ALEXIS Biochemicals: Pterostilbene

You are here: Product Lines > Natural Products / Antibiotics > Natural Products > Polyphenols (Flavonoids, Stilbenoids, Phenolic Acids)

Anthocyanidins

Chalcones

Polyphenols Other Products

ALX-350-320

Revised 11-Mar-08

3,5-Di-O-caffeoylquinic acid
SYNONYMS	3,5-CQA Isochlorogenic acid
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-320-M001		1 mg	95.00 USD
ALX-350-320-M005		5 mg	380.00 USD

Product Specification

FORMULA:	C₂₅H₂₄O₁₂
MW:	516.5
CAS NUMBER:	2450-53-5
SOURCE/HOST:	Isolated from Cynara scolymus.
PURITY:	≥97% (HPLC)
APPEARANCE:	Grey to yellow crystalline solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
IDENTITY:	Identity determined by ¹H-NMR, ¹³C-NMR and MS.

Product Description

Antioxidant. Shows antiproliferative activity.

Product Specific Literature References

Biochemistry on postharvest metabolism and deterioration of some tropical tuberous crops: I. Uritani; Bot. Bull. Acad. Sinica 40, 177 (1999)
In vitro antioxidative effects and tyrosinase inhibitory activities of seven hydroxycinnamoyl derivatives in green coffee beans: K. Iwai, et al.; J. Agric. Food Chem. 52, 4893 (2004) Abstract
Antioxidant and antiproliferative activities of sweet potato (Ipomoea batatas [L.] Lam "Tainong 57"): D.J. Huang, et al.; Bot. Bull. Acad. Sinica 45, 179 (2004)
Changes in caffeic acid derivatives in sweet potato (Ipomoea batatas L.) during cooking and processing: M. Takenaka, et al.; Biosci. Biotechnol. Biochem. 70, 172 (2006) Abstract; Full Text

Further Categories Containing This Product:

Active Substances from Fruit and Vegetables • Free Radical Scavengers • Phenolic Acids

ALX-350-353

Revised 16-Jun-08

Chlorogenic acid
SYNONYMS	1,3,4,5-Tetrahydroxycyclohexanecarboxylic acid 3-(3,4-dihydroxycinnamate) 3-O-Caffeoylquinic acid Heriguard NSC 407296
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Chemopreventive Agents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-353-M500		500 mg	35.00 USD
ALX-350-353-G001		1 g	65.00 USD

Product Specification

FORMULA:	C₁₆H₁₈O₉
MW:	354.3
CAS NUMBER:	327-97-9
MERCK INDEX:	14: 2142
RTECS:	GU8480000
SOURCE/HOST:	Isolated from the leaves and fruits of dicotyledonous plants (e.g. coffee beans).
PURITY:	≥95%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	25mg/ml soluble in 100% ethanol, DMSO, dimethyl formamide or PBS (pH 7.2).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	We do not recommend storing the aqueous solution for more than one day.

Product Description

Analog of caffeic acid (Prod. No. ALX-270-231). Shows antioxidant, analgesic, antipyretic and chemopreventive activity. Inhibits Bcr-Abl tyrosine kinase and triggers MAP kinases p38-dependent apoptosis. Inhibitor of the tumor promoting activity of phorbol esters.

Product Specific Literature References

[Chlorogenic acid in coffee beans and their change during the roasting process. Report 1. Qualitative studies]: R. Krasemann; Arch. Pharm. 293, 721 (1960) Abstract
Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes: Y. Kimura, et al.; J. Nat. Prod. 50, 392 (1987) Abstract
Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate: M.T. Huang, et al.; Cancer Res. 48, 5941 (1988) Abstract; Full Text
Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin: A.H. Conney, et al.; Adv. Enzyme Regul. 31, 385 (1991) Abstract
Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells: G. Bandyopadhyay, et al.; Blood 104, 2514 (2004) Abstract; Full Text
Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid: R. Feng, et al.; J. Biol. Chem. 280, 27888 (2005) Abstract; Full Text
The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression: A. Belkaid, et al.; Cancer Cell Int. 6, 7 (2006) Abstract; Full Text
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid: M.D. dos Santos, et al.; Biol. Pharm. Bull. 29, 2236 (2006) Abstract; Full Text
Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols: W.J. Lee & B.T. Zhu; Carcinogenesis 27, 269 (2006) Abstract; Full Text

