ALEXIS Biochemicals: DL-Sulforaphane

ALX-350-232

Revised 17-Jul-08

DL-Sulforaphane
SYNONYMS	R,S-Sulforaphane 1-Isothiocyanato-4-methylsulfinyl-butane
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Chemopreventive Agents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-232-M025		25 mg	140.00 USD

Product Specification

FORMULA:	C₆H₁₁NOS₂
MW:	177.3
CAS NUMBER:	142825-10-3; 4478-93-7 (unspecified stereo)
MERCK INDEX:	14: 8962
SOURCE/HOST:	Synthetic.
PURITY:	≥98% (UPLC)
APPEARANCE:	Slightly yellowish liquid.
SOLUBILITY:	Soluble in methanol or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
IDENTITY:	Identity determined by ¹H-NMR and MS.

Product Description

Potent, selective inducer of phase II detoxification enzymes. Inhibits chemically induced mammary tumor formation in rats. Inhibits LPS-induced HMGB1 (high mobility group box 1) secretion.

Product Specific Literature References

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure: Y. Zhang, et al.; PNAS 89, 2399 (1992) Abstract; Full Text
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates: Y. Zhang, et al.; PNAS 91, 3147 (1994) Abstract; Full Text
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase: M.C. Myzak, et al.; Cancer Res. 64, 5767 (2004) Abstract; Full Text
The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells: M.E. Killeen, et al.; J. Pharmacol. Exp. Ther. 316, 1070 (2006) Abstract

Further Categories Containing This Product:

Antitumor Agents (Enzyme Activators & Inducers) • Glutathione S-Transferase • Respiratory Chain Other Products • Cytochrome P450 [CYP450]/Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Active Substances from Fruit and Vegetables

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