ALEXIS Biochemicals: DMPO (high purity)

ALX-430-129

Revised 31-Jul-07

DMPO (high purity)
SYNONYMS	5,5-Dimethyl-1-pyrroline-N-oxide (high purity) 2,2-Dimethyl-3,4-dihydro-2H-pyrrole 1-oxide (high purity)
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Spin Traps, Spin Probes & Spin Labels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-129-M100		100 mg	60.00 USD
ALX-430-129-M500		500 mg	185.00 USD

Product Specification

FORMULA:	C₆H₁₁NO
MW:	113.2
PURITY:	≥99% (¹H-NMR, EPR)
APPEARANCE:	Colorless crystals.
SOLUBILITY:	Soluble in water, DMSO, methanol, 100% ethanol or methylene chloride.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	-20°C
LONG TERM STORAGE:	-80°C
HANDLING:	Hygroscopic. Protect from light and moisture.

Product Description

Cell permeable hydrophilic spin trap for both in vivo and in vitro studies of superoxide, O-, C-, S- and N- centered free radicals. Low paramagnetic impurities. No further purification required.

Product Specific Literature References

The spin trapping of superoxide and hydroxyl free radicals with DMPO (5,5-dimethylpyrroline-N-oxide): more about iron: G.R. Buettner; Free Radic. Res. Comm. 19 Suppl 1, S79 (1993) Abstract
Nitric oxide, superoxide and peroxynitrite: putative mediators of NMDA-induced cell death in cerebellar granule cells: M. Lafon-Cazal, et al.; Neuropharmacology 32, 1259 (1993) Abstract
Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis: A.F. Slater, et al.; Biochem. J. 306, 771 (1995) Abstract
Oxygen-centered spin adducts of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) and 2H-imidazole 1-oxides: A.G. Krainev, et al.; J. Magn. Reson. B. 111, 272 (1996) Abstract
Formation of reactive oxygen species by pentaerithrityltetranitrate and glyceryl trinitrate in vitro and development of nitrate tolerance: S. Dikalov, et al.; J. Pharmacol. Exp. Ther. 286, 938 (1998) Abstract; Full Text
Formation of spin trap adducts during the decomposition of peroxynitrite: R.M. Gatti, et al.; Arch. Biochem. Biophys. 349, 36 (1998) Abstract
MDL 101,002, a free radical spin trap, is efficacious in permanent and transient focal ischemia models: M.P. Johnson, et al.; Life Sci. 63, 241 (1998) Abstract
Generation of nitric oxide from spin-trapping agents under oxidative conditions: K. Saito, et al.; Biosci. Biotech. Biochem. 62, 275 (1998)
Electron spin resonance detection of extracellular superoxide anion released by cultured endothelial cells: J.P. Souchard, et al.; Free Radic. Res. 29, 441 (1998) Abstract
Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process: Y. Xia, et al.; J. Biol. Chem. 273, 25804 (1998) Abstract; Full Text

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