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ALX-550-088 Revised 28-Jan-05
Clozapine
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SYNONYMS 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e]-[1,4]diazepine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Dopaminergics & Dopamine Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-088-M005   5 mg 15.00 USD Add To Cart
ALX-550-088-M025   25 mg 35.00 USD Add To Cart
ALX-550-088-M100   100 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C18H19ClN4
MW: 326.8
CAS NUMBER: 5786-21-0
MERCK INDEX: 14: 2423
PURITY: ≥98%
APPEARANCE: Pale yellow powder.
SOLUBILITY: Soluble in DMSO or dilute aqueous acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Selective antagonist for D4-dopamine receptor. Antagonist at 5HT2A, 5HT2C, 5HT3, 5HT6 and 5HT7 receptors.
Product Specific Literature References
Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites: H. Canton, et al.; Eur. J. Pharmacol. 191, 93 (1990) Abstract
The involvement of dopamine D1 and D2 receptors in the effects of the classical neuroleptic haloperidol and the atypical neuroleptic clozapine: B.A. Ellenbroek, et al.; Eur. J. Pharmacol. 196, 103 (1991) Abstract
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine: H.H. Van Tol, et al.; Nature 350, 610 (1991) Abstract
Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists: M. Kuoppamaki, et al.; Eur. J. Pharmacol. 245, 179 (1993) Abstract
5-HT1C receptor-mediated phosphoinositide hydrolysis in the rat choroid plexus after chronic treatment with clozapine: M. Kuoppamaki, et al.; Eur. J. Pharmacol. 255, 91 (1994) Abstract
Clozapine is a potent and selective muscarinic M4 receptor agonist: S.H. Zorn, et al.; Eur. J. Pharmacol. 269, R1 (1994) Abstract
Interaction of clozapine with the histamine H3 receptor in rat brain: A.A. Rodrigues, et al.; Br. J. Pharmacol. 114, 1523 (1995) Abstract
Further Categories Containing This Product:
Serotonergics & Serotonin Receptors / Related Products
 
 
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