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ALX-420-027 Revised 26-Mar-08
DMNQ
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SYNONYMS 2,3-Dimethoxy-1,4-naphthoquinone
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-027-M005   5 mg 68.00 USD Add To Cart
ALX-420-027-M010   10 mg 115.00 USD Add To Cart
ALX-420-027-M025   25 mg 225.00 USD Add To Cart
Product Specification
FORMULA: C12H10O4
MW: 218.2
CAS NUMBER: 6956-96-3
PURITY: ≥99%
APPEARANCE: Yellow crystalline solid.
SOLUBILITY: Soluble in acetone, DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necrosis. DMNQ does not react with free thiol groups, is non-alkylating and adduct-forming in contrast to other quinones. Thus, DMNQ is a valuable tool for the generation of reactive oxygen species (ROS) in order to study the role of ROS in cell toxicity, apoptosis and necrosis.
Product Specific Literature References
Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells: J.M. Dypbukt, et al.; J. Biol. Chem. 269, 30553 (1994) Abstract; Full Text
DNA single-strand breakage in mammalian cells induced by redox cycling quinones in the absence of oxidative stress: W.A. Morgan; J. Biochem. Toxicol. 10, 227 (1995) Abstract
Potentiation of nitric oxide synthase expression by superoxide in interleukin 1 beta-stimulated rat mesangial cells: K.F. Beck, et al.; FEBS Lett. 435, 35 (1998) Abstract
The relative importance of oxidative stress versus arylation in the mechanism of quinone-induced cytotoxicity to platelets: S.A. Seung, et al.; Chem. Biol. Interact. 113, 133 (1998) Abstract
Further Categories Containing This Product:
Non-apoptotic Cell Death / Necrosis • Apoptosis Inducers & Inhibitors Other Products
 
 
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