ALEXIS Biochemicals: Chlorambucil

ALX-400-049

Revised 14-Nov-07

Chlorambucil
SYNONYMS	4-[Bis(2-chloroethyl)amino]benzenebutanoic acid
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Antitumor Agents (DNA Interaction & Gene Regulation)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-400-049-G001		1 g	45.00 USD
ALX-400-049-G005		5 g	180.00 USD
ALX-400-049-M250		250 mg	25.00 USD

Product Specification

FORMULA:	C₁₄H₁₉Cl₂NO₂
MW:	304.2
CAS NUMBER:	305-03-3
MERCK INDEX:	14: 2073
RTECS:	ES7525000
SOURCE/HOST:	Synthetic.
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in ether or ethanol:chloroform:acetone (3:5:4) (warm); practically insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	TOXIC. MAY BE CARCINOGENIC.

Product Description

A nitrogen mustard bifunctional alkylating agent. Shows antineoplastic and immunosuppressant effect. Induces apoptosis in chronic lymphocytic leukemia cells.

Product Specific Literature References

DNA damage and mutagenesis induced by nitrogen mustards: L.F. Povirk & D.E. Shuker; Mutat. Res. 318, 205 (1994) Abstract
Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress: I. Boldogh, et al.; Toxicology 193, 137 (2003) Abstract
Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase: L. Amrein, et al.; J. Pharmacol. Exp. Ther. 321, 848 (2007) Abstract

Further Categories Containing This Product:

Apoptosis Inducers & Inhibitors Other Products

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.