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Signal Transduction
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ALX-151-026 Revised 20-Jun-08
N-Acetyl-Asp-Tyr(2-malonyl)-Val-Pro-Met-Leu-NH2
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrosine Kinase Inhibitors
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ALX-151-026-M001   1 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C39H57N7O14S
MW: 880.0
PURITY: ≥96% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Peptide is very unstable.
Product Description
Peptide containing a phosphotyrosyl mimetic. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.
Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides: B. Ye, et al.; J. Med. Chem. 38, 4270 (1995) Abstract
Further Categories Containing This Product:
Peptides • Phosphoinositide 3-kinase [PI(3)K] / Related Products
 
 
ALX-151-027 Revised 17-Jan-05
N-Acetyl-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrosine Kinase Inhibitors
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ALX-151-027-M001   1 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C36H57N7O13SP
MW: 858.9
PURITY: ≥96%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Phosphotyrosine containing peptide. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.
Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides: B. Ye, et al.; J. Med. Chem. 38, 4270 (1995) Abstract
Further Categories Containing This Product:
Peptides • Phosphoinositide 3-kinase [PI(3)K] / Related Products
 
 
ALX-201-006 Revised 04-Sep-08
N-Acetyl-eglin C (recombinant)
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PRODUCT LINE Cancer
PRODUCT CATEGORY Cathepsin Inhibitors
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ALX-201-006-MC01   0.1 mg 95.00 USD Add To Cart
ALX-201-006-MC05   0.5 mg 380.00 USD Add To Cart
ALX-201-006-M001   1 mg 670.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Thr-Glu-Phe-Gly-Ser-Glu-Leu-Lys-Ser-Phe-Pro-Glu-Val-Val-Gly-Lys-Thr-Val-Asp-Gln-Ala-Arg-Glu-Tyr-Phe-Thr-Leu-His-Tyr-Pro-Gln-Tyr-Asn-Val-Tyr-Phe-Leu-Pro-Glu-Gly-Ser-Pro-Val-Thr-Leu-Asp-Leu-Arg-Tyr-Asp-Arg-Val-Arg-Val-Phe-Tyr-Asn-Pro-Gly-Thr-Asn-Val-Val-Asn-His-Val-Pro-His-Val-Gly-OH
FORMULA: C377H552N96O107
MW: 8141.1
CAS NUMBER: 96380-69-7
SOURCE/HOST: Produced in E. coli.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Eglin C was originally isolated from the leech Hirudo medicinalis [1]. Recombinant N-acetyl-eglin C is a 70 amino acid peptide with identical biological activity to native eglin C. An effective inhibitor of chymotrypsin and subtilisin as well as of leukocyte elastase and cathepsin G.
Product Specific Literature References
[1] Structure of the elastase-cathepsin G inhibitor of the leech Hirudo medicinalis: U. Seemüller, et al.; Hoppe-Seyler's Z. Physiol. Chem. 361, 1841 (1980) Abstract
[2] A large fragment approach to DNA synthesis: total synthesis of a gene for the protease inhibitor eglin c from the leech Hirudo medicinalis and its expression in E. coli: H. Rink, et al.; Nucl. Acids Res. 12, 6369 (1984) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P01051: Eglin C (Hirudo medicinalis)
Further Categories Containing This Product:
Proteases Other Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-290-001 Revised 29-Nov-04
N-Acetyl-S-farnesyl-L-cysteine
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SYNONYMS AFC
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Farnesylation / Isoprenylation Reagents
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ALX-290-001-M005   5 mg 50.00 USD Add To Cart
ALX-290-001-M025   25 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C20H33NO3S
MW: 367.6
CAS NUMBER: 135304-07-3
PURITY: ≥97%
APPEARANCE: Clear oil.
SOLUBILITY: Soluble in DMSO, methanol or ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Specific inhibitor of S-farnesylcysteine methyl transferase.
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ALX-290-010 Revised 20-Apr-07
N-Acetyl-S-farnesyl-L-cysteine-methyl ester
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SYNONYMS AFCME
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Farnesylation / Isoprenylation Reagents
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ALX-290-010-M010   10 mg 40.00 USD Add To Cart
Product Specification
FORMULA: C21H35NO3S
MW: 381.6
CAS NUMBER: 135304-08-4
PURITY: ≥95%
APPEARANCE: White to slightly yellow powder.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.

Product Description
Substrate for studying the reversibility of carboxyl methylation in signal-transducing G-proteins.
Product Specific Literature References
Methylation and demethylation reactions of guanine nucleotide-binding proteins of retinal rod outer segments: D. Pérez-Sala, et al.; PNAS 88, 3043 (1991) Abstract
Identifying the recognition unit for G protein methylation: E.W. Tan, et al.; J. Biol. Chem. 266, 10719 (1991) Abstract; Full Text
 
 
ALX-290-007 Revised 02-Jun-08
N-Acetyl-S-geranyl-L-cysteine
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SYNONYMS AGC
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Geranyl-related Reagents
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ALX-290-007-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C15H25NO3S
MW: 299.4
PURITY: ≥98% (TLC)
APPEARANCE: Clear to pale yellow viscous oil.
SOLUBILITY: > 25mg/ml soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Solutions may be stored at -20 °C for up to 3 months. Product is not sterile.

