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ALX-270-381
Revised 28-Sep-07
Anacardic acid
SYNONYMS
2-Hydroxy-6-pentadecylbenzoic acid
6-Pentadecylsalicylic acid
AA
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-381-M005
5 mg
40.00 USD
ALX-270-381-M025
25 mg
140.00 USD
Product Specification
FORMULA:
C
22
H
36
O
3
MW:
348.5
MERCK INDEX:
14:
621
SOURCE/HOST:
Synthetic.
PURITY:
≥95% (
1
H-NMR)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, DMSO, dichloromethane or ethylacetate.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Protect from light. After reconstitution, prepare aliquots and store at -20°C. Packaged under inert gas.
Product Description
Cell permeable salicylic acid analog that acts as a potent, non-competitive inhibitor of p300 and PCAF (p300/CBP-associated factor) histone acetyltransferase (HAT) activities (IC
50
~8.5µM and ~5µM, respectively). Displays a variety of other biological activities, such as antibacterial, antimicrobial, prostaglandin synthase inhibition, tyrosinase, and lipoxygenase inhibition.
Product Specific Literature References
Anacardic Acid: molluscicide in cashew nut shell liquid:
J.T. Sullivan, et al.; Planta Med.
44
, 175 (1982)
Abstract
Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids:
R. Grazzini, et al.; BBRC
176
, 775 (1991)
Abstract
Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus:
H. Muroi & I. Kubo; J. Appl. Bacteriol.
80
, 387 (1996)
Abstract
Small molecule modulators of histone acetyltransferase p300
:
K. Balasubramanyam, et al.; J. Biol. Chem.
278
, 19134 (2003)
Abstract
;
Full Text
Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation:
Y. Sun, et al.; FEBS Lett.
580
, 4353 (2006)
Abstract
General Literature References
Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus
:
H. Muroi and I. Kubo; J. Appl. Bacteriol.
80
, 387 (1996)
Abstract
Synthesis of sildenafil analogues from anacardic acid and their phosphodiesterase-5 inhibition
:
R. Paramashivappa, et al.; J. Agric. Food Chem.
50
, 7709 (2002)
Abstract
Further Categories Containing This Product:
Prostaglandin Synthases / Related Products
•
Lipoxygenases / Related Products
•
Antibiotics Other Products
ALX-300-071
Revised 03-Jan-08
1-O-Dodecyl-rac-glycerol
SYNONYMS
1-O-Lauryl-
rac
-glycerol
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Mono- & Diacylglycerols
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ALX-300-071-G001
1 g
60.00 USD
Product Specification
FORMULA:
C
15
H
32
O
3
MW:
260.4
CAS NUMBER:
1561-07-5
SOURCE/HOST:
Synthetic.
PURITY:
≥99%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
This lipid was shown to exhibit excellent bacteriostatic effects. Moreover, it is a mild nonionic surfactant qualitatively similar to monoglyceride surfactants that are frequently used as food emulsifiers. Its use as a potential food additive and its metabolism and nutritional effects in mice have been described.
Product Specific Literature References
Dodecylglycerol. A new type of antibacterial agent which stimulates autolysin activity in Streptococcus faecium ATCC 9790:
H.S. Ved, et al.; J. Biol. Chem.
259
, 8115 (1984)
Abstract
;
Full Text
The involvement of the proteinase of Streptococcus faecium ATCC 9790 in the stimulation of its autolysin activity by dodecylglycerol:
H.S. Ved, et al.; J. Biol. Chem.
259
, 8122 (1984)
Abstract
;
Full Text
Metabolism of orally administered rac-1-O-[1'-14C]dodecylglycerol and nutritional effects of dietary rac-1-O-dodecylglycerol in mice:
N. Weber; J. Lipid Res.
26
, 1412 (1985), and references cited therein.
Abstract
;
Full Text
Activation of mouse peritoneal macrophages by lysophospholipids and ether derivatives of neutral lipids and phospholipids:
N. Yamamoto & B. Z. Ngwenya; Cancer Res
47
, 2008 (1987)
Abstract
Participation of serum proteins in the inflammation-primed activation of macrophages:
N. Yamamoto, et al.; Inflammation
18
, 311 (1994)
Abstract
Inhibition of phorbol ester-stimulated arachidonic acid release by alkylglycerols:
M. Robinson, et al.; Biochim. Biophys. Acta
1254
, 361 (1995)
Abstract
Further Categories Containing This Product:
Antibiotics Other Products
ALX-350-136
Revised 05-Dec-07
Viridicatin
SYNONYMS
3-Hydroxy-4-phenyl-1H-chinolin-2-one
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
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ALX-350-136-M001
1 mg
160.00 USD
Product Specification
FORMULA:
C
15
H
11
NO
2
MW:
237.3
CAS NUMBER:
129-24-8
SOURCE/HOST:
Isolated from
Penicillium
sp.
PURITY:
≥98% (HPLC)
APPEARANCE:
Off-white to brown solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by MS,
1
H-NMR.
Product Description
Metabolic product of
Penicillium viridicatum
. Exhibits strong antibiotic activity against
M. tuberculosis
and also against
B. subtilis
,
S. aureus
and
S. cerevisiae
.
Product Specific Literature References
The Isolation and some Chemical Properties of Viridicatin, a Metabolic Product of Penicillium viridicatum Westling:
K.G. Cunningham and G.G. Freeman; Biochem J.
53
, 328 (1953)
Abstract
Determination of viridicatin in Penicillium cyclopium by capillary gas chromatography:
G. Bringmann, et al.; Anal. Biochem.
253
, 18 (1997)
Abstract
The biosynthesis of low-molecular-weight nitrogen-containing secondary metabolite-alkaloids by the resident strains of Penicillium chrysogenum and Penicillium expansum isolated on the board of the Mir space station:
A.G. Kozlovskii, et al.; Mikrobiologiia
71
, 773 (2002), Russian
Abstract
Further Categories Containing This Product:
Alkaloids
ALX-350-238
Revised 03-Apr-08
Chlortetracycline . hydrochloride
SYNONYMS
Aureomycin . HCI
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
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ALX-350-238-G001
1 g
20.00 USD
ALX-350-238-G005
5 g
35.00 USD
Product Specification
FORMULA:
C
22
H
23
ClN
2
O
8
. HCl
MW:
478.9 . 36.5
CAS NUMBER:
64-72-2
MERCK INDEX:
14:
2192
SOURCE/HOST:
Isolated from
Streptomyces aureofaciens
.
PURITY:
~80%
APPEARANCE:
Yellow powder.
SOLUBILITY:
Soluble in water or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Antibiotic. Inhibits protein synthesis in prokaryotes and eukaryotes. Inhibits binding of aminoacyl-tRNA to ribosomes. Used as a fluorescent Ca
2+
probe.
Product Specific Literature References
Inhibition of thrombin-induced secretion from platelets by chlortetracycline and its analogs:
E.H. Murer and E. Siojo; Thromb. Haemost.
47
, 62 (1982)
Abstract
Characterization of chlortetracycline (aureomycin) as a calcium ionophore:
J.R. White & F.L. Pearce; Biochemistry
21
, 6309 (1982)
Abstract
Effect of bile acids on intracellular calcium in isolated rat hepatocyte couplets:
N. Thibault & F. Ballett; Biochem. Pharmacol.
45
, 289 (1993)
Abstract
Chlortetracycline, oxytetracycline, and tetracycline in edible animal tissues, liquid chromatographic method: collaborative study:
J.D. MacNeil, et al.; J. AOAC Int.
79
, 405 (1996)
Abstract
The effect of chlortetracycline treatment and its subsequent withdrawal on multi-resistant Salmonella enterica serovar Typhimurium DT104 and commensal Escherichia coli in the pig:
A.A. Delsol, et al.; J. Appl. Microbiol.
95
, 1226 (2003)
Abstract
Further Categories Containing This Product:
tRNA / Related Products
•
Calcium Indicators / Probes
•
Dyes / Stains / Fluorescent Probes / Fluorescent Labels
ALX-350-297
Revised 07-Apr-08
Meleagrin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
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ALX-350-297-M001
1 mg
195.00 USD
Product Specification
FORMULA:
C
23
H
23
N
5
O
4
MW:
433.5
CAS NUMBER:
71751-77-4
SOURCE/HOST:
Isolated from
Penicillium meleagrinum
.
PURITY:
≥98 (HPLC)
APPEARANCE:
Yellow oil.
SOLUBILITY:
Soluble in 100% ethanol or DMSO.
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Antibiotic.
Product Specific Literature References
The biosynthesis of low-molecular-weight nitrogen-containing secondary metabolite-alkaloids by the resident strains of Penicillium chrysogenum and Penicillium expansum isolated on the board of the Mir space station:
A.G. Kozlovskii, et al.; Mikrobiologiia
71
, 773 (2002)
Abstract
Formation of alkaloids from Penicillium species fungi during growth on wheat kernels:
N.G. Vinokurova, et al.; Prikl. Biokhim. Mikrobiol.
39
, 457 (2003)
Abstract
Roquefortine/oxaline biosynthesis pathway metabolites in Penicillium ser. Corymbifera: in planta production and implications for competitive fitness:
D.P. Overy, et al.; J. Chem. Ecol.
31
, 2373 (2005)
Abstract
Further Categories Containing This Product:
Alkaloids
ALX-350-300
Revised 14-Dec-07
Pseurotin A
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
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ALX-350-300-M001
1 mg
60.00 USD
Product Specification
FORMULA:
C
22
H
25
NO
8
MW:
431.5
CAS NUMBER:
58523-30-1
SOURCE/HOST:
Isolated from
Aspergillus fumigatus
.
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in methanol or ethyl acetate; poorly soluble in water.
SHIPPING:
AMBIENT
SHORT TERM STORAGE:
-20°C
LONG TERM STORAGE:
-20°C
Product Description
Antibiotic. Inhibitor of chitin synthase. Cytotoxic. Has nematicidal activity.
Product Specific Literature References
Novel neuritogenic activities of pseurotin A and penicillic acid
:
D. Komagata, et al.; J. Antibiot.
49
, 958 (1996)
Abstract
Directed biosynthesis of fluorinated pseurotin A, synerazol and gliotoxin
:
Y. Igarashi, et al.; J. Antibiot.
57
, 748 (2004)
Abstract
Fumiquinones A and B, nematicidal quinones produced by Aspergillus fumigatus:
A. Hayashi, et al.; Biosci. Biotechnol. Biochem.
71
, 1697 (2007)
Abstract
Identification of a hybrid PKS/NRPS required for pseurotin A biosynthesis in the human pathogen Aspergillus fumigatus:
S. Maiya, et al.; Chembiochem
8
, 1736 (2007)
Abstract
Further Categories Containing This Product:
Pesticides / Related Products
ALX-380-003
Revised 13-May-08
Gentamicin sulfate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
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ALX-380-003-G001
1 g
45.00 USD
ALX-380-003-G005
5 g
140.00 USD
ALX-380-003-G010
10 g
220.00 USD
ALX-380-003-G025
25 g
460.00 USD
Product Specification
CAS NUMBER:
1405-41-0
MERCK INDEX:
14:
4392
RTECS:
LY2625000
SOURCE/HOST:
Isolated from
Micromonospora sp
.
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water; almost insoluble in alcohol or ether.
ACTIVITY:
Potency is ≥590 IU/mg (anhydrous material).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Hygroscopic.
HAZARD:
HARMFUL.
Product Description
Broad-spectrum cell culture antibiotic that is nontoxic to viruses and mammalian cells at antibacterial and antimycoplasmal concentrations. Due to its extended stability and slow development of bacterial resistance, it is a useful antibiotic in long-term virus und tissue culture studies.
Product Specific Literature References
Microbiological Assay of Gentamicin:
E.M. Oden, et al.; Antimicrobial Agents Chemother. (Bethesda)
161
, 8 (1963)
Abstract
Isolation, Purification, and Characterization of Gentamicin:
J.P. Rosselet, et al.; Antimicrobial Agents Chemother. (Bethesda)
161
, 14 (1963)
Abstract
Pharmacology of Gentamicin, a New Broad-Spectrum Antibiotic:
J. Black, et al.; Antimicrobial Agents Chemother. (Bethesda)
161
, 138 (1963)
Abstract
Molecular insights into aminoglycoside action and resistance:
S. Magnet and J.S. Blanchard; Chem. Rev.
105
, 477 (2005), Review
Abstract
Aminoglycoside antibiotics: old drugs and new therapeutic approaches:
T. Hermann; Cell. Mol. Life. Sci.
64
, 1841 (2007), Review
Abstract
ALX-380-016
Revised 30-Oct-07
Cefaclor
SYNONYMS
7-(D-2-Amino-2-phenylacetamido)-3-chloro-3-cephem-4-carboxylic acid
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
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ALX-380-016-M050
50 mg
20.00 USD
ALX-380-016-M250
250 mg
50.00 USD
ALX-380-016-G001
1 g
150.00 USD
ALX-380-016-G005
5 g
350.00 USD
Product Specification
FORMULA:
C
15
H
14
ClN
3
O
4
S
MW:
367.8
CAS NUMBER:
53994-73-3
MERCK INDEX:
14:
1912
PURITY:
≥97%
APPEARANCE:
Light yellow powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Broad-spectrum antibiotic acting by inhibiting bacterial cell wall synthesis.
Product Specific Literature References
Chemistry of cephalosporin antibiotics. 30. 3-methoxy- and 3-halo-3-cephems:
R. R. Chauvette & P. A. Pennington; J. Med. Chem.
18
, 403 (1975)
Abstract
Cefaclor into the millennium:
W. Brumfitt & J. M. Hamilton-Miller; J. Chemother.
11
, 163 (1999), (Review)
Abstract
Cefaclor revisited:
B. R. Meyers; Clin. Ther.
22
, 154 (2000), (Review)
Abstract
Immunomodulatory properties of cefaclor: in vivo effect on cytokine release and lymphoproliferative response in rats:
K. Mangano, et al.; J. Chemother.
18
, 641 (2006)
Abstract
ALX-380-018
Revised 07-Feb-08
Tobramycin
SYNONYMS
Deoxykanamycin B
Distobram
Gernebcin
Obramycin
Tobradistin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
Ordering Information
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Format:
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ALX-380-018-M010
10 mg
10.00 USD
ALX-380-018-M050
50 mg
30.00 USD
ALX-380-018-M250
250 mg
90.00 USD
ALX-380-018-G001
1 g
270.00 USD
Product Specification
FORMULA:
C
18
H
37
N
5
O
9
MW:
467.5
CAS NUMBER:
32986-56-4
MERCK INDEX:
14:
9490
RTECS:
WK2100000
SOURCE/HOST:
Isolated from
Streptomyces tenebarius
.
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
FORMULATION:
Free base.
SOLUBILITY:
Soluble in water; very slightly soluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
TOXIC. MAY BE TERATOGENIC.
Product Description
Aminoglycoside antibiotic with similar structure to the kanamycins and the gentamycins. Used in the treatment of respiratory infection and cystic fibrosis.
Product Specific Literature References
Tobramycin: a review of its antibacterial and pharmacokinetic properties and therapeutic use:
R. N. Brogden, et al.; Drugs
12
, 166 (1976), Review
Abstract
Inhaled tobramycin (TOBI): a review of its use in the management of Pseudomonas aeruginosa infections in patients with cystic fibrosis:
S.M. Cheer, et al.; Drugs
63
, 2501 (2003), Review
Abstract
Tobramycin solution for inhalation in cystic fibrosis patients: a review of the literature:
J.K. Hagerman, et al.; Expert Opin. Pharmacother.
8
, 467 (2007), Review
Abstract
ALX-380-025
Revised 14-Oct-08
Streptothricin . sulfate
<
