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Growth Factors / Related Products
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ALX-804-736 Revised 03-Sep-08 New product
Monoclonal Antibody to FGF-21 (FG224-7)
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SYNONYMS anti-Fibroblast Growth Factor 21 MAb (FG224-7)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Fibroblast Growth Factors [FGFs] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-736-C100   100 µg 310.00 USD Add To Cart
Product Specification
CLONE: FG224-7
ISOTYPE: Rat IgG1
FORMULATION: Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant mouse FGF-21.
SPECIFICITY: Recognizes human and mouse FGF-21. Detects a band of ~25kDa by Western blot.
APPLICATION: ELISA (direct and indirect: 1:2’000-1:5’000)
Western Blot (1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for up to 6 months after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-382 Revised 21-Feb-08
Monoclonal Antibody to Hrs and Hrs-2 (A-5)
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SYNONYMS anti-HGS MAb (A-5)
anti-Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate MAb (A-5)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Hepatocyte Growth Factor [HGF] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-382-C050   50 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Monkey
CLONE: A-5
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In PBS containing 10% glycerol.
IMMUNOGEN: Recombinant full length rat Hrs-2 (hepatocyte growth factor-regulated tyrosine kinase substrate).
SPECIFICITY: Recognizes human, mouse, rat and monkey Hrs (HGS) and Hrs-2.
APPLICATION: Immunohistochemistry (1:100-1:1'000)
Immunoprecipitation (2µg/ml)
Western Blot (1:2'000-1:3'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 3 months when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Isoform-specific exocytotic protein mRNA expression in hypothalamic magnocellular neurons: regulation after osmotic challenge: G. Jacobsson, et al.; Neuroendocrinology 70, 392 (1999) Abstract
The cellular and developmental expression of hrs-2 in rat: S. Tsujimoto, et al.; Eur. J. Neurosci. 11, 3047 (1999) Abstract
Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15: A.J. Bean, et al.; J. Biol. Chem. 275, 15271 (2000) Abstract; Full Text
Distinct protein domains are responsible for the interaction of Hrs-2 with SNAP-25. The role of Hrs-2 in 7 S complex formation: S. Tsujimoto & A.J. Bean; J. Biol. Chem. 275, 2938 (2000) Abstract; Full Text
SNAP-25-associated Hrs-2 protein colocalizes with AQP2 in rat kidney collecting duct principal cells: A. Shukla, et al.; Am. J. Physiol. Renal. Physiol. 281, F546 (2001) Abstract; Full Text
CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling: Q. Yan, et al.; Mol. Biol. Cell 16, 2470 (2005) Abstract; Full Text
Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) interacts with PELP1 and activates MAPK: S.K. Rayala, et al.; J. Biol. Chem. 281, 4395 (2006) Abstract; Full Text
General Information
Hrs/Hgs (hepatocyte growth factor-regulated tyrosine kinase substrate) is a tyrosine-phosphorylated member of a protein family characterized by a conserved 3´-phosphoinositide-interacting RING zinc finger domain, the so called FYVE finger. A variant of Hrs, Hrs-2 is an ATPase that has been shown to play a regulatory role in the docking and/or fusion of synaptic vesicles to plasma membranes through a calcium-regulated interaction with SNAP-25. Hrs-2 physically interacts with Eps15, a protein required for receptor-mediated endocytosis. The Hrs-2/Eps15 interaction is calcium dependent, inhibited by SNAP-25 and alpha-adaptin, and results in the inhibition of receptor-mediated endocytosis. Immunoelectron microscopy reveals Hrs-2 localization on the limiting membrane of multivesicular bodies, organelles in the endosomal pathway. Recent data suggest that Hrs-2 acts to provide communication between endo- and exocytic processes.
Further Categories Containing This Product:
Vesicles & Membrane Trafficking Other Products • Monoclonal Antibodies • Autophagy-related Proteins [APG; ATG] / Related Products
 
