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Growth Factors / Related Products
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AG-P0731 Revised 16-Oct-08
Progranulin (human) ELISA Kit
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SYNONYMS Proepithelin (human) ELISA Kit
PEPI (human) ELISA Kit
PC Cell-derived Growth Factor (human) ELISA Kit
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Progranulin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
AG-P0731EK-KI01   96 wells 640.00 USD Add To Cart
AG-P0731TP-KI01 Twin Plex 2x96 wells 940.00 USD Add To Cart
AG-P0731PP-KI01 Penta Plex 5x96 wells 1'880.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 32pg/ml (range 0 to 8ng/ml)
SPECIFICITY: Does not cross-react with mouse and rat progranulin.
APPLICATION: For the quantitative determination of progranulin in human serum, plasma or cell culture supernatant.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Specific Literature References
Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration: R. Ghidoni, et al.; Neurology 71, 1235 (2008) Abstract
General Information
Progranulin (PGRN) has been shown to be a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signalling cascades that control cell cycle progression and cell motility. PGRN has also been linked to tumorigenesis. The function of PGRN in the central nervous system (CNS) is also of interest, because mutations in the PGRN gene have been identified in cases of frontotemporal degeneration (FTD).
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Granulins, a novel class of peptide from leukocytes: A. Bateman, et al.; BBRC 173, 1161 (1990) Abstract
Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis: Z. He & A. Bateman; J. Mol. Med. 81, 600 (2003) Abstract
Progranulin is a mediator of the wound response: Z. He, et al.; Nat. Med. 9, 225 (2003) Abstract
Progranulin in frontotemporal lobar degeneration and neuroinflammation: Z. Ahmed, et al.; J. Neuroinflammation 4, 7 (2007), (Review) Abstract; Full Text
Progranulin: normal function and role in neurodegeneration: J. L. Eriksen & I.R. Mackenzie; J. Neurochem. 104, 287 (2008), (Review) Abstract
Related Products
Further Categories Containing This Product:
ELISA & EIA Kits • Inflammation Other Products
 
 
AG-PM0731 Revised 23-Apr-08
Progranulin (mouse) ELISA Kit
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SYNONYMS Proepithelin (mouse) ELISA Kit
PEPI (mouse) ELISA Kit
PC Cell-derived Growth Factor (mouse) ELISA Kit
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Progranulin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
AG-PM0731EK-KI01   96 wells 645.00 USD Add To Cart
AG-PM0731TP-KI01 Twin Plex 2x96 wells 945.00 USD Add To Cart
AG-PM0731PP-KI01 Penta Plex 5x96 wells 1'885.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SENSITIVITY: 60pg/ml (range 0 to 16 ng/ml)
SPECIFICITY: Does not cross-react with human and rat progranulin
APPLICATION: For the quantitative determination of progranulin in mouse serum or cell culture supernatants.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
Progranulin (PGRN) has been shown to be a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signalling cascades that control cell cycle progression and cell motility. PGRN has also been linked to tumorigenesis. The function of PGRN in the central nervous system (CNS) is also of interest, because mutations in the PGRN gene have been identified in cases of frontotemporal degeneration (FTD).
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Granulins, a novel class of peptide from leukocytes: A. Bateman, et al.; BBRC 173, 1161 (1990) Abstract
Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis: Z. He & A. Bateman; J. Mol. Med. 81, 600 (2003) Abstract
Progranulin is a mediator of the wound response: Z. He, et al.; Nat. Med. 9, 225 (2003) Abstract
Progranulin in frontotemporal lobar degeneration and neuroinflammation: Z. Ahmed, et al.; J. Neuroinflammation 4, 7 (2007), (Review) Abstract; Full Text
Progranulin: normal function and role in neurodegeneration: J.L. Eriksen & I.R. Mackenzie; J. Neurochem. 104, 287 (2008), (Review) Abstract
Related Products
Further Categories Containing This Product:
ELISA & EIA Kits • Inflammation Other Products
 
