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Chemokines & Cytokines
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ALX-210-621 Revised 31-Jul-07
Polyclonal Antibody to CCR4 (mouse)
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SYNONYMS anti-C-C Chemokine Receptor 4 (mouse) PAb
anti-CD194 (mouse) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-621-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml.
PURITY DETAIL: Epitope-affinity purified F(ab`)2 fragment.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 8-26 (D8TTQDETVYNS
YYFYESMP26C) of the N-terminal extracellular domain of mouse CCR4 (C-C chemokine receptor 4).
SPECIFICITY: Recognizes mouse CCR4. Does not cross-react with human CCR4.
APPLICATION: Flow Cytometry (1-3µl per 2x105 cells per 50µl)
Immunocytochemistry (1:500)
Western Blot  (1:1’000)
QUALITY CONTROL: Immunocytochemistry on mouse spleen cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-020.
General Information
Mouse CCR4 is the homolog of human CCR4 receptor (85% identical), binding macrophage inflammatory protein-1α (MIP-1α) and RANTES. Mouse CCR4 transcripts are expressed in the thymus and in T-cell lines.
General Literature References
Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4: A. Hoogewerf, et al.; BBRC 218, 337 (1996) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-742 Revised 31-Jul-07
Polyclonal Antibody to CCR4 (mouse)
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SYNONYMS anti-C-C Chemokine Receptor 4 (mouse) PAb
anti-CD194 (mouse) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-742-R100   100 µl 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified F(ab)2 fragment.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 8-26 (D8TTQDETVYNSYYFY
ESMP26) of the N-terminal extracellular domain of mouse CCR4 (C-C chemokine receptor 4).
SPECIFICITY: Recognizes mouse CCR4. Does not cross-react with human CCR4.
APPLICATION: Immunocytochemistry (1:500)
Immunohistochemistry (paraffin sections)
Western Blot (1:1’000)
QUALITY CONTROL: Immunocytochemistry on mouse spleen cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-020.
Product Specific Literature References
Dendritic cell immunization route determines CD8+ T cell trafficking to inflamed skin: role for tissue microenvironment and dendritic cells in establishment of T cell-homing subsets: J.C. Dudda, et al.; J. Immunol. 172, 857 (2004) Abstract
General Information
Mouse CCR4 is the homolog of human CCR4 receptor (85% identical), binding macrophage inflammatory protein-1α (MIP-1α) and RANTES. Mouse CCR4 transcripts are expressed in the thymus and in T-cell lines.
General Literature References
Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4: A. Hoogewerf, et al.; BBRC 218, 337 (1996) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies • CD Antibodies
 
 
ALX-210-823 Revised 25-Jan-07
Polyclonal Antibody to CCR5 (human)
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SYNONYMS anti-C-C Chemokine Receptor 5 (human) PAb
anti-CD195 (human) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-823-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 3-30 (Y3QVSSPIYDINYYTSEPCQKINVKQIAA30) of the N-terminal domain of human CCR5 (C-C chemokine receptor 5).
SPECIFICITY: Recognizes human CCR5.
APPLICATION: ELISA (1:100’000)
Immunocytochemistry (1:300)
Immunohistochemistry (paraffin sections (1:300))
Western Blot (1:1’000)
QUALITY CONTROL: Immunocytochemistry on human peripheral blood or immunohistochemistry on paraffin sections of human spleen.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-039.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-843 Revised 25-Jan-07
Polyclonal Antibody to CCR6
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SYNONYMS anti-C-C Chemokine Receptor 6 PAb
anti-CD196 PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-843-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 18-46 (Y18FVSVNTSYYSVDSEMLLCSLQEVRQFSR46) of human CCR6 (C-C chemokine receptor 6). Peptide sequence is <50% identical to other human chemokine receptors in this region.
SPECIFICITY: Recognizes human and mouse CCR6.
APPLICATION: ELISA (1:75'000)
Flow Cytometry (1-3µl per 106 cells/50-100µl)
Immunocytochemistry (1:300)
Immunohistochemistry (paraffin sections (1:250))
Western Blot
QUALITY CONTROL: Immunocytochemistry on human spleen or peripheral blood.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-045.
General Literature References
Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC: M. Baba, et al.; J. Biol. Chem. 272, 14893 (1997) Abstract; Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-844 Revised 25-Jan-07
Polyclonal Antibody to CCR7
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SYNONYMS anti-C-C Chemokine Receptor 7 PAb
anti-CD197 PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-844-C100   100 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From goat.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 2-22 (D2PGKPRKNVLVVALLVIFQVC22) of mouse CCR7 (C-C chemokine receptor 7).
SPECIFICITY: Recognizes human and mouse CCR7.
APPLICATION: Flow Cytometry (1:10)
Immunocytochemistry (1:500)
Immunohistochemistry (paraffin sections (1:250))
Western Blot (1:1’000)
QUALITY CONTROL: Immunohistochemistry on mouse spleen.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-046.
General Information
BACKGROUND/TECHNICAL INFORMATION Sequence comparison:
Mouse CCR7: DPGKPRKNVLVVALLVIFQVC
Human CCR7: DLGHPMKSVLVVALLVIFQVC
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-764 Revised 24-Jan-07
Polyclonal Antibody to CCR8 (human)
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SYNONYMS anti-C-C Chemokine Receptor 8 (human) PAb
anti-CD198 (human) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-764-C100   100 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From goat.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 184-193 (Y184SFYNQQTLK193) of the 2nd extracellular domain of human CCR8 (C-C Chemokine Receptor 8).
SPECIFICITY: Recognizes human CCR8.
APPLICATION: Immunocytochemistry (acetone fixed cells (1:800))
Immunohistochemistry (paraffin sections (1:300))
Western Blot (1:2'000)
QUALITY CONTROL: Immunocytochemistry on human K562 cells.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-025.
Product Specific Literature References
Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor: M. Samson, et al.; Eur. J. Immunol. 26, 3021 (1996) Abstract
The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains: R. Horuk, et al.; J. Biol. Chem. 273, 386 (1998) Abstract; Full Text
The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium: N.S. Haque, et al.; Blood 97, 39 (2001) Abstract; Full Text
CC Chemokine I-309 is the Principal Monocyte Chemoattractant Induced by Apolipoprotein(a) in Human Vascular Endothelial Cells: N.S. Haque, et al.; Circulation 102, 786 (2000) Abstract; Full Text
Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL: N.E. Annels, et al.; Blood 103, 2806 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Immunohistochemistry on paraffin sections:

Fix paraffin sections in 10% formalin.  De-wax sections and block endogenous peroxide by incubating sections with 3% H2O2 for 15 minutes at room temperature (RT).  Wash sections with PBS and incubate with 2% normal rabbit serum at room temperature to block the non-specific binding sites.  Wash  sections with PBS and incubate with primary antibody (anti-chemokine receptor) at recommended dilution for 60 minutes at RT.  Wash slides and incubate at RT with biotinylated rabbit anti-goat IgG H+L (Vector Labs) at 1:200 dilution for 30 minutes.  Wash slides and incubate with HRP-Streptavidin (Vector Labs) 1:400 dilution for 30 minutes.  Wash slides and incubate with DAB for 5-7 minutes at RT.  Wash slides with PBS and counter stain with hematoxylin.

Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-762 Revised 25-Jan-07
Polyclonal Antibody to CCR8 (human) (NT)
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SYNONYMS anti-C-C Chemokine Receptor 8 (human) (NT) PAb
anti-CD198 (human) (NT) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-762-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 12-36 (V12TDYYYPDIFSSPCDAELIQTNGKL36) of the N-terminal extracellular domain of human CCR8 (C-C chemokine receptor 8).
SPECIFICITY: Recognizes human CCR8.
