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Adipokines / Related Products
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ALX-201-035 Revised 18-May-06
Leptin (mouse) (recombinant)
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SYNONYMS OB Gene Product (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-035-M001   1 mg 190.00 USD Add To Cart
Product Specification
MW: ~16kDa.
MERCK INDEX: 14: 5443
SOURCE/HOST: Produced in E. coli. Homologous to mouse serum leptin.
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Lyophilized from 0.0045mM sodium bicarbonate.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein.
RECONSTITUTION: Reconstitute with sterile water or 0.4% sodium bicarbonate, pH 8-9. Do not reconstitute to less than 0.1mg/ml. Further dilutions should be made with medium containing a carrier protein.
BIOLOGICAL ACTIVITY: Induces proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted protein is stable for 4 weeks when stored at +4°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
Leptin, the product of the ob (obese) gene, is a 16kDa protein consisting of 146 amino acid residues. Leptin is produced in the adipose tissue, and is considered to play an important role in appetite control, fat metabolism and regulation of body weight. Studies have shown that it may also influence reproductive function. Mice with ob/ob genotype develop a form of diabetes similar to type II in humans.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link 41160: Leptin (mouse) (precursor)
AfCS Signalling Gateway link A001397: Leptin (mouse)
General Literature References
Positional cloning of the mouse obese gene and its human homologue: Y. Zhang, et al.; Nature 372, 425 (1994) Abstract
Effects of the obese gene product on body weight regulation in ob/ob mice: M.A. Pelleymounter, et al.; Science 269, 540 (1995) Abstract
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects: M. Maffei, et al.; Nature Med. 1, 1155 (1995) Abstract
Weight-reducing effects of the plasma protein encoded by the obese gene: J.L. Halaas, et al.; Science 269, 543 (1995) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-195 Revised 30-Oct-06
Resistin (human) (recombinant)
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SYNONYMS ADSF (human) (recombinant)
FIZZ3 (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Resistin & Resistin-like Molecules [RELMs] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-195-C100   100 µg 532.00 USD Add To Cart
Product Specification
MW: ~9.9kDa.
SOURCE/HOST: Produced in E. coli.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized from 25mM TRIS, pH 7.5, containing 25mM sodium chloride.
RECONSTITUTION: Reconstitute with 200µl deionized water.
APPLICATION: ELISA
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted protein is stable for 4 weeks when stored at +4°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
Resistin (also called adipose tissue-specific secretory factor [ADSF] or found in inflammatory zone 3 [FIZZ3]) is another hormone secreted by adipocytes that acts on skeletal muscle myocytes, hepatocytes and adipocytes themselves, where it is suggested to reduce insulin sensitivity leading to type 2 diabetes.
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q9HD89: Resistin (human) (precursor)
General Literature References
Dimerization of resistin and resistin-like molecules is determined by a single cysteine: R.R. Banerjee & M.A. Lazar; J. Biol. Chem. 276, 25970 (2001) Abstract; Full Text
A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation: K.H. Kim, et al.; J. Biol. Chem. 276, 11252 (2001) Abstract; Full Text
The hormone resistin links obesity to diabetes: C.M. Steppan, et al.; Nature 409, 307 (2001) Abstract
Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists: J.M. Way, et al.; J. Biol. Chem. 276, 25651 (2001) Abstract; Full Text
Resistin and obesity-associated insulin resistance: C.M. Steppan & M.A. Lazar; Trends Endocrinol. Metab. 13, 18 (2002) Abstract
Mechanisms regulating adipocyte expression of resistin: H.B. Hartman, et al.; J. Biol. Chem. 277, 19754 (2002) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-231 Revised 18-Mar-08
Leptin (rat) (recombinant)
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SYNONYMS OB Gene Product (rat) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-231-M001   1 mg 190.00 USD Add To Cart
Product Specification
MW: ~16kDa.
MERCK INDEX: 14: 5443
SOURCE/HOST: Produced in E. coli. Homologous to rat serum leptin.
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Lyophilized from 0.0045mM sodium bicarbonate.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein.
RECONSTITUTION: Reconstitute with sterile water or 0.4% sodium bicarbonate, pH 8-9. Do not reconstitute to less than 0.1mg/ml. Further dilutions should be made with medium containing a carrier protein.
