kDa (Globular Domain) (mouse) (recombinant) (His)
AdipoQ (Globular Domain) (mouse) (recombinant) (His)
apM1 (Globular Domain) (mouse) (recombinant) (His)
GBP28 (Globular Domain) (mouse) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
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ALX-201-306-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The globular domain of mouse adiponectin (aa 104-247) is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 30mM TRIS-Cl, pH 8.5.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL test; Bio Whittaker).
BIOLOGICAL ACTIVITY: Induces the phosphorylation of acetyl-CoA carboxylase (ACC) in C2C12 cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q60994: Adiponectin (mouse) (precursor)
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism: A.H. Berg, et al.; Trends Endocrinol. Metab. 13, 84 (2002), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-307 Revised 22-May-06
GITRL, Soluble (mouse) (recombinant)
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SYNONYMS TNFSF 18, Soluble (mouse) (recombinant)
Glucocorticoid-induced TNF Receptor Ligand, Soluble (mouse) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY GITR & GITRL
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ALX-201-307-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 10mM glycine, pH 10.0.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; Bio Whittaker).
SPECIFICITY: Binds to mouse GITR.
APPLICATION: rmsGITRL can be used for GITR-mediated NF-κB activation.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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Product Specific Literature References
Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells: K.Y. Yu, et al.; BBRC 310, 433 (2003) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q7TS55: GITR Ligand (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-308 Revised 31-Aug-06
GITRL, Soluble (mouse) (recombinant) (His)
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SYNONYMS TNFSF 18, Soluble (mouse) (recombinant) (His)
Glucocorticoid-induced TNF Receptor Ligand, Soluble (mouse) (recombinant) (His)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY GITR & GITRL
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ALX-201-308-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The extracellular domain of mouse GITRL (aa 45-173) is fused at the C-terminus to a His-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 10mM glycin, pH 10.0.
ENDOTOXIN CONTENT: <1EU/mg protein (LAL test; Bio Whittaker).
SPECIFICITY: Binds to mouse GITR.
APPLICATION: rmsGITRL can be used for GITR-mediated NF-κB activation.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Specific Literature References
Soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) stimulates osteoclast differentiation in response to receptor activator of NF-kappaB ligand (RANKL) in osteoclast cells: H.H. Shin, et al.; Bone 36, 832 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q7TS55: GITR Ligand (mouse)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-309 Revised 09-Dec-06
Resistin (human) (recombinant)
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SYNONYMS ADSF (human) (recombinant)
FIZZ3 (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Resistin & Resistin-like Molecules [RELMs] / Related Products
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ALX-201-309-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Mature human resistin (aa 20-108) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS, pH 7.2.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; Bio Whittaker).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q9HD89: Resistin (human) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-310 Revised 09-Dec-06
Resistin (mouse) (recombinant)
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SYNONYMS ADSF (mouse) (recombinant)
FIZZ3 (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Resistin & Resistin-like Molecules [RELMs] / Related Products
Ordering Information
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ALX-201-310-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Full length mouse resistin (aa 21-114) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 1mg/ml 
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS, pH 7.2.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; Bio Whittaker).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q99P87: Resistin (mouse) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-311 Revised 01-Oct-08
Resistin (rat) (recombinant)
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SYNONYMS ADSF (rat) (recombinant)
FIZZ3 (rat) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Resistin & Resistin-like Molecules [RELMs] / Related Products
Ordering Information
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ALX-201-311-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The mature chain of rat resistin (aa 19-114) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: ~0.5mg/ml
PURITY: ≥95% (SDS-PAGE).
FORMULATION: Liquid. 0.2 µm-filtered solution in PBS, pH 7.2.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; Bio Whittaker).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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