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DNA Regulation / Transcription
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ALX-840-602 Revised 24-Nov-05
Positive Control (Cell Lysate) for Antibodies to Asc (human)
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SYNONYMS Positive Control (Cell Lysate) for Antibodies to Pycard (human)
PRODUCT LINE Immunology
PRODUCT CATEGORY Positive Controls (Cell Lysates & Extracts)
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-840-602-R100   100 µl 70.00 USD Add To Cart
Product Specification
SOURCE/HOST: Whole cell lysate of HEK 293T cells transfected with an expression plasmid for human Asc (aa 1-195) fused at the C-terminus to a FLAG®-tag.
QUANTITY: 100µl corresponding to 2x105 cells.
FORMULATION: Liquid. In 5x sample buffer (312.5mM TRIS, pH 6.8, containing 10% SDS, 6% glycerol, 0.075% bromophenol blue, 10% β-mercaptoethanol and 10mM DTT).
APPLICATION: Positive control in Western blot for PAb to Asc (human) (AL177) (Prod. No. ALX-210-905). Add 13µl sterile water and 2µl DTT (100mM) to 5µl of cell lysate.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products • Inflammasome
 
 
ALX-430-115 Revised 14-Aug-08
Aspirin
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SYNONYMS Acetylsalicylic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-430-115-G005   5 g 10.00 USD Add To Cart
Product Specification
FORMULA: C9H8O4
MW: 180.2
CAS NUMBER: 50-78-2
MERCK INDEX: 14: 851
RTECS: VO0700000
PURITY: ≥99%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol (80mg/ml), DMSO (41mg/ml) or dimethyl formamide (30mg/ml); slightly soluble in PBS, pH 7.2 (2.7mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stable for at least 2 years when stored at room temperature. Keep aqueous solutions on ice and use within 30 minutes. Unstable in basic solutions pH>7.4.
HAZARD: HARMFUL.

Product Specific Literature References
Inhibition of NF-kappa B by sodium salicylate and aspirin: E. Kopp & S. Ghosh; Science 265, 956 (1994) Abstract
Neuroprotection by aspirin and sodium salicylate through blockade of NF- kappaB activation: M. Grilli, et al.; Science 274, 1383 (1996) Abstract
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta: M.J. Yin, et al.; Nature 396, 77 (1998) Abstract
The pleiotropic functions of aspirin: mechanisms of action: A.R. Amin, et al.; Cell Mol. Life Sci. 56, 305 (1999) Abstract
Further Categories Containing This Product:
COX Inhibitors • NF-kB Pathway Inhibitors • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products
 
 
ALX-350-361 Revised 17-Mar-08
Auraptene
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SYNONYMS 7-Geranyloxycoumarin
7-[(2E)-3,7-Dimethylocta-2,6-dienoxy]chromen-2-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-361-M005   5 mg 25.00 USD Add To Cart
ALX-350-361-M025   25 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C19H22O3
MW: 298.4
CAS NUMBER: 495-02-3
SOURCE/HOST: Isolated from citrus fruit.
PURITY: ≥98% (HPLC)
SOLUBILITY: Soluble in methanol or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by NMR.

Product Description
Anti-inflammatory and chemopreventive compound. Exerts tumor preventive effects through apoptosis. Suppresses cell proliferation and lipid peroxidation. Acts as an agonist of PPARs. Induces phase II drug-metabolizing enzymes.
Product Specific Literature References
Citrus auraptene exerts dose-dependent chemopreventive activity in rat large bowel tumorigenesis: the inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drug-metabolizing enzymes: T. Tanaka, et al.; Cancer Res. 58, 2550 (1998) Abstract; Full Text
Immunomodulatory action of citrus auraptene on macrophage functions and cytokine production of lymphocytes in female BALB/c mice: T. Tanaka, et al.; Carcinogenesis 20, 1471 (1999) Abstract; Full Text
Cell proliferation in cancer prevention; effects of preventive agents on estrogen-related endometrial carcinogenesis model and on an in vitro model in human colorectal cells: H. Mori, et al.; Mutat. Res. 480-481, 201 (2001) Abstract
Synthesis and anti-inflammatory activity of natural and semisynthetic geranyloxycoumarins: M. Curini, et al.; Bioorg. Med. Chem. Lett. 14, 2241 (2004) Abstract
Citrus auraptene targets translation of MMP-7 (matrilysin) via ERK1/2-dependent and mTOR-independent mechanism: K. Kawabata, et al.; FEBS Lett. 580, 5288 (2006) Abstract
Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes: K. Kuroyanagi, et al.; BBRC 366, 219 (2008) Abstract
Further Categories Containing This Product:
PPAR Agonists • Antitumor Agents (Apoptosis Inducers) • Natural Products - Anti-inflammatory Agents • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-380-240 Revised 03-Apr-08
Aureothricin
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SYNONYMS Propionylpyrrothione
Farcinicin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-240-MC05   0.5 mg 220.00 USD Add To Cart
Product Specification
FORMULA: C9H10N2O2S2
MW: 242.3
CAS NUMBER: 574-95-8
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS4782.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow to orange solid.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; partially soluble in methanol or 100% ethanol; poorly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Antibiotic. More hydrophobic analog of the antibiotic thiolutin (Prod. No. ALX-380-200) with selective antitumor activity. Potent inhibitor of bacterial and yeast RNA polymerases and of fungal mannan and glucan formation.
Product Specific Literature References
Studies on a common hydrolysis product of thiolutin and aureothricin: W.D. Celmer & I.A. Solomons; Antibiot. Annu. 622, (1953)
Anticancer properties of dithiolopyrrolones: J.M. Webster, et al.; US Patent 6,020,360, (2000)
Related Products
Further Categories Containing This Product:
Other Antibiotics - DNA Regulation / Transcription • Antitumor Antibiotics • RNA Polymerases / Related Products
 