BIOLOGICAL ACTIVITY: Induces proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted protein is stable for 4 weeks when stored at +4°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
Leptin, the product of the ob (obese) gene, is a 16kDa protein consisting of 146 amino acid residues. Leptin is produced in the adipose tissue, and is considered to play an important role in appetite control, fat metabolism and regulation of body weight. It targets the central nervous system, particularly hypothalamus, affecting food intake. Leptin levels are high in most obese individuals. Studies have shown that it may also influence reproductive function.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P50596: Leptin (rat) (precursor)
General Literature References
Leptin and the regulation of body weight in mammals: J.M. Friedman and J.L. Halaas; Nature 395, 763 (1998), review Abstract
Mutation screening and identification of a sequence variation in the human ob gene coding region: R.V. Considine, et al.; BBRC 220, 735 (1996) Abstract
Serum immunoreactive leptin concentrations in normal-weight and obese humans  : R.V. Considine, et al. ; New Engl. J. Med. 334, 292 (1996) Abstract
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects  : M. Maffei, et al.; Nature Medicine 1, 1155 (1995) Abstract
Effects of the obese gene product on body weight regulation in ob/ob mice  : M.A. Pelleymounter, et al. ; Science 269, 540 (1995) Abstract
Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity  : R.V. Considine, et al. ; J. Clin. Invest 95, 2986 (1995) Abstract
Overexpression of the obese (ob) gene in adipose tissue of the human subjects  : F. Lönnqvist, et al. ; Nature Medicine 1, 950 (1995) Abstract
Positional cloning of the mouse obese gene and its human homologue  : Y. Zhang, et al.; Nature 372, 425 (1994) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-303 Revised 10-Jul-08
Adiponectin (rat) (recombinant)
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SYNONYMS ACRP30 (rat) (recombinant)
Adipocyte Complement Related Protein of 30kDa (rat) (recombinant)
AdipoQ (rat) (recombinant)
apM1 (rat) (recombinant)
GBP28 (rat) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-303-C050   50 µg 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Rat adiponectin (aa 16-244) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION:

PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 30mM TRIS-HCl, pH 8.5.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; Bio Whittaker).
BIOLOGICAL ACTIVITY: Induces the phosphorylation of acetyl-CoA carboxylase (ACC) in C2C12 cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism: A.H. Berg, et al.; Trends Endocrinol. Metab. 13, 84 (2002), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-304 Revised 12-Nov-08
Adiponectin (Globular Domain) (human) (recombinant) (His)
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SYNONYMS ACRP30 (Globular Domain) (human) (recombinant) (His)
Adipocyte Complement Related Protein of 30kDa (Globular Domain) (human) (recombinant) (His)
AdipoQ (Globular Domain) (human) (recombinant) (His)
apM1 (Globular Domain) (human) (recombinant) (His)
GBP28 (Globular Domain) (human) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-304-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The globular domain of human adiponectin (aa 104-244) is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 30mM TRIS-Cl, pH 8.5.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL test; Bio Whittaker).
BIOLOGICAL ACTIVITY: Effect on phosphorylation of acetyl-CoA carboxylase (ACC) in C2C12 cells (see Fig. 2).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q15848: Adiponectin (human) (precursor)
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism: A.H. Berg, et al.; Trends Endocrinol. Metab. 13, 84 (2002), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-305 Revised 08-Dec-06
Adiponectin (Globular Domain) (human) (recombinant)
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SYNONYMS ACRP30 (Globular Domain) (human) (recombinant)
Adipocyte Complement Related Protein of 30kDa (Globular Domain) (human) (recombinant)
AdipoQ (Globular Domain) (human) (recombinant)
apM1 (Globular Domain) (human) (recombinant)
GBP28 (Globular Domain) (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-305-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The globular domain of human adiponectin (aa 104-244) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION:   
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 30mM TRIS, pH 8.5.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; Bio Whittaker).
BIOLOGICAL ACTIVITY: Induces the phosphorylation of acetyl-CoA carboxylase (ACC) in C2C12 cells. Activates AMPK in HUVEC cells in a PI(3)K-independent way.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q15848: Adiponectin (human) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism: A.H. Berg, et al.; Trends Endocrinol. Metab. 13, 84 (2002), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-306 Revised 28-Nov-07
Adiponectin (Globular Domain) (mouse) (recombinant) (His)
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SYNONYMS ACRP30 (Globular Domain) (mouse) (recombinant) (His)
Adipocyte Complement Related Protein of 30kDa (Globular Domain) (mouse) (recombinant) (His)
AdipoQ (Globular Domain) (mouse) (recombinant) (His)
apM1 (Globular Domain) (mouse) (recombinant) (His)
GBP28 (Globular Domain) (mouse) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-306-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The globular domain of mouse adiponectin (aa 104-247) is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 30mM TRIS-Cl, pH 8.5.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL test; Bio Whittaker).
BIOLOGICAL ACTIVITY: Induces the phosphorylation of acetyl-CoA carboxylase (ACC) in C2C12 cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q60994: Adiponectin (mouse) (precursor)
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism: A.H. Berg, et al.; Trends Endocrinol. Metab. 13, 84 (2002), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-309 Revised 09-Dec-06
Resistin (human) (recombinant)
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SYNONYMS ADSF (human) (recombinant)
FIZZ3 (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Resistin & Resistin-like Molecules [RELMs] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-309-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Mature human resistin (aa 20-108) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS, pH 7.2.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; Bio Whittaker).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q9HD89: Resistin (human) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-310 Revised 09-Dec-06
Resistin (mouse) (recombinant)
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SYNONYMS ADSF (mouse) (recombinant)
FIZZ3 (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Resistin & Resistin-like Molecules [RELMs] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-310-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Full length mouse resistin (aa 21-114) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 1mg/ml 
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS, pH 7.2.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; Bio Whittaker).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q99P87: Resistin (mouse) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-311 Revised 01-Oct-08
Resistin (rat) (recombinant)
Add to Clipboard
SYNONYMS ADSF (rat) (recombinant)
FIZZ3 (rat) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Resistin & Resistin-like Molecules [RELMs] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-311-C050 &nb