ALEXIS Biochemicals: Clinafloxacin

ALX-380-289

Revised 05-Aug-08

Clinafloxacin
SYNONYMS	7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-289-M250		250 mg	55.00 USD
ALX-380-289-G001		1 g	160.00 USD

Product Specification

FORMULA:	C₁₇H₁₇ClFN₃O₃
MW:	365.8
CAS NUMBER:	105956-97-6
MERCK INDEX:	14: 2355
PURITY:	≥95% (Assay)
APPEARANCE:	White to light yellow crystalline powder.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
IDENTITY:	Identity determined by NMR.

Product Description

Fluoroquinolone with broad-spectrum activity against Gram-negative and Gram-positive bacteria, aerobes and anaerobes. Inhibits bacterial DNA topoisomerase IV and DNA gyrase.

Product Specific Literature References

DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae: X.S. Pan & L.M. Fisher; Antimicrob. Agents Chemother. 42, 2810 (1998) Abstract; Full Text
Streptococcus pneumoniae DNA gyrase and topoisomerase IV: overexpression, purification, and differential inhibition by fluoroquinolones: X.S. Pan and L.M. Fisher; Antimicrob. Agents Chemother. 43, 1129 (1999) Abstract; Full Text
Fluoroquinolones inhibit preferentially Streptococcus pneumoniae DNA topoisomerase IV than DNA gyrase native proteins: E. Fernandez-Moreira, et al.; Microb. Drug Resist. 6, 259 (2000) Abstract
Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae: J.H. Jorgensen, et al.; Antimicrob. Agents Chemother. 44, 2962 (2000) Abstract; Full Text

Further Categories Containing This Product:

Antibiotics - DNA Replication Inhibitors • Antibiotics - Topoisomerase Inhibitors

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