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ALX-805-064 Revised 04-Jan-06
Monoclonal Antibody to CD50 (human) (MEM-171)
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SYNONYMS anti-Intercellular Adhesion Molecule-3 (human) MAb (MEM-171)
anti-ICAM-3 (human) MAb (MEM-171)
PRODUCT LINE Immunology
PRODUCT CATEGORY CD11a, CD18 [LFA-1] & CD54 [ICAM-1], CD102 [ICAM-2], CD50 [ICAM-3]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-064-C100   100 µg 195.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MEM-171
ISOTYPE: Mouse IgG1
IMMUNOGEN: Human granulocytes.
SPECIFICITY: Recognizes the D2 domain of human CD50 (ICAM-3).
APPLICATION: Flow Cytometry
Immunoprecipitation
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
Product Specific Literature References
Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules: L. Cermak, et al.; J. Biol. Chem. 277, 7955 (2002) Abstract; Full Text
Further Categories Containing This Product:
CD Antibodies • Adhesion Molecules & Receptors Antibodies • Monoclonal Antibodies
 
 
ALX-803-304 Revised 01-Jul-08
Monoclonal Antibody to CD51 (human) (L230)
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SYNONYMS anti-αV Integrin (human) MAb (L230)
anti-Vitronectin Receptor (α Subunit) (human) MAb (L230)
PRODUCT LINE Immunology
PRODUCT CATEGORY CD Antibodies
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-803-304-C100   100 µg 240.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: L230
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.2mg/ml
PURITY: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
PURITY DETAIL: Protein A-affinity purified.
IMMUNOGEN: Human endothelial cells.
SPECIFICITY: Recognizes human CD51 (αV integrin). Recognizes heterodimers αVβ3, αVβ1, αVβ5 and αVβ6. Does not cross-react with other species.
APPLICATION: ELISA
Flow Cytometry
Immunohistochemistry (frozen section, paraffin sections)
Immunoprecipitation
Note: Does not work in Western Blot.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Specific Literature References
A novel beta 1 integrin-dependent mechanism of leukocyte adherence to apoptotic cells: B.R. Schwartz, et al.; J. Immunol. 162, 4842 (1999) Abstract; Full Text
Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines: L. Moro, et al.; J. Biol. Chem. 277, 9405 (2002) Abstract; Full Text
P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading: P. Di Stefano, et al.; Mol. Biol. Cell 15, 787 (2004) Abstract; Full Text
Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9: C.H. Williams, et al.; J. Virol. 78, 6967 (2004) Abstract; Full Text
General Information
CD51 (integrin αV subunit) associates with CD61 (integrin β3 subunit) binding to the RGD sequence in extracellular matrix proteins like vitronectin, fibrinogen, thrombospondin, von Willebrand factor and osteopontin. The αV/β3 heterodimer is expressed in endothelial cells, leukocytes, NK cells, macrophages, neutrophils, platelets and several malignant tumor cells and seems to play a role in embryo implantation, angiogenesis, wound healing and cancer. αV/β3  is also highly expressed in osteoclasts being important for bone resorption.
Further Categories Containing This Product:
Angiogenesis Other Products • Bone Metabolism Other Products • Monoclonal Antibodies • Adhesion Molecules & Receptors Antibodies
 
 
ALX-805-016 Revised 21-Aug-08
Monoclonal Antibody to CD54 (human) (Domain D1) (RR1/1)
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SYNONYMS anti-Intercellular Adhesion Molecule-1 (human) (Domain D1) MAb (RR1/1)
anti-ICAM-1 (human) (Domain D1) MAb (RR1/1)
PRODUCT LINE Immunology
PRODUCT CATEGORY CD11a, CD18 [LFA-1] & CD54 [ICAM-1], CD102 [ICAM-2], CD50 [ICAM-3]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-016-C050 Purified 50 µg 259.00 USD Add To Cart
ALX-805-016B-T100 Biotin 100 tests 308.00 USD Add To Cart
ALX-805-016F-T100 FITC 100 tests 308.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: RR1/1
ISOTYPE: Mouse IgG1
PURITY: ≥95% (SDS-PAGE)
FORMULATION: RR1/1: Liquid. 0.5mg/ml in PBS.
RR1/1-Biotin and -FITC: Liquid. In 1ml 50mM TRIS, pH 7.4, containing 100mM sodium chloride, 1% BSA and 0.02% sodium azide.
IMMUNOGEN: Human CD54 (ICAM-1).
SPECIFICITY: Recognizes the D1 domain of human CD54. Detects a band of ~90kDa by Western blot. Does not cross-react with mouse or rhesus monkey CD54.
APPLICATION: RR1/1:
Flow Cytometry: suitable as primary antibody in staining for FACS analysis.
Immunohistochemistry (frozen sections): stains aceton-fixed cryostat sections or cell smears. Alkaline phosphatase-anti-alkaline phosphatase (APAAP) procedure, peroxidase anti-peroxidase (PAP) procedure or the three stage immunoperoxidase technique are recommended; use at a concentration of 0.5-1.25µg/ml.
Western Blot
ELISA
Functional Application: blocks adhesion of leukocytes to endothelial cells.

