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Accessory Proteins & Motor Proteins
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ALX-105-011 Revised 18-Sep-06
S-Trityl-L-cysteine
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SYNONYMS NSC 83265
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Cell Cycle Blockers & Inhibitors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-105-011-M100   100 mg 20.00 USD Add To Cart
ALX-105-011-M500   500 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C22H21NO2S
MW: 363.5
CAS NUMBER: 2799-07-7
RTECS: AY7710000
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or acetic acid
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Potent, cell permeable cysteine thioether displaying anti-mitotic and anti-tumor properties. Inhibits mitosis by blocking basal and microtubule-activated ATPase activities of the mitotic kinesin Eg5 (IC50=1µM and 140nm). Induces mitotic arrest in HeLa cells (IC50=700nM) and inhibits the growth of NCI tumor cell line panel (GI50=1.31µM).
Product Specific Literature References
In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities: S. DeBonis, et al.; Mol. Cancer Ther. 3, 1079 (2004) Abstract; Full Text
S-trityl-l-cysteine is a reversible, tight-binding inhibitor of the human kinesin eg5 that specifically blocks mitotic progression: D.A. Skoufias, et al.; J. Biol. Chem. 281, 17559 (2006) Abstract; Full Text
Further Categories Containing This Product:
Kinesin & Kinesin-like Proteins / Related Products • Antitumor Agents (Anti-proliferative)
 
 
ALX-270-438 Revised 06-Dec-06
Dimethylenastron
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SYNONYMS 7,7-Dimethyl-4-(3-hydroxyphenyl)-5-oxo-3,4,5,6,7,8-hexahydroquinazolin-2(1H)-thione
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Cell Cycle Blockers & Inhibitors / Related Products
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ALX-270-438-M001   1 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C16H18N2O2S
MW: 302.4
CAS NUMBER: 863774-58-7
PURITY: ≥95%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO (10mg/ml) or methanol (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months when stored at -20°C in the dark.
HANDLING: Protect from light.
HAZARD: HARMFUL.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Potent, cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=200nM) by binding to the mitotic kinesin Eg5.
Product Specific Literature References
Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5: M. Gartner, et al.; ChemBioChem. 6, 1173 (2005) Abstract
Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5: N. Sunder-Plassmann, et al.; Bioorg. Med. Chem. 13, 6094 (2005) Abstract
Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells: C. Muller, et al.; Cancer Chemother. Pharmacol. 59, 157 (2007) Abstract
Further Categories Containing This Product:
Kinesin & Kinesin-like Proteins / Related Products
 
 
ALX-270-373 Revised 11-Aug-06
trans-HR22C16
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PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Cell Cycle Blockers & Inhibitors / Related Products
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ALX-270-373-M001   1 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C23H23N3O3
MW: 389.5
CAS NUMBER: 462630-41-7
PURITY: ≥95%
APPEARANCE: Yellow to ocher solid.
SOLUBILITY: Soluble in DMSO (10mg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL. MAY BE TERATOGENIC. MAY BE CARCINOGENIC.

Product Description

Cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=800nM) by binding to the mitotic kinesin Eg5.
Product Specific Literature References
HR22C16: A Potent Small-Molecule Probe for the Dynamics of Cell Division: S. Hotha, et al.; Angew. Chem. Int. Ed. Engl. 42, 2379 (2003) Abstract
Further Categories Containing This Product:
Kinesin & Kinesin-like Proteins / Related Products
 
