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ALX-505-005
Revised 23-Jul-08
KillerTRAIL™ Storage and Dilution Buffer
PRODUCT LINE
Molecular Biology
PRODUCT CATEGORY
Buffers/Detergents/Solutions
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-505-005-R500
500 µl
60.00 USD
Product Specification
PURITY DETAIL:
Sterile filtered.
FORMULATION:
Liquid. 20mM HEPES, pH 7.4, containing 300mM NaCl, 0.01% Tween 20, 1% sucrose and 1mM DTT.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Description
Storage and dilution buffer for use with the following products:
Killer
TRAIL™, Soluble (human) (recombinant) (Prod. No.
ALX-201-073
)
Super
Killer
TRAIL™, Soluble (human) (recombinant) (Prod. No.
ALX-201-115
)
Super
Killer
TRAIL™, Soluble (mouse) (recombinant) (Prod. No.
ALX-201-130
)
Useful for prediluting the above mentioned products before preparing aliquots or performing experiments. Predilution with
Killer
TRAIL™ Storage and Dilution Buffer allows for easier handling of small working concentrations (sometimes only 0.1µl of the
Killer
TRAIL™ or Super
Killer
TRAIL™ stock solution is necessary because of their high activity). Predilution with
Killer
TRAIL™ Storage and Dilution Buffer instead of medium or PBS prevents loss of biological activity. Can also be used as negative control.
General Information
BACKGROUND/TECHNICAL INFORMATION
Prepare a 1:10 dilution of
Killer
TRAIL™ or Super
Killer
TRAIL™ with
Killer
TRAIL™ Storage and Dilution Buffer. For immediate use, keep prediluted
Killer
TRAIL™ or Super
Killer
TRAIL™ on ice until adding to cells. For storage, prepare aliquots and freeze at -80°C.
Related Products
ALX-201-115
Super
Killer
TRAIL™, Soluble (human) (recombinant)
ALX-201-073
Killer
TRAIL™, Soluble (human) (recombinant)
ALX-201-130
Super
Killer
TRAIL™, Soluble (mouse) (recombinant)
Further Categories Containing This Product:
TRAIL [Apo-2L]
ALX-270-113
Revised 08-Apr-08
Phloretin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Protein Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-113-M100
100 mg
37.00 USD
Product Specification
FORMULA:
C
15
H
14
O
5
MW:
274.3
CAS NUMBER:
60-82-2
MERCK INDEX:
14:
7326
PURITY:
≥98%
APPEARANCE:
Off-white to beige solid.
SOLUBILITY:
Soluble in acetone, DMSO, 100% ethanol or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Flavonoid. Protein kinase C (PKC) inhibitor. PGF
2a
receptor antagonist. In astrocytes, these receptors are linked to phospholipase C, thus affecting phosphoinositide hydrolysis and intracellular Ca
2+
levels. Inhibits
myo
-inositol uptake and 5’-iodothyronine deiodinase. Prevents TNF-α stimulated upregulation of VCAM-1, ICAM-1 and E-selectin. Enhances adiponectin expression.
Product Specific Literature References
Effects on water diffusion of inhibitors affecting various transport processes in human red blood cells:
G. Benga, et al.; Eur. J. Cell Biol.
59
, 219 (1992)
Abstract
Phloretin as an antagonist of prostaglandin F2 alpha receptor in cultured rat astrocytes:
J. Kitanaka, et al.; J. Neurochem.
60
, 704 (1993)
Abstract
Characterization of the inhibition by stilbene disulphonates and phloretin of lactate and pyruvate transport into rat and guinea-pig cardiac myocytes suggests the presence of two kinetically distinct carriers in heart cells:
X. Wang, et al.; Biochem. J.
290
, 249 (1993)
Abstract
The effect of glucose and galactose toxicity on myo-inositol transport and metabolism in human skin fibroblasts in culture:
G.T. Berry, et al.; Pediat. Res.
35
, 141 (1994)
Abstract
Activating effect of the flavonoid phloretin on Ca(2+)-activated K+ channels in myelinated nerve fibers of Xenopus laevis:
D.S. Koh, et al.; Neurosci. Lett.
