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Platelet-derived Growth Factors [PDGFs] & Receptors / Related Products
You are here: Product Lines > Chemokines & Cytokines > Growth Factors / Related Products > Platelet-derived Growth Factors [PDGFs] & Receptors / Related Products
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ALX-165-019 Revised 24-Feb-05
PDGF Fragment (phosphorylated) (cyclic)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY SH2 & SH3 Domains
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-165-019-MC01   0.1 mg 50.00 USD Add To Cart
ALX-165-019-M001   1 mg 250.00 USD Add To Cart
Product Specification
SEQUENCE: cyclo(Gly-Tyr(PO3H2)-Val-Pro-Met-Leu)
FORMULA: C32H49N6O10PS
MW: 740.8
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Cyclic hexapeptide inhibitor of SH2 interactions. The peptide sequence represents the autophosphorylation region around Tyr751 of the PDGF β-receptor.
Product Specific Literature References
Synthesis of phosphonomethyl-phenylalanine and phosphotryrosine containing cyclic peptides as inhibitors of protein kinase/SN2 interactions: M. Nomizu, et al.; Tetrahedron 50, 2691 (1994)
Further Categories Containing This Product:
Peptides • Platelet-derived Growth Factors [PDGFs] & Receptors / Related Products
 
 
ALX-165-005 Revised 16-Feb-05
PDGF β-Receptor (719-723) (phosphorylated)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY SH2 & SH3 Domains
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-165-005-M001   1 mg 130.00 USD Add To Cart
ALX-165-005-M005   5 mg 520.00 USD Add To Cart
Product Specification
SEQUENCE: H-Tyr(PO3H2)-Val-Pro-Met-Leu-OH
FORMULA: C30H48N5O10PS
MW: 701.8
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Contains the PDGF β-receptor recognition sequence which specifically interacts with the SH2 domain of PI(3)K (phosphoinositide 3-kinase). In this phosphorylated form the peptide inhibits the binding of the 85kDa subunit of PI(3)K to the PDGF β-receptor.
Product Specific Literature References
Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways: W.J. Fantl, et al.; Cell 69, 413 (1992) Abstract
Closing in on SH2 specificity: R.B. Birge & H. Hanafusa; Science 262, 1522 (1993) Abstract
Further Categories Containing This Product:
Peptides • Platelet-derived Growth Factors [PDGFs] & Receptors / Related Products
 
 
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