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PARP Other Products
You are here: Product Lines > DNA Regulation / Transcription > Poly(ADP-ribose) Polymerase [PARP] / Related Products > PARP Other Products
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ALX-201-286 Revised 19-May-08
Minor Vault p193 Protein (human) (recombinant) (His)
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SYNONYMS VPARP (human) (recombinant) (His)
PARP-4 (human) (recombinant) (His)
PRODUCT LINE Cancer
PRODUCT CATEGORY Minor Vault Protein p193 / Related Products
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ALX-201-286-C010   10 µg 270.00 USD Add To Cart
Product Specification
EC: 2.4.2.30
SOURCE/HOST: Produced in E. coli. Human minor vault p193 protein is fused at the C-terminus to a His-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥98%
FORMULATION: Liquid. In PBS containing 50% glycerol.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs): H. Otto, et al.; BMC Genomics 6, 139 (2005) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9UKK3: PARP4 (human)
General Literature References
The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase: V.A. Kickhoefer, et al.; J. Cell Biol. 146, 917 (1999) Abstract; Full Text
Further Categories Containing This Product:
PARP Other Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-210-304 Revised 27-Dec-06
Polyclonal Antibody to XRCC1 (human)
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SYNONYMS anti-X-ray Repair Cross-complementing Group 1 (human) PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY XRCC Proteins / Related Products
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ALX-210-304-R050   50 µl 235.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Contains 0.1% sodium azide.
IMMUNOGEN: Recombinant human XRCC1 (X-ray repair cross-complementing group 1).
SPECIFICITY: Recognizes human XRCC1.
APPLICATION: ELISA
Immunocytochemistry
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage: M. Masson, et al.; Mol. Cell. Biol. 18, 3563 (1998) Abstract; Full Text
Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1: V. Schreiber, et al.; J. Biol. Chem. 277, 23028 (2002) Abstract; Full Text
General Information
XRCC1 (X-ray repair cross-complementing 1) exerts multiple functions in repairing base damage and frank single strand breaks. These functions include stabilizing DNA ligase 3, bridging the steps in base excision repair (BER) through protein interactions (via its BRCT motif), directly detecting breaks produced by chemical or enzymatic action, coordinating the binding and polymerase activity of DNA polymerase β, promoting an S phase-specific mode of single strand break repair. XRCC1 is specifically associated with poly(ADP-ribose) polymerase (PARP) and negatively regulates its activity following DNA damage.
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Further Categories Containing This Product:
PARP Other Products • Polyclonal Antibodies
 
 
ALX-210-539 Revised 27-Oct-06
Polyclonal Antibody to XRCC1 (human)
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SYNONYMS anti-X-ray Repair Cross-complementing Group 1 (human) PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY XRCC Proteins / Related Products
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ALX-210-539-R100   100 µl 250.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Antiserum containing 0.1% sodium azide.
IMMUNOGEN: Recombinant human XRCC1 (X-ray repair cross-complementing group 1) fused to a His-tag.
SPECIFICITY: Recognizes human XRCC1.
APPLICATION: Immunocytochemistry (1:1’000)
Immunoprecipitation (1:200)
Western Blot (1:2’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least one year when stored at +4°C.
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Product Specific Literature References
XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage: M. Masson, et al.; Mol. Cell. Biol. 18, 3563 (1998) Abstract; Full Text
XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage: N. Levy, et al.; Nucl. Acids Res. 34, 32 (2006) Full Text
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Further Categories Containing This Product:
PARP Other Products • Polyclonal Antibodies
 
 
ALX-400-036 Revised 31-Oct-06
Peroxynitrite . tetramethylammonium
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SYNONYMS ONOO- . C4H12N
Oxoperoxonitrate(1-) . C4H12N
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Peroxynitrite / Scavengers / Detection
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ALX-400-036-L001   1 ml 152.00 USD Add To Cart
ALX-400-036-5001   5x1 ml 475.00 USD Add To Cart
Product Specification
FORMULA: NO3 . C4H12N
MW: 62.0 . 74.1
CAS NUMBER: 14042-01-4
CONCENTRATION: ~10mM
FORMULATION: Liquid. In 0.01M KOH.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 month after receipt when stored at -80°C.
HANDLING: Protect from light.
HAZARD: OXIDIZING. CORROSIVE.

