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TNF & TNF Receptor Superfamily / Related Products
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ALX-804-824 Revised 31-Oct-06
Monoclonal Antibody to BAFF-R (mouse) (7H22-E16)
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SYNONYMS anti-BR3 (mouse) MAb (7H22-E16)
anti-BlySR3 (mouse) MAb (7H22-E16)
anti-TNFRSF 13C (mouse) MAb (7H22-E16)
anti-CD268 (mouse) MAb (7H22-E16)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BAFF-R
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-824-C100   100 µg 320.00 USD Add To Cart
ALX-804-824TD-T100 ATTO 488 100 tests 380.00 USD Add To Cart
ALX-804-824TS-T100 ATTO 647N 100 tests 380.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: 7H22-E16
ISOTYPE: Rat IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: >95% (SDS-PAGE).
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant mouse BAFF-R extracellular domain (aa 2-70).
SPECIFICITY: Recognizes mouse BAFF-R.
APPLICATION: Flow Cytometry (1:100)
Western Blot (1:500)
Note: Not recommended for immunoprecipitation.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
HANDLING: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep ATTO, Biotin- and FITC-conjugated formats at +4°C. Do not freeze. Protect from light.
Product Specific Literature References
B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells: L.G. Ng, et al.; J. Immunol. 173, 807 (2004) Abstract
CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers: N.D. Huntington, et al.; Nat. Immunol. 7, 190 (2006) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION 1 test means: 1µl of MAb is used to stain 500’000 cells in a sample volume of 50µl.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
The BAFF/APRIL system: an important player in systemic rheumatic diseases: F. Mackay, et al.; Curr. Dir. Autoimmun. 8, 243 (2005) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-151 Revised 27-Jun-07
Monoclonal Antibody to BCMA (human) (Vicky-1)
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SYNONYMS anti-B Cell Maturation Protein (human) MAb (Vicky-1)
anti-TNFRSF 17 (human) MAb (Vicky-1)
anti-CD269 (human) MAb (Vicky-1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BCMA
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-151-C100   100 µg 360.00 USD Add To Cart
ALX-804-151F-T100 FITC 100 tests 390.00 USD Add To Cart
ALX-804-151TD-T100 ATTO 488 100 tests 395.00 USD Add To Cart
ALX-804-151TS-T100 ATTO 647N 100 tests 395.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Vicky-1
ISOTYPE: Rat IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: 95% (SDS-PAGE).
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human BCMA extracellular domain (aa 2-54) (Prod. No. ALX-522-026).
SPECIFICITY: Recognizes human BCMA. Does not cross-react with mouse BCMA.
APPLICATION: Flow Cytometry
Immunocytochemistry
Functional Application (blocks binding of BAFF to human BCMA)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep ATTO, Biotin- and FITC-conjugated formats at +4°C. Do not freeze. Protect from light.
Product Images
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Product Specific Literature References
TACI regulates IgA production by APRIL in collaboration with HSPG: D. Sakurai, et al.; Blood 109, 2961 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION 1 test means: 1µl of MAb is used to stain 500’000 cells in a sample volume of 50µl.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population: J.S. Thompson, et al.; J. Exp. Med. 192, 129 (2000) Abstract; Full Text
BAFF AND APRIL: a tutorial on B cell survival: F. Mackay, et al.; Annu. Rev. Immunol. 21, 231 (2003) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-826 Revised 21-Aug-08
Monoclonal Antibody to BCMA (mouse) (Vicky-2)
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SYNONYMS anti-B Cell Maturation Protein (mouse) MAb (Vicky-2)
anti-TNFRSF 17 (mouse) MAb (Vicky-2)
anti-CD269 (mouse) MAb (Vicky-2)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BCMA
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-826-C100   100 µg 320.00 USD Add To Cart
ALX-804-826TD-T100 ATTO 488 100 Tests 380.00 USD Add To Cart
ALX-804-826TS-T100 ATTO 647N 100 Tests 380.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: Vicky-2
ISOTYPE: Rat IgG2a
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant mouse BCMA extracellular domain (aa 1-46) (Prod. No. ALX-522-079).
SPECIFICITY: Recognizes mouse BCMA. Does not cross-react with human BCMA.
APPLICATION: Immunoprecipitation (1:200)
Flow Cytometry (1:1’000)
Western Blot (1:1’000)
Functional Application (blocks binding of BAFF to mouse BCMA)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
Product Images
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Product Specific Literature References
APRIL facilitates viral-induced erythroleukemia but is dispensable for T cell immunity and lymphomagenesis: G. Hardenberg, et al.; J. Leukoc. Biol. 84, 380 (2008) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION 1 test means: 1µl of MAb is used to stain 500’000 cells in a sample volume of 50µl.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation: S. Shulga-Morskaya, et al.; J. Immunol. 173, 2331 (2004) Abstract
TACI and BAFF-R mediate isotype switching in B cells: E. Castigli, et al.; J. Exp. Med. 201, 35 (2005) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-747 Revised 08-Dec-08 New product
Monoclonal Antibody to CD137 (mouse) (M4202)
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SYNONYMS anti-4-1BB (mouse) MAb (M4202)
anti-TNFRSF 9 (mouse) MAb (M4202)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD137 & CD137L / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-747-C050   50 µg 220.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: M4202
ISOTYPE: Rat IgG1
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant mouse CD137.
SPECIFICITY: Recognizes mouse CD137. Detects a band of ~40kDa by Western blot. Does not cross-react with human CD137.