165
, 167 (1994)
Abstract
Thyroid hormones in tissues from fetal and adult rats:
G. Morreale de Escobar; Endocrinology
134
, 2410 (1994)
Abstract
Gonadotropin-releasing hormone induced Ca2+ influx in nonsecreting pituitary adenoma cells: role of voltage-dependent Ca2+ channels and protein kinase C:
N. Prevarskaya, et al.; Mol. Cell. Neurosci.
5
, 699 (1994)
Abstract
The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets:
V. Stangl, et al.; J. Nutr.
135
, 172 (2005)
Abstract
Phloretin enhances adipocyte differentiation and adiponectin expression in 3T3-L1 cells:
M. Hassan, et al.; BBRC
361
, 208 (2007)
Abstract
Further Categories Containing This Product:
Adiponectin [ACRP30]/Related Products
•
PKC Inhibitors
•
Adhesion Molecules & Receptors Other Products
•
Active Substances from Fruit and Vegetables
ALX-350-335
Revised 14-Nov-07
Cochlioquinone A
SYNONYMS
Luteoleersin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Angiogenesis Research
Ordering Information
Product Numbers:
Format:
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ALX-350-335-MC05
0.5 mg
260.00 USD
Product Specification
FORMULA:
C
30
H
44
O
8
MW:
532.7
CAS NUMBER:
32450-25-2
SOURCE/HOST:
Isolated from
Bipolaris leersia
MST-FP107.
PURITY:
≥99% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Shows antiangiogenic and nematocidal activities. Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of diacylglycerol acyltransferase, diacylglycerol kinase and NADH-ubiquinone reductase.
Product Specific Literature References
Cochlioquinone A, a nematocidal agent which competes for specific [3H]ivermectin binding sites:
J.M. Schaeffer, et al.; J. Antibiot. (Tokyo)
43
, 1179 (1990)
Abstract
Epi-cochlioquinone A, a novel acyl-CoA : cholesterol acyltransferase inhibitor produced by Stachybotrys bisbyi:
T. Fujioka, et al.; J. Antibiot. (Tokyo)
49
, 409 (1996)
Abstract
Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola:
H.J. Jung, et al.; Bioorg. Med. Chem.
11
, 4743 (2003)
Abstract
Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1:
H.B. Lee, et al.; J. Antibiot. (Tokyo)
56
, 967 (2003)
Abstract
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum:
K. Yoganathan, et al.; J. Antibiot. (Tokyo)
57
, 59 (2004)
Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors/Related Products
•
Vitamins
•
NAD+ Metabolism/Related Products
ALX-350-341
Revised 14-Nov-07
Cochlioquinone B
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Angiogenesis Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-341-MC05
0.5 mg
260.00 USD
Product Specification
FORMULA:
C
28
H
40
O
6
MW:
472.6
CAS NUMBER:
32450-26-3
SOURCE/HOST:
Isolated from
Bipolaris leersia
MST-FP107.
PURITY:
≥99% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of NADH-ubiquinone reductase. Phytotoxic agent inhibiting root growth.
Product Specific Literature References
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum:
K. Yoganathan, et al.; J. Antibiot. (Tokyo)
57
, 59 (2004)
Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors/Related Products
•
Vitamins
•
NAD+ Metabolism/Related Products
ALX-270-478
Revised 29-Jan-08
SB 225002
SYNONYMS
N-(2-Bromophenyl)-N’-(2-hydroxy-4-nitrophenyl)urea
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CXC Chemokines & Receptors/Related Products
Ordering Information
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Format:
Size:
Unit Price:
Quantity:
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ALX-270-478-M001
1 mg
30.00 USD
ALX-270-478-M005
5 mg
90.00 USD
Product Specification
FORMULA:
C
13
H
10
BrN
3
O
4
MW:
352.1
CAS NUMBER:
182498-32-4
PURITY:
≥98% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO (40mg/ml), 100% ethanol or methanol (15mg/ml); slightly soluble in acetonitrile (2mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent and selective antagonist of CXCR2 chemokine receptor (IC
50
=22nM). >150-fold more selective over CXCR1 receptor. Inhibits IL-8- (IC
50
=8nM) and GROα-mediated (IC
50
=10nM) calcium mobilisation. Prevents IL-8-induced neutrophil migration. Inhibits HIV replication in lymphocytes and macrophages.
Product Specific Literature References
Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration:
J.R. White, et al.; J. Biol. Chem.
273
, 10095 (1998)
Abstract
;
Full Text
Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen alpha (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2:
J. Catusse, et al.; Biochem. Pharmacol.
65
, 813 (2003)
Abstract
A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer:
B. Wang, et al.; Cancer Res.
66
, 3071 (2006)
Abstract
;
Full Text
Further Categories Containing This Product:
Interleukins Other Products
•
HIV/AIDS/Related Products
ALX-350-119
Revised 20-Feb-08
Fumagillin
SYNONYMS
Fumidil B
Fumadil B
TNP-470
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics for Angiogenesis Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-119-MC05
0.5 mg
65.00 USD
ALX-350-119-M001
1 mg
105.00 USD
Product Specification
FORMULA:
C
26
H
34
O
7
MW:
458.6
CAS NUMBER:
23110-15-8
MERCK INDEX:
14:
4286
SOURCE/HOST:
Isolated from
Aspergillus fumigatus.
PURITY:
≥95%
APPEARANCE:
Light yellow solid
SOLUBILITY:
Soluble in chloroform or diluted aqueous bases. Slightly soluble in methanol and other alcoholic solvents. Insoluble in water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Unstable in aqueous solutions with pH >9.0 or pH <5.0.
HANDLING:
Packaged under inert gas. Protect from light.
HAZARD:
HARMFUL.
Product Description
Inhibitor of angiogenesis and endothelial cell proliferation. Specific inhibitor of methionine aminopeptidase type II (MetAP-II). Antineoplastic. Anti-infective.
Product Specific Literature References
Fumagillin (H-3), a new antibiotic with amebicidal properties
:
C.M. Mc, et al.; Science
113
, 202 (1951)
Abstract
Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth
:
D. Ingber, et al.; Nature
348
, 555 (1990)
Abstract
The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase
:
W.T. Lowther, et al.; PNAS
95
, 12153 (1998)
Abstract
;
Full Text
Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2:
E.C. Griffith, et al.; PNAS
95
, 15183 (1998)
Abstract
Fumagillin treatment of intestinal microsporidiosis:
J.M. Molina, et al.; N. Engl. J. Med.
346
, 1963 (2002)
Abstract
Whirling disease of salmonid fish: life cycle, biology, and disease:
M.A. Gilbert & W.O. Granath, Jr.; J. Parasitol.
89
, 658 (2003)
Abstract
Fumagillin treatment of hepatocellular carcinoma in rats: an in vivo study of antiangiogenesis:
I.S. Sheen, et al.; World J. Gastroenterol.
11
, 771 (2005)
Abstract
Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors:
B. Lefkove, et al.; Expert Rev. Anti Infect. Ther.
5
, 573 (2007), Review
Abstract
FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin (TNP-470):
G.J. Chen, et al.; J. Cell Biochem.
101
, 1492 (2007)
Abstract
Further Categories Containing This Product:
Aminopeptidases/Related Products
•
Fibroblast Growth Factors [FGFs] & Receptors/Related Products
•
Antitumor Agents (Anti-proliferative)
•
Natural Products - Other Anti-infective Agents
•
Antitumor Antibiotics
ALX-350-280
Revised 03-Jul-08
Xanthohumol
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products - DNA Regulation/Transcription
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-350-280-M005
5 mg
135.00 USD
Product Specification
FORMULA:
C
21
H
22
O
5
MW:
354.4
CAS NUMBER:
569-83-5, 6754-58-1
SOURCE/HOST:
Isolated from hops (
Humulus lupulus
).
PURITY:
≥98% (NMR)
APPEARANCE:
Yellow to orange powder.
SOLUBILITY:
Soluble in DMSO (25mg/ml) or methanol (10mg/ml); soluble in aqueous buffers up to 20μM.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stable as powder for at least 6 months when stored at +4°C in the dark. Stock solution made in DMSO should not be stored for longer than one month. Working solution is stable for 24 hours at 37°C and up to one week when stored at +4°C. Unstable in acidic (pH < 4.5) and alkaline (pH > 7.5) systems.