RR1/1-FITC:
Flow Cytometry: direct staining of cells.

RR1/1-Biotin:
Flow Cytometry: can be used in a two-step procedure using the biotin-(strept-)avidin system; recommended dilution is 1:20 as determined on RPMI8866 cells.

Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Specific Literature References
CD13 is a novel mediator of monocytic/endothelial cell adhesion: P. Mina-Osorio; J. Leukoc. Biol. 84, 448 (2008) Abstract; Full Text
Further Categories Containing This Product:
CD Antibodies • Adhesion Molecules & Receptors Antibodies • Monoclonal Antibodies
 
 
ALX-805-065 Revised 28-Feb-08
Monoclonal Antibody to CD54 (MEM-111)
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SYNONYMS anti-Intercellular Adhesion Molecule-1 MAb (MEM-111)
anti-ICAM-1 MAb (MEM-111)
PRODUCT LINE Immunology
PRODUCT CATEGORY CD11a, CD18 [LFA-1] & CD54 [ICAM-1], CD102 [ICAM-2], CD50 [ICAM-3]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-065-C100   100 µg 195.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Others
CLONE: MEM-111
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Human Burkitt's lymphoma cell line Raji.
SPECIFICITY: Recognizes human, rat and bovine CD54 (ICAM-1).
APPLICATION: ELISA
Flow Cytometry
Immunoprecipitation
Western Blot (non-reducing conditions)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro: J.F. Leeuwenberg, et al.; Immunology 77, 543 (1992) Abstract
Further Categories Containing This Product:
CD Antibodies • Adhesion Molecules & Receptors Antibodies • Monoclonal Antibodies
 
 
ALX-805-077 Revised 14-Sep-07
Monoclonal Antibody to CD66e (human) (26/3/13)
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SYNONYMS anti-CEACAM5 (human) MAb (26/3/13)
anti-CEA (human) MAb (26/3/13)
anti-Carcinoembryonic Antigen (human) MAb (26/3/13)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY CEACAM [CD66]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-077-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 26/3/13
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.2, containing 0.01% sodium azide.
IMMUNOGEN: CD66e (CEACAM5; CEA) partially purified from a perchloric acid extract from liver metastases of colonic tumors.
SPECIFICITY: Recognizes human CD66e. Does not cross-react with human CEACAM1, 3, 4, 6, 7, 8 or PSG.
APPLICATION: ELISA
Flow Cytometry
Immunohistochemistry (frozen sections)
Western Blot
Optimal conditions must be determined individually for each application.
QUALITY CONTROL: Routinely tested by flow cytometry on BOSC cells transiently transfected with a CD66e expression vector.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
Two CEA and three NCA species, although distinguishable by monoclonal antibodies, have nearly identical peptide patterns: F. Grunert, et al.; Int. J. Cancer 36, 357 (1985) Abstract
Effects of human bone marrow stroma on the growth of human tumor cells: E.S. Strobel, et al.; Cancer Res. 49, 1001 (1989) Abstract
A polymerase-chain-reaction assay for the specific identification of transcripts encoded by individual carcinoembryonic antigen (CEA)-gene-family members: J. Thompson, et al.; Int. J. Cancer 55, 311 (1993) Abstract
CD66 family workshop: binding of myeloid blind panel antibodies and CD66 Subsection antibodies to HeLa transfectants expressing individual CD66 molecules: F. Grunert, et al.; Leukocyte Typing VI: White cell Differentiation Antigens (T. Kishimoto, et al., eds.), Garland Publishing Inc., New York and London 1012 (1996)
CEA-related proteins on human urothelial cell lines of different transformation grades: A. Krop-Watorek, et al.; Cancer Lett. 139, 15 (1999) Abstract
Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas: S. Scholzel, et al.; Am. J. Pathol. 156, 595 (2000) Abstract; Full Text
General Information
CD66e (CEACAM5; CEA) belongs to the carcinoembryonic antigen (CEA) gene family. It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein with a Mr of 180'000-200'000 which is most strongly expressed on epithelial cells of the fetal and adult colon and to a minor extent on epithelial cells of the stomach and sweat glands, squamous epithelial cells of the tongue, esophagus and cervix. CD66e is used as a tumor marker for early detection of recurrent disease due to its expression in adenocarcinomas of the colon, lung, breast, stomach and pancreas and in mucinous ovarian carcinomas. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by six immunoglobulin constant-like A (A1, A2, A3) and B domains (B1, B2, B3).
MANUFACTURER Manufactured by GENOVAC GmbH.
General Literature References
Carcinoembryonic antigen gene family: molecular biology and clinical perspectives: J.A. Thompson, et al.; J. Clin. Lab. Anal. 5, 344 (1991), (Review) Abstract
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues: S. Hammarström; Semin. Cancer Biol. 9, 67 (1999), (Review) Abstract
Carcinoembryonic antigen: W. Zimmermann; Wiley Encyclopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc., New York 459 (2002)
Further Categories Containing This Product:
CD Antibodies • Monoclonal Antibodies
 