 
ALX-804-857 Revised 18-Jun-08
Monoclonal Antibody to ILEI (Delphy-1)
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SYNONYMS anti-Interleukin-like EMT Inducer MAb (Delphy-1)
anti-FAM3C MAb (Delphy-1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Chemokines & Cytokines Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-857-C100   100 µg 360.00 USD Add To Cart
ALX-804-857B-C100 Biotin 100 µg 395.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Delphy-1
ISOTYPE: Mouse IgG2a
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human ILEI (aa 42-227).
SPECIFICITY: Recognizes human and mouse ILEI.
APPLICATION: ELISA
Immunoprecipitation (1:100)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep ATTO, Biotin- and FITC-conjugated formats at +4°C. Do not freeze. Protect from light.
General Information
In 2006, T. Waerner, et al. characterized ILEI as a key player in both epithelial to mesenchymal transition and late-stage carcinoma progression. EMT is a process that involves changes in gene expression, cytoskeleton organization, cell adhesion, and extracellular matrix composition. This process is important during tissue formation and organogenesis, but also during cancer progression, metastasis and chronic inflammation. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Cloning, expression, and initial characterization of a novel cytokine-like gene family: Y. Zhu, et al.; Genomics 80, 144 (2002) Abstract
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells: T. Waerner, et al.; Cancer Cell 10, 227 (2006) Abstract
Further Categories Containing This Product:
Cancer Other Products • Transforming Growth Factor beta [TGFbeta] & Receptors / Related Products • Monoclonal Antibodies
 
 
ALX-804-858 Revised 18-Jun-08
Monoclonal Antibody to ILEI (Delphy-2)
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SYNONYMS anti-Interleukin-like EMT Inducer MAb (Delphy-2)
anti-FAM3C MAb (Delphy-2)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Chemokines & Cytokines Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-858-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Delphy-2
ISOTYPE: Mouse IgM
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human ILEI (aa 42-227).
SPECIFICITY: Recognizes human and mouse ILEI.
APPLICATION: ELISA
Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
In 2006, T. Waerner, et al. characterized ILEI as a key player in both epithelial to mesenchymal transition and late-stage carcinoma progression. EMT is a process that involves changes in gene expression, cytoskeleton organization, cell adhesion, and extracellular matrix composition. This process is important during tissue formation and organogenesis, but also during cancer progression, metastasis and chronic inflammation. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Cloning, expression, and initial characterization of a novel cytokine-like gene family: Y. Zhu, et al.; Genomics 80, 144 (2002) Abstract
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells: T. Waerner, et al.; Cancer Cell 10, 227 (2006) Abstract
Further Categories Containing This Product:
Transforming Growth Factor beta [TGFbeta] & Receptors / Related Products • Monoclonal Antibodies
 
 
ALX-804-574 Revised 25-Oct-05
Monoclonal Antibody to Nerve Growth Factor Receptor (human) (MGR15)
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SYNONYMS anti-NGFR (human) MAb (MGR15)
anti-TNFRSF 16 (human) MAb (MGR15)
anti-p75NTR (human) MAb (MGR15)
anti-p75 Neurotrophin Receptor (human) MAb (MGR15)
anti-CD271 (human) MAb (MGR15)
anti-Low-affinity Nerve Growth Factor Receptor (human) MAb (MGR15)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Nerve Growth Factors [NGF] & Receptors / Related Products
Ordering Information
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ALX-804-574-C050   50 µg 210.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MGR15
ISOTYPE: Mouse IgM
CONCENTRATION: 0.4mg/ml
FORMULATION: Liquid. In 20mM TRIS, pH 7.4, containing 1.25M sodium chloride and 0.02% sodium azide.
IMMUNOGEN: SKNBE neuroblastoma cell line transfected with human NGFR (nerve growth factor receptor; p75NTR).
SPECIFICITY: Recognizes an epitope present in the extracellular domain of human NGFR.
APPLICATION: Flow Cytometry
Immunohistochemistry (frozen sections)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Do not freeze.
General Literature References
Trk receptors: roles in neuronal signal transduction: E.J. Huang, et al.; Annu. Rev. Biochem. 72, 609 (2003) Abstract
Neurotrophin signaling through the p75 neurotrophin receptor: P.P. Roux, et al.; Prog. Neurobiol. 67, 203 (2002) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-833 Revised 21-Dec-06
Monoclonal Antibody to Nerve Growth Factor Receptor (human) (Nagy-1)
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SYNONYMS anti-NGFR (human) MAb (Nagy-1)
anti-TNFRSF 16 (human) MAb (Nagy-1)
anti-p75NTR (human) MAb (Nagy-1)
anti-p75 Neurotrophin Receptor (human) MAb (Nagy-1)
anti-CD271 (human) MAb (Nagy-1)
anti-Low-affinity Nerve Growth Factor Receptor (human) MAb (Nagy-1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Nerve Growth Factors [NGF] & Receptors / Related Products
Ordering Information
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ALX-804-833-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Nagy-1
ISOTYPE: Rat IgG2a
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human NGFR (nerve growth factor receptor; p75NTR):Fc (Prod. No. ALX-522-044).
SPECIFICITY: Recognizes human NGFR.
APPLICATION: Flow Cytometry (1:1'000)
Immunoprecipitation (1:200)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
An autocrine function of nerve growth factor for cell cycle regulation of vascular endothelial cells: A. Tanaka, et al.; BBRC 313, 1009 (2004) Abstract
p75NTR--live or let die: A. Nykjaer, et al.; Curr. Opin. Neurobiol. 15, 49 (2005) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-737 Revised 08-Oct-08 New product
Monoclonal Antibody to Progranulin (human) (PG359-7)
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SYNONYMS anti-Proepithelin (human) MAb (PG359-7)
anti-PEPI (human) MAb (PG359-7)
anti-PC Cell-derived Growth Factor (human) MAb (PG359-7)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Progranulin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-737-C100   100 µg 310.00 USD Add To Cart
Product Specification
CLONE: PG359-7
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant human progranulin.
SPECIFICITY: Recognizes human progranulin. Detects a band of ~90kDa by Western blot.
APPLICATION: ELISA (direct and indirect: 1:2’000-1:5’000)
Immunohistochemistry (1:100)
Western Blot (1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for up to 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
Inflammation Other Products • Monoclonal Antibodies
 
