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ALX-350-373 Revised 10-Jul-08 New product
Cytisine
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Acetylcholine Receptors (Nicotinic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-373-M005   5 mg 35.00 USD Add To Cart
ALX-350-373-M025   25 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C11H14N2O
MW: 190.2
CAS NUMBER: 485-35-8
MERCK INDEX: 14:2789
RTECS: HA4025000
SOURCE/HOST: Isolated from seeds of Laburnum anagyroides
PURITY: ≥95% (HPLC)
APPEARANCE: Light to dark yellow powder.
SOLUBILITY: Soluble in benzene, acetone, ethyl acetate or 100% ethanol; sparingly soluble in water or methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Pyridine-like alkaloid. Nicotine agonist. Potent ligand for many nAChR subtypes. Potent agonist at α3β4 and α7 nicotinic acetylcholine receptors and partial agonist at α4β2 nicotinic acetylcholine receptors. Shows analgesic, antihypertensive and inotropic activities.
Product Specific Literature References
Some studies on cytisine and its methylated derivatives: R.B. Barlow & L.J. McLeod; Br. J. Pharmacol. 35, 161 (1969) Abstract; Full Text
Release of [3H]-noradrenaline from rat hippocampal synaptosomes by nicotine: mediation by different nicotinic receptor subtypes from striatal [3H]-dopamine release: P.B. Clarke & M. Reuben; Br. J. Pharmacol. 117, 595 (1996) Abstract; Full Text
Evaluation of anti-nociceptive effects of neuronal nicotinic acetylcholine receptor (NAChR) ligands in the rat tail-flick assay: T.S. Rao, et al.; Neuropharmacology 35, 393 (1996) Abstract
Somatic and prejunctional nicotinic receptors in cultured rat sympathetic neurones show different agonist profiles: D. Kristufek, et al.; J. Physiol. 516, 739 (1999) Abstract; Full Text
Inherited, selective hypoanalgesic response to cytisine in the tail-flick test in CF-1 mice: T.W. Seale, et al.; Neuroreport 9, 201 (1998) Abstract
Effects of cytisine on hydroxyl radicals in vitro and MPTP-induced dopamine depletion in vivo: B. Ferger, et al.; Eur. J. Pharmacol. 360, 155 (1998) Abstract
Cytisine derivatives as ligands for neuronal nicotine receptors and with various pharmacological activities: C.C. Boido, et al.; Farmaco 58, 265 (2003) Abstract
Pharmacological characterization of recombinant bovine alpha3beta4 neuronal nicotinic receptors stably expressed in HEK 293 cells: R.B. Free, et al.; Neurosci. Lett. 343, 180 (2003) Abstract
Nitrogen substitution modifies the activity of cytisine on neuronal nicotinic receptor subtypes: E. Carbonnelle, et al.; Eur. J. Pharmacol. 471, 85 (2003) Abstract
Cytisine binds with similar affinity to nicotinic alpha4beta2 receptors on the cell surface and in homogenates: J. Zhang & J.H. Steinbach; Brain Res. 959, 98 (2003) Abstract
Pharmacological characterization of recombinant bovine alpha3beta4 neuronal nicotinic receptors stably expressed in HEK 293 cells: R.B. Free, et al.; Neurosci. Lett. 343, 180 (2003) Abstract
Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice: Y.S. Mineur, et al.; Neuropharmacology 52, 1256 (2007) Abstract; Full Text
Ligands selective for alpha4beta2 but not alpha3beta4 or alpha7 nicotinic receptors generalise to the nicotine discriminative stimulus in the rat: J.W. Smith, et al.; Psychopharmacology (Berl) 190, 157 (2007) Abstract
 
 

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