APPLICATION: Flow Cytometry (1:500)
Western Blot (1:2’000)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for up to 6 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-805-046 Revised 21-Feb-07
Monoclonal Antibody to CD40 (mouse) (FGK45)
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SYNONYMS anti-TNFRSF 5 (mouse) MAb (FGK45)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD40 & CD40L [CD154] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-046B-C050 Biotin 50 µg 150.00 USD Add To Cart
ALX-805-046-C100   100 µg 165.00 USD Add To Cart
ALX-805-046-C500   500 µg 440.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: FGK45
ISOTYPE: Rat IgG2a
CONCENTRATION: FGK45: 1mg/ml
FGK45-Biotin: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In sterile PBS.
IMMUNOGEN: Recombinant mouse CD40 fusion protein.
SPECIFICITY: Recognizes mouse CD40.
APPLICATION: Flow Cytometry
Functional Application (activates B and NK cells in vivo and in vitro)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
USE/STABILITY:

For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep Biotin-conjugated formats at +4°C. Do not freeze. Protect from light.
Product Images
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Product Description
Widely used stimulatory MAb to CD40 [1,2]. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects [3]. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes [4]. 
Product Specific Literature References
[1] The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching: A. Rolink, et al.; Immunity 5, 319 (1996) Abstract
[2] Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity: A.G. Rolink, et al.; Eur. J. Immunol. 28, 3738 (1998) Abstract
[3] Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells: J.G. Turner, et al.; J. Immunol. 166, 89 (2001) Abstract
[4] Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process: C. Mauri, et al.; Nat. Med. 6, 673 (2000) Abstract
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[40] Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system: A. Erlebacher, et al.; J. Clin. Invest. 114, 39 (2004) Abstract; Full Text
[41] CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes: C.M. McGregor, et al.; PNAS 101, 9345 (2004) Abstract; Full Text
[42] IRF-7 is the master regulator of type-I interferon-dependent immune responses: K. Honda, et al.; Nature 434, 772 (2005) Abstract
[43] In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and type II IFN: J.A. Greene, et al.; J. Immunol. 176, 5995 (2006) Abstract
[44] IL-10- and IL-12-independent down-regulation of allergic sensitization by stimulation of CD40 signaling: P.W. Hellings, et al.; J. Immunol. 177, 5138 (2006) Abstract
[45] Agonistic Anti-CD40 Antibody Profoundly Suppresses the Immune Response to Infection with Lymphocytic Choriomeningitis Virus: C. Bartholdy, et al.; J. Immunol. 178, 1662 (2007) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-805-037 Revised 13-Feb-07
Monoclonal Antibody to CD40L (human) (blocking) (MK13A4)
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SYNONYMS anti-CD154 (human) MAb (blocking) (MK13A4)
anti-gp39 (human) MAb (blocking) (MK13A4)
anti-TNFSF 5 (human) MAb (blocking) (MK13A4)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD40 & CD40L [CD154] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-037-C100 Purified 100 µg 259.00 USD Add To Cart
ALX-805-037B-T100 Biotin 100 tests 308.00 USD Add To Cart
ALX-805-037F-T100 FITC 100 tests 308.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MK13A4
ISOTYPE: Mouse IgG1
QUANTITY: MK13A4: 100µl
MK13A4-Biotin: 1ml
MK13A4-FITC: 1ml
FORMULATION: MK13A4: Liquid. 1mg/ml in PBS.
MK13A4-Biotin and -FITC: Liquid. In 50mM TRIS, pH 7.4, containing 100mM sodium chloride, 1% BSA and 0.02% sodium azide.
IMMUNOGEN: Recombinant human CD40L (CD154).
SPECIFICITY: Recognizes human CD40L.
APPLICATION: Flow Cytometry
Functional Application (blocks binding of CD40L to its receptor CD40)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-331 Revised 14-Mar-06
Monoclonal Antibody to CD40L (mouse) (MR1)
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SYNONYMS anti-CD154 (mouse) MAb (MR1)
anti-gp39 (mouse) MAb (MR1)
anti-TNFSF 5 (mouse) MAb (MR1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD40 & CD40L [CD154] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-331-C100   100 µg 259.00 USD Add To Cart
ALX-804-331-C500   500 µg 490.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: MR1
ISOTYPE: Hamster IgG1
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS.
IMMUNOGEN: Recombinant mouse CD40L (CD154).
SPECIFICITY: Recognizes mouse CD40L.
APPLICATION: Functional Application (blocks T cell co-stimulation in vivo, promoting allograft acceptance and donor-specific tolerance to secondary skin grafts).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway: C.P. Larsen, et al.; Transplantation 61, 4 (1996) Abstract
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Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-845 Revised 02-Apr-07
Monoclonal Antibody to CD134 (human) (Nicky-1)
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SYNONYMS anti-OX40 (human) MAb (Nicky-1)
anti-TNFRSF 4 (human) MAb (Nicky-1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD134 [OX40] & CD134L [OX40L] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-845-C100   100 µg 320.00 USD Add To Cart
ALX-804-845TD-T100 ATTO 488 100 tests 390.00 USD Add To Cart
ALX-804-845TS-T100 ATTO 647N 100 tests 390.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Nicky-1
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human CD134 (OX40) (aa 29-214) (Prod. No. ALX-522-022).
SPECIFICITY: Recognizes human CD134.
APPLICATION: Flow Cytometry
Immmunoprecipitation (1:200)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
Product Images
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Product Description
New ATTO-fluorescent antibodies show increased photostability, outstanding brightness and intense signals. ATTO dyes are thermally stable, resistant to environmental changes and show no significant isomerization. ATTO 488 shows bright green fluorescence (λabs (max): 501nm, λem (max): 523nm, εmax: 90’000).
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor-reactive cytotoxic T lymphocytes: E. Biagi, et al.; Blood 105, 2436 (2005) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-138 Revised 14-Dec-06
Monoclonal Antibody to CD134L (mouse) (blocking) (MGP34)