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Chemokines & Cytokines
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ALX-201-401 Revised 11-Jun-08
FGF-21 (mouse) (recombinant)
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SYNONYMS Fibroblast Growth Factor 21 (mouse) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Fibroblast Growth Factors [FGFs] & Receptors/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-401-C010   10 µg 270.00 USD Add To Cart
ALX-201-401-C050   50 µg 780.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Mature mouse fibroblast growth factor 21 (FGF-21) (aa 1-210) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION: 250μg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9JJN1: Fibroblast Growth Factor 21 (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-201-406 Revised 27-Mar-08
FGF-21 (mouse):Fc (human) (recombinant)
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SYNONYMS Fibroblast Growth Factor 21 (mouse):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Fibroblast Growth Factors [FGFs] & Receptors/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-406-C010   10 µg 260.00 USD Add To Cart
ALX-201-406-C050   50 µg 560.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Mature mouse fibroblast growth factor 21 (FGF-21) (aa 1-210) is fused at the C-terminus to the Fc portion of human IgG.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9JJN1: Fibroblast Growth Factor 21 (mouse)
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-201-423 Revised 25-Jun-08 New product
FGF-23 (human) (recombinant) (His)
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SYNONYMS Fibroblast Growth Factor 23 (human) (recombinant) (His)
Tumor-derived Hypophosphatemia Inducing Factor (human) (recombinant) (His)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Fibroblast Growth Factors [FGFs] & Receptors/Related Products
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ALX-201-423-C010   10 µg 240.00 USD Add To Cart
ALX-201-423-C050   50 µg 580.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The original signal peptide and the mature peptide of human FGF-23 (aa 1-251) are fused at the C-terminus to a His-tag.
CONCENTRATION:  
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9GZV9: Fibroblast Growth Factor-23 (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-522-086 Revised 08-Jan-07
Fn14 (human):Fc (human) (recombinant)
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SYNONYMS TWEAK-R (human):Fc (human) (recombinant)
TNFRSF 12A (human):Fc (human) (recombinant)
Fibroblast Growth Factor-inducible Immediate-early Response Protein 14 (human):Fc (human) (recombinant)
CD266 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY TWEAK & FN14/DR3/Related Products
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ALX-522-086-C050   50 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~36kDa for the chimeric protein (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human Fn14 (aa 1-75) is fused at the C-terminus to the Fc portion of human IgG1 and a linker peptide (2 aa).
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: >95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg (LAL test; BioWhittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds human and mouse TWEAK.
BIOLOGICAL ACTIVITY: Inhibits TWEAK-mediated killing of Kym-1 target cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least six months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
Intraovarian TWEAK/Fn14 ligand-receptor system limits ovarian preovulatory follicles from excessive luteinization: A. De, et al.; Mol. Endocrinol. 20, 2528 (2006) Abstract; Full Text
General Information
The fibroblast growth factor-inducible-14 (Fn14) is a 129 aa type Ia transmembrane protein. Fn14 is a growth-factor regulated, immediate-early response protein. It is expressed in a developmental and adult tissue-specific manner. Fn14 expression decreases cellular adhesion to extracellular matrix proteins fibronectin and vitronectin and reduces cell growth and migration. It is expressed at high levels in liver cancer cells, in hepatocellular carcinoma specimens as well as in regenerating liver cells showing Fn14 may play a role in hepatocyte growth and liver neoplasia. Fn14 binds to TWEAK [Apo-3 Ligand], a member of the TNF family.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis: S.R. Wiley, et al.; Immunity 15, 837 (2001) Abstract
The molecular architecture of the TNF superfamily: J.L. Bodmer, et al.; TIBS 27, 19 (2002) Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-522-036 Revised 29-Sep-05
Fn14 (mouse):Fc (human) (recombinant)
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SYNONYMS TWEAK-R (mouse):Fc (human) (recombinant)
TNFRSF 12A (mouse):Fc (human) (recombinant)
Fibroblast Growth Factor-inducible Immediate-early Response Protein 14 (mouse):Fc (human) (recombinant)
CD266 (mouse):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY TWEAK & FN14/DR3/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-036-C050   50 µg 360.00 USD Add To Cart
ALX-522-036F-C050 FITC 50 µg 380.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~34kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse Fn14 (aa 1-75) is fused to the Fc portion of human IgG1.
CONCENTRATION: Fn14:Fc: 1mg/ml after reconstitution.
Fn14:Fc-FITC: 1mg/ml.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Fn14:Fc:  Lyophilized. Contains PBS.
Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum. After reconstitution, prepare aliquots and store at -20°C. 
Fn14:Fc-FITC: Liquid. In PBS containing 0.02% sodium azide. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; BioWhittaker).
SPECIFICITY: Binds human and mouse TWEAK.
BIOLOGICAL ACTIVITY: Inhibits TWEAK-mediated killing of Kym-1 target cells.