Related Products

ALX-270-231

Caffeic acid

Further Categories Containing This Product:

Active Substances from Fruit and Vegetables • MAPK Pathway Activators • Tyrosine Kinase Inhibitors • Natural Products - Protein Kinase Inhibitors • Natural Products - Antioxidants • Natural Products for Neurological Research • Natural Products - Apoptosis Inducers & Inhibitors • Analgesic / Anti-nociceptive Agents / Related Products • Phenolic Acids

ALX-380-015

Revised 08-Oct-07

Mycophenolic acid
SYNONYMS	6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexanoic acid
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Immunomodulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-015-M050		50 mg	30.00 USD
ALX-380-015-M250		250 mg	105.00 USD
ALX-380-015-G001		1 g	310.00 USD

Product Specification

FORMULA:	C₁₇H₂₀O₆
MW:	320.3
CAS NUMBER:	24280-93-1
MERCK INDEX:	14: 6327
SOURCE/HOST:	Isolated from Penicillium brevi-compactum.
PURITY:	≥98%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in methanol or methylene chloride; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HAZARD:	TOXIC.

Product Description

Immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of inosine-5’-monophosphate (IMP). Prevents the formation of xanthosine-5’-monophosphate (XMP) and guanosine-5’-monophosphate (GMP). Depletes tetrahydrobiopterin and decreases nitric oxide (NO) production by iNOS (NOS II) without affecting nNOS (NOS I) activity. Suppresses cytokine-induced nitric oxide (NO) production in mouse and rat vascular endothelial cells.

Product Specific Literature References

Guanine nucleotide depletion and toxicity in mouse T lymphoma (S-49) cells: M.B. Cohen, et al.; J. Biol. Chem. 256, 8713 (1981) Abstract; Full Text
Pharmacodynamic assessment of mycophenolic acid-induced immunosuppression by measuring IMP dehydrogenase activity: L.J. Langman, et al.; Clin. Chem. 41, 295 (1995) Abstract
Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells: M. Senda, et al.; Transplantation 60, 1143 (1995) Abstract
Mycophenolate mofetil and its mechanisms of action: A.C. Allison & E.M. Eugui; Immunopharmacology 47, 85 (2000) Abstract
Mycophenolic acid downregulates inducible nitric oxide synthase induction in astrocytes: D. Miljkovic, et al.; Glia 39, 247 (2002) Abstract
Mycophenolic acid inhibits inosine 5´-monophosphate dehydrogenase and suppresses production of pro-inflammatory cytokines, nitric oxide, and LDH in macrophages: C.A. Jonsson & H. Carlsten; Cell Immunol. 216, 93 (2002) Abstract
Inducible nitric oxide synthase inhibition by mycophenolic acid: D. Miljkovic, et al.; Mini Rev. Med. Chem. 4, 741 (2004), Review Abstract
Antifibrotic actions of mycophenolic acid: C. Morath, et al.; Clin. Transplant. 20, 25 (2006), Review Abstract

Further Categories Containing This Product:

Antibiotics - Nitric Oxide Pathway Modulators • Phenolic Acids

ALX-270-125

Revised 25-Apr-08

Resveratrol
SYNONYMS	trans-3,4’,5-Trihydroxystilbene
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-125-M050		50 mg	36.00 USD
ALX-270-125-M100		100 mg	50.00 USD
ALX-270-125-M250		250 mg	95.00 USD

Product Specification

FORMULA:	C₁₄H₁₂O₃
MW:	228.2
CAS NUMBER:	501-36-0
MERCK INDEX:	14: 8158
SOURCE/HOST:	Isolated from Polygonum cuspidatum.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	~65mg/ml soluble in DMSO, 100% ethanol or dimethyl formamide; slightly soluble in PBS, pH 7.2 (~100 µg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	IRRITANT.

Product Description

Shows cancer chemopreventive activity. Specific inhibitor of cyclooxygenase-1 (COX-1). Inhibits the hydroperoxidase activity of COX-1. Antioxidant. Potent activator of human deacetylase SIRT1. Protects against 4-hydroxynonenal (4-HNE) induced oxidative stress and apoptosis.