 
ALX-430-094 Revised 04-Jul-07
Monastrol
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SYNONYMS 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic acid ethyl ester
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Cell Cycle Blockers & Inhibitors / Related Products
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ALX-430-094-M001   1 mg 60.00 USD Add To Cart
ALX-430-094-M005   5 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C14H16N2O3S
MW: 292.4
CAS NUMBER: 329689-23-8
PURITY: ≥95%
APPEARANCE: White to light yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=14µM) by binding to the mitotic kinesin Eg5.
Product Specific Literature References
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen: T.U. Mayer, et al.; Science 286, 971 (1999) Abstract
A combinatorial approach to recognition of chirality: preparation of highly enantioselective aryl-dihydropyrimidine selectors for chiral HPLC: K. Lewandowski, et al.; J. Comb. Chem. 1, 105 (1999) Abstract
Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5: Z. Maliga, et al.; Chem. Biol. 9, 989 (2002) Abstract
Inhibition of a mitotic motor protein: where, how, and conformational consequences: Y. Yan, et al.; J. Mol. Biol. 335, 547 (2004) Abstract
Monastrol, a selective inhibitor of the mitotic kinesin Eg5, induces a distinctive growth profile of dendrites and axons in primary cortical neuron cultures: S.Y. Yoon, et al.; Cell Motil. Cytoskeleton 60, 181 (2005) Abstract
Interaction of the mitotic kinesin Eg5 inhibitor monastrol with P-glycoprotein: T. Peters, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 372, 291 (2006) Abstract
A pathway of structural changes produced by monastrol binding to Eg5: Z. Maliga, et al.; J. Biol. Chem. 281, 7977 (2006) Abstract
Allosteric inhibition of kinesin-5 modulates its processive directional motility: B.H. Kwok, et al.; Nat. Chem. Biol. 2, 480 (2006) Abstract
Further Categories Containing This Product:
Kinesin & Kinesin-like Proteins / Related Products
 
 
ALX-804-340 Revised 18-Sep-07
Monoclonal Antibody to DLC1 (10D6)
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SYNONYMS anti-Dynein Light Chain 1 MAb (10D6)
anti-LC8 MAb (10D6)
anti-Protein Inhibitor of nNOS MAb (10D6)
anti-PIN MAb (10D6)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Accessory Proteins & Motor Proteins Other Products
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ALX-804-340-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 10D6
ISOTYPE: Rat IgM
CONCENTRATION: 1mg/ml
PURITY DETAIL: Affinity purified.
FORMULATION: Liquid. In PBS containing 10mM sodium azide.
IMMUNOGEN: Recombinant mouse DLC1 (dynein light chain 1; LC8; PIN).
SPECIFICITY: Recognizes human and mouse DLC1. Does not cross-react with DLC2.
For detection of both DLC1 and DLC2 see MAb to DLC1 and DLC2 (11F7) (Prod. No. ALX-804-341).
APPLICATION: Flow Cytometry
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis: H. Puthalakath, et al.; Science 293, 1829 (2001) Abstract
Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells: Y. Zhu, et al.; PNAS 101, 7681 (2004) Abstract; Full Text
Related Products
Further Categories Containing This Product:
NOS Regulation • Monoclonal Antibodies
 
 
ALX-804-341 Revised 05-Mar-07
Monoclonal Antibody to DLC1 and DLC2 (11F7)
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SYNONYMS anti-Dynein Light Chain 1/2 MAb (11F7)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Accessory Proteins & Motor Proteins Other Products
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ALX-804-341-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 11F7
ISOTYPE: Rat IgG2a
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant mouse DLC1 (dynein light chain 1; LC8; PIN).
SPECIFICITY: Recognizes human and mouse DLC1 and DLC2.
APPLICATION: Flow Cytometry
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Interaction of the postsynaptic density-95/guanylate kinase domain- associated protein complex with a light chain of myosin-V and dynein: S. Naisbitt, et al.; J. Neurosci. 20, 4524 (2000) Abstract; Full Text
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis: H. Puthalakath, et al.; Science 293, 1829 (2001) Abstract
Further Categories Containing This Product:
NOS Regulation • Monoclonal Antibodies
 
 
ALX-804-406 Revised 09-Nov-04
Monoclonal Antibody to Kinesin (KN-01)
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PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Kinesin & Kinesin-like Proteins / Related Products
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ALX-804-406-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
Pig
CLONE: KN-01
ISOTYPE: Mouse IgM
FORMULATION: Contains 0.05% sodium azide.
IMMUNOGEN: Purified pig kinesin.
SPECIFICITY: Recognizes mouse, rat and pig kinesin heavy chain.
APPLICATION: ELISA
Immunocytochemistry
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-210-207 Revised 13-Jan-05
Polyclonal Antibody to Dynamin I (rat)
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SYNONYMS anti-Dyn1 (rat) PAb
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Dynamins / Related Products
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ALX-210-207-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 633-647 (CK633EKASETEE
NGSDSF647) of rat Dyn1 (dynamin I). This sequence is completely conserved in human and mouse Dyn1.
SPECIFICITY: Recognizes rat Dyn1. Detects a band of ~100kDa by Western blot.
APPLICATION: Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-154-001.
Product Description
The dynamins are a family of 100kDa GTPases transcribed from at least three seperate genes. At least four mRNA splice variants for each dynamin have been described. Dynamins contain several conserved regions including the conserved, amino-terminal GTPase domain, a centrally located membrane-binding plekstrin homology domain (PHD), and a coiled-coil region located in front of a proline-rich domain (PRD). The PRD is thought to mediate interactions between dynamin and numerous other cellular proteins. Dynamin I is expressed exclusively in neurons, dynamin II is ubiquitously expressed, and dynamin III is only found in the brain, testis, heart, and lung. The dynamins participate in the cellular process of clathrin-mediated and fluid-phase endocytosis.
Product Specific Literature References
Dynamin: a molecular motor with pinchase action: M. McNiven; Cell 94, 151 (1998) Abstract
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Further Categories Containing This Product:
Endocytosis • Polyclonal Antibodies
 
 
ALX-210-262 Revised 13-Jan-05
Polyclonal Antibody to Dynamin II
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SYNONYMS anti-Dyn2 PAb
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Dynamins / Related Products
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ALX-210-262-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. Total IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 762-781(CS762HSPTPQRR
PVSSIHPPGRP781) of human Dyn2 (dynamin II)
SPECIFICITY: Recognizes human, mouse and rat Dyn2. Detects a band of ~100kDa by Western blot.
APPLICATION: Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-154-002.
Product Description
The dynamins are a family of 100kDa GTPases transcribed from at least three separate genes. At least four mRNA splice variants for each dynamin have been described. Dynamins contain several conserved regions including the conserved, amino-terminal GTPase domain, a centrally located membrane-binding plekstrin homology domain (PHD), and a coiled-coil region located in front of a proline-rich domain (PRD). The PRD is thought to mediate interactions between dynamin and numerous other cellular proteins. Dynamin I is expressed exclusively in neurons, dynamin II is ubiquitously expressed, and dynamin III is only found in the brain, testis, heart, and lung. The dynamins participate in the cellular process of clathrin-mediated and fluid-phase endocytosis.
Related Products
Further Categories Containing This Product:
Endocytosis • Polyclonal Antibodies
 
 
ALX-210-263 Revised 13-Jan-05
Polyclonal Antibody to Dynamin III
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SYNONYMS anti-Dyn3 PAb
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Dynamins / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-263-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Total IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 623-639 (CP623DKSFTEN
DENGQAENF639) of rat Dyn3 (dynamin III).
SPECIFICITY: Recognizes human, mouse and rat Dyn3. Detects a band of  ~100kDa by Western blot.
APPLICATION: Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-154-003.
Product Description
The dynamins are a family of 100kDa GTPases transcribed from at least three separate genes. At least four mRNA splice variants for each dynamin have been described. Dynamins contain several conserved regions including the conserved, amino-terminal GTPase domain, a centrally located membrane-binding plekstrin homology domain (PHD), and a coiled-coil region located in front of a proline-rich domain (PRD). The PRD is thought to mediate interactions between dynamin and numerous other cellular proteins. Dynamin I is expressed exclusively in neurons, dynamin II is ubiquitously expressed, and dynamin III is thought to be restricted to expression in the brain, testis, heart, and lung. The dynamins participate in the cellular process of clathrin-mediated and fluid-phase endocytosis.
Related Products
Further Categories Containing This Product:
Endocytosis • Polyclonal Antibodies
 
 
ALX-210-203 Revised 30-Oct-06
Polyclonal Antibody to Kinesin-like Protein (mouse)
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SYNONYMS