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Chemokines & Cytokines
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ALX-270-066 Revised 07-Apr-08
Lavendustin C
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SYNONYMS Compound 5
5-(N-2,5-Dihydroxybenzyl)aminosalicylic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-066-M001   1 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C14H13NO5
MW: 275.3
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Potent inhibitor of protein tyrosine kinases and Ca2+/calmodulin-dependent kinase II. Acts also as an inhibitor of EGFR tyrosine kinase and pp60c-src kinase.
Product Specific Literature References
Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus: T. Onoda, et al.; J. Nat. Prod. 52, 1252 (1989) Abstract
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors: T.J. O'Dell, et al.; Nature 353, 558 (1991) Abstract
Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity: I. Takahashi, et al.; BBRC 165, 1207 (1989) Abstract
Inhibition of crystal-induced neutrophil activation by a protein tyrosine kinase inhibitor: H.M. Burt, et al.; J. Leukoc. Biol. 55, 112 (1994) Abstract
Endotoxin increases intercellular resistance in microvascular endothelial cells by a tyrosine kinase pathway: D. Lidington, et al.; J. Cell Physiol. 185, 117 (2000) Abstract
Related Products
Further Categories Containing This Product:
CAM Kinase Inhibitors • Tyrosine Kinase Inhibitors • EGFR Kinase Inhibitors • Lipopolysaccharides [LPS] / Related Products
 
 
ALX-270-098 Revised 16-Nov-06
Erbstatin analog
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SYNONYMS Methyl 2,5-dihydroxycinnamate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGFR Kinase Inhibitors
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ALX-270-098-M005   5 mg 55.00 USD Add To Cart
Product Specification
FORMULA: C10H10O4
MW: 194.2
CAS NUMBER: 63177-57-1
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to light brown crystalline solid.
SOLUBILITY: Soluble in methanol, DMSO or dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Considerably longer half-life in aqueous solution than erbstatin itself. Induces apoptosis.
Product Specific Literature References
Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors: K. Umezawa, et al.; FEBS Lett. 260, 198 (1990) Abstract
Inhibition of epidermal growth factor receptor functions by tyrosine kinase inhibitors in NIH3T3 cells: K. Umezawa, et al.; FEBS Lett. 314, 289 (1992) Abstract
Induction of mouse thymocyte apoptosis by inhibitors of tyrosine kinases is associated with dephosphorylation of nuclear proteins: Y. Azuma, et al.; Cell Immunol. 152, 271 (1993) Abstract
Inhibition of Abelson oncogene function by erbstatin analogues: M. Kawada, et al.; Drugs Exp. Clin. Res. 19, 235 (1993) Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-270-129 Revised 18-Jan-08
Tyrphostin AG 18
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SYNONYMS Tyrphostin A23
Tyrphostin RG 50858
Tyrphostin RG 50810
(3,4-Dihydroxybenzylidene)malononitrile
α-Cyano-(3,4-dihydroxy)cinnamonitrile
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
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ALX-270-129-M005   5 mg 35.00 USD Add To Cart
ALX-270-129-M025   25 mg 100.00 USD Add To Cart
Product Specification
FORMULA: C10H6N2O2
MW: 186.2
CAS NUMBER: 118409-57-7
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO or ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Store tightly sealed in the dark. Protect from light.

Product Specific Literature References
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem. 32, 2344 (1989) Abstract
Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation: R.M. Lyall, et al.; J. Biol. Chem. 264, 14503 (1989) Abstract; Full Text
Cholecystokinin rapidly activates mitogen-activated protein kinase in rat pancreatic acini: R.D. Duan & J.A. Williams; Am. J. Physiol. 267, G401 (1994) Abstract
Role of tyrosine kinase and protein kinase C in the steroidogenic actions of angiotensin II, alpha-melanocyte-stimulating hormone and corticotropin in the rat adrenal cortex: S. Kapas, et al.; Biochem. J. 305, 433 (1995) Abstract
Differential activation of mitogen-activated protein kinase and S6 kinase signaling pathways by 12-O-tetradecanoylphorbol-13-acetate (TPA) and insulin. Evidence for involvement of a TPA-stimulated protein- tyrosine kinase: R. Seger, et al.; J. Biol. Chem. 270, 28325 (1995) Abstract; Full Text
Further Categories Containing This Product:
EGFR Kinase Inhibitors • Tyrosine Kinase Inhibitors
 
 
ALX-270-141 Revised 07-Dec-04
Tyrphostin AG 527
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SYNONYMS Tyrphostin B44
(-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
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ALX-270-141-M005   5 mg 25.00 USD Add To Cart
ALX-270-141-M025   25 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C18H16N2O3
MW: 308.3
CAS NUMBER: 133550-32-0
PURITY: ≥98%
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Store tightly sealed in the dark. Protect from light.

Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases: A. Gazit, et al.; J. Med. Chem. 34, 1896 (1991) Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors • Tyrosine Kinase Inhibitors
 
 
ALX-270-142 Revised 11-Dec-04
Tyrphostin AG 555
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SYNONYMS Tyrphostin B46
N-(3-Phenylpropyl)-3,4-dihydroxy-benzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
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ALX-270-142-M005   5 mg 25.00 USD Add To Cart
ALX-270-142-M025   25 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C19H18N2O3
MW: 322.4
PURITY: ≥98%
SOLUBILITY: Soluble in DMSO or ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Store tightly sealed in the dark. Protect from light.

Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases: A. Gazit, et al.; J. Med. Chem. 34, 1896 (1991) Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors • Tyrosine Kinase Inhibitors
 
 
ALX-270-143 Revised 20-Feb-08
Tyrphostin AG 494
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SYNONYMS Tyrphostin B48
N-Phenyl-3,4-dihydroxybenzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-phenylcinnamamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
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ALX-270-143-M005   5 mg 25.00 USD Add To Cart
ALX-270-143-M025   25 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C16H12N2O3
MW: 280.3
CAS NUMBER: 133550-35-3
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Blocks CDK2 activation and causes cells to arrest at late G1 and during S phase.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases: A. Gazit, et al.; J. Med. Chem. 34, 1896 (1991) Abstract
Tyrphostin AG 494 blocks Cdk2 activation: N. Osherov & A. Levitzki; FEBS Lett. 410, 187 (1997) Abstract
Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase: N. Kleinberger-Doron, et al.; Exp. Cell Res. 241, 340 (1998) Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors • Tyrosine Kinase Inhibitors • CDK & Cyclin Inhibitors • Cell Cycle Blockers & Inhibitors / Related Products
 
 
ALX-270-144 Revised 07-Dec-04
Tyrphostin AG 835
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SYNONYMS Tyrphostin B50
(+)-(S)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
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ALX-270-144-M005   5 mg 25.00 USD Add To Cart
ALX-270-144-M025   25 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C18H16N2O3
MW: 308.3
CAS NUMBER: 133550-37-5
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Store tightly sealed in the dark. Protect from light.

Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases: A. Gazit, et al.; J. Med. Chem. 34, 1896 (1991) Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors • Tyrosine Kinase Inhibitors
 
 
ALX-270-146 Revised 11-Dec-04
Tyrphostin AG 556
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SYNONYMS Tyrphostin B56
N-(4-Phenylbutyl)-3,4-dihydroxybenzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-(4-phenylbutyl)cinnamamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
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ALX-270-146-M005   5 mg 25.00 USD Add To Cart
ALX-270-146-M025   25 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C20H20N2O3
MW: 336.4
CAS NUMBER: 133550-41-1
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Store tightly sealed in the dark. Protect from light.

Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases: A. Gazit, et al.; J. Med. Chem. 34, 1896 (1991) Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors • Tyrosine Kinase Inhibitors
 
 
ALX-270-215 Revised 15-Apr-05
Tyrphostin AG 1517
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SYNONYMS PD 153,035
SU 5271
4-(3-Bromoanilino)-6,7-dimethoxyquinazoline
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
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ALX-270-215-M005   5 mg 85.00 USD Add To Cart
ALX-270-215-M025   25 mg 330.00 USD Add To Cart
Product Specification
FORMULA: C16H14BrN3O2
MW: 360.2
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Store tightly sealed in the dark. Protect from light.

Further Categories Containing This Product:
EGFR Kinase Inhibitors
 
 
ALX-270-263 Revised 03-Apr-08
(-)-Epigallocatechin gallate
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SYNONYMS EGCG
(2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
Ordering Information
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ALX-270-263-M010   10 mg 20.00 USD Add To Cart
ALX-270-263-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C22H18O11
MW: 458.4
CAS NUMBER: 989-51-5
MERCK INDEX: 14: 3526
SOURCE/HOST: Isolated from green tea.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in 100% ethanol, dimethyl formamide or DMSO; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stock solutions in DMSO are stable for up to 3 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Keep under inert gas. Protect from light.

Product Description
Antitumor reagent. Antioxidant. Protects cells from lipid peroxidation and DNA damage induced by reactive free radicals. Inhibits inducible nitric oxide synthase (iNOS; NOS II). Chemopreventive anticancer agent. Induces apoptosis in human cancer cell lines. Inhibits MAP kinase mediated signalling pathways. Inhibits angiogenesis. Inhibits telomerase and DNA methyltransferase. Anti-inflammatory agent.
Product Specific Literature References
Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin: M.T. Huang, et al.; Carcinogenesis 13, 947 (1992) Abstract
Inhibition of 12-O-tetradecanoylphorbol-13-acetate and other skin tumor-promoter-caused induction of epidermal interleukin-1 alpha mRNA and protein expression in SENCAR mice by green tea polyphenols: S.K. Katiyar, et al.; J. Invest. Dermatol. 105, 394 (1995) Abstract
Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate: S. Liao, et al.; Cancer Lett. 96, 239 (1995) Abstract
Inhibition of N-methyl-N'-nitro-N-nitrosoguanidine-induced carcinogenesis by (-)-epigallocatechin gallate in the rat glandular stomach: T. Yamane, et al.; Cancer Res. 55, 2081 (1995) Abstract
(-)-Epigallocatechin gallate, a polyphenolic tea antioxidant, inhibits peroxynitrite-mediated formation of 8-oxodeoxyguanosine and 3-nitrotyrosine: E.S. Fiala, et al.; Experientia 52, 922 (1996) Abstract
Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells: N. Ahmad, et al.; J. Natl. Cancer Inst. 89, 1881 (1997) Abstract
Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea: M.M. Chan, et al.; Biochem. Pharmacol. 54, 1281 (1997) Abstract
(-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB: Y.L. Lin & J.K. Lin; Mol. Pharmacol. 52, 465 (1997) Abstract
Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins: I. Naasani, et al.; BBRC 249, 391 (1998) Abstract
Epigallocatechin suppression of proliferation of vascular smooth muscle cells: correlation with c-jun and JNK: L.H. Lu, et al.; Br. J. Pharmacol. 124, 1227 (1998) Abstract
ESR study on the structure-antioxidant activity relationship of tea catechins and their epimers: Q. Guo, et al.; Biochim. Biophys. Acta 1427, 13 (1999) Abstract
Pharmacokinetics of the green tea derivative, EGCG, by the topical route of administration in mouse and human skin: K. Dvorakova, et al.; Cancer Chemother. Pharmacol. 43, 331 (1999) Abstract
Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin: S.K. Katiyar, et al.; Photochem. Photobiol. 69, 148 (1999)