APPLICATION: Fn14:Fc-FITC: Flow Cytometry.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor: T.C. Polek, et al.; J. Biol. Chem. 278, 32317 (2003) Abstract; Full Text
BAFF production by antigen-presenting cells provides T cell co-stimulation: B. Huard, et al.; Int. Immunol. 16, 467 (2004) Abstract
Potential role of APRIL as autocrine growth factor for megakaryocytopoiesis: D. Bonci, et al.; Blood 104, 3169 (2004) Abstract
General Information
The fibroblast growth factor-inducible-14 (Fn14) is a 129 aa type Ia transmembrane protein. Fn14 is a growth-factor regulated, immediate-early response protein. It is expressed in a developmental and adult tissue-specific manner. Fn14 expression decreases cellular adhesion to extracellular matrix proteins fibronectin and vitronectin and reduces cell growth and migration. It is expressed at high levels in liver cancer cells, in hepatocellular carcinoma specimens as well as in regenerating liver cells showing Fn14 may play a role in hepatocyte growth and liver neoplasia. Fn14 has recently been described to bind TWEAK [Apo-3 Ligand], a member of the TNF family.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9CR75: Fn14 (mouse) (precursor)
AfCS Signalling Gateway link A003364: Fn14 (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis: S.R. Wiley, et al.; Immunity 15, 837 (2001) Abstract
The molecular architecture of the TNF superfamily: J.L. Bodmer, et al.; TIBS 27, 19 (2002), (Review) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-270-312 Revised 03-Jan-08
Formononetin (high purity)
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SYNONYMS 7-Hydroxy-4’-methoxyisoflavone (high purity)
7-Hydroxy-3-(4’-methoxyphenyl)-4H-benzopyran-4-one (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonoids/Related Products
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ALX-270-312-M005   5 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C16H12O4
MW: 268.3
CAS NUMBER: 485-72-3
MERCK INDEX: 14: 4244
PURITY: ≥97%
APPEARANCE: White to greyish powder.
SOLUBILITY: Soluble in DMSO (200mg/ml) or methanol (2mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Place in a desiccator under vacuum for 48 hours before use.
HANDLING: Protect from light.

Product Description
Interacts with human estrogen receptors with low potency. Enhances IL-4 production in a dose-dependent manner. Inhibits lecithin peroxidation induced by hydroxyl radicals. Selective inhibitor of the γ-isoform of alcohol dehydrogenase. Antioxidant.
Product Specific Literature References
Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor: R.J. Miksicek; J. Steroid Biochem. Mol. Biol. 49, 153 (1994) Abstract
Dietary estrogenic isoflavones are potent inhibitors of beta-hydroxysteroid dehydrogenase of P. testosteronii: W.M. Keung; BBRC 215, 1137 (1995) Abstract
Proliferative response of mammary glandular tissue to formononetin: W. Wang, et al.; Nutr. Cancer 23, 131 (1995) Abstract
Antioxidant activity of phytoestrogenic isoflavones: M.B. Ruiz-Larrea, et al.; Free Radic. Res. 26, 63 (1997) Abstract
Inhibitory effects of isoflavones on lipid peroxidation by reactive oxygen species: S. Toda and Y. Shirataki; Phytother. Res. 13, 163 (1999) Abstract
Isoflavonoids and lignans have different potentials to modulate oxidative genetic damage in human colon cells: B.L. Pool-Zobel, et al.; Carcinogenesis 21, 1247 (2000) Abstract
Disposition of flavonoids via enteric recycling: enzyme-transporter coupling affects metabolism of biochanin A and formononetin and excretion of their phase II conjugates: X. Jia, et al.; J. Pharmacol. Exp. Ther. 310, 1103 (2004) Abstract
Formononetin, a phyto-oestrogen, and its metabolites up-regulate interleukin-4 production in activated T cells via increased AP-1 DNA binding activity: J. Park, et al.; Immunology 116, 71 (2005) Abstract
Further Categories Containing This Product:
Other Natural Products for Inflammation Research • Natural Products - Antioxidants • Interleukins Other Products • Active Substances from Fruit and Vegetables • Estrogen & Estrogen Receptors/Related Products
 
 
APO-54N-028 Revised 02-Apr-08
Free Osteoprotegerin (human) Detection Set [For ELISA Application]
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SYNONYMS Free OPG (human) Detection Set [For ELISA Application]
Free TNFRSF 11B (human) Detection Set [For ELISA Application]
Free Osteoclastogenesis Inhibitory Factor (human) Detection Set [For ELISA Application]
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY OPG
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APO-54N-028-KI01   1 Set 540.00 USD Add To Cart
Product Specification
SENSITIVITY: 2pg/ml (range 0 to 250 pg/ml).
QUANTITY: 5x96 wells.
