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Vascular Endothelial Growth Factors [VEGFs] & Receptors [VEGF-Rs] / Related Products
You are here: Product Lines > Chemokines & Cytokines > Growth Factors / Related Products > Vascular Endothelial Growth Factors [VEGFs] & Receptors [VEGF-Rs] / Related Products
 
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ALX-385-008 Revised 13-Mar-08
Apigenin
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SYNONYMS 4',5,7-Trihydroxyflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavones
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ALX-385-008-M010   10 mg 35.00 USD Add To Cart
ALX-385-008-M050   50 mg 105.00 USD Add To Cart
Product Specification
FORMULA: C15H10O5
MW: 270.2
CAS NUMBER: 520-36-5
MERCK INDEX: 14: 730
SOURCE/HOST: Synthetic.
PURITY: ≥90% (HPLC)
APPEARANCE: Light yellow to slightly brown powder.
SOLUBILITY: Soluble in diluted potassium hydroxide or DMSO; slightly soluble in 100% ethanol (hot). Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT.

Product Description
Antioxidant flavonoid. Has chemopreventive and antitumor properties. Induces apoptosis. Inhibits the proliferation of malignant tumor cells by G2/M arrest. MAP kinase (MAPK/ERK) inhibitor. Inhibits hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression.
Product Specific Literature References
Apigenin and tangeretin enhance gap junctional intercellular communication in rat liver epithelial cells: C. Chaumontet, et al.; Carcinogenesis 15, 2325 (1994) Abstract
Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells: F. Sato, et al.; BBRC 204, 578 (1994) Abstract
Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes: M.L. Kuo and N.C. Yang; BBRC 212, 767 (1995) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression: V. Trochon, et al.; Int. J. Cancer 85, 691 (2000) Abstract
Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma: R. Torkin, et al.; Mol. Cancer Ther. 4, 1 (2005) Abstract
Apigenin and cancer chemoprevention: progress, potential and promise: D. Patel, et al.; Int. J. Oncol. 30, 233 (2007), (Review) Abstract
Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression: J. Fang, et al.; Carcinogenesis 28, 858 (2007) Abstract
Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells: S. Shukla & S. Gupta; Cell Cycle 6, 1102 (2007) Abstract
Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation: C. Nicholas, et al.; J. Immunol. 179, 7121 (2007) Abstract
Further Categories Containing This Product:
MAPK Pathway Inhibitors • Hypoxia-inducible Factor [HIF] / Related Products • Natural Products - Protein Kinase Inhibitors • VEGFs & VEGF-Rs Other Products • Natural Products for Angiogenesis Research • Natural Products - Chemopreventive Agents • Antitumor Agents (Enzyme Inhibitors) • Natural Products - Apoptosis Inducers & Inhibitors • Antitumor Agents (Anti-proliferative) • Natural Products - Antitumor Reagents • Natural Products - Antioxidants
 
 
ALX-380-208 Revised 03-Apr-08
Asterric acid
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SYNONYMS Dimethylosoic acid
TAN 1415A
WF 12880A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Angiogenesis Research
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ALX-380-208-M001   1 mg 220.00 USD Add To Cart
Product Specification
FORMULA: C17H16O8
MW: 348.3
CAS NUMBER: 577-64-0
SOURCE/HOST: Isolated from Aspergillus terreus MST-FP1370.
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Antibiotic. Inhibitor of vascular endothelial growth factor (VEGF).
Product Specific Literature References
Studies in the biochemistry of micro-organisms. 115. Metabolites of Penicillium frequentans Westling: isolation of sulochrin, asterric acid, (+)-bisdechlorogeodin and two new substituted anthraquinones, questin and questinol: A. Mahmoodian and C.E. Stickings; Biochem. J. 92, 369 (1964) Abstract; Full Text
Asterric acid, a new endothelin binding inhibitor: H. Ohashi, et al.; J. Antibiot. (Tokyo) 45, 1684 (1992) Abstract
Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs: H.J. Lee, et al.; J. Antibiot. (Tokyo) 55, 552 (2002) Abstract
Further Categories Containing This Product:
VEGFs & VEGF-Rs Other Products • Tyrosine Kinase Inhibitors
 
