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ALX-303-003 Revised 29-Jan-05
D-erythro-Sphingosine, N-Hexanoyl-
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SYNONYMS N-Hexanoyl-D-erythro-sphingosine
C6-Ceramide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Ceramides/Cerebrosides/Sphingolipids/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-303-003-M001   1 mg 38.00 USD Add To Cart
ALX-303-003-M005   5 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C24H47NO3
MW: 397.6
CAS NUMBER: 124753-97-5
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Cell permeable, biologically active, nonphysical ceramide analog. Activates protein phosphatase 2A and MAP kinase (MAPK/ERK). Induces an arrest at the G0/G1 transition of the cell cycle. Inhibits diacylglycerol accumulation and phospholipase D activation in fibroblasts. Induces apoptosis.
Product Specific Literature References
Ceramide stimulates a cytosolic protein phosphatase: R.T. Dobrowsky & Y.A. Hannun; J. Biol. Chem. 267, 5048 (1992) Abstract; Full Text
Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells: M. A. Raines, et al.; J. Biol. Chem. 268, 14572 (1993) Abstract; Full Text
Ceramide activates heterotrimeric protein phosphatase 2A: R.T. Dobrowsky, et al.; J. Biol. Chem. 268, 15523 (1993) Abstract; Full Text
Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway: W.D. Jarvis, et al.; PNAS 91, 73 (1994) Abstract; Full Text
Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence: M.E. Venable, et al.; J. Biol. Chem. 269, 26040 (1994) Abstract; Full Text
Role for ceramide in cell cycle arrest: S. Jayadev, et al.; J. Biol. Chem. 270, 2047 (1995) Abstract; Full Text
Further Categories Containing This Product:
Phospholipase D/Related Products • Apoptosis Inducers & Inhibitors Other Products • MAPK Pathway Activators • Cell Cycle Blockers & Inhibitors/Related Products
 
 
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