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ALX-804-824
Revised 31-Oct-06
Monoclonal Antibody to BAFF-R (mouse) (7H22-E16)
SYNONYMS
anti-BR3 (mouse) MAb (7H22-E16)
anti-BlySR3 (mouse) MAb (7H22-E16)
anti-TNFRSF 13C (mouse) MAb (7H22-E16)
anti-CD268 (mouse) MAb (7H22-E16)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
BAFF-R
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-824-C100
100 µg
320.00 USD
ALX-804-824TD-T100
ATTO 488
100 tests
380.00 USD
ALX-804-824TS-T100
ATTO 647N
100 tests
380.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
7H22-E16
ISOTYPE:
Rat IgG1
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
>95% (SDS-PAGE).
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse BAFF-R extracellular domain (aa 2-70).
SPECIFICITY:
Recognizes mouse BAFF-R.
APPLICATION:
Flow Cytometry (1:100)
Western Blot (1:500)
Note:
Not recommended for immunoprecipitation.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
HANDLING:
For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep ATTO, Biotin- and FITC-conjugated formats at +4°C. Do not freeze. Protect from light.
Product Specific Literature References
B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells
:
L.G. Ng, et al.; J. Immunol.
173
, 807 (2004)
Abstract
CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers:
N.D. Huntington, et al.; Nat. Immunol.
7
, 190 (2006)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
1 test means: 1µl of MAb is used to stain 500’000 cells in a sample volume of 50µl.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
The BAFF/APRIL system: an important player in systemic rheumatic diseases
:
F. Mackay, et al.; Curr. Dir. Autoimmun.
8
, 243 (2005)
Abstract
Further Categories Containing This Product:
CD Antibodies
•
Monoclonal Antibodies
ALX-804-151
Revised 27-Jun-07
Monoclonal Antibody to BCMA (human) (Vicky-1)
SYNONYMS
anti-B Cell Maturation Protein (human) MAb (Vicky-1)
anti-TNFRSF 17 (human) MAb (Vicky-1)
anti-CD269 (human) MAb (Vicky-1)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
BCMA
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-151-C100
100 µg
360.00 USD
ALX-804-151F-T100
FITC
100 tests
390.00 USD
ALX-804-151TD-T100
ATTO 488
100 tests
395.00 USD
ALX-804-151TS-T100
ATTO 647N
100 tests
395.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
Vicky-1
ISOTYPE:
Rat IgG1
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
95% (SDS-PAGE).
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human BCMA extracellular domain (aa 2-54) (Prod. No.
ALX-522-026
).
SPECIFICITY:
Recognizes human BCMA. Does not cross-react with mouse BCMA.
APPLICATION:
Flow Cytometry
Immunocytochemistry
Functional Application (blocks binding of BAFF to human BCMA)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored as recommended.
HANDLING:
For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep ATTO, Biotin- and FITC-conjugated formats at +4°C. Do not freeze. Protect from light.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
TACI regulates IgA production by APRIL in collaboration with HSPG:
D. Sakurai, et al.; Blood
109
, 2961 (2007)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
1 test means: 1µl of MAb is used to stain 500’000 cells in a sample volume of 50µl.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population
:
J.S. Thompson, et al.; J. Exp. Med.
192
, 129 (2000)
Abstract
;
Full Text
BAFF AND APRIL: a tutorial on B cell survival:
F. Mackay, et al.; Annu. Rev. Immunol.
21
, 231 (2003)
Abstract
Further Categories Containing This Product:
CD Antibodies
•
Monoclonal Antibodies
ALX-804-826
Revised 21-Aug-08
Monoclonal Antibody to BCMA (mouse) (Vicky-2)
SYNONYMS
anti-B Cell Maturation Protein (mouse) MAb (Vicky-2)
anti-TNFRSF 17 (mouse) MAb (Vicky-2)
anti-CD269 (mouse) MAb (Vicky-2)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
BCMA
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-826-C100
100 µg
320.00 USD
ALX-804-826TD-T100
ATTO 488
100 Tests
380.00 USD
ALX-804-826TS-T100
ATTO 647N
100 Tests
380.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
Vicky-2
ISOTYPE:
Rat IgG2a
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse BCMA extracellular domain (aa 1-46) (Prod. No.