Product Description
Negative control for AFC (Prod. No. ALX-290-001) and AGGC (Prod. No. ALX-290-008). Has a closely similar structure to these two compounds but lacks their biological activity.
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ALX-290-008 Revised 13-Jul-06
N-Acetyl-S-geranylgeranyl-L-cysteine
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SYNONYMS AGGC
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Geranyl-related Reagents
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ALX-290-008-M005   5 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C25H41NO3S
MW: 435.7
CAS NUMBER: 139332-94-8
PURITY: ≥98%
APPEARANCE: Viscous yellow oil.
SOLUBILITY: Soluble in 100% ethanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Specifically blocks methyl esterification of geranylgeranylated proteins such as Rab proteins. Blocks receptor-mediated signal transduction in human neutrophils (IC50=4µM). Induces insulin release from HIT-T15 cells by mimicking the action of Rab3A. Inhibits β2-integrin-induced actin polymerization (IC50~45nM) in neutrophils.
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ALX-550-208 Revised 17-Dec-04
N-Acetyl-5-hydroxytryptamine
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SYNONYMS N-Acetylserotonin
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-208-M010   10 mg 10.00 USD Add To Cart
ALX-550-208-M050   50 mg 25.00 USD Add To Cart
ALX-550-208-M500   500 mg 125.00 USD Add To Cart
Product Specification
FORMULA: C12H14N2O2
MW: 218.3
CAS NUMBER: 1210-83-9; 17994-17-1
PURITY: ≥99%
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Metabolite of serotonin (Prod. No. ALX-550-328). Precursor of melatonin (Prod. No. ALX-550-071). Inhibitor of hydroxyindole-O-methyltransferase.
Product Specific Literature References
The metabolism of serotonin (5-hydroxytryptamine): W.M. McIsaac and I.H. Page; J. Biol. Chem. 234, 858 (1959) Full Text
Hydroxyindole-O-methyltransferase. I. Substrate binding: B.T. Ho, et al.; J. Pharm. Sci. 58, 130 (1969) Abstract
Hydroxyindole-O-methyltransferase. II. Inhibitory activities of some N- acyltryptamines: B.T. Ho, et al.; J. Pharm. Sci. 57, 1998 (1968) Abstract
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Serotonergics & Serotonin Receptors / Related Products
 
 
ALX-350-310 Revised 03-Apr-08
3-O-Acetyl-11-keto-β-boswellic acid
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SYNONYMS AKβBA
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-310-M005   5 mg 130.00 USD Add To Cart
Product Specification
FORMULA: C32H48O5
MW: 512.7
CAS NUMBER: 67416-61-9
SOURCE/HOST: Isolated from Boswellia serrata.
PURITY: ≥99% (HPLC, NMR)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in acetone, dichloromethane, diethyl ether or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Protect from light.
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Shows antitumor and anti-inflammatory activities. Potent non-redox, noncompetitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. 10-times more potent than 3-O-acetyl-β-boswellic acid (Prod. No. ALX-350-308). Exhibits in vivo efficacy in tumor growth and inhibition.
Product Specific Literature References
Acetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I: R.F. Hoernlein, et al.; J. Pharmacol. Exp. Ther. 288, 613 (1999) Abstract; Full Text
Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization: A. Altmann, et al.; BBRC 290, 185 (2002) Abstract
Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes: A. Altmann, et al.; Br. J. Pharmacol. 141, 223 (2004) Abstract; Full Text
Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo: T. Syrovets, et al.; J. Biol. Chem. 280, 6170 (2005) Abstract; Full Text
Boswellic acids: biological actions and molecular targets: D. Poeckel & O. Werz; Curr. Med. Chem. 13, 3359 (2006), Review Abstract
Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis: C. Anthoni, et al.; Am. J. Physiol. Gastrointest. Liver Physiol. 290, G1131 (2006) Abstract
Potentiation of antinociceptive effect of NSAIDs by a specific lipooxygenase inhibitor, acetyl 11-keto-beta boswellic acid: M. Bishnoi, et al.; Indian J. Exp. Biol. 44, 128 (2006) Abstract
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Further Categories Containing This Product:
NF-kB Pathway Inhibitors • Natural Products - NF-kB Pathway Inhibitors • Antitumor Agents (Apoptosis Inducers) • Natural Products - Protein Kinase Inhibitors • Natural Products - Topoisomerase Inhibitors • Natural Products - Anti-inflammatory Agents • Natural Products - Apoptosis Inducers & Inhibitors • Lipoxygenases / Related Products
 
 
ALX-550-200 Revised 09-Aug-02
N-Acetyltryptamine
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-200-M005   5 mg 50.00 USD Add To Cart
ALX-550-200-M025   25 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C12H14N2O
MW: 202.3
CAS NUMBER: 1016-47-3
PURITY: ≥97%
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Partial agonist for melatonin receptors.
Product Specific Literature References
Characterization of a retinal melatonin receptor: M.L. Dubocovich; J. Pharmacol. Exp. Ther. 234, 395 (1985) Abstract
Luzindole (N-0774): a novel melatonin receptor antagonist: M.L. Dubocovich; J. Pharmacol. Exp. Ther. 246, 902 (1988) Abstract
 
 
ALX-550-232 Revised 13-May-08
Aconitine
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SYNONYMS (1α,3α,6α,14α,15α,16β)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol 8-acetate 14-benzoate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-550-232-M025   25 mg 45.00 USD Add To Cart
Product Specification
FOR