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ALX-850-238 Revised 17-Apr-08
CD162, Soluble (human) ELISA Kit
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SYNONYMS PSGL-1, Soluble (human) ELISA Kit
PRODUCT LINE Immunology
PRODUCT CATEGORY CD Kits & Sets
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-238-KI01   1 Kit 619.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.99U/ml (range 1.6 to 50U/ml)
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of soluble human CD162 (sPSGL-1) in cell culture supernatants, serum and other body fluids. No cross-reaction with circulating factors of the immune system.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
Adhesion Molecules & Receptors Kits & Sets • ELISA & EIA Kits
 
 
ALX-430-033 Revised 19-Jul-07
Colcemid
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SYNONYMS Demecolcine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-033-M001   1 mg 30.00 USD Add To Cart
ALX-430-033-M005   5 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C21H25NO5
MW: 371.4
CAS NUMBER: 477-30-5
MERCK INDEX: 14: 2887
SOURCE/HOST: Semisynthetic from colchicine (Prod. No. ALX-380-033).
PURITY: ≥99%
APPEARANCE: Light yellow powder.
SOLUBILITY: Soluble in 100% ethanol, chloroform or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY:

Stock solutions are stable for at least 6 months when stored at -20°C.
HAZARD: MAY BE MUTAGENIC. MAY BE TERATOGENIC. TOXIC.

Product Description
Depolymerizes microtubules and inhibits their formation. Induces apoptosis.
Product Specific Literature References
Laminin-induced process outgrowth from isolated fetal rat C-cells: I. Nishiyama & T. Fujii; Exp. Cell. Res. 198, 214 (1992) Abstract
Colcemid and the mitotic cycle: C.L. Rieder & R.E. Palazzo; J. Cell. Sci. 102, 387 (1992) Abstract
Cytoskeletal elements regulate the distribution of nerve growth factor receptors in PC12 cells: P.E. Spoerri & F.J. Roisen; J. Neurosci. Res. 31, 494 (1992) Abstract
Effect of colcemid on the water permeability response to vasopressin in isolated perfused rabbit collecting tubules: M.E. Phillips & A. Taylor; J. Physiol. 456, 591 (1992) Abstract
Effects of colcemid concentration on chromosome aberration analysis in human lymphocytes: R. Kanda, et al.; J. Radiat. Res. (Tokyo) 35, 41 (1994) Abstract
Induction of apoptosis by the anti-tubulin drug colcemid: relationship of mitotic checkpoint control to the induction of apoptosis in HeLa S3 cells: S.W. Sherwood, et al.; Exp. Cell. Res. 215, 373 (1994) Abstract
Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization: L. Urbani, et al.; Exp. Cell. Res. 219, 159 (1995) Abstract
Colcemid-induced apoptosis of cultured human glioma: electron microscopic and confocal laser microscopic observation of cells sorted in different phases of cell cycle: T. Tsuchida, et al.; Cytometry 31, 295 (1998) Abstract
Protein phosphatase-1 activation and association with the retinoblastoma protein in colcemid-induced apoptosis: F. Puntoni & E. Villa-Moruzzi; BBRC 266, 279 (1999) Abstract
Expression of apoptosis and cell cycle related genes in proliferating and colcemid arrested cells of divergent lineage: B.W. Gallaher, et al.; Cell. Mol. Biol. 46, 79 (2000) Abstract
Spontaneous chromosome loss and colcemid resistance in lymphocytes from patients with myotonic dystrophy type 1: M. Casella, et al.; Cytogenet. Genome Res. 100, 224 (2003) Abstract
Further Categories Containing This Product:
Natural Products - Apoptosis Inducers & Inhibitors • Microtubule Modulators
 
 
ALX-380-033 Revised 17-Oct-07
Colchicine
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-380-033-G001   1 g 58.00 USD Add To Cart
Product Specification
FORMULA: C22H25NO6
MW: 399.4
CAS NUMBER: 64-86-8
MERCK INDEX: 14: 2471
RTECS: GH0700000
SOURCE/HOST: Isolated from Colchicum autumnale.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and moisture.
HAZARD: VERY TOXIC.