ALX-522-079
).
SPECIFICITY:
Recognizes mouse BCMA. Does not cross-react with human BCMA.
APPLICATION:
Immunoprecipitation (1:200)
Flow Cytometry (1:1’000)
Western Blot (1:1’000)
Functional Application (blocks binding of BAFF to mouse BCMA)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
APRIL facilitates viral-induced erythroleukemia but is dispensable for T cell immunity and lymphomagenesis:
G. Hardenberg, et al.; J. Leukoc. Biol.
84
, 380 (2008)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
1 test means: 1µl of MAb is used to stain 500’000 cells in a sample volume of 50µl.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation:
S. Shulga-Morskaya, et al.; J. Immunol.
173
, 2331 (2004)
Abstract
TACI and BAFF-R mediate isotype switching in B cells:
E. Castigli, et al.; J. Exp. Med.
201
, 35 (2005)
Abstract
Further Categories Containing This Product:
CD Antibodies
•
Monoclonal Antibodies
ALX-804-489
Revised 02-Jun-05
Monoclonal Antibody to CCL1 (human) (8P16-N4-L21)
SYNONYMS
anti-I-309 (human) MAb (8P16-N4-L21)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-489-C100
100 µg
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
8P16-N4-L21
ISOTYPE:
Mouse IgM
CONCENTRATION:
1mg/ml
PURITY DETAIL:
DEAE purified.
FORMULATION:
Liquid. In PBS.
IMMUNOGEN:
Recombinant human CCL1 (I-309).
SPECIFICITY:
Recognizes human CCL1.
APPLICATION:
Immunohistochemistry (frozen sections (5µg/ml))
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-594
Revised 10-Jun-05
Monoclonal Antibody to CCL2 (human) (5J.1)
SYNONYMS
anti-MCP-1 (human) MAb (5J.1)
anti-Monocyte Chemotactic Protein-1 (human) MAb (5J.1)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-594-C100
100 µg
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
5J.1
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS.
IMMUNOGEN:
Recombinant human CCL2 (monocyte chemotactic protein-1; MCP-1).
SPECIFICITY:
Recognizes human CCL2.
APPLICATION:
Immunohistochemistry (frozen sections (5µg/ml))
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-465
Revised 29-Feb-08
Monoclonal Antibody to CCL2 (human) (5D3-F7)
SYNONYMS
anti-MCP-1 (human) MAb (5D3-F7)
anti-Monocyte Chemotactic Protein-1 (human) MAb (5D3-F7)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-465-C100
100 µg
350.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
5D3-F7
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Purified antibody in PBS containing 0.1% sodium azide.
IMMUNOGEN:
Recombinant human CCL2 (monocyte chemotactic protein-1; MCP-1).
SPECIFICITY:
Recognizes human CCL2.
APPLICATION:
ELISA (capture)
Immunocytochemistry (1:1'000)
Immunohistochemistry (frozen sections, paraffin sections (1:250-1:500))
Immunoprecipitation
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
A new monoclonal antibody (5D3-F7) which recognizes human monocyte chemotactic protein-1 but not related chemokines. Development of a sandwich ELISA and in situ detection of producing cells
:
G. Peri, et al.; J. Immunol. Methods
174
, 249 (1994)
Abstract
Analysis of the Gene Expression Profile Activated by the CC Chemokine Ligand 5/RANTES and by Lipopolysaccharide in Human Monocytes:
M. Locati, et al.; J. Immunol.
168
, 3557 (2002)
Full Text
Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation:
L. Piemonti, et al.; Diabetes
51
, 55 (2002)
Full Text
Further Categories Containing This Product:
Osteocalcin & Matrix Gla-protein [MGP] Family/Related Products
•
Monoclonal Antibodies
ALX-804-549
Revised 29-Feb-08
Monoclonal Antibody to CCL2 (human) (D9)
SYNONYMS
anti-MCP-1 (human) MAb (D9)
anti-Monocyte Chemotactic Protein-1 (human) MAb (D9)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-549-C100
100 µg
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
D9
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Protein G purified antibody in PBS.
