ALEXIS Biochemicals: Cyclosporin D

ALX-380-284

Revised 08-Apr-08

Cyclosporin D
SYNONYMS	Val²-cyclosporin 7-L-Valine-cyclosporin A
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Immunomodulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-284-M001		1 mg	80.00 USD
ALX-380-284-M005		5 mg	320.00 USD

Product Specification

FORMULA:	C₆₃H₁₁₃N₁₁O₁₂
MW:	1216.6
CAS NUMBER:	63775-96-2
MERCK INDEX:	14: 2752
SOURCE/HOST:	Isolated from Fusarium solani.
PURITY:	≥95% (HPLC)
APPEARANCE:	Colorless to off-white crystalline solid.
SOLUBILITY:	Soluble in 100% ethanol, acetone or ethyl acetate; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	MAY BE TERATOGENIC. TOXIC. MAY BE CARCINOGENIC.

Product Description

Weak immunosuppressor. Potent inhibitor of tumor promoting phorbol ester TPA/PMA (Prod. No. ALX-445-004) in vivo. Potent inhibitor of Ca²⁺/calmodulin dependent EF-2 phosphorylation in vitro.

Product Specific Literature References

The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro: M. Gschwendt, et al.; BBRC 150, 545 (1988) Abstract

Further Categories Containing This Product:

MPTP [Mitochondrial Transition Pore]/Related Products • CAM Kinase Inhibitors

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