 
ALX-270-469 Revised 06-Jun-08
BAY 43-9006
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SYNONYMS N-[4-Chloro-3-(trifluoromethyl)phenyl]-([4-[2-(N-methylcarbamoyl)(4-pyridyloxy)]phenyl]amino)-carboxamide
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY VEGFs & VEGF-Rs Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-469-M001   1 mg 60.00 USD Add To Cart
ALX-270-469-M005   5 mg 240.00 USD Add To Cart
ALX-270-469-M025   25 mg 720.00 USD Add To Cart
Product Specification
FORMULA: C21H16ClF3N4O3
MW: 464.8
CAS NUMBER: 284461-73-0
SOURCE/HOST: Synthetic.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol, methanol or ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description
Broad-spectrum kinase inhibitor.
Product Specific Literature References
Sorafenib (BAY 43-9006, Nexavar((R))), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature: L. Adnane, et al.; Meth. Enzymol. 407, 597 (2005) Abstract
The kinase inhibitor Sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress: M. Rahmani, et al.; Mol. Cell. Biol. 27, 5499 (2007) Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
 
 
ALX-270-442 Revised 21-Oct-08
CDK1/2 Inhibitor III
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SYNONYMS 5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-270-442-M001   1 mg 118.00 USD Add To Cart
Product Specification
FORMULA: C15H13F2N7O2S2
MW: 425.4
CAS NUMBER: 443798-55-8
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (10mg/ml), tetrahydro-furan or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING: Protect from light.
HAZARD: HARMFUL.
IDENTITY: Identity determined by NMR.

Product Description
Cell permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50=20nM, 35nM and 92nM in HCT-116, HeLa, and A375 cells). Acts as a highly potent, ATP-competitive inhibitor of CDK1/cyclin B and CDK2/cyclin A (IC50=600pM and 500pM) with selectivity over VEGF-R2 and GSK-3β (IC50=32nM and 140nM).
Product Specific Literature References
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities: R. Lin, et al.; J. Med. Chem. 48, 4208 (2005) Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • GSK-3 Inhibitors • VEGFs & VEGF-Rs Other Products • Antitumor Agents (Anti-proliferative)
 
 
ALX-270-342 Revised 06-Dec-04
MAZ51
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SYNONYMS 3-(4-Dimethylamino-naphthalen-1-yl-methylene)-1,3-dihydro-indol-2-one
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY VEGFs & VEGF-Rs Other Products
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ALX-270-342-M002   2 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C21H18N2O
MW: 314.4
CAS NUMBER: 163655-37-6
PURITY: ≥98%
APPEARANCE: Orange crystals.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep under inert gas. Protect from light.
HAZARD: TOXIC.

Product Description
Inhibits vascular endothelial cell growth factor-C (VEGF-C)-induced intracellular phosphorylation of VEGFR-3 (Flt-4) (IC50=1µM).
Product Specific Literature References
Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2: V. Kirkin, et al.; Eur. J. Biochem. 268, 5530 (2001) Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
 
 
ALX-380-221 Revised 14-Nov-07
Sulochrin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Angiogenesis Research
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ALX-380-221-M001   1 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C17H16O7
MW: 332.3
CAS NUMBER: 519-57-3
SOURCE/HOST: Isolated from Aspergillus terreus MST-FP1370.
PURITY: ≥99% (HPLC)
APPEARANCE: Pale yellow solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Fungal metabolite found in a number of Aspergillus and Penicillium sp. Inhibitor of vascular endothelial growth factor (VEGF). Antiangiogenic agent. Inhibits eosinophil activation and chemotaxis.
Product Specific Literature References
Studies in the biochemistry of micro-organisms. 115. Metabolites of Penicillium frequentans Westling: isolation of sulochrin, asterric acid, (+)-bisdechlorogeodin and two new substituted anthraquinones, questin and questinol: A. Mahmoodian and C.E. Stickings; Biochem. J. 92, 369 (1964) Abstract; Full Text
Sulochrin inhibits eosinophil degranulation: H. Ohashi, et al.; J. Antibiot. (Tokyo) 50, 972 (1997) Abstract
Sulochrin inhibits eosinophil activation and chemotaxis: H. Ohashi, et al.; Inflamm. Res. 47, 409 (1998) Abstract
Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs: H.J. Lee, et al.; J. Antibiot. (Tokyo) 55, 552 (2002) Abstract
Further Categories Containing This Product:
Antibiotics - Immunomodulators • VEGFs & VEGF-Rs Other Products • Tyrosine Kinase Inhibitors
 