IMMUNOGEN:
Recombinant human CCL2 (monocyte chemotactic protein-1; MCP-1).
SPECIFICITY:
Recognizes human CCL2.
APPLICATION:
Immunoprecipitation
Western Blot (5µg/ml)
Functional Application (blocks CCL2 [MCP-1]; 2µg/ml)
Not recommended for immunohistochemistry.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-470
Revised 10-May-06
Monoclonal Antibody to CCL22 (human) (152/11)
SYNONYMS
anti-MDC (human) MAb (152/11)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-470-C250
250 µg
540.00 USD
ALX-804-470E-C250
Peroxidase
250 µg
580.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
152/11
ISOTYPE:
Rat IgG
CONCENTRATION:
ALX-804-470
: 2.3mg/ml
ALX-804-470E
: 0.36mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
ALX-804-470
: Liquid. In PBS, pH 7.4.
ALX-804-470E
: Liquid. In PBS, pH 7.4, containing 0.2% bronidox and 0.05% phenol.
IMMUNOGEN:
Recombinant human CCL22 (macrophage-derived chemokine; MDC).
SPECIFICITY:
Recognizes human CCL22.
APPLICATION:
ALX-804-470
: Western Blot (2-4µg/ml)
Detection Limit: 0.2µg/lane.
ALX-804-470E
: ELISA (detection (1-2µ/ml))
Use microtiter plates coated with primary antibody (Prod. No.
ALX-804-469
, MAb to CCL22 (human) (349/6) at 20µg/ml in 0.05M carbonate/bicarbonate buffer, pH 9.6) to detect human fractalkine.
Detection Limit: ~60pg/ml.
Substrate: 0.26mg/ml tetramethyl benzydine and 0.01% hydrogen peroxide stabilized in 0.05M citrate buffer, pH 3.8.
SHIPPING:
SHIPPED ON BLUE ICE
USE/STABILITY:
ALX-804-470
: Short Term Storage: +4°C. Long Term Storage: After opening, prepare aliquots and store at -20°C.
ALX-804-470E
: Long Term Storage: +4°C.
HANDLING:
For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-469
Revised 07-May-08
Monoclonal Antibody to CCL22 (human) (349/6)
SYNONYMS
anti-MDC (human) MAb (349/6)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-469-C250
250 µg
540.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
349/6
ISOTYPE:
Rat IgG
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant human CCL22 (macrophage-derived chemokine; MDC).
SPECIFICITY:
Recognizes human CCL22.
APPLICATION:
ELISA
(capture (20µg/ml))
Use microtiter plates coated with this antibody in 0.05M carbonate/bicarbonate buffer, pH 9.6, in combination with secondary antibody (Prod. No.
ALX-804-470
, MAb to CCL22 (human) (152/11)) at 1-2µg/ml to detect human MDC.
Detection Limit: ~40pg/ml.
Substrate: 0.26mg/ml tetramethyl benzydine and 0.01% hydrogen peroxide stabilized in 0.05M citrate buffer, pH 3.8.
Western Blot
(1-2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Preservative may be added for storage at +4°C.
HANDLING:
For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-591
Revised 20-Nov-06
Monoclonal Antibody to CCR3 (human) (5E8)
SYNONYMS
anti-C-C Chemokine Receptor 3 (human) MAb (5E8)
anti-Eotaxin Receptor (human) MAb (5E8)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-591-C100
100 µg
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
5E8
ISOTYPE:
Mouse IgG2a
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS.
IMMUNOGEN:
L1.2 cells expressing human CCR3 (C-C Chemokine Receptor 3).
SPECIFICITY:
Recognizes human CCR3.
APPLICATION:
Flow Cytometry
SHIPPING:
