ALEXIS Biochemicals: Cycloheximide

ALX-380-269

Revised 03-Apr-08

Cycloheximide
SYNONYMS	Actidione Naramycin A 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Apoptosis Inducers & Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-269-G001		1 g	50.00 USD
ALX-380-269-G005		5 g	150.00 USD

Product Specification

FORMULA:	C₁₅H₂₃NO₄
MW:	281.4
CAS NUMBER:	66-81-9
MERCK INDEX:	14: 2728
RTECS:	MA4375000
SOURCE/HOST:	Isolated from Streptomyces griseus.
PURITY:	≥95% (TLC)
APPEARANCE:	White to light yellow powder.
SOLUBILITY:	Soluble in 100% ethanol, methanol, DMSO or acetone.
ACTIVITY:	Potency is >900units/mg.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	MAY BE TERATOGENIC. MAY BE MUTAGENIC. VERY TOXIC.

Product Description

Antibiotic. Inhibits translation in eukaryotes resulting in cell growth arrest and cell death. Induces apoptosis in tumor cell lines. Widely used for selection of resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression.

Product Specific Literature References

The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes: T.G. Obrig, et al.; J. Biol. Chem. 246, 174 (1971) Abstract; Full Text
Effects of cycloheximide on thermotolerance expression, heat shock protein synthesis, and heat shock protein mRNA accumulation in rat fibroblasts: R.B. Widelitz, et al.; Mol. Cell. Biol. 6, 1088 (1986) Abstract; Full Text
Early estrogen-induced metabolic changes and their inhibition by actinomycin D and cycloheximide in human breast cancer cells: 31P and 13C NMR studies: M. Neeman & H. Degani; PNAS 86, 5585 (1989) Abstract; Full Text
DNA fragmentation induced in macrophages by gliotoxin does not require protein synthesis and is preceded by raised inositol triphosphate levels: P. Waring; J. Biol. Chem. 265, 14476 (1990) Abstract; Full Text
Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis: S.C. Chow, et al.; Exp. Cell Res. 216, 149 (1995) Abstract
Calpain inhibitors and serine protease inhibitors can produce apoptosis in HL-60 cells: Q. Lu & R.L. Mellgren; Arch. Biochem. Biophys. 334, 175 (1996) Abstract
Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties: C. Christner, et al.; J. Med. Chem. 42, 3615 (1999) Abstract

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