Product Description
Inhibitor of microtubules by specific binding to tubulin. Induces apoptosis.
Product Specific Literature References
A new colchicine binding assay for tubulin: P. Sherline, et al.; Anal. Biochem. 62, 400 (1974) Abstract
Fluorometric assay of tubulin-colchicine complex: T. Arai & T. Okuyama; Anal. Biochem. 69, 443 (1975) Abstract
Kinetics and mechanism of colchicine binding to tubulin: evidence for ligand-induced conformational change: D.L. Garland; Biochemistry 17, 4266 (1978) Abstract
Proposed mechanism for colchicine poisoning of microtubules reassembled in vitro from Strongylocentrotus purpuratus sperm tail outer doublet tubulin: K.W. Farrell & L. Wilson; Biochemistry 19, 3048 (1980) Abstract
Rapid rate of tubulin dissociation from microtubules in the mitotic spindle in vivo measured by blocking polymerization with colchicine: E.D. Salmon, et al.; J. Cell. Biol. 99, 1066 (1984) Abstract
The effects of microtubule disrupting drugs on the differentiation of HL-60 leukemia cells: M.F. Lueng & A.C. Sartorelli; Leuk. Res. 16, 929 (1992) Abstract
Disruption of microtubules inhibits the stimulation of tissue plasminogen activator expression and promotes plasminogen activator inhibitor type 1 expression in human endothelial cells: L. Santell, et al.; Exp. Cell. Res. 201, 358 (1992) Abstract
Colchicine induces apoptosis in cerebellar granule cells: E. Bonfoco, et al.; Exp. Cell. Res. 218, 189 (1995) Abstract
Inhibition of drug-induced apoptosis by survival factors in PC12 cells: L. Lindenboim, et al.; J. Neurochem. 64, 1054 (1995) Abstract
General features of the recognition by tubulin of colchicine and related compounds: Y. Engelborghs; Eur. Biophys. J. 27, 437 (1998) Abstract
Sustained JNK activation induces endothelial apoptosis: studies with colchicine and shear stress: Y.L. Hu, et al.; Am. J. Physiol. 277, H1593 (1999) Abstract
Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells: A.M. Gorman, et al.; Eur. J. Neurosci. 11, 1067 (1999) Abstract
Colchicine protects mice from the lethal effect of an agonistic anti- Fas antibody: G. Feng & N. Kaplowitz; J. Clin. Invest. 105, 329 (2000) Abstract
Update on colchicine and its mechanism of action: Y. Molad; Curr. Rheumatol. Rep. 4, 252 (2002) Abstract
Further Categories Containing This Product:
Microtubule Modulators • Natural Products - Apoptosis Inducers & Inhibitors • Alkaloids • Natural Products with Antibiotic Activity
 
 
ALX-350-100 Revised 03-Apr-08
Convulxin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Toxins
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ALX-350-100-C050   50 µg 565.00 USD Add To Cart
Product Specification
MW: ~84kDa.
CAS NUMBER: 37206-04-5
SOURCE/HOST: Isolated from Crotalus durissus terrificus snake venom.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in organic buffer (HEPES).
ACTIVITY: <50ng/ml (minimal concentration to induce maximum activation of washed human platelets).
APPLICATION: Studies on platelet receptors.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for 8 hours at +20°C, for 2 days at +4°C or for 1 month when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
HAZARD: TOXIC.
Product Description
Heterodimeric C-type lectin. Activates mammalian platelets via binding and clustering of p62/GPVI-receptors under physiological conditions.
Product Specific Literature References
Convulxin, a new toxin from the venom of the South American rattlesnake Crotalus durissus terrificus: J. Prado-Franceschi & O.V. Brazil; Toxicon 19, 875 (1981) Abstract
Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor: J. Polgar, et al.; J. Biol. Chem. 272, 13576 (1997) Abstract
Convulxin-induced platelet adhesion and aggregation: involvement of glycoproteins VI and IaIIa: M. Jandrot-Perrus, et al.; Platelets 9, 207 (1998) Abstract
Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases: M. Cicmil, et al.; J. Biol. Chem. 275, 27339 (2000) Abstract
Convulxin binds to native, human glycoprotein Ib alpha: S. Kanaji, et al.; J. Biol. Chem. 278, 39452 (2003) Abstract
Structure of the snake-venom toxin convulxin: T. Batuwangala, et al.; Acta Crystallogr. D. Biol. Crystallogr. 60, 46 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Assay performed in aggregometer:
- Incubate 485µl platelets suspension (5x108 platelets/ml) for 1-2 minutes at 37°C until base line is stable.
- Add 5µl 200mM CaCl2.
- Add 5µl 200mM MgCl2.
- Wait until baseline is stable.
- Add 5µl collagen solution (0.5mg/ml) for positive control OR add 5µl convulxin (0.1µg/ml in HEPES).
- Measure aggregation at 37°C.
Further Categories Containing This Product:
Unconjugated Lectins • Platelet Activating Factors [PAF] & Receptors / Related Products
 