 
ALX-155-021 Revised 29-Jun-05
EGF Receptor (human) (651-658)
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SYNONYMS Epidermal Growth Factor Receptor (human) (651-658)
EGFR (human) (651-658)
HER-1 (human) (651-658)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGF / EGF Receptor [EGFR] Kinase Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-155-021-M001   1 mg 50.00 USD Add To Cart
ALX-155-021-M005   5 mg 200.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH
FORMULA: C46H91N21O10
MW: 1098.4
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
LONG TERM STORAGE: -20°C
Product Description
Substrate for protein kinase C (PKC).
Product Specific Literature References
A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to adriamycin: C.A. O'Brian, et al.; Invest. New Drugs 9, 169 (1991) Abstract
Further Categories Containing This Product:
Peptides • PKC Substrates
 
 
ALX-155-022 Revised 29-Jun-05
EGF Receptor (human) (651-658) (N-Myristoylated)
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SYNONYMS Epidermal Growth Factor Receptor (human) (651-658) (N-Myristoylated)
EGFR (human) (651-658) (N-Myristoylated)
HER-1 (human) (651-658) (N-Myristoylated)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGF / EGF Receptor [EGFR] Kinase Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-155-022-M001   1 mg 60.00 USD Add To Cart
ALX-155-022-M005   5 mg 240.00 USD Add To Cart
Product Specification
SEQUENCE: Myr-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH
FORMULA: C60H117N21O11
MW: 1308.7
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Potent, cell permeable and possibly selective inhibitor of protein kinase C (PKC). This product is the N-terminal myristoylated form of Prod. No. ALX-155-021.
Product Specific Literature References
A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to adriamycin: C.A. O'Brian, et al.; Invest. New Drugs 9, 169 (1991) Abstract
Cyanobacteria secondary metabolites-the cyanotoxins: W.W. Carmichael; J. Appl. Bacteriol. 72, 445 (1992) Abstract
Inhibition of protein kinase C by N-myristoylated peptide substrate analogs: N.G. Ward & C.A. O'Brian; Biochemistry 32, 11903 (1993) Abstract
Further Categories Containing This Product:
Peptides • PKC Inhibitors
 
 
ALX-155-023 Revised 29-Jun-05
EGF Receptor (human) (652-657)
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SYNONYMS Epidermal Growth Factor Receptor (human) (652-657)
EGFR (human) (652-657)
HER-1 (human) (652-657)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGF / EGF Receptor [EGFR] Kinase Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-155-023-M001   1 mg 45.00 USD Add To Cart
ALX-155-023-M005   5 mg 180.00 USD Add To Cart
Product Specification
SEQUENCE: H-Lys-Arg-Thr-Leu-Arg-Arg-OH
FORMULA: C34H68N16O8
MW: 829.0
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Specific substrate (aa 652-657 of mature EGF receptor, without signal peptide (aa 1-24)) for protein kinase C (PKC).
Product Specific Literature References
Regulation of protein kinase C by nerve growth factor, epidermal growth factor, and phorbol esters in PC12 pheochromocytoma cells: L. Heasley & G.L. Johnson; J. Biol. Chem. 264, 8646 (1989) Abstract; Full Text
Further Categories Containing This Product:
Peptides • PKC Substrates
 
 
ALX-165-005 Revised 16-Feb-05
PDGF β-Receptor (719-723) (phosphorylated)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY SH2 & SH3 Domains
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-165-005-M001   1 mg 130.00 USD Add To Cart
ALX-165-005-M005   5 mg 520.00 USD Add To Cart
Product Specification
SEQUENCE: H-Tyr(PO3H2)-Val-Pro-Met-Leu-OH
FORMULA: C30H48N5O10PS
MW: 701.8
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Contains the PDGF β-receptor recognition sequence which specifically interacts with the SH2 domain of PI(3)K (phosphoinositide 3-kinase). In this phosphorylated form the peptide inhibits the binding of the 85kDa subunit of PI(3)K to the PDGF β-receptor.
Product Specific Literature References
Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways: W.J. Fantl, et al.; Cell 69, 413 (1992) Abstract
Closing in on SH2 specificity: R.B. Birge & H. Hanafusa; Science 262, 1522 (1993) Abstract
Further Categories Containing This Product:
Peptides • Platelet-derived Growth Factors [PDGFs] & Receptors / Related Products
 