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Prenylated chalcone found in beer. Potent inhibitor of diacylglycerol acetyltransferase (DGAT), which catalyzes the final step in mammalian triacylglycerol synthesis. Inhibits DNA polymerase and induces cell differentiation. Has antiproliferative and cytotoxic effects in human cancer cell lines. Inhibits human P450 enzymes. Induces quinone reductase. Inhibits the expression of HIF-1α and VEGF under hypoxic conditions. Induces apoptosis in mature adipocytes.
Product Specific Literature References
Xanthohumols, diacylglycerol acyltransferase inhibitors, from
Humulus lupulus
:
N. Tabata, et al.; Phytochemistry
46
, 683 (1997)
Abstract
Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (
Humulus lupulus
) in human cancer cell lines:
C.L. Miranda, et al.; Food Chem. Toxicol.
37
, 271 (1999)
Abstract
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops,
Humulus lupulus
:
M.C. Henderson, et al.; Xenobiotica
30
, 235 (2000)
Abstract
Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells:
C.L. Miranda, et al.; Cancer Lett.
149
, 21 (2000)
Abstract
Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop
:
C. Gerhauser, et al.; Mol. Cancer Ther.
1
, 959 (2002)
Abstract
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
:
J.F. Stevens & J.E. Page; Phytochemistry
65
, 1317 (2004), (Review)
Abstract
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis:
J.Y. Yang, et al.; Apoptosis
12
, 1953 (2007)
Abstract
Further Categories Containing This Product:
Antitumor Agents (Anti-proliferative)
•
Hypoxia-inducible Factor [HIF]/Related Products
•
Cell Differentiation
•
Estrogen & Estrogen Receptors/Related Products
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Respiratory Chain Other Products
•
Obesity & Diabetes Other Products
•
Active Substances from Fruit and Vegetables
•
Natural Products - Antitumor Reagents
•
VEGFs
•
Lipid Metabolism Other Products
•
Flavonoids/Related Products
ALX-270-342
Revised 06-Dec-04
MAZ51
SYNONYMS
3-(4-Dimethylamino-naphthalen-1-yl-methylene)-1,3-dihydro-indol-2-one
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
VEGFs & VEGF-Rs Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-342-M002
2 mg
90.00 USD
Product Specification
FORMULA:
C
21
H
18
N
2
O
MW:
314.4
CAS NUMBER:
163655-37-6
PURITY:
≥98%
APPEARANCE:
Orange crystals.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Keep under inert gas. Protect from light.
HAZARD:
TOXIC.
Product Description
Inhibits vascular endothelial cell growth factor-C (VEGF-C)-induced intracellular phosphorylation of VEGFR-3 (Flt-4) (IC
50
=1µM).
Product Specific Literature References
Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2
:
V. Kirkin, et al.; Eur. J. Biochem.
268
, 5530 (2001)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
ALX-270-442
Revised 12-Jun-08
CDK1/2 Inhibitor III
SYNONYMS
5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1
H
-1,2,4-triazole-1-carbothioamide
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
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ALX-270-442-M001
1 mg
118.00 USD
Product Specification
FORMULA:
C
15
H
13
F
2
N
7
O
2
S
2
MW:
425.4
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING:
Protect from light.
HAZARD:
HARMFUL.
IDENTITY:
Identity determined by NMR.
Product Description
Cell permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC
50
=20nM, 35nM and 92nM in HCT-116, HeLa, and A375 cells). Acts as a highly potent, ATP-competitive inhibitor of CDK1/cyclin B and CDK2/cyclin A (IC
50
=600pM and 500pM) with selectivity over VEGF-R2 and GSK-3β (IC
50
=32nM and 140nM).
Product Specific Literature References
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities:
R. Lin, et al.; J. Med. Chem.
48
, 4208 (2005)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
Antitumor Agents (Anti-proliferative)
•
VEGFs & VEGF-Rs Other Products
•
GSK-3 Inhibitors
ALX-270-469
Revised 06-Jun-08
BAY 43-9006
SYNONYMS
N-[4-Chloro-3-(trifluoromethyl)phenyl]-([4-[2-(N-methylcarbamoyl)(4-pyridyloxy)]phenyl]amino)-carboxamide