Product Description
Produced from the reaction of nitrogen monoxide with tetramethylammonium superoxide according to the method of D.S. Bohle, et al. described in Meth. Enzymol. 269, 302 (1996), and dissolved in 0.01M potassium hydroxide (KOH). This formulation of peroxynitrite has a low nitrite content (~1%), no hydrogen peroxide.
Product Specific Literature References
DNA damage induced by peroxynitrite: subsequent biological effects: C. Szabo & H. Ohshima; Nitric Oxide 1, 373 (1997), (Review) Abstract
Peroxynitrite: a biologically significant oxidant: M.P. Murphy, et al.; Gen. Pharmacol. 31, 179 (1998), (Review) Abstract
Peroxynitrite: an endogenous oxidizing and nitrating agent: C. Ducrocq, et al.; Cell. Mol. Life Sci. 55, 1068 (1999), (Review) Abstract
The chemistry of DNA damage from nitric oxide and peroxynitrite: S. Burney, et al.; Mutat. Res. 424, 37 (1999), (Review) Abstract
Reactions of *NO, *NO2 and peroxynitrite in membranes: physiological implications: S.P. Goss, et al.; Free Radic. Res. 31, 597 (1999), (Review) Abstract
Peroxynitrite: reactive, invasive and enigmatic: J.T. Groves; Curr. Opin. Chem. Biol. 3, 226 (1999), (Review) Abstract
Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: a personal view of recent controversies: B. Halliwell, et al.; Free Radic. Res. 31, 651 (1999), (Review) Abstract
Assessment of peroxynitrite scavengers in vitro: B. Halliwell, et al.; Meth. Enzymol. 301, 333 (1999), (Review) Abstract
Chemistry of peroxynitrite and its relevance to biological systems: W.H. Koppenol; Met. Ions Biol. Syst. 36, 597 (1999), (Review) Abstract
Conformation of peroxynitrite: determination by crystallographic analysis: M. Worle, et al.; Chem. Res. Toxicol 12, 305 (1999) Abstract
Peroxynitrite scavenging by metalloporphyrins and thiolates: J.P. Crow; Free Radic. Biol. Med. 28, 1487 (2000), (Review) Abstract
Interaction of peroxynitrite with selenoproteins and glutathione peroxidase mimics: H. Sies & G.E. Arteel; Free Radic. Biol. Med. 28, 1451 (2000), (Review) Abstract
Reactions of Peroxynitrite with Phenolic and Carbonyl Compounds: Flavonoids are not Scavengers of Peroxynitrite: S. Tibi & W.H. Koppenol; Helv. Chim. Acta 83, 2412 (2000)
BCL-2 protects peroxynitrite-treated thymocytes from poly(ADP-ribose) synthase (PARS)-independent apoptotic but not from PARS-mediated necrotic cell death: L. Virag & C. Szabo; Free Radic. Biol. Med. 29, 704 (2000) Abstract
Peroxynitrite promotes mitochondrial permeability transition-dependent rapid u937 cell necrosis: survivors proliferate with kinetics superimposable on those of untreated cells: P. Sestili, et al.; Free Radic Res. 34, 513 (2001) Abstract
Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention: L. Virag, et al.; Toxicol. Lett. 140-141, 113 (2003), (Review) Abstract
Preventing nitrite contamination in tetramethylammonium peroxynitrite solutions: P. Latal, et al.; Inorg. Chem. 43, 6519 (2004) Abstract
Further Categories Containing This Product:
PARP Other Products • DNA Repair Other Products
 
 
ALX-840-040 Revised 09-Oct-07
DNA (purified) (DNAse I activated)
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY DNA Repair Other Products
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ALX-840-040-C010   10 µg 58.00 USD Add To Cart
Product Specification
SOURCE/HOST: Purified from calf thymus and activated by digestion with DNAse I.
CONCENTRATION: 0.2mg/ml
PURITY: ≥99% (SDS-PAGE)
FORMULATION: Liquid. In TRIS-EDTA.
APPLICATION: For use with PARP-1 (Prod. No. ALX-201-063) or PARP-2 (Prod. No. ALX-201-064) in vitro activity tests.
For details please see protocol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Images
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Product Specific Literature References
PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase: J.C. Ame, et al.; J. Biol. Chem. 274, 17860 (1999) Abstract; Full Text
Related Products
Further Categories Containing This Product:
PARP Other Products
 
 
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