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ALX-210-166
Revised 13-Dec-04
Polyclonal Antibody to Leptin
SYNONYMS
anti-OB Gene Product PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Leptin / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-166-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Pig
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Purified IgG in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 91-106 (S
91
RNVIQIS
NDLENLRD
106
) of human leptin.
SPECIFICITY:
Recognizes human, mouse and pig leptin. Detects a band of ~16kDa by Western blot.
APPLICATION:
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
General Information
Leptin, the obese (ob) gene product, is a small protein expressed in and secreted from adipose tissue of normal rodents. Studies suggest leptin acts as a circulating hormone capable of regulating body-weight homeostasis and energy balance. One possible target tissue for leptin is the hypothalamus, a proposed control center for satiety and energy expenditure.
Ob knockout mice are characterized by several metabolic abnormalities including, hyperglucocorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered central nervous system activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue. Studies show that the administration of recombinant leptin to ob knockout mice reduces food intake and increases energy expenditure.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-168
Revised 07-May-07
Polyclonal Antibody to Leptin Receptor
SYNONYMS
anti-OB-R PAb
anti-CD295 PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Leptin / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-168-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Purified IgG.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 577-594 (K
577
EIQWKTHEVFDAKSKSA
594
) of the extracellular domain of rat leptin receptor.
SPECIFICITY:
Recognizes human, mouse and rat leptin receptor. Detects bands of ~100kDa and ~125kDa by Western blot, representing the short and long forms of leptin receptor. Also detects two unrelated bands of ~31kDa and ~35kDa.
APPLICATION:
Western Blot (1:2'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-161-003
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
A leptin dose response study in obese (ob/ob) and lean (+/?) mice:
R.B.S. Harris, et al.; Endocrinology
139
, 8 (1998)
Abstract
Related Products
ALX-161-003
Blocking Peptide for PAb to Leptin Receptor (Prod. No.
ALX-210-168
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-230
Revised 10-Oct-06
Polyclonal Antibody to Nerve Growth Factor Receptor
SYNONYMS
anti-NGFR PAb
anti-TNFRSF 16 PAb
anti-p75
NTR
PAb
anti-p75 Neurotrophin Receptor PAb
anti-CD271 PAb
anti-Low-affinity Nerve Growth Factor Receptor PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Nerve Growth Factors [NGF] & Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-230-R100
100 µl
280.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum containing 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to a portion of C-terminal human NGFR (nerve growth factor receptor; p75
NTR
).
SPECIFICITY:
Recognizes human, rat and chicken NGFR.
APPLICATION:
Immunoprecipitation (2µl/sample)
Western Blot (1:250-1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-335
Revised 29-Aug-06
Polyclonal Antibody to TNF-α
SYNONYMS
anti-Tumor Necrosis Factor-α PAb
anti-TNFSF 2 PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
TNF-alpha
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-335-C100
100 µg
259.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY:
≥99% (SDS-PAGE).
FORMULATION:
Liquid. In PBS.
ENDOTOXIN CONTENT:
≤0.0005EU/µg protein.
IMMUNOGEN:
Recombinant rat TNF-α (tumor necrosis factor-α).
SPECIFICITY:
Recognizes human, mouse and rat TNF-α.
APPLICATION:
ELISA
Western Blot
: 10ng recombinant rat TNF-α by 40-60µg/ml Prod. No. ALX-210-335.
Functional Application
: Neutralizes cytotoxic activity of recombinant rat TNF-α (Neutralizing activity: >2x10
5
U/mg. One unit is defined as the amount of antibody sufficient for neutralizing the cytotoxic activity of 1 unit recombinant rat TNF-α).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-345
Revised 12-Jan-05
Polyclonal Antibody to Adiponectin (mouse)
SYNONYMS
anti-ACRP30 (mouse) PAb
anti-Adipocyte Complement Related Protein of 30kDa (mouse) PAb
anti-AdipoQ (mouse) PAb
anti-apM1 (mouse) PAb
anti-GBP28 (mouse) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-345-C200
200 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. Protein A purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 18-32 and 187-200 of mouse adiponectin.
SPECIFICITY:
Recognizes mouse adiponectin. Detects a band of ~30kDa by Western blot.
APPLICATION:
Immunoprecipitation
Western Blot (4-8µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-352
Revised 30-Oct-06
Polyclonal Antibody to MDA5 (mouse) (AL180)
SYNONYMS
anti-Melanoma Differentiation-associated Gene 5 (mouse) PAb (AL180)
anti-Helicard (mouse) PAb (AL180)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
RNA Helicases / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-210-352-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Contains 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse MDA5 (melanoma differentiation-associated gene 5) (aa 2-208).