APPLICATION: Flow Cytometry (2-5µl per 106 cells/50-100µl)
Immunocytochemistry (acetone fixed cells (1:800))
Immunohistochemistry (paraffin sections (1:250))
Western Blot (1:2’000)
Functional Application (neutralizing; inhibits Lp(a) induced MCA in HUVECS)
QUALITY CONTROL: Immunocytochemistry on human K562 cells and immunohistochemistry on human spleen tissue slices.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-024.
Product Specific Literature References
The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains: R. Horuk, et al.; J. Biol. Chem. 273, 386 (1998) Abstract; Full Text
Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor: M. Samson, et al.; Eur. J. Immunol. 26, 3021 (1996) Abstract
CC Chemokine I-309 is the Principal Monocyte Chemottractant Induced by Apolipoprotein(a) in Human Vascular Endothelial Cells: N.S. Haque; Circulation 102, 786 (2000) Abstract
The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium: N.S. Haque; Blood 97, 39 (2001) Abstract
CCL16 activates an angiogenic program in vascular endothelial cells: M. Strasly, et al.; Blood 103, 40 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Immunohistochemistry on paraffin sections:
Fix paraffin sections in 10% formalin. De-wax sections and block endogenous peroxide by incubating sections with 3% H2O2 for 15 min. at room temperature (RT).  Wash sections with PBS and incubate with 2% normal rabbit serum at room temperature to block non-specific binding sites.  Wash sections with PBS and incubate with primary antibody (anti-chemokine receptor) at recommended dilution for 60 min. at RT.  Wash slides and incubate at RT with biotinylated rabbit anti-goat IgG H+L (Vector Labs) at 1:200 dilution for 30 min.  Wash slides and incubate with HRP-Streptavidin (Vector Labs) 1:400 dilution for 30 min.  Wash slides and incubate with DAB for 5-7 min. at RT.  Wash slides with PBS and counter stain with hematoxylin.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-845 Revised 25-Jan-07
Polyclonal Antibody to CCR8 (mouse)
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SYNONYMS anti-C-C Chemokine Receptor 8 (mouse) PAb
anti-CD198 (mouse) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-845-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 7-33 (P7NVTMTDYYPDFFTA
PCDAEFLLRGSM33) of mouse CCR8 (C-C chemokine receptor 8).
SPECIFICITY: Recognizes mouse CCR8.
APPLICATION: Immunocytochemistry (1:500)
Immunohistochemistry (paraffin sections (1:400))
Western Blot (1:1’000)
QUALITY CONTROL: Immunocytochemistry on mouse spleen cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-047.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-846 Revised 25-Jan-07
Polyclonal Antibody to CCR9
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SYNONYMS anti-C-C Chemokine Receptor 9 PAb
Polyclonal Antibody to CDw199
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-846-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 10-38 (I10PGMFDDFSYDSTASTDDYMNLNFSSFFC38) of mouse CCR9 (C-C chemokine receptor 9). Peptide sequence is <50% identical to other mouse chemokine receptors in this region.
SPECIFICITY: Recognizes human and mouse CCR9.
APPLICATION: Flow Cytometry (2-5µg/50µl per 2x105 cells)
Immunocytochemistry (1:500)
Immunohistochemistry (paraffin sections (1:250))
Western Blot (1:1’000)
QUALITY CONTROL: Immunocytochemistry on mouse thymus or lymph nodes.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-048.
General Literature References
Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK: A. Zaballos, et al.; J. Immunol. 162, 5671 (1999) Abstract; Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-847 Revised 25-Jan-07
Polyclonal Antibody to CCR9 (human)
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SYNONYMS anti-C-C Chemokine Receptor 9 (human) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-847-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 10-38 (I10PNMADDYGSESTSSMEDYVNFNFTDFYC38) of human CCR9 (C-C chemokine receptor 9).
SPECIFICITY: Recognizes human CCR9.
APPLICATION: ELISA
Immunocytochemistry (1:300)
Immunohistochemistry (paraffin sections (1:250))
Western Blot (1:1’000)
Functional Application (blocks TECK mediated stimulation of ES-2 cells)
QUALITY CONTROL: Immunocytochemistry on human thymus, spleen or MOLT4 cell line.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.