 
ALX-270-201 Revised 18-Sep-07
Aurintricarboxylic acid
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SYNONYMS ATA
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Topoisomerase Inhibitors Other Products
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ALX-270-201-G001   1 g 15.00 USD Add To Cart
Product Specification
FORMULA: C22H14O9
MW: 422.4
CAS NUMBER: 4431-00-9
PURITY: ~85%
APPEARANCE: Red solid.
SOLUBILITY: Soluble in aqueous alkali.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: IRRITANT.

Product Description
Potent inhibitor of DNA topoisomerase II in vitro and protein-nucleic acid interactions. Stimulates the tyrosine phosphorylation of MAP kinases. Inhibits both major calpain isoforms. Potent and selective inhibitor of SARS coronavirus replication. Apoptosis inhibitor.
Product Specific Literature References
Mechanism of action of polymeric aurintricarboxylic acid, a potent inhibitor of protein--nucleic acid interactions: R.G. Gonzalez, et al.; Biochemistry 19, 4299 (1980) Abstract
Delayed application of aurintricarboxylic acid reduces glutamate- induced cortical neuronal injury: C.A. Csernansky, et al.; J. Neurosci. Res. 38, 101 (1994) Abstract
Inhibition of topoisomerase II by aurintricarboxylic acid: implications for mechanisms of apoptosis: D.R. Catchpoole & B.W. Stewart; Anticancer Res. 14, 853 (1994) Abstract
Aurintricarboxylic acid, a putative inhibitor of apoptosis, is a potent inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells: Y. Benchokroun, et al.; Biochem. Pharmacol. 49, 305 (1995) Abstract
A neuroprotective compound, aurin tricarboxylic acid, stimulates the tyrosine phosphorylation cascade in PC12 cells: N. Okada & S. Koizumi; J. Biol. Chem. 270, 16464 (1995) Abstract; Full Text
Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid: R. He, et al.; BBRC 320, 1199 (2004) Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-480-096 Revised 18-Aug-08
5-Aza-2'-deoxycytidine
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SYNONYMS 5-Aza-CdR
5-Aza-dC
5-Deoxy-2'-azacytidine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Nucleobases
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ALX-480-096-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C8H12N4O4
MW: 228.2
CAS NUMBER: 2353-33-5
RTECS: XZ3012000
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: 25mg/ml soluble in DMSO or 50% acetic acid; 1mg/ml soluble in methanol. (Warming may be required to achieve complete solubilization.)
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.
HAZARD: HARMFUL.

Product Description
Inhibitor of DNA methyltransferase. Restores mRNA and protein expression of caspase-8 and TRAIL (tumor necrosis factor-related apoptosis inducing ligand) sensitivity of resistant cell lines. Enhances apoptosis induced by HDAC (histone deacetylase) inhibitors.
Product Specific Literature References
Incorporation of a potent antileukemic agent, 5-aza-2'-deoxycytidine, into DNA of cells from leukemic mice: J. Vesely and A. Cihak; Cancer Res. 37, 3684 (1977) Abstract
Cellular differentiation, cytidine analogs and DNA methylation: P.A. Jones and S.M. Taylor; Cell 20, 85 (1980) Abstract
The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: implications for methylation-associated cellular processes: T. Haaf; Pharmacol. Ther. 65, 19 (1995) Abstract
Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis: S. Hopkins-Donaldson, et al.; Cancer Res. 60, 4315 (2000) Abstract; Full Text
Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression: A. Eggert, et al.; Cancer Res. 61, 1314 (2001) Abstract; Full Text
5-Aza-2'-deoxycytidine induces histone hyperacetylation of mouse centromeric heterochromatin by a mechanism independent of DNA demethylation: S. Takebayashi, et al.; BBRC 288, 921 (2001) Abstract
DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors: W.G. Zhu, et al.; Cancer Res. 61, 1327 (2001) Abstract; Full Text
Further Categories Containing This Product:
DNA & RNA Methyl & Alkyl Transferases / Related Products
 