 
ALX-165-019 Revised 24-Feb-05
PDGF Fragment (phosphorylated) (cyclic)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY SH2 & SH3 Domains
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-165-019-MC01   0.1 mg 50.00 USD Add To Cart
ALX-165-019-M001   1 mg 250.00 USD Add To Cart
Product Specification
SEQUENCE: cyclo(Gly-Tyr(PO3H2)-Val-Pro-Met-Leu)
FORMULA: C32H49N6O10PS
MW: 740.8
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Cyclic hexapeptide inhibitor of SH2 interactions. The peptide sequence represents the autophosphorylation region around Tyr751 of the PDGF β-receptor.
Product Specific Literature References
Synthesis of phosphonomethyl-phenylalanine and phosphotryrosine containing cyclic peptides as inhibitors of protein kinase/SN2 interactions: M. Nomizu, et al.; Tetrahedron 50, 2691 (1994)
Further Categories Containing This Product:
Peptides • Platelet-derived Growth Factors [PDGFs] & Receptors / Related Products
 
 
ALX-200-088 Revised 26-Mar-08
TGF-β1 (human)
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PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Transforming Growth Factor beta [TGFbeta] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-200-088-C002   2 µg 240.00 USD Add To Cart
Product Specification
MW: 12.5kDa for one subunit.
SOURCE/HOST: Human platelets tested negative for HBsAG-, HCV- and HIV-antibodies.
CONCENTRATION: 10μg/ml (determined by induction of 5-lipoxygenase activity in Mono Mac 6 cells)
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Acid-ethanol extraction of platelets followed by gel filtration and cation exchange column chromatography.
FORMULATION: Liquid. In 25% actonitrile containing 0.1% BSA and 0.1% trifluoroacetic acid.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 3 months when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Natural Proteins
 
 
ALX-201-204/1 Revised 06-Jun-08 New product
pro-Bone Morphogenetic Protein 2 (human) (recombinant)
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SYNONYMS proBMP-2 (human) (recombinant)
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-204/1-C010   10 µg 380.00 USD Add To Cart
Product Specification
MW: ~85.5kDa.
SOURCE/HOST: Produced in E. coli and renatured from inclusion body material.
CONCENTRATION: 100μg/ml after reconstitution.
PURITY: ≥98% (SDS-PAGE, UV, MS)
FORMULATION: Lyophilized from 0.1M K-HEPES, pH 7.0, containing 3% mannitol.
ENDOTOXIN CONTENT: <0.02EU/mg protein.
RECONSTITUTION: Reconstitute with 100μl distilled water at +4°C for 30 minutes.
BIOLOGICAL ACTIVITY: Administration leads to ectopic bone formation in rats.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: The reconstituted solution can be diluted into other aqueous buffers and stored at +4°C for up to two weeks. Below 10μg/ml, 0.5% BSA or serum should be added.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Product Specific Literature References
Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor : F. Hillger, et al.; J. Biol. Chem. 280, 14974 (2005) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-205/1 Revised 17-Jun-08 New product
Bone Morphogenetic Protein 2 (human) (recombinant)
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SYNONYMS BMP-2 (human) (recombinant)
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-205/1-C010   10 µg 280.00 USD Add To Cart
Product Specification
MW: ~25.9kDa.
SOURCE/HOST: Produced in E. coli and renatured from inclusion body material.
CONCENTRATION: 100-500μg/ml after reconstitution. 
PURITY: ≥98% (SDS-PAGE, UV, MS)
FORMULATION: Lyophilized.
ENDOTOXIN CONTENT: <0.02EU/mg protein.
RECONSTITUTION: Reconstitute with 20-100μl 50mM sodium acetate solution, pH 4.3.
BIOLOGICAL ACTIVITY: Induces alkaline phosphatase expression at an EC50 = 14nM in C2C12 cells.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY:

The reconstituted solution can be further diluted in sodium acetate solution and stored at +4°C for up to two weeks. Below 10μg/ml, 0.5% BSA or serum should be added.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Product Specific Literature References
Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor: F. Hillger, et al.; J. Biol. Chem. 280, 14974 (2005) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-207 Revised 14-Oct-08
pro-β-Nerve Growth Factor (human) (recombinant)