SPECIFICITY:
Recognizes mouse MDA5.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored as recommended.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Overexpression of Helicard, a CARD-Containing Helicase Cleaved during Apoptosis, Accelerates DNA Degradation:
M. Kovacsovics, et al.; Curr. Biol.
12
, 838 (2002)
Abstract
General Information
MDA5 is a highly conserved helicase whose ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. The helicase domain, once freed from the CARD domains, then translocates from the cytoplasm to the nucleus where it acts on chromatin architecture. This could allow a more easy access of CAD, thereby accelerating the degradation of genomic DNA.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties
:
D.C. Kang, et al.; PNAS
99
, 637 (2002)
Abstract
Related Products
ALX-210-935
Polyclonal Antibody to MDA5 (human) (AT113)
ALX-804-863
Monoclonal Antibody to MDA5 (human) (Hely-1)
APO-54N-035
MDA5 (human) (IntraCellular) Detection Set [For ELISA Application]
APO-54N-039
MDA5 (human) (IntraCellular) ELISA Kit
Further Categories Containing This Product:
NF-kB Pathway Other Products
•
Antiviral Signalling / Related Products
•
Caspase Recruitment Domain [CARD] Proteins / Related Products
•
Interferons & Interferon Receptors Other Products
•
Polyclonal Antibodies
ALX-210-354
Revised 30-Oct-06
Polyclonal Antibody to Resistin (human)
SYNONYMS
anti-ADSF (human) PAb
anti-FIZZ3 (human) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Resistin & Resistin-like Molecules [RELMs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-354-C100
100 µg
399.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml after reconstitution.
FORMULATION:
Lyophilized from sterile filtered solution of affinity purified antibody in 0.1M phosphate buffer, pH 7.2, containing 0.1M sodium chloride.
RECONSTITUTION:
Reconstitute with 100µl of distilled water and let the lyophilized pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect the activity of the antibody. In this case clarify the solution by centrifugation.
IMMUNOGEN:
Recombinant human resistin.
SPECIFICITY:
Recognizes human resistin.
APPLICATION:
ELISA
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Reconstituted antibody can be stored at +4°C for two weeks.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-357
Revised 02-Feb-06
Polyclonal Antibody to Resistin (mouse)
SYNONYMS
anti-ADSF (mouse) PAb
anti-FIZZ3 (mouse) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Resistin & Resistin-like Molecules [RELMs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-357-C200
200 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 21-39 (S
21
SMPLCPIDEAIDKKIKQD
39
) of mouse resistin.
SPECIFICITY:
Recognizes mouse resistin. Detects a band of ~14kDa by Western blot.
APPLICATION:
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-166-009
.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-358
Revised 30-Jul-07
Polyclonal Antibody to Perilipin A (mouse)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Perilipins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-358-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Purified IgG.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 502-517 (E
502
PILGRTQYSQLRKKS
517
) of rat perilipin A. This sequence is 93% conserved in human perilipin A.
SPECIFICITY:
Recognizes mouse perilipin A. Detects a band of ~62kDa by Western blot.
APPLICATION:
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-053
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysisv
:
D.L. Brasaemle, et al.; J. Biol. Chem.
275
, 38486 (2000)
Abstract
;
Full Text
Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes
:
G.M. Clifford, et al.; J. Biol. Chem.
275
, 5011 (2000)
Abstract
;
Full Text
Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis
:
P.J. Havel; Exp. Biol. Med. (Maywood)
226
, 963 (2001)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-359
Revised 06-Jun-06
Polyclonal Antibody to Perilipin A/B (mouse)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Perilipins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-359-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
Purified IgG.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-17 (M
1
SMNKGPTLLDGDLPEQ
17
) of rat perilipin A and B. This sequence is 82% conserved in human perilipin.
SPECIFICITY:
Recognizes mouse perilipin A and B. Detects bands of ~62kDa (perilipin A) and ~46kDa (perilipin B) by Western blot.
APPLICATION:
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-054
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis
:
D.L. Brasaemle, et al.; J. Biol. Chem.
275
, 38486 (2000)
Abstract
;
Full Text
Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes
:
G.M. Clifford, et al.; J. Biol. Chem.
275
, 5011 (2000)
Abstract
;
Full Text
Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis
:
P.J. Havel; Exp. Biol. Med. (Maywood)
226
, 963 (2001)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-360
Revised 29-Sep-05
Polyclonal Antibody to ANGPTL4 (rat)
SYNONYMS
anti-Angiopoietin-like Protein 4 (rat) PAb
anti-FIAF (rat) PAb
anti-Fasting-induced Adipose Factor (rat) PAb
anti-HFARP (rat) PAb
anti-Hepatic Fibrinogen/Angiopoietin-related Protein (rat) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-360-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 80-94 (C
80
QGPKGKDAPFKDSE
94
) of mouse ANGPTL4 (angiopoietin-like protein 4).
SPECIFICITY:
Recognizes rat ANGPTL4. Detects a band of ~50kDa by Western blot.
APPLICATION:
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
