ALEXIS Biochemicals: Compound 48/80 . trihydrochloride

ALX-420-008

Revised 04-Dec-07

Compound 48/80 . trihydrochloride
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Calmodulin Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-420-008-M100		100 mg	95.00 USD

Product Specification

FORMULA:	C₃₂H₄₆N₃O₃. 3HCl
MW:	520.7 . 109.4
CAS NUMBER:	94724-12-6
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water (100mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions are stable for up to 3 months when stored at -20°C.
HAZARD:	TOXIC.

Product Description

Oligomeric mixture of condensation products of N-methyl-p-methoxyphenethylamine and formaldehyde. The trimer is the most abundant oligomere in the mixture. Blocks calmodulin and human platelet phospholipase C and ADP ribosylation. Activates G-proteins in a manner similar to G-protein-coupled receptors.

Product Specific Literature References

Activation of bovine rod outer segment phosphatidylinositol-4,5- bisphosphate phospholipase C by calmodulin antagonists does not depend on calmodulin: B.D. Gehm, et al.; Biochemistry 30, 11302 (1991) Abstract
Biscoclaurine alkaloids inhibit receptor-mediated phospholipase A2 activation probably through uncoupling of a GTP-binding protein from the enzyme in rat peritoneal mast cells: S. Akiba, et al.; Biochem. Pharmacol. 44, 45 (1992) Abstract
Phosphorylation of smg p21B in rat peritoneal mast cells in association with histamine release inhibition by dibutyryl-cAMP: K. Izushi, et al.; FEBS Lett. 314, 241 (1992) Abstract
ADP-ribosylation of rho proteins is inhibited by melittin, mast cell degranulating peptide and compound 48/80: G. Koch, et al.; Eur. J. Pharmacol. 226, 87 (1992) Abstract
Activation of the Na+/K(+)-pump in rat peritoneal mast cells following histamine release: a possible role in cell recovery: T. Knudsen, et al.; Br. J. Pharmacol. 108, 120 (1993) Abstract
Eclosion hormone activates phosphatidylinositol hydrolysis in silkworm abdominal ganglia during adult metamorphosis: Y. Shibanaka, et al.; Eur. J. Biochem. 211, 427 (1993) Abstract

Further Categories Containing This Product:

G-proteins & GTPases Other Products • Phospholipase C / Related Products

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