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Cyclic Nucleotides
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ALX-480-085 Revised 05-Sep-07
Adenosine-3’,5’-cyclic Monophosphothioate, Rp-Isomer . sodium salt
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SYNONYMS Rp-cAMPS . Na
cAMPS . Na, Rp-Isomer
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cAMP Derivatives
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-085-M001   1 mg 120.00 USD Add To Cart
ALX-480-085-M005   5 mg 490.00 USD Add To Cart
Product Specification
FORMULA: C10H11N5NaO5PS
MW: 367.3
CAS NUMBER: 73208-40-9
PURITY: ≥99% (low adenosine, cAMP and Sp-cAMPS content)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water or aqueous buffers.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
For application and literature references see the triethylammonium salt (Prod. No. ALX-480-012).
Further Categories Containing This Product:
PKA Inhibitors
 
 
ALX-480-086 Revised 30-Aug-06
Adenosine 3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt
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SYNONYMS Sp-cAMPS . Na
cAMPS . Na, Sp-Isomer
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cAMP Derivatives
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-086-M001   1 mg 75.00 USD Add To Cart
ALX-480-086-M005   5 mg 300.00 USD Add To Cart
Product Specification
FORMULA: C10H11N5NaO5PS
MW: 367.3
CAS NUMBER: 717794-13-5
PURITY: ≥99% (low adenosine, cAMP and Rp-cAMPS content)
APPEARANCE: White to off-white lyophilized powder.
SOLUBILITY: Soluble in water or aqueous buffers.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
For application and literature references see the triethylammonium salt (Prod. No. ALX-480-013).
Further Categories Containing This Product:
PKA Activators
 
 
ALX-480-087 Revised 21-Dec-06
8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . sodium salt
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SYNONYMS Rp-8-pCPT-cGMPS . Na
8-pCPT-cGMPS . Na, Rp-Isomer
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cGMP Derivatives
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-087-C100   100 µg 50.00 USD Add To Cart
ALX-480-087-M001   1 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C16H14ClN5O6PS2 . Na
MW: 502.9 . 23.0
CAS NUMBER: 153660-09-9
PURITY: ≥99%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent selective inhibitor of cGMP-dependent protein kinase (PKG) 1α, 1β and type II. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. No metabolic side effects. Significantly more lipophilic and membrane permeant as compared to Rp-cGMPS (Prod. No. ALX-480-072) or Rp-8-Br-cGMPS (Prod. No. ALX-480-026).
Product Specific Literature References
(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor: E. Butt, et al.; Eur. J. Pharmacol. 269, 265 (1994) Abstract
The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms: D.M. Gamm, et al.; J. Biol. Chem. 270, 27380 (1995) Abstract; Full Text
Antagonists of cyclic nucleotide-gated channels and molecular mapping of their site of action: R.H. Kramer & G.R. Tibbs; J. Neurosci. 16, 1285 (1996) Abstract
Further Categories Containing This Product:
PKG Inhibitors
 
 
ALX-480-088 Revised 31-Oct-06
8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate . sodium salt
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SYNONYMS 8-pCPT-cGMP . Na
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cGMP Derivatives
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ALX-480-088-M001   1 mg 50.00 USD Add To Cart
ALX-480-088-M005   5 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C16H14ClN5O7PS . Na
MW: 486.8 . 23.0
CAS NUMBER: 51239-26-0
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Selective activator of cGMP-dependent protein kinase (PKG) Iα, Iβ, and type II as well as of cGMP-gated ion channels. Higher activation potential as compared to cGMP; excellent cell membrane permeability and phosphodiesterase stability. Preferred alternative to unsuitable analogs such as dibutyryl-cGMP.
Product Specific Literature References
Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets: J. Geiger, et al.; PNAS 89, 1031 (1992) Abstract
Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP: E. Butt, et al.; Biochem. Pharmacol. 43, 2591 (1992) Abstract
Further Categories Containing This Product:
PKG Activators
 
 
ALX-480-093 Revised 07-Feb-08
8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic Monophosphate . sodium salt
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SYNONYMS 8-CPT-2'-O-Me-cAMP . Na
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cAMP Derivatives
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ALX-480-093-M001   1 mg 130.00 USD Add To Cart
ALX-480-093-M005   5 mg 520.00 USD Add To Cart
Product Specification
FORMULA: C17H16ClN5O6PS . Na
MW: 484.8 . 23.0
CAS NUMBER: 510774-50-2
PURITY: ≥98% (HPLC)
PURITY DETAIL: Product is not sterile.
FORMULATION: White to off-white powder.
SOLUBILITY: Soluble in water, aqueous buffers, DMSO, dimethyl formamide or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Hygroscopic.
IDENTITY: Determined by 1H-NMR, MS and UV (λmax: 282nm, ε: 16’000, pH 7).

Product Description
Specific, potent and membrane permeant activator of the Epac cAMP receptor. Activates Epac1 and Epac2, the guanine nucleotide-exchange factors (GEFs) for the small GTPases Rap1 and Rap2. Does not activate protein kinase A (PKA), neither in vitro nor in vivo and is therefore a valuable tool to specifically discriminate between PKA- and Epac-mediated effects. Since a free 2'-ribose hydroxyl group in cyclic AMP is essential for stimulation of PKA, the methylated structure of 8-CPT-2'-O-Me-cAMP is an extremely poor PKA activator. Its high lipophilicity allows for good membrane permeability in most biosystems and its increased resistance towards phosphodiesterases prevents rapid hydrolysis.
Product Specific Literature References
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK: J.M. Enserink, et al.; Nat. Cell Biol. 4, 901 (2002) Abstract; Full Text
Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells: G. Kang, et al.; J. Biol. Chem. 278, 8279 (2003) Abstract; Full Text
Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the {beta}2-adrenergic receptor: S. Rangarajan, et al.; J. Cell Biol. 160, 487 (2003) Abstract
General Literature References
Signal transduction. New exchange, new target: J. Downward; Nature 396, 416 (1998), Comment Abstract
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP: J. de Rooij, et al.; Nature 396, 474 (1998) Abstract
A family of cAMP-binding proteins that directly activate Rap1: H. Kawasaki, et al.; Science 282, 2275 (1998) Abstract
Further Categories Containing This Product:
PKA Activators • Guanine-nucleotide Exchange Factors [GEFs]
 
 
ALX-850-013 Revised 24-Feb-05
cAMP EIA Kit
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cAMP Derivatives
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-013-KI01   1 Kit 412.00 USD Add To Cart
Product Specification
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the measurement of cAMP.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
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