Product Specific Literature References

Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta: C.K. Chen, et al.; Gen. Pharmacol. 27, 363 (1996) Abstract
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes: M. Jang, et al.; Science 275, 218 (1997) Abstract
Cancer chemopreventive activity of resveratrol: M. Jang & J.M. Pezzuto; Drugs Exp. Clin. Res. 25, 65 (1999) Abstract
Capillary electrophoresis determination, synthesis, and stability of resveratrol and related 3-O-beta-D-glucopyranosides: V. Brandolini, et al.; J. Agric. Food Chem. 50, 7407 (2002) Abstract
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature 425, 191 (2003) Abstract
Resveratrol protects against 4-HNE induced oxidative stress and apoptosis in Swiss 3T3 fibroblasts: O. Kutuk, et al.; Biofactors 20, 1 (2004) Abstract
Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats: A.R. Martin, et al.; Biochem. Pharmacol. 67, 1399 (2004) Abstract
Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells: E. Sexton, et al.; Mol. Cancer 5, 45 (2006) Abstract
Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad?: P. Saiko, et al.; Mutat. Res. 658, 68 (2008) Abstract

Related Products

ALX-385-034

Pterostilbene

Further Categories Containing This Product:

Natural Products - Chemopreventive Agents • Active Substances from Fruit and Vegetables • Sirtuins / Related Products • Stilbenoids • COX Inhibitors

ALX-270-202

Revised 07-Oct-08

Piceatannol
SYNONYMS	3,4,3',5'-Tetrahydroxy-trans-stilbene
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Protein Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-202-M001		1 mg	22.00 USD
ALX-270-202-M005		5 mg	62.00 USD
ALX-270-202-M010		10 mg	105.00 USD
ALX-270-202-M050		50 mg	375.00 USD

Product Specification

FORMULA:	C₁₄H₁₂O₄
MW:	244.3
CAS NUMBER:	10083-24-6
SOURCE/HOST:	Synthetic.
PURITY:	≥98%
APPEARANCE:	Off-white to light pink crystalline solid.
SOLUBILITY:	Soluble in DMSO, dimethyl formamide, 100% ethanol, methanol, acetone or ethyl acetate; slightly soluble in water (1mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Unstable in sodium hydroxide.
HANDLING:	Protect from light and oxygen.

Product Description

Originally isolated from Euphorbia lagascae. Selective protein tyrosine kinase Syk inhibitor. Activator of human deacetylase SIRT1.

Product Specific Literature References

Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization: M. Cushman, et al.; J. Med. Chem. 34, 2579 (1991) Abstract
Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol: J.M. Oliver, et al.; J. Biol. Chem. 269, 29697 (1994) Abstract; Full Text
The tyrosine phosphorylation of a p72syk-like protein in activated murine resident peritoneal macrophages: K.I. Abu-Lawi & B.M. Sultzer; Cell Mol. Biol. Res. 41, 49 (1995) Abstract
Calcium signaling in endothelial cells involves activation of tyrosine kinases and leads to activation of mitogen-activated protein kinases: I. Fleming, et al.; Circul. Res. 76, 522 (1995) Abstract
Coronary arteriolar flow-induced vasodilation signals through tyrosine kinase: J.M. Muller, et al.; Am. J. Physiol. 270, H1878 (1996) Abstract
Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine: J.D. Peters, et al.; J. Biol. Chem. 271, 4755 (1996) Abstract; Full Text
Src-regulated extracellular signal-related kinase and Syk-regulated c-Jun N-terminal kinase pathways act in conjunction to induce IL-1 synthesis in response to microtubule disruption in HL60 cells: B. Cambien, et al.; J. Immunol. 163, 5079 (1999) Abstract; Full Text
FcepsilonRI-mediated antigen endocytosis turns interferon-gamma-treated mouse mast cells from inefficient into potent antigen-presenting cells: C .Tkaczyk, et al.; Immunology 97, 333 (1999) Abstract
Piceatannol, a stilbene phytochemical, inhibits mitochondrial F0F1-ATPase activity by targeting the F1 complex: J. Zheng & V.D. Ramirez; BBRC 261, 499 (1999) Abstract
Microarray analysis of piceatannol-induced changes in gene expression in human gastric cancer cells : D. Jeoung, et al.; Biotechnology Lett. 24, 463 (2002) Abstract; Full Text
Piceatannol, a Syk-selective tyrosine kinase inhibitor, attenuated antigen challenge of guinea pig airways in vitro: C.J. Seow, et al.; Eur. J. Pharmacol. 443, 189 (2002) Abstract
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature 425, 191 (2003)