 
ALX-804-851 Revised 03-May-07
Monoclonal Antibody to RGMC (human) (Fery-1)
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SYNONYMS anti-Repulsive Guidance Molecule C (human) MAb (Fery-1)
anti-Hemojuvelin (human) MAb (Fery-1)
anti-Hemochromatosis Type 2 Protein (human) MAb (Fery-1)
anti-HFE2 (human) MAb (Fery-1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Repulsive Guidance Molecules [RGMs] & Neogenin / Related Products
Ordering Information
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ALX-804-851-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Fery-1
ISOTYPE: Mouse IgG2b
SOURCE/HOST: Purified from concentrated hybridoma tissue cell culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human RGMC (aa 36-398) (Prod. No. ALX-522-104).
SPECIFICITY: Recognizes human RGMC.
APPLICATION: Flow Cytometry
Immunoprecipitation
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products • Polyclonal Antibodies
 
 
ALX-804-871 Revised 14-Oct-08 New product
Monoclonal Antibody to TGF-βRIII (human) (Jack-1)
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SYNONYMS anti-TGFR-3 (human) MAb (Jack-1)
anti-Transforming Growth Factor β Receptor III (human) MAb (Jack-1)
anti-Betaglycan (human) MAb (Jack-1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Transforming Growth Factor beta [TGFbeta] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-871-C100   100 µg 380.00 USD Add To Cart
Product Specification
CLONE: Jack-1
ISOTYPE: Mouse IgG2b
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human TGFβRIII cytoplasmic domain (aa 809-850).
SPECIFICITY: Recognizes human TGFβRIII.
APPLICATION: Immunoprecipitation (1:200)
Western Blot (1:1‘000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
General Information
TGF-β receptor III (TGF-βRIII; betaglycan) is an ubiquitously expressed transmembrane proteoglycan TGF-β co-receptor [1] that regulates TGF-β signaling by increasing the binding of TGF-β to the TGF-β receptor. (Note: The TGF-β receptor III is a co-receptor of TGF-β receptor, composed of subunit I and II; TGF-β receptor III increases the binding of TGF-β to the subunit II. In this way it can regulate the signaling.) TGF-β receptor III expression is lost in many human breast and prostate cancers and correlates with the resistance to the tumor suppressor effects of TGF-β  [2] . The overexpression of TGF-β receptor III in breast cancer cells suppresses their tumorigenicity in an animal model [3].
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] Expression of the type III TGF-beta receptor is negatively regulated by TGF-beta: N. Hempel, et al.; Carcinogenesis 29, 905 (2008) Abstract
[2] The type III transforming growth factor-beta receptor as a novel tumor suppressor gene in prostate cancer: R.S. Turley, et al.; Cancer Res. 67, 1090 (2007) Abstract; Full Text
[3] The type III TGF-beta receptor suppresses breast cancer progression: M. Dong, et al.; J. Clin. Invest. 117, 206 (2006) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies