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CD137 & CD137L / Related Products
You are here: Product Lines > Chemokines & Cytokines > TNF & TNF Receptor Superfamily / Related Products > CD137 & CD137L / Related Products
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ALX-522-031 Revised 20-Jun-05
CD137 (human):Fc (human) (recombinant)
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SYNONYMS 4-1BB (human):Fc (human) (recombinant)
TNFRSF 9 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD137 & CD137L / Related Products
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ALX-522-031-C050   50 µg 360.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~50kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The cysteine-rich region of human CD137 (4-1BB) (aa 1-186) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds human CD137L (4-1BBL).
APPLICATION: Can be used together with anti-human IgG1 PAb to detect membrane-bound human CD137.
Functional Application: Induces proliferation of monocytes.
Note: Induction of monocyte proliferation by CD137 required immobilization of the CD137 protein, e.g. by coating of the protein to the surface of the tissue culture dishes.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
CD137 induces proliferation and endomitosis in monocytes: J. Langstein, et al.; Blood 94, 3161 (1999) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q07011: CD137 (human) (precursor)
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
ALX-201-329 Revised 18-Mar-08
CD137 (mouse):Fc (human) (recombinant)
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SYNONYMS 4-1BB (mouse):Fc (human) (recombinant)
TNFRSF9 (mouse):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD137 & CD137L / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-329-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse CD137 (4-1BB) (aa 1-185) is fused at the C-terminus to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P20334: Tumor necrosis factor receptor superfamily member 9 (human) (precursor)
MANUFACTURER Manufactured by Adipogen, Inc.
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
ALX-201-321 Revised 28-Jan-08
CD137L, Soluble (mouse) (recombinant)
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SYNONYMS 4-1BBL, Soluble (mouse) (recombinant)
TNFSF 9, Soluble (mouse) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD137 & CD137L / Related Products
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ALX-201-321-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse CD137L (4-1BBL) (aa 104-309) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY:

Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P41274: CD137L (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-115 Revised 27-Mar-08
CD137L, Soluble (mouse) (recombinant)
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SYNONYMS 4-1BBL, Soluble (mouse) (recombinant)
TNFSF 9, Soluble (mouse) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD137 & CD137L / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-115-C010   10 µg 140.00 USD Add To Cart
ALX-522-115-3010 SuperPack 3x10 µg 260.00 USD Add To Cart
Product Specification
MW: ~40kDa
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse CD137L (aa 104-309) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophillized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to mouse CD137 (4-1BB).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
The CD137 ligand (CD137L, 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response.
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P41274: CD137L (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • CD Proteins
 
 
ALX-201-376 Revised 28-Jan-08
CD137L, Soluble (mouse) (recombinant) (His)
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SYNONYMS 4-1BBL, Soluble (mouse) (recombinant) (His)
TNFSF 9, Soluble (mouse) (recombinant) (His)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD137 & CD137L / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-376-C010   10 µg 140.00 USD Add To Cart
ALX-201-376-C050   50 µg 390.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The extracellular domain of mouse CD137L (4-1BBL) (aa 106-309) is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 55mM TRIS-HCl, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY:

Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P41274: CD137L (mouse)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • CD Proteins
 
 
ALX-522-032 Revised 25-Feb-08
CD137L, Soluble (human) (recombinant)  - Replaced by Prod. No. ALX-522-111
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PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD137 & CD137L / Related Products
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not sold in USA
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-111 Revised 27-Mar-08
CD137L, Soluble (human) (recombinant)
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SYNONYMS 4-1BBL, Soluble (human) (recombinant)
TNFSF 9, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD137 & CD137L / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-111-C010   10 µg 140.00 USD Add To Cart
ALX-522-111-3010 SuperPack 3x10 µg 260.00 USD Add To Cart
Product Specification
MW: ~27kDa
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human CD137L (aa 49-254) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS and 5% trehalose.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to human CD137 (4-1BB).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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Product Description
Biologically active CD137L (4-1BBL; TNFSF 9) comprising the whole extracellular tail domain (aa 49-93), which is important for the cross-linking of the protein that is essential for its biological activity [1].
Product Specific Literature References
[1] Production of recombinant human trimeric CD137L (4-1BBL). Cross-linking is essential to its T cell co-stimulation activity: C. Rabu, et al.; J. Biol. Chem. 280, 41472 (2005) Abstract; Full Text
General Information
The CD137 ligand (CD137L, 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P41274: CD137L (human)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • CD Proteins
 
 
ALX-805-066 Revised 11-Apr-07
Monoclonal Antibody to CD137 (mouse) (M4173)
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SYNONYMS anti-4-1BB (mouse) MAb (M4173)
anti-TNFRSF 9 (mouse) MAb (M4173)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD137 & CD137L / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-066-C050   50 µg 220.00 USD Add To Cart
ALX-805-066-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: M4173
ISOTYPE: Rat IgG1
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant mouse CD137 (4-1BB).
SPECIFICITY: Recognizes mouse CD137. Detects a band of ~40kDa by Western blot. Does not cross-react with human CD137.
APPLICATION: ELISA
Flow Cytometry (1:500)
Western Blot (1:2’000-1:5’000)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-714 Revised 11-Jun-08
Monoclonal Antibody to CD137L (human) (41B436)
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SYNONYMS anti-4-1BBL (human) MAb (41B436)
anti-TNFSF 9 (human) MAb (41B436)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD137 & CD137L / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-714-C050   50 µg 195.00 USD Add To Cart
ALX-804-714-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 41B436
ISOTYPE: Mouse IgG1κ
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant human CD137L (4-1BBL) extracellular domain.
SPECIFICITY: Recognizes extracellular domain of human CD137L. Does not cross-react with mouse CD137L.
APPLICATION: ELISA (direct and indirect (1:500-1:5’000))
Flow Cytometry (1:1’000)
Western Blot (1:2’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-210-414 Revised 03-Oct-05
Polyclonal Antibody to CD137 (human)
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SYNONYMS anti-4-1BB (human) PAb
anti-TNFRSF 9 (human) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD137 & CD137L / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-414-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Human CD137.
SPECIFICITY: Recognizes human CD137. Detects a band of ~29kDa by Western blot. Does not cross-react with mouse CD137.
APPLICATION: Flow Cytometry (1:500-1:1'000)
Western Blot (1:2'000-1:5'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Polyclonal Antibodies • CD Antibodies
 
 
ALX-210-825 Revised 08-Dec-04
Polyclonal Antibody to CD137 (mouse)
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SYNONYMS anti-4-1BB (mouse) PAb
anti-TNFRSF 9 (mouse) PAb
PRODUCT LINE Chemokines & Cytokines