 
ALX-105-011 Revised 18-Sep-06
S-Trityl-L-cysteine
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SYNONYMS NSC 83265
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Cell Cycle Blockers & Inhibitors / Related Products
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ALX-105-011-M100   100 mg 20.00 USD Add To Cart
ALX-105-011-M500   500 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C22H21NO2S
MW: 363.5
CAS NUMBER: 2799-07-7
RTECS: AY7710000
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or acetic acid
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Potent, cell permeable cysteine thioether displaying anti-mitotic and anti-tumor properties. Inhibits mitosis by blocking basal and microtubule-activated ATPase activities of the mitotic kinesin Eg5 (IC50=1µM and 140nm). Induces mitotic arrest in HeLa cells (IC50=700nM) and inhibits the growth of NCI tumor cell line panel (GI50=1.31µM).
Product Specific Literature References
In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities: S. DeBonis, et al.; Mol. Cancer Ther. 3, 1079 (2004) Abstract; Full Text
S-trityl-l-cysteine is a reversible, tight-binding inhibitor of the human kinesin eg5 that specifically blocks mitotic progression: D.A. Skoufias, et al.; J. Biol. Chem. 281, 17559 (2006) Abstract; Full Text
Further Categories Containing This Product:
Kinesin & Kinesin-like Proteins / Related Products • Antitumor Agents (Anti-proliferative)
 
 
ALX-380-057 Revised 03-Apr-08
Cytochalasin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-057-M001   1 mg 50.00 USD Add To Cart
ALX-380-057-M005   5 mg 170.00 USD Add To Cart
ALX-380-057-M010   10 mg 290.00 USD Add To Cart
Product Specification
FORMULA: C29H35NO5
MW: 477.6
CAS NUMBER: 14110-64-6
MERCK INDEX: 14: 2790
SOURCE/HOST: Isolated from Helminthosporium dematioideum.
PURITY: ≥98% (HPLC)
APPEARANCE: White powder.
SOLUBILITY: Soluble in acetone, DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Antibiotic. Fungal toxin. Inhibits glucose transport, actin polymerisation and blocks the formation of microtubuli. Inhibits cell division. Inhibits HIV-1 protease.
Product Specific Literature References
The action of cytochalasin A on the in vitro polymerization of brain tubulin and muscle G-actin: R.H. Himes & L.L. Houston; J. Supramol. Struct. 5, 81 (1976) Abstract
Cytochalasin A inhibits B-lymphocyte capping and activation by antigens: G. Teti, et al.; Immunol. Lett. 3, 151 (1981) Abstract
L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. III. Biological activity: R.B. Lingham, et al.; J. Antibiot. 45, 686 (1992) Abstract
Effect of cytochalasin A on apical growth, actin cytoskeleton organization and enzyme secretion in Aspergillus nidulans: S. Torralba, et al.; Microbiology 144 (Pt 1), 45 (1998) Abstract
Further Categories Containing This Product:
Microtubule Modulators • Alkaloids • Mycotoxins
 
