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ALX-350-335
Revised 14-Nov-07
Cochlioquinone A
SYNONYMS
Luteoleersin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Angiogenesis Research
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ALX-350-335-MC05
0.5 mg
260.00 USD
Product Specification
FORMULA:
C
30
H
44
O
8
MW:
532.7
CAS NUMBER:
32450-25-2
SOURCE/HOST:
Isolated from
Bipolaris leersia
MST-FP107.
PURITY:
≥99% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Shows antiangiogenic and nematocidal activities. Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of diacylglycerol acyltransferase, diacylglycerol kinase and NADH-ubiquinone reductase.
Product Specific Literature References
Cochlioquinone A, a nematocidal agent which competes for specific [3H]ivermectin binding sites:
J.M. Schaeffer, et al.; J. Antibiot. (Tokyo)
43
, 1179 (1990)
Abstract
Epi-cochlioquinone A, a novel acyl-CoA : cholesterol acyltransferase inhibitor produced by Stachybotrys bisbyi:
T. Fujioka, et al.; J. Antibiot. (Tokyo)
49
, 409 (1996)
Abstract
Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola:
H.J. Jung, et al.; Bioorg. Med. Chem.
11
, 4743 (2003)
Abstract
Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1:
H.B. Lee, et al.; J. Antibiot. (Tokyo)
56
, 967 (2003)
Abstract
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum:
K. Yoganathan, et al.; J. Antibiot. (Tokyo)
57
, 59 (2004)
Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors / Related Products
•
NAD+ Metabolism / Related Products
•
Vitamins
ALX-350-341
Revised 14-Nov-07
Cochlioquinone B
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Angiogenesis Research
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ALX-350-341-MC05
0.5 mg
260.00 USD
Product Specification
FORMULA:
C
28
H
40
O
6
MW:
472.6
CAS NUMBER:
32450-26-3
SOURCE/HOST:
Isolated from
Bipolaris leersia
MST-FP107.
PURITY:
≥99% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of NADH-ubiquinone reductase. Phytotoxic agent inhibiting root growth.
Product Specific Literature References
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum:
K. Yoganathan, et al.; J. Antibiot. (Tokyo)
57
, 59 (2004)
Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors / Related Products
•
NAD+ Metabolism / Related Products
•
Vitamins
ALX-201-388
Revised 08-Oct-08
CX3CL1, Soluble (human) (recombinant)
SYNONYMS
Fractalkine, Soluble (human) (recombinant)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CX3C Chemokines & Receptors / Related Products
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ALX-201-388-C010
10 µg
170.00 USD
ALX-201-388-C050
50 µg
590.00 USD
Product Specification
SOURCE/HOST:
Produced in HEK 293 cells. Signal peptide and extracellular domain of human CX3CL1 (fractalkine) (aa 1-339) is fused at the C-terminus to a FLAG
®
-tag.
CONCENTRATION:
0.5mg/ml
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg protein (LAL-test).
BIOLOGICAL ACTIVITY:
Chemotaxis effect of soluble recombinant human CX3CL1 (fractalkine) in THP-1 cells (see Figure 2).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P78423:
Fractalkine (human) [Precursor]
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-804-489
Revised 02-Jun-05
Monoclonal Antibody to CCL1 (human) (8P16-N4-L21)
SYNONYMS
anti-I-309 (human) MAb (8P16-N4-L21)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
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ALX-804-489-C100
100 µg
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
8P16-N4-L21
ISOTYPE:
Mouse IgM
CONCENTRATION:
1mg/ml
PURITY DETAIL:
DEAE purified.
FORMULATION:
Liquid. In PBS.
IMMUNOGEN:
Recombinant human CCL1 (I-309).
SPECIFICITY:
Recognizes human CCL1.
APPLICATION:
Immunohistochemistry (frozen sections (5µg/ml))
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-594
Revised 10-Jun-05
Monoclonal Antibody to CCL2 (human) (5J.1)
SYNONYMS
anti-MCP-1 (human) MAb (5J.1)
anti-Monocyte Chemotactic Protein-1 (human) MAb (5J.1)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
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ALX-804-594-C100
100 µg
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
5J.1
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS.
IMMUNOGEN:
Recombinant human CCL2 (monocyte chemotactic protein-1; MCP-1).
SPECIFICITY:
Recognizes human CCL2.
APPLICATION:
Immunohistochemistry (frozen sections (5µg/ml))
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-465
Revised 29-Feb-08
Monoclonal Antibody to CCL2 (human) (5D3-F7)
SYNONYMS
anti-MCP-1 (human) MAb (5D3-F7)
anti-Monocyte Chemotactic Protein-1 (human) MAb (5D3-F7)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
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ALX-804-465-C100
100 µg
350.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
5D3-F7
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Purified antibody in PBS containing 0.1% sodium azide.
IMMUNOGEN:
Recombinant human CCL2 (monocyte chemotactic protein-1; MCP-1).
SPECIFICITY:
Recognizes human CCL2.