 
ALX-301-013 Revised 08-Jul-08
Azelaoyl-PAF
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SYNONYMS 1-O-Hexadecyl-2-O-(9-carboxyoctanoyl)-sn-glyceryl-3-phosphocholine
PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
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ALX-301-013-M001   1 mg 58.00 USD Add To Cart
ALX-301-013-M005   5 mg 261.00 USD Add To Cart
Product Specification
FORMULA: C33H66NO9P
MW: 651.9
SOURCE/HOST: Synthetic.
PURITY: ≥98%
FORMULATION: Liquid. Solution in ethanol.
SOLUBILITY: Soluble in DMSO (8mg/ml) or dimethyl formamide (33mg/ml) or PBS, pH 7.2 (10mg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.

Product Description
Potent PPARγ agonist which competes for the thiazoladinedione binding site. More potent than 15-deoxy-Δ12,14-prostaglandin J2 (Prod. No. ALX-340-022) and equipotent with rosiglitazone (Prod. No. ALX-350-125) as a ligand for this receptor.
Product Specific Literature References
Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists: S.S. Davies, et al.; J. Biol. Chem. 276, 16015 (2001) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Phospholipids / Related Products • PPAR Agonists
 
 
ALX-270-485 Revised 07-Apr-08
B2
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SYNONYMS CPNQ
5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Sirtuins / Related Products
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ALX-270-485-MC05   0.5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C20H17ClN4O3
MW: 396.8
CAS NUMBER: 115687-05-3
PURITY: ≥95%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO (>5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and oxygen.
HAZARD: TOXIC.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Cell permeable inhibitor of sirtuin 2 (SIRT2) (IC50=35μM). Promotes inclusion formation in cellular models of both Huntington’s disease and Parkinson’s disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.
Product Specific Literature References
Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington’s and Parkinson’s diseases: R.A. Bodner, et al.; PNAS 103, 4246 (2006) Abstract; Full Text
Related Products
Further Categories Containing This Product:
Parkinson's Disease Other Products
 
 
ALX-270-353 Revised 16-Feb-07
BADGE
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SYNONYMS Bisphenol A diglycidyl ether
2,2'-[(1-Methylethylidene)bis(4,1-phenyleneoxymethylene)]bis-oxirane
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Antagonists
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ALX-270-353-G025   25 g 19.00 USD Add To Cart
Product Specification
FORMULA: C21H24O4
MW: 340.4
CAS NUMBER: 1675-54-3
PURITY: ≥85%
FORMULATION: Neat oil.
SOLUBILITY: Miscible in organic solvents as 100% ethanol, DMSO or dimethyl formamide. Insoluble in PBS, pH 7.2.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions in 100% ethanol, DMSO or dimethyl formamide are stable for at least 1 year if stored at -20°C.

Product Description
Antagonist of PPARγ. Binds to PPARγ with an apparent Kd of 100µM.
Product Specific Literature References
A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation: H.M. Wright, et al.; J. Biol. Chem. 275, 1873 (2000) Abstract; Full Text
Bisphenol A diglycidyl ether induces apoptosis in tumour cells independently of peroxisome proliferator-activated receptor-gamma, in caspase-dependent and -independent manners: S. Fehlberg, et al.; Biochem. J. 362, 573 (2002) Abstract; Full Text
Bisphenol a diglycidyl ether (BADGE) suppresses tumor necrosis factor-alpha production as a PPARgamma agonist in the murine macrophage-like cell line, RAW 264.7: M. Nakamuta, et al.; Cell Biol. Int. 26, 235 (2002) Abstract
Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma: T. Zander, et al.; J. Neurochem. 81, 1052 (2002) Abstract
General Information
Interferes with the ability of 3T3-L1 and 3T3-F442A cells to undergo hormone-mediated cell differentiation.
 
 
ALX-350-144 Revised 03-Apr-08
Bakuchiol
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SYNONYMS 4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-350-144-M001   1 mg 170.00 USD Add To Cart
Product Specification