Further Categories Containing This Product:

Kinases in T Cell Signal Transduction / Related Products • B Cell Receptor [BCR] & Co-Receptors / Related Products • Tyrosine Kinase Inhibitors • Sirtuins / Related Products • Stilbenoids

ALX-350-114

Revised 03-Dec-07

Polydatin
SYNONYMS	Piceid Resveratrol-3β-mono-D-glucoside 3-Hydroxy-5-(2-(4-hydroxyphenyl)ethenyl)phenyl-β-D-glucoside
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-114-M010		10 mg	90.00 USD

Product Specification

FORMULA:	C₂₀H₂₂O₈
MW:	390.4
CAS NUMBER:	65914-17-2
SOURCE/HOST:	Isolated from Polygonum cuspidatum.
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in ethyl acetate, DMSO or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	HARMFUL. IRRITANT.

Product Description

Platelet aggregation inhibitor. Shows multiple effects on vascular smooth muscle cells, myocardial cells, endothelial cells and white blood cells after shock. May inhibit phospholipase A2. Inhibits the expression of various cell adhesion molecules.

Product Specific Literature References

Wine as a biological fluid: history, production, and role in disease prevention: G.J. Soleas, et al.; J. Clin. Lab. Anal. 11, 287 (1997) Abstract
Protective effects of polydatin against CCl(4)-induced injury to primarily cultured rat hepatocytes: Z.S. Huang, et al.; World J. Gastroenterol. 5, 41 (1999) Abstract
Capillary electrophoresis determination, synthesis, and stability of resveratrol and related 3-O-beta-D-glucopyranosides: V. Brandolini, et al.; J. Agric. Food Chem. 50, 7407 (2002) Abstract
The mechanism of Polydatin in shock treatment: K.S. Zhao, et al.; Clin. Hemorheol. Microcirc. 29, 211 (2003) Abstract
Effect of polydatin on phospholipase A2 in lung tissues in rats with endotoxic shock: S.Y. Shu, et al.; Chin. J. Traumatol. 7, 239 (2004) Abstract
Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury: Y. Cheng, et al.; Brain Res. 1110, 193 (2006) Abstract

Further Categories Containing This Product:

PLA2 Inhibitors • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Natural Products - Chemopreventive Agents • COX Inhibitors • CD11a, CD18 [LFA-1] & CD54 [ICAM-1], CD102 [ICAM-2], CD50 [ICAM-3] / Related Products • Stilbenoids

ALX-350-345

Revised 21-May-08

trans-3,4’,5-Trimethoxy-stilbene
SYNONYMS	Trimethoxy-resveratrol MR-3
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products for Angiogenesis Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-345-M025		25 mg	20.00 USD
ALX-350-345-M100		100 mg	60.00 USD

Product Specification

FORMULA:	C₁₇H₁₈O₃
MW:	270.3
CAS NUMBER:	22255-22-7
PURITY:	≥97% (TLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO (40mg/ml), 100% ethanol (15mg/ml) or dimethyl formamide.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions are stable for up to 3 months when stored at -20°C.

Product Description

Analog of resveratrol (Prod. No. ALX-270-125). Shows powerful anti-angiogenic activity.

Product Specific Literature References

Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4’-trimethoxystilbene: M. Belleri, et al.; Mol. Pharmacol. 67, 1451 (2005) Abstract; Full Text
Anti-allergic activity of stilbenes from Korean rhubarb (Rheum undulatum L.): structure requirements for inhibition of antigen-induced degranulation and their effects on the release of TNF-alpha and IL-4 in RBL-2H3 cells: H. Matsuda, et al.; Bioorg. Med. Chem. 12, 4871 (2004) Abstract
Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators: P. de Medina, et al.; J. Med. Chem. 48, 287 (2005) Abstract
Antitumor activity of 3,5,4’-trimethoxystilbene in COLO 205 cells and xenografts in SCID mice: M.H. Pan, et al.; Mol. Carcinog. 47, 184 (2008) Abstract

FORMULA:	C₁₆H₁₆O₃
MW:	256.3
CAS NUMBER:	537-42-8
SOURCE/HOST:	Synthetic.
PURITY:	≥98% (HPLC)
APPEARANCE:	Off-white to light brown powder.
SOLUBILITY:	Soluble in DMSO (20mg/ml) or methanol; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light and oxygen.
HAZARD:	IRRITANT.