ALEXIS Biochemicals: D-erythro-Sphingosine, Dihydro-

ALX-306-008

Revised 07-Feb-05

D-erythro-Sphingosine, Dihydro-
SYNONYMS	D-erythro-Dihydrosphingosine
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Ceramides / Cerebrosides / Sphingolipids / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-306-008-M010		10 mg	70.00 USD

Product Specification

FORMULA:	C₁₈H₃₉NO₂
MW:	301.5
CAS NUMBER:	3102-56-5
SOURCE/HOST:	Synthetic.
PURITY:	≥98%
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Inhibitor of protein kinase C (PKC). Blocks phospholipases A₂ (PLA2) and the D-sphingosine precursor.

Product Specific Literature References

Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds: A.H. Merrill, Jr., et al.; Biochemistry 28, 3138 (1989) Abstract
Sphingolipid metabolism and signal transduction: inhibition of in vitro phospholipase activity by sphingosine: R.C. Franson, et al.; Biochim. Biophys. Acta 1136, 169 (1992) Abstract
Glucocorticoid stimulation of amnion cell prostaglandin synthesis: suppression by protein kinase C inhibitors and independence of phorbol ester-sensitive protein kinase C: T. Zakar, et al.; Biochim. Biophys. Acta 1136, 161 (1992) Abstract
Sphinganine potentiation of dimethyl sulfoxide-induced granulocyte differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60): B.Y. Yung, et al.; BBRC 199, 888 (1994) Abstract

Further Categories Containing This Product:

PKC Inhibitors • PLA2 Inhibitors

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