 
ALX-380-012 Revised 16-Jun-08
Cytochalasin B
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SYNONYMS Phomin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-012-M001   1 mg 35.00 USD Add To Cart
ALX-380-012-M005   5 mg 90.00 USD Add To Cart
ALX-380-012-M025   25 mg 380.00 USD Add To Cart
Product Specification
FORMULA: C29H37NO5
MW: 479.6
CAS NUMBER: 14930-96-2
MERCK INDEX: 14: 2790
SOURCE/HOST: Isolated from Drechslera dematoidea.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Antibiotic. Cell permeable mycotoxin. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Shortens actin filaments by blocking monomer addition at the fast-growing end of polymers. Inhibits glucose transport and platelet aggregation. Blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.
Product Specific Literature References
Cytochalasin B: effects on cell morphology, cell adhesion, and mucopolysaccharide synthesis (cultured cells-contractile microfilaments-glycoproteins-embryonic cells-sorting-out): J.W. Sanger & H. Holtzer; PNAS 69, 253 (1972) Abstract
Cytochalasin B: inhibition of glucose and glucosamine transport: R.D. Ebstensen & P.G. Plagemann; PNAS 69, 1430 (1972) Abstract
Effects of cytochalasin B on endocytosis and exocytosis: P. Davies & A.C. Allison; Front. Biol. 46, 143 (1978), Review Abstract
Effect of cytochalasin B on glucose uptake, utilization, oxidation and insulinotropic action in tumoral insulin-producing cells: W.J. Malaisse, et al.; Cell Biochem. Funct. 5, 183 (1987) Abstract
Apoptosis induced by adenosine in human leukemia HL-60 cells: Y. Tanaka, et al.; Exp. Cell Res. 213, 242 (1994) Abstract
Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping: P.A. Theodoropoulos, et al.; Biochem. Pharmacol. 47, 1875 (1994) Abstract
The inhibition of GLUT1 glucose transport and cytochalasin B binding activity by tricyclic antidepressants: H.B. Pinkofsky, et al.; Life Sci. 66, 271 (2000) Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products • Microtubule Modulators • Actin / Related Products • Alkaloids
 
 
ALX-350-053 Revised 03-Apr-08
Cytochalasin B, Dihydro-
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
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ALX-350-053-M001   1 mg 285.00 USD Add To Cart
Product Specification
FORMULA: C29H39NO5
MW: 481.6
CAS NUMBER: 39156-67-7
MERCK INDEX: 14: 2790
SOURCE/HOST: Semisynthetic. Derived from cytochalasin B (Prod. No. ALX-380-012), which was isolated from Drechslera dematoidea.
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in or acetone, DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Used as tool in cytological research and in characterization of polymerization properties of actin.
Product Specific Literature References
Dihydrocytochalasin B. Biological effects and binding to 3T3 cells: S.J. Atlas & S. Lin; J. Cell. Biol. 76, 360 (1978) Abstract
Microfilament modification by dihydrocytochalasin B causes retinoic acid-modulated chondrocytes to reexpress the differentiated collagen phenotype without a change in shape: P.D. Benya, et al.; J. Cell Biol. 106, 161 (1988) Abstract
Dihydrocytochalasin B enhances transforming growth factor-beta-induced reexpression of the differentiated chondrocyte phenotype without stimulation of collagen synthesis: P.D. Benya & S.R. Padilla; Exp. Cell Res. 204, 268 (1993) Abstract
Complex regulation of human neutrophil activation by actin filaments: dihydrocytochalasin B and botulinum C2 toxin uncover the existence of multiple cation entry pathways: K. Wenzel-Seifert, et al.; J. Leukoc. Biol. 61, 703 (1997) Abstract
Further Categories Containing This Product:
Microtubule Modulators • Alkaloids • Actin / Related Products
 
 
ALX-380-069 Revised 26-Jun-08
Cytochalasin C
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
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ALX-380-069-M001   1 mg 60.00 USD Add To Cart
ALX-380-069-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C30H37NO6
MW: 507.6
CAS NUMBER: 22144-76-9
MERCK INDEX: 14: 2790
RTECS: HA5300500
SOURCE/HOST: Isolated from