ALEXIS Biochemicals: Citrinin

ALX-380-058

Revised 20-Oct-08

Citrinin
SYNONYMS	Antimycin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-058-M001		1 mg	15.00 USD
ALX-380-058-M005		5 mg	60.00 USD
ALX-380-058-M010		10 mg	105.00 USD
ALX-380-058-M025		25 mg	210.00 USD

Product Specification

FORMULA:	C₁₃H₁₄O₅
MW:	250.3
CAS NUMBER:	518-75-2
MERCK INDEX:	14: 2327
RTECS:	DJ2275000
SOURCE/HOST:	Isolated from Penicillium citrinum.
PURITY:	≥97% (HPLC)
APPEARANCE:	Yellow crystalline solid.
SOLUBILITY:	Soluble in 100% ethanol, methanol, dioxane, pyridine or dichlormethane; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Solutions change color with changes in pH from yellow (pH 4.6) to red (pH 9.9).
HAZARD:	TOXIC.
MELTINGPOINT:	110-112°C

Product Description

Antibiotic. Induces mitochondrial permeability pore opening and inhibits respiration by interfering with complex I of the respiratory chain. Mycotoxin. Acts as nephrotoxin in all species in which it has been tested. Has been implicated as a cause of Balkan nephropathy and yellow rice fever in humans. Induces apoptosis.

Product Specific Literature References

Mechanism of citrinin-induced dysfunction of mitochondria. III. Effects on renal cortical and liver mitochondrial swelling: G.M. Chagas, et al.; J. Appl. Toxicol. 15, 91 (1995) Abstract
Mycotoxins: J.W. Bennett & M. Klich; Clin. Microbiol. Rev. 16, 497 (2003) Abstract
Citrinin induces apoptosis in HL-60 cells via activation of the mitochondrial pathway: F.Y. Yu, et al.; Toxicol. Lett. 161, 143 (2006) Abstract
Citrinin induces apoptosis via a mitochondria-dependent pathway and inhibition of survival signals in embryonic stem cells, and causes developmental injury in blastocysts: W.H. Chan; Biochem. J. 404, 317 (2007) Abstract

Further Categories Containing This Product:

Respiratory Chain Other Products • Antibiotics - Apoptosis Inducers & Inhibitors • Mycotoxins

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