APPLICATION:
ELISA (capture)
Immunocytochemistry (1:1'000)
Immunohistochemistry (frozen sections, paraffin sections (1:250-1:500))
Immunoprecipitation
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
A new monoclonal antibody (5D3-F7) which recognizes human monocyte chemotactic protein-1 but not related chemokines. Development of a sandwich ELISA and in situ detection of producing cells
:
G. Peri, et al.; J. Immunol. Methods
174
, 249 (1994)
Abstract
Analysis of the Gene Expression Profile Activated by the CC Chemokine Ligand 5/RANTES and by Lipopolysaccharide in Human Monocytes:
M. Locati, et al.; J. Immunol.
168
, 3557 (2002)
Full Text
Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation:
L. Piemonti, et al.; Diabetes
51
, 55 (2002)
Full Text
Further Categories Containing This Product:
Osteocalcin & Matrix Gla-protein [MGP] Family / Related Products
•
Monoclonal Antibodies
ALX-804-549
Revised 29-Feb-08
Monoclonal Antibody to CCL2 (human) (D9)
SYNONYMS
anti-MCP-1 (human) MAb (D9)
anti-Monocyte Chemotactic Protein-1 (human) MAb (D9)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
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ALX-804-549-C100
100 µg
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
D9
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Protein G purified antibody in PBS.
IMMUNOGEN:
Recombinant human CCL2 (monocyte chemotactic protein-1; MCP-1).
SPECIFICITY:
Recognizes human CCL2.
APPLICATION:
Immunoprecipitation
Western Blot (5µg/ml)
Functional Application (blocks CCL2 [MCP-1]; 2µg/ml)
Not recommended for immunohistochemistry.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-470
Revised 10-May-06
Monoclonal Antibody to CCL22 (human) (152/11)
SYNONYMS
anti-MDC (human) MAb (152/11)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
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ALX-804-470-C250
250 µg
540.00 USD
ALX-804-470E-C250
Peroxidase
250 µg
580.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
152/11
ISOTYPE:
Rat IgG
CONCENTRATION:
ALX-804-470
: 2.3mg/ml
ALX-804-470E
: 0.36mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
ALX-804-470
: Liquid. In PBS, pH 7.4.
ALX-804-470E
: Liquid. In PBS, pH 7.4, containing 0.2% bronidox and 0.05% phenol.
IMMUNOGEN:
Recombinant human CCL22 (macrophage-derived chemokine; MDC).
SPECIFICITY:
Recognizes human CCL22.
APPLICATION:
ALX-804-470
: Western Blot (2-4µg/ml)
Detection Limit: 0.2µg/lane.
ALX-804-470E
: ELISA (detection (1-2µ/ml))
Use microtiter plates coated with primary antibody (Prod. No.
ALX-804-469
, MAb to CCL22 (human) (349/6) at 20µg/ml in 0.05M carbonate/bicarbonate buffer, pH 9.6) to detect human fractalkine.
Detection Limit: ~60pg/ml.
Substrate: 0.26mg/ml tetramethyl benzydine and 0.01% hydrogen peroxide stabilized in 0.05M citrate buffer, pH 3.8.
SHIPPING:
SHIPPED ON BLUE ICE
USE/STABILITY:
ALX-804-470
: Short Term Storage: +4°C. Long Term Storage: After opening, prepare aliquots and store at -20°C.
ALX-804-470E
: Long Term Storage: +4°C.
HANDLING:
For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-469
Revised 07-May-08
Monoclonal Antibody to CCL22 (human) (349/6)
SYNONYMS
anti-MDC (human) MAb (349/6)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
Ordering Information
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ALX-804-469-C250
250 µg
540.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
349/6
ISOTYPE:
Rat IgG
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant human CCL22 (macrophage-derived chemokine; MDC).
SPECIFICITY:
Recognizes human CCL22.
APPLICATION:
ELISA
(capture (20µg/ml))
Use microtiter plates coated with this antibody in 0.05M carbonate/bicarbonate buffer, pH 9.6, in combination with secondary antibody (Prod. No.
ALX-804-470
, MAb to CCL22 (human) (152/11)) at 1-2µg/ml to detect human MDC.
Detection Limit: ~40pg/ml.
Substrate: 0.26mg/ml tetramethyl benzydine and 0.01% hydrogen peroxide stabilized in 0.05M citrate buffer, pH 3.8.
Western Blot
(1-2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Preservative may be added for storage at +4°C.
HANDLING:
For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-591
Revised 20-Nov-06
Monoclonal Antibody to CCR3 (human) (5E8)
SYNONYMS
anti-C-C Chemokine Receptor 3 (human) MAb (5E8)
anti-Eotaxin Receptor (human) MAb (5E8)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
Ordering Information
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ALX-804-591-C100
100 µg
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
5E8
ISOTYPE:
Mouse IgG2a
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS.
IMMUNOGEN:
L1.2 cells expressing human CCR3 (C-C Chemokine Receptor 3).
SPECIFICITY:
Recognizes human CCR3.
APPLICATION:
Flow Cytometry
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-472
Revised 10-Feb-05
Monoclonal Antibody to CX3CL1 (human) (20/20)
SYNONYMS
anti-Fractalkine (human) MAb (20/20)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CX3C Chemokines & Receptors / Related Products
Ordering Information
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ALX-804-472-C250
250 µg
540.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
20/20
ISOTYPE:
Rat IgG
PURITY DETAIL:
Purified by protein G affinity chromatography.
FORMULATION:
Liquid. In PBS, pH 7.4.
IMMUNOGEN:
Recombinant human CX3CL1 (fractalkine).
SPECIFICITY:
Recognizes human CX3CL1.
APPLICATION:
ELISA
(detection (1-2µg/ml))
Upon conjugation with a suitable label this antibody can be used with primary antibody (Prod. No.
ALX-804-471
, MAb to CX3CL1 (human) (28/31) at 20µg/ml) to detect human fractalkine.
Detection Limit: ~0.5ng/ml.
Western Blot
(1-2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-471
Revised 05-Aug-05
Monoclonal Antibody to CX3CL1 (human) (28/31)
SYNONYMS
anti-Fractalkine (human) MAb (28/31)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