 
ALX-850-298 Revised 11-Apr-08
VEGF-A (human) BioLISA Kit
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SYNONYMS Vascular Endothelial Growth Factor A (human) BioLISA Kit
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY VEGFs
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ALX-850-298-KI01   1 Kit 682.00 USD Add To Cart
Product Specification
SENSITIVITY: 7.26pg/ml (range 15.6 to 1000pg/ml)
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of active human VEGF-A in cell culture supernatant, serum, plasma and other body fluids.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Description
Compared to normal ELISA kits, this kit uses rsVEGFR-1 to capture the antigen instead of an antibody, thus only biologically active VEGF-A will be measured.
Product Specific Literature References
Anti-angiogenic effect of silymarin on colon cancer LoVo cell line: S.H. Yang, et al.; J. Surg. Res. 113, 133 (2003) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P15692: VEGF-A (human) (precursor)
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-850-306 Revised 14-Apr-08
VEGF-C (human) ELISA Kit
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SYNONYMS Vascular Endothelial Growth Factor C (human) ELISA Kit
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY VEGFs
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ALX-850-306-KI01   1 Kit 619.00 USD Add To Cart
Product Specification
SENSITIVITY: 12.8pg/ml (range 46.9 to 3000pg/ml)
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of active human VEGF-C (vascular endothelial growth factor C) in cell culture supernatants, serum and other body fluids.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-850-264 Revised 07-May-08
sVEGFR-1 (human) ELISA Kit
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SYNONYMS Vascular Endothelial Growth Factor Receptor 1, Soluble (human) ELISA Kit
Flt-1, Soluble (human) ELISA Kit
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY VEGF Receptors
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ALX-850-264-KI01   1 Kit 619.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.06ng/ml (range 0.16 to 10ng/ml)
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of human sVEGFR-1 in cell culture supernatants, serum and other body fluids.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Specific Literature References
Poor responder-high responder: the importance of soluble vascular endothelial growth factor receptor 1 in ovarian stimulation protocols: J. Neulen, et al.; Hum. Reprod. 16, 621 (2001) Abstract; Full Text
Identification of a soluble form of the angiopoietin receptor TIE-2 released from endothelial cells and present in human blood: P. Reusch, et al.; Angiogenesis 4, 123 (2001) Abstract
Soluble VEGFR-1 secreted by endothelial cells and monocytes is present in human serum and plasma from healthy donors: B. Barleon, et al.; Angiogenesis 4, 143 (2001) Abstract
Significance of vascular endothelial growth factor (VEGF)/soluble VEGF receptor-1 relationship in breast cancer: M. Toi, et al.; Int. J. Cancer 98, 14 (2002) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P17948: VEGFR-1 (human) (precursor)
AfCS Signalling Gateway link A000948: VEGFR-1 (mouse)
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-350-280 Revised 07-Oct-08
Xanthohumol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-280-M005   5 mg 135.00 USD Add To Cart
Product Specification
FORMULA: C21H22O5
MW: 354.4
CAS NUMBER: 569-83-5, 6754-58-1
SOURCE/HOST: Isolated from hops (Humulus lupulus).
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow to orange powder.
SOLUBILITY: Soluble in DMSO (25mg/ml), methanol (10mg/ml) or 100% ethanol; soluble in aqueous buffers up to 20μM.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable as powder for at least 6 months when stored at +4°C in the dark. Stock solution made in DMSO should not be stored for longer than one month. Working solution is stable for 24 hours at 37°C and up to one week when stored at +4°C. Unstable in acidic (pH < 4.5) and alkaline (pH > 7.5) systems.
IDENTITY: Identity determined by NMR.

Product Description
Prenylated chalcone found in beer. Potent inhibitor of diacylglycerol acetyltransferase (DGAT). Inhibits DNA polymerase and induces cell differentiation. Has antiproliferative and cytotoxic effects in human cancer cell lines. Inhibits human P450 enzymes. Induces quinone reductase. Inhibits the expression of HIF-1α and VEGF under hypoxic conditions. Induces apoptosis in mature adipocytes.
Product Specific Literature References
Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus: N. Tabata, et al.; Phytochemistry 46, 683 (1997) Abstract
Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines: C.L. Miranda, et al.; Food Chem. Toxicol. 37, 271 (1999) Abstract
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus: M.C. Henderson, et al.; Xenobiotica 30, 235 (2000) Abstract
Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells: C.L. Miranda, et al.; Cancer Lett. 149, 21 (2000) Abstract
Can