 
ALX-805-080 Revised 14-Sep-07
Monoclonal Antibody to pan-CEACAM (1,3,4,5,6) (human) (D14HD11)
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PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY CEACAM [CD66]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-080-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: D14HD11
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.2, containing 0.01% sodium azide.
IMMUNOGEN: CEACAM5 partially purified from a perchloric acid extract from liver metastases of colonic tumors.
SPECIFICITY: Recognizes human CEACAM1, 3, 4, 5 and 6.
APPLICATION: ELISA
Flow Cytometry
Immunohistochemistry (frozen sections)
Western Blot
Optimal conditions must be determined individually for each application.
QUALITY CONTROL: Routinely tested by flow cytometry on BOSC23 cells transiently transfected with a CEACAM5 expression vector.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Product Images
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Product Specific Literature References
Production and characterization of monoclonal antibodies against carcinoembryonic antigen (CEA): P. Jantscheff, et al.; Biomed. Biochim. Acta 50, 1261 (1991) Abstract
CD66 family Workshop: binding of myeloid blind panel antibodies and CD66 Subsection antibodies to HeLa transfectants expressing individual CD66 molecules: F. Grunert, et al.; Leukocyte Typing VI: White cell Differentiation Antigens (T. Kishimoto, et al., eds.), Garland Publishing Inc., New York 1012 (1996)
CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes: S.D. Gray-Owen, et al.; EMBO J. 16, 3435 (1997) Abstract; Full Text
CEA-related proteins on human urothelial cell lines of different transformation grades: A. Krop-Watorek, et al.; Cancer Lett. 139, 15 (1999) Abstract
Molecular analysis of neisserial Opa protein interactions with the CEA family of receptors: identification of determinants contributing to the differential specificities of binding: A. Popp, et al.; Cell. Microbiol. 1, 169 (1999) Abstract; Full Text
Recruitment of CD55 and CD66e brush border-associated glycosylphosphatidylinositol-anchored proteins by members of the Afa/Dr diffusely adhering family of Escherichia coli that infect the human polarized intestinal Caco-2/TC7 cells J. Guignot, et al.; Infect. Immun. 68, 3554 (2000) Abstract; Full Text
Carcinoembryonic antigen family receptor specificity of Neisseria meningitidis Opa variants influences adherence to and invasion of proinflammatory cytokine-activated endothelial cells: P. Muenzner, et al.; Infect. Immun. 68, 3601 (2000) Abstract; Full Text
Pathogenic Neisseria trigger expression of their carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1; previously CD66a) receptor on primary endothelial cells [...]: P. Muenzner, et al.; J. Biol. Chem. 276, 24331 (2001) Abstract; Full Text
Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site: S.M. Watt, et al.; Blood 98, 1469 (2001) Abstract; Full Text
Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways: O. Billker, et al.; EMBO J. 21, 560 (2002) Abstract; Full Text
Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes: I.C. Boulton & S.D. Gray-Owen; Nat. Immunol. 3, 229 (2002) Abstract
The tumorigenic potential of human CX-1 colon adenocarcinoma cells depends on carcinoembryonic antigen (CEACAM5) expression: D. Baczynska, et al.; Cell. Mol. Biol. Lett. 8, 471 (2003) Abstract; Full Text
General Information
CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM1, CEACAM3-CEACAM8) and 11 pregnancy-specific glycoprotein (PSG1-PSG11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leukocytes. Overexpression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocytes and dendritic cell activation, receptors of Neisseria species and other bacteria.
MANUFACTURER Manufactured by GENOVAC GmbH.
General Literature References
Carcinoembryonic antigen gene family: molecular biology and clinical perspectives: J.A. Thompson, et al.; J. Clin. Lab. Anal. 5, 344 (1991), (Review) Abstract
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues: S. Hammarström; Semin. Cancer Biol. 9, 67 (1999), (Review) Abstract
Carcionembryonic antigen: W. Zimmermann; Wiley Encyclopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc. New York 459 (2002)
Further Categories Containing This Product:
CD Antibodies • Monoclonal Antibodies
 
