ALEXIS Biochemicals: DEDPI

ALX-430-120

Revised 02-Nov-07

DEDPI
SYNONYMS	4-(Dimethylamino)-2-ethyl-5,5-dimethyl-2-pyridine-4-yl-2,5-dihydro-1H-imidazol-1-oxyl
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Spin Traps, Spin Probes & Spin Labels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-120-M010		10 mg	60.00 USD
ALX-430-120-M050		50 mg	210.00 USD

Product Specification

FORMULA:	C₁₄H₂₁N₄O
MW:	261.3
PURITY:	≥99% (HPLC; EPR)
APPEARANCE:	Orange crystalline solid.
SOLUBILITY:	Highly soluble in DMSO, methanol or 100% ethanol; moderately soluble in water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

Product Description

pH-sensitive nitroxide for in vivo studies. The presence of two ionizable groups in the side-chains extends the range of pH sensitivity. The relatively high solubility in water and broad range of pH-sensitivity makes the probe particularly suitable for pH monitoring in stomach using non-invasive low-field EPR techniques.

Product Specific Literature References

Grignard reagent addition to 5-alkylamino-4H-imidazole 3-oxides: synthesis of new pH-sensitive spin probes : T.G. Shevelev, et al.; Synthesis 2003, 871
Synthesis of the tetraethyl substituted pH-sensitive nitroxides of imidazole series with enhanced stability towards reduction: I.A. Kirilyuk, et al.; Org. Biomol. Chem. 2, 1025 (2004) Abstract
In vitro and in vivo measurement of pH and thiols by EPR-based techniques: V.V. Khramtsov, et al.; Antioxid. Redox Signal. 6, 667 (2004) Abstract
Nitroxides with two pK values--useful spin probes for pH monitoring within a broad range: I.A. Kirilyuk, et al.; Org. Biomol. Chem. 3, 1269 (2005) Abstract
Real-time monitoring of drug-induced changes in the stomach acidity of living rats using improved pH-sensitive nitroxides and low-field EPR techniques: D.I. Potapenko, et al.; J. Magn. Reson. 182, 1 (2006) Abstract

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