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ALX-380-031 Revised 29-Apr-08
Cytochalasin D
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-031-M001   1 mg 60.00 USD Add To Cart
ALX-380-031-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C30H37NO6
MW: 507.6
CAS NUMBER: 22144-77-0
MERCK INDEX: 14: 2790
RTECS: GZ4850000
SOURCE/HOST: Isolated from Zygosporium mansonii.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methylene chloride (10mg/ml); slighly soluble in DMSO (2mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Antibiotic. Is ~10-fold more potent than cytochalasin B (Prod. No. ALX-380-012) in inhibiting actin filament function, but does not inhibit sugar transport in cells. Inactivates low conductance K+ channels. Modulates CD4 cross-linking in T-lymphocytes and increases intracellular Ca2+ levels. Exhibits antitumor activity. Induces apoptosis.
Product Specific Literature References
Antitumor activity of cytochalasin D: K. Katagiri & S. Matsuura; J. Antibiot. (Tokyo) 24, 722 (1971) Abstract
Effects of cytochalasin and phalloidin on actin: J.A. Cooper; J. Cell. Biol. 105, 1473 (1987) Abstract
Cytochalasin D modulates CD4 crosslinking sensitive mitogenic signal in T lymphocytes: A. Aszalos, et al.; Cell Immunol. 157, 81 (1994) Abstract
Involvement of actin cytoskeleton in modulation of apical K channel activity in rat collecting duct: W.H. Wang, et al.; Am. J. Physiol. 267, F592 (1994) Abstract
Myosin-actin interaction plays an important role in human immunodeficiency virus type 1 release from host cells: H. Sasaki, et al.; PNAS 92, 2026 (1995) Abstract
Signaling pathways involved in thrombin-induced cell protection: F.M. Donovan & D.D. Cunningham; J. Biol. Chem. 273, 12746 (1998) Abstract; Full Text
The role of actin-binding protein 280 in integrin-dependent mechanoprotection: M. Glogauer, et al.; J. Biol. Chem. 273, 1689 (1998) Abstract; Full Text
Disruption of actin microfilaments by cytochalasin D leads to activation of p53: S.N. Rubtsova, et al.; FEBS Lett. 430, 353 (1998) Abstract
Hexokinase translocation during neutrophil activation, chemotaxis, and phagocytosis: disruption by cytochalasin D, dexamethasone, and indomethacin: J.B. Huang, et al.; Cell Immunol. 218, 95 (2002) Abstract
Human chorionic gonadotropin and decidualization in vitro inhibits cytochalasin-D-induced apoptosis in cultured endometrial stromal fibroblasts: A. Jasinska, et al.; Endocrinology 147, 4112 (2006) Abstract
Further Categories Containing This Product:
Microtubule Modulators • Antitumor Antibiotics • Alkaloids • Antibiotics - Apoptosis Inducers & Inhibitors
 
 
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