 
ALX-805-081 Revised 18-Aug-06
Monoclonal Antibody to pan-CEACAM (1,5,6,8) (human) (TET2)
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SYNONYMS anti-CD66a/CD66b/CD66c/CD66e (human) MAb (TET2)
anti-BGP/CEA/NCA/CGM5 (human) MAb (TET2)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY CEACAM [CD66]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-081-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: TET2
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.2, containing 0.01% sodium azide.
IMMUNOGEN: CEACAM5 (CEA) partially purified from a perchloric acid extract from liver metastases of colonic tumors.
SPECIFICITY: Recognizes human CEACAM1, 5, 6 and 8.
APPLICATION: ELISA
Flow Cytometry
Immunohistochemistry (frozen sections)
Western Blot.
Optimal conditions must be determined individually for each application.
QUALITY CONTROL: Routinely tested by flow cytometry on BOSC23 cells transiently transfected with a CEACAM5 expression vector.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Two CEA and three NCA species, although distinguishable by monoclonal antibodies, have nearly identical peptide patterns: F. Grunert, et al.; Int. J. Cancer 36, 357 (1985) Abstract
CD66 family Workshop: Binding of myeloid blind panel antibodies and CD66 Subsection antibodies to HeLa transfectants expressing individual CD66 molecules: F. Grunert, et al.; Leukocyte Typing VI: White cell Differentiation Antigens (T. Kishimoto, et al., eds.), Garland Publishing Inc., New York 1012 (1996)
Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site: S.M. Watt, et al.; Blood 98, 1469 (2001) Abstract; Full Text
General Information
CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM1, CEACAM3-CEACAM8) and 11 pregnancy-specific glycoprotein (PSG1-PSG11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leukocytes. Overexpression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocytes and dendritic cell activation, receptors of Neisseria species and other bacteria.
MANUFACTURER Manufactured by GENOVAC GmbH.
General Literature References
Carcinoembryonic antigen gene family: molecular biology and clinical perspectives: J.A. Thompson, et al.; J. Clin. Lab. Anal. 5, 344 (1991), (Review) Abstract
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues: S. Hammarström; Semin. Cancer Biol. 9, 67 (1999), (Review) Abstract
Carcinoembryonic antigen: W. Zimmermann; Wiley Encylopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc., New York 459 (2002)
Further Categories Containing This Product:
CD Antibodies • Monoclonal Antibodies
 
 
ALX-805-076 Revised 05-May-08
Monoclonal Antibody to CEACAM1 (human) (GM8G5)
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SYNONYMS anti-CD66a (human) MAb (GM8G5)
anti-Biliary Glycoprotein 1 (human) MAb (GM8G5)
anti-BGP (human) MAb (GM8G5)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY CEACAM [CD66]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-076-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: GM8G5
ISOTYPE: Mouse IgG1
CONCENTRATION: 2mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.2. Contains no preservatives.
IMMUNOGEN: Vector containing the cDNA of human CEACAM1 A2 domain.
SPECIFICITY: Recognizes human CEACAM1. Does not cross-react with human CEACAM3, 4, 5, 6 or 8.
APPLICATION: Flow Cytometry
Immunohistochemistry (frozen sections)
Optimal conditions must be determined individually for each application.
QUALITY CONTROL: Routinely tested on BOSC cells transiently transfected with a CEACAM1 expression vector.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Product Images
Please click on thumbnails to enlarge.
General Information
CEACAM1 (CD66a, BGP) belongs to the carcinoembryonic antigen (CEA) gene family. It is expressed on cells of epithelial and myeloid origin. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like A (A1, A2) and one B domain. While N, A1 and B domains can also be found in other CEA-family members, the A2 domain of CEACAM1 differs from those found in other CEACAMs.
MANUFACTURER Manufactured by GENOVAC GmbH.
General Literature References
Carcinoembryonic antigen gene family: molecular biology and clinical perspectives: J.A. Thompson, et al.; J. Clin. Lab. Anal. 5, 344 (1991), (Review) Abs