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION: For the quantitative determination of human free osteoprotegerin (not bound to RANKL or TRAIL) in cell culture supernatant, plasma and serum.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
OPG (Osteoprotegerin; also called Osteoclastogenesis Inhibitory Factor or TNFRSF11B) is a secreted member of the TNF (Tumor necrosis factor) receptor superfamily of proteins [1]. OPG, composed of 380 amino acids, is expressed as monomer and secreted as disulphide-homodimeric protein [2]. Produced by numerous cell types and tissues, its expression pattern targets the skeletal, immune, and vascular systems. Osteoblasts secrete OPG that protects the skeleton from excessive bone resorption by acting as a decoy receptor for the ligand nuclear factor-κB ligand (RANKL), preventing it from interacting with its receptor RANK [3]. OPG/RANK/RANKL molecular triumvirat plays a pivotal function in the regulation of the immune system through dendritic cells [4]. OPG-deficient mice exhibit severe osteoporosis and vascular calcification of the aorta and renal arteries [5]. Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD), a bone disease [6]. OPG also functions as a soluble receptor for the TNF ligand TRAIL (TNF-related apoptosis-inducing ligand) preventing it to activate apoptotic signaling cascase and therefore providing cancer cells with a survival advantage [7].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O00300: Osteoprotegerin (human)
General Literature References
[1] Biology of RANK, RANKL, and osteoprotegerin: B.F. Boyce & L. Xing; Arthritis Res. Ther. 9 Suppl 1, S1 (2007) Abstract
[2] Osteoprotegerin: a novel secreted protein involved in the regulation of bone density: W.S. Simonet, et al.; Cell 89, 309 (1997) Abstract
[3] Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation: D.L. Lacey, et al.; Cell 93, 165 (1998) Abstract
[4] RANKL, RANK, osteoprotegerin: key partners of osteoimmunology and vascular diseases: M. Baud huin, et al.; Cell Mol. Life Sci. 64, 2334 (2007) Abstract
[5] Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis: H. Min, et al.; J. Exp. Med. 192, 463 (2000) Abstract
[6] Paget’s disease of bone and genetic disorders of RANKL/OPG/RANK/NF-kappaB signaling: M.P. Whyte; Ann. N. Y. Acad. Sci. 1068, 143 (2006) Abstract
[7] Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL: J.G. Emery, et al.; J. Biol. Chem. 273, 14363 (1998) Abstract; Full Text
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-350-119 Revised 20-Feb-08
Fumagillin
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SYNONYMS Fumidil B
Fumadil B
TNP-470
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Angiogenesis Research
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ALX-350-119-MC05   0.5 mg 65.00 USD Add To Cart
ALX-350-119-M001   1 mg 105.00 USD Add To Cart
Product Specification
FORMULA: C26H34O7
MW: 458.6
CAS NUMBER: 23110-15-8
MERCK INDEX: 14: 4286
SOURCE/HOST: Isolated from Aspergillus fumigatus.
PURITY: ≥95%
APPEARANCE: Light yellow solid
SOLUBILITY: Soluble in chloroform or diluted aqueous bases. Slightly soluble in methanol and other alcoholic solvents. Insoluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Unstable in aqueous solutions with pH >9.0 or pH <5.0.
HANDLING: Packaged under inert gas. Protect from light.
HAZARD: HARMFUL.

Product Description
Inhibitor of angiogenesis and endothelial cell proliferation. Specific inhibitor of methionine aminopeptidase type II (MetAP-II). Antineoplastic. Anti-infective.
Product Specific Literature References
Fumagillin (H-3), a new antibiotic with amebicidal properties: C.M. Mc, et al.; Science 113, 202 (1951) Abstract
Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth: D. Ingber, et al.; Nature 348, 555 (1990) Abstract
The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase: W.T. Lowther, et al.; PNAS 95, 12153 (1998) Abstract; Full Text
Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2: E.C. Griffith, et al.; PNAS 95, 15183 (1998) Abstract
Fumagillin treatment of intestinal microsporidiosis: J.M. Molina, et al.; N. Engl. J. Med. 346, 1963 (2002) Abstract
Whirling disease of salmonid fish: life cycle, biology, and disease: M.A. Gilbert & W.O. Granath, Jr.; J. Parasitol. 89, 658 (2003) Abstract
Fumagillin treatment of hepatocellular carcinoma in rats: an in vivo study of antiangiogenesis: I.S. Sheen, et al.; World J. Gastroenterol. 11, 771 (2005) Abstract
Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors: B. Lefkove, et al.; Expert Rev. Anti Infect. Ther. 5, 573 (2007), Review Abstract
FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin (TNP-470): G.J. Chen, et al.; J. Cell Biochem. 101, 1492 (2007) Abstract
Further Categories Containing This Product:
Aminopeptidases/Related Products • Fibroblast Growth Factors [FGFs] & Receptors/Related Products • Antitumor Agents (Anti-proliferative) • Natural Products - Other Anti-infective Agents • Antitumor Antibiotics
 
 
ALX-201-198 Revised 15-Mar-05
G-CSF (human) (recombinant)
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SYNONYMS Granulocyte-colony Stimulating Factor (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY