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Items 9 of 9
ALX-522-102
Revised 27-Mar-08
CTRP5 (mouse) (recombinant)
SYNONYMS
C1q Tumor Necrosis Factor-α-related Protein 5, Soluble (mouse) (recombinant)
C1qTNF5, Soluble (mouse) (recombinant)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
C1q Tumor Necrosis Factor-alpha-related Proteins [CTRPs]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-522-102-C010
10 µg
290.00 USD
Product Specification
SOURCE/HOST:
Produced in
E. coli
. Recombinant mouse CTRP5 (aa 16-243) is fused at the N-terminus to a linker peptide (14 aa) and a FLAG
®
-tag.
CONCENTRATION:
0.1mg/ml after reconstitution.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:
Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
CTRP5 is a member of the CTRP familly designated as C1q tumor necrosis factor-related proteins. The CTRPs are paralogs of the adiponectin protein caracterized by an N-termius variable region and C-terminal globular domain (C1q). CTRP5 is a putative secreted protein. A mutation in CTRP5 gene has been genetically linked to the Late-onset retinal degeneration (L-ORD) disease wich lead to severe visual loss.
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q8K479:
CTRP5 (mouse)
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
A family of Acrp30/adiponectin structural and functional paralogs:
G.W. Wong, et al.; PNAS
101
, 10302 (2004)
Abstract
Mutation in a short-chain collagen gene, CTRP5, results in extracellular deposit formation in late-onset retinal degeneration: a genetic model for age-related macular degeneration:
C. Hayward, et al.; Hum. Mol. Genet.
12
, 2657 (2003)
Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-201-352
Revised 13-Aug-08
CTRP2 (Globular Domain) (human) (recombinant)
SYNONYMS
C1q Tumor Necrosis Factor-α-related Protein 2 (Globular Domain) (human) (recombinant)
C1QTNF2 (Globular Domain) (human) (recombinant)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
C1q Tumor Necrosis Factor-alpha-related Proteins [CTRPs]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-352-C010
10 µg
295.00 USD
ALX-201-352-C050
50 µg
795.00 USD
Product Specification
SOURCE/HOST:
Produced in HEK 293 cells. The globular domain of human CTRP2 (c1q tumor necrosis factor-α-related protein 2) (aa 144-285) is fused at the N-terminus to a FLAG
®
-tag.
CONCENTRATION:
0.25mg/ml
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg protein (LAL-test).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q9BXJ5:
CTRP2 (human)
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER
Manufactured by AdipoGen, Inc.
General Literature References
A family of Acrp30/adiponectin structural and functional paralogs:
G.W. Wong, et al.; PNAS
101
, 10302 (2004)
Abstract
;
Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-201-369
Revised 22-Oct-08
CTRP2 (Globular Domain) (mouse) (recombinant)
SYNONYMS
C1q Tumor Necrosis Factor-α-related Protein 2 (Globular Domain) (mouse) (recombinant)
C1QTNF2 (Globular Domain) (mouse) (recombinant)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
C1q Tumor Necrosis Factor-alpha-related Proteins [CTRPs]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-369-C010
10 µg
295.00 USD
ALX-201-369-C050
50 µg
795.00 USD
Product Specification
SOURCE/HOST:
Produced in HEK 293 cells. The globular domain of mouse CTRP2 (c1q tumor necrosis factor-α-related protein 2) (aa 151-294) is fused at the N-terminus to a FLAG
®
-tag.
CONCENTRATION:
0.25mg/ml
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg protein (LAL-test).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
APO-54N-023
Revised 22-Oct-07
CTRP7 Detection Set [For ELISA Application]
SYNONYMS
C1q Tumor Necrosis Factor-α-related Protein 7 Detection Set [For ELISA Application]
C1qTNF7 Detection Set [For ELISA Application]
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
C1q Tumor Necrosis Factor-alpha-related Proteins [CTRPs]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
APO-54N-023-KI01
1 Set
560.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SENSITIVITY:
0.1ng/ml (range 0 to 10ng/ml).
QUANTITY:
For 5x96 wells.
KIT/SET CONTAINS:
1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION:
For the quantitative determination of human and mouse CTRP7 from biological fluids (serum and cell culture supernatant).
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
General Information
Adipose tissue functions as storage of energy and plays an active role in monitoring and controlling whole-body metabolism by secreting a number of proinflammatory adipokines, (such as leptin, resistin, tumor necrosis factor-α and interleukin-6), as well as one anti-inflammatory adipokine, adiponectin. Adiponectin is involved in controlling the whole-body metabolism, particularly by increasing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle [1]. Recently, a new highly conserved family of adiponectin paralogs designated as C1q/Tumor Necrosis Factor-α-Related Proteins (CTRPs) 1-7, has been described in mouse and human [2-5]. This family of proteins exhibits similar structural and biological properties to adiponectin. The CTRPs, unlike adiponectin whose expression is restricted to adipose tissue, are widely expressed by many different adult tissues. Like adiponectin, CTRP2 rapidly induces acetyl-CoA carboxylase, and mitogen-activated protein kinase phosphorylation in C2C12 myotubes, which resulted in increased glycogen accumulation and fatty acid oxidation, and CTRP7 (as well as CTRPs 1, 2 and 3) induces AMP-activated protein kinase phosphorylation. The activity of the CTRPs suggests that some members of the CTRP family of proteins could substitute for adiponectin function
in vivo
.
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q8BVD7:
CTRP7 (mouse)
Swiss-Prot link Q9BXJ2:
CTRP7 (human)
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
[1]
Adipose tissue, adipokines, and inflammation:
G. Fantuzzi; J. Allergy Clin. Immunol.
115
, 911 (2005)
Abstract
[2]
A family of Acrp30/adiponectin structural and functional paralogs:
G.W. Wong, et al.; PNAS
101
, 10302 (2004)
Abstract
[3]
C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen:
G. Lasser, et al.; Blood
107
, 423 (2006)
Abstract
[4]
Cartducin, a paralog of Acrp30/adiponectin, is induced during chondrogenic differentiation and promotes proliferation of chondrogenic precursors and chondrocytes:
T. Maeda, et al.; J. Cell Physiol.
206
, 537 (2006)
Abstract
[5]
The adiponectin paralog CORS-26 has anti-inflammatory properties and is produced by human monocytic cells:
J. Weigert, et al.; FEBS Lett.
579
, 5565 (2005)
Abstract
Related Products
ALX-210-924
Polyclonal Antibody to CTRP7 (AT103)
ALX-804-835
Monoclonal Antibody to CTRP7 (Anna-1)
Further Categories Containing This Product:
ELISA Sets
ALX-804-834
Revised 31-Oct-06
Monoclonal Antibody to CTRP2 (mouse) (Didoo-1)
SYNONYMS
anti-C1q Tumor Necrosis Factor-α-related Protein 2 (mouse) MAb (Didoo-1)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
C1q Tumor Necrosis Factor-alpha-related Proteins [CTRPs]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-834-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
Didoo-1
ISOTYPE:
Mouse IgG2b
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse CTRP2 (C1q tumor necrosis factor-α-related protein 2) (aa 26-260).
SPECIFICITY:
Recognizes mouse CTRP2.
APPLICATION:
ELISA
Immunoprecipitation (1:200)
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
Adiponectin is involved in controlling the whole-body metabolism, particularly by increasing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle. CTRP2 belongs to a new highly conserved family of adiponectin paralogs designated as C1q tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. CTRP2 (mouse) has been reported to rapidly induce phosphorylation of AMP-activated protein kinase, acetyl-CoA carboxylase, and mitogen-activated protein kinase in C2C12 myotubes, which resulted in increased glycogen accumulation and fatty acid oxidation.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
A family of Acrp30/adiponectin structural and functional paralogs:
G.W. Wong, et al.; PNAS
101
, 10302 (2004)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-835
Revised 04-Jan-07
Monoclonal Antibody to CTRP7 (Anna-1)
SYNONYMS
anti-C1q Tumor Necrosis Factor-α-related Protein 7 MAb (Anna-1)
anti-C1qTNF7 MAb (Anna-1)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
C1q Tumor Necrosis Factor-alpha-related Proteins [CTRPs]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-835-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE:
Anna-1
ISOTYPE:
Mouse IgG1
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse CTRP7 (C1q tumor necrosis factor-α-related protein 7) (aa 18-290).
SPECIFICITY:
Recognizes human and mouse CTRP7.
APPLICATION:
ELISA
Immunohistochemistry (paraffin sections)
Immunoprecipitation (1:200)
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
Adiponectin is involved in controlling the whole-body metabolism, particularly by increasing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle. CTRP7 belongs to a new highly conserved family of adiponectin paralogs designated as C1q tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. A member of this family, CTRP2 (mouse) has been reported to rapidly induce phosphorylation of AMP-activated protein kinase, acetyl-CoA carboxylase, and mitogen-activated protein kinase in C2C12 myotubes, which resulted in increased glycogen accumulation and fatty acid oxidation.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
A family of Acrp30/adiponectin structural and functional paralogs:
G.W. Wong, et al.; PNAS
101
, 10302 (2004)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-210-923
Revised 31-Oct-06
Polyclonal Antibody to CTRP2 (mouse) (AT102)
SYNONYMS
anti-C1q Tumor Necrosis Factor-α-related Protein 2 (mouse) PAb (AT102)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
C1q Tumor Necrosis Factor-alpha-related Proteins [CTRPs]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-923-C050
50 µg
280.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse CTRP2 (C1q tumor necrosis factor-α-related protein 2) (aa 26-260).
SPECIFICITY:
Recognizes mouse CTRP2.
APPLICATION:
Immunoprecipitation (1:200)
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
General Information
Adiponectin is involved in controlling the whole-body metabolism, particularly by increasing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle. CTRP2 belongs to a new highly conserved family of adiponectin paralogs designated as C1q tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. CTRP2 (mouse) has been reported to rapidly induce phosphorylation of AMP-activated protein kinase, acetyl-CoA carboxylase, and mitogen-activated protein kinase in C2C12 myotubes, which resulted in increased glycogen accumulation and fatty acid oxidation.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
A family of Acrp30/adiponectin structural and functional paralogs:
G.W. Wong, et al.; PNAS
101
, 10302 (2004)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-936
Revised 12-Oct-06
Polyclonal Antibody to CTRP5 (mouse) (AT114)
SYNONYMS
anti-C1q Tumor Necrosis Factor-α-related Protein 5 (mouse) PAb (AT114)
anti-C1qTNF5 (mouse) PAb (AT114)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
C1q Tumor Necrosis Factor-alpha-related Proteins [CTRPs]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-936-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein A-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse CTRP5 (aa 16-243) (Prod. No.
ALX-522-102
).
SPECIFICITY:
Recognizes mouse CTRP5.
APPLICATION:
Immunoprecipitation (1:100)
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-924
Revised 31-Oct-06
Polyclonal Antibody to CTRP7 (AT103)
SYNONYMS
anti-C1q Tumor Necrosis Factor-α-related Protein 7 PAb (AT103)
anti-C1qTNF7 PAb (AT103)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
C1q Tumor Necrosis Factor-alpha-related Proteins [CTRPs]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-924-C050
50 µg
280.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse CTRP7 (C1q tumor necrosis factor-α-related protein 7) (aa 18-290).
SPECIFICITY:
Recognizes human, mouse and rat CTRP7.
APPLICATION:
Immunoprecipitation (1:200)
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
General Information
Adiponectin is involved in controlling the whole-body metabolism, particularly by increasing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle. CTRP2 belongs to a new highly conserved family of adiponectin paralogs designated as C1q tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. CTRP2 (mouse) has been reported to rapidly induce phosphorylation of AMP-activated protein kinase, acetyl-CoA carboxylase, and mitogen-activated protein kinase in C2C12 myotubes, which resulted in increased glycogen accumulation and fatty acid oxidation.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
A family of Acrp30/adiponectin structural and functional paralogs:
G.W. Wong, et al.; PNAS
101
, 10302 (2004)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
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