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IkB Kinases [IKKs] / Related Products
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ALX-350-246 Revised 07-Oct-08
Butein
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SYNONYMS 2',3,4,4'-Tetrahydroxychalcone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-246-M010   10 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C15H12O5
MW: 272.3
CAS NUMBER: 487-52-5
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO (>50mg/ml) or methanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep cool and dry under inert gas.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Plant polyphenol. Specific tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor and p60c-src. Potent antioxidant and anti-inflammatory agent. Inhibits glutathione reductase and rat liver glutathione S-transferase. Activator of human deacetylase SIRT1. Inhibits aromatase, showing chemopreventive properties. Directly inhibits IKK.
Product Specific Literature References
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects: E. Aizu, et al.; Carcinogenesis 7, 1809 (1986) Abstract
Protective effects of hydroxychalcones on free radical-induced cell damage: S. Sogawa, et al.; Biol. Pharm. Bull. 17, 251 (1994) Abstract
Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation: C.C. Yit & N.P. Das; Cancer Lett. 82, 65 (1994) Abstract
Inhibitory effects of plant polyphenols on rat liver glutathione S-transferase: K. Zhang & N.P. Das; Biochem. Pharmacol. 47, 2063 (1994) Abstract
Endothelium-dependent relaxation of rat aorta by butein, a novel cyclic AMP-specific phosphodiesterase inhibitor: S.M. Yu, et al.; Eur. J. Pharmacol. 280, 69 (1995) Abstract
Butein (3,4,2',4'-tetrahydroxychalcone) ameliorates experimantal anti-glomerular basement membrane antibody-associated glomerulonephritis (3): K. Hayashi, et al.; Eur. J. Pharmacol. 316, 297 (1996) Abstract
Inhibition of glutathione reductase by plant polyphenols: K. Zhang, et al.; Biochem. Pharmacol 54, 1047 (1997) Abstract
Butein, a specific protein tyrosine kinase inhibitor: E.-B. Yang, et al.; BBRC 245, 435 (1998) Abstract
Antioxidant properties of butein isolated from Dalbergia odorifera: Z.J. Cheng, et al.; Biochim. Biophys. Acta 1392, 291 (1998) Abstract
Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells: K. Iwashita, et al.; Biosci. Biotechnol. Biochem. 64, 1813 (2000) Abstract
Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells: N.Y. Kim, et al.; Pharmacol. Toxicol. 88, 261 (2001) Abstract
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature 425, 191 (2003) Abstract
The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase: Y. Wang, et al.; Life Sci. 77, 39 (2005) Abstract
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue: M.K. Pandey, et al.; J. Biol. Chem. 282, 17340 (2007) Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • Natural Products - Anti-inflammatory Agents • EGFR Kinase Inhibitors • Glutathione / Related Products • Chalcones • Phosphodiesterases / Related Products • Natural Products - Chemopreventive Agents • Glutathione S-Transferase • Natural Products - Antioxidants • Sirtuins / Related Products • IkB Kinases [IKKs] / Related Products
 
 
ALX-804-236 Revised 27-Feb-07
Monoclonal Antibody to IKKα (14A231)
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SYNONYMS anti-Inhibitor of Nuclear Factor κ-B Kinase α MAb (14A231)
anti-IKK1 MAb (14A231)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY IkB Kinases [IKKs] / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-236-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Monkey
CLONE: 14A231
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G affinity-purified.
FORMULATION: Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN: Recombinant human IKKα (inhibitor of NF-κB kinase α; IKK1).
SPECIFICITY: Recognizes human, mouse and monkey IKKα. Detects a band of ~85kDa by Western blot.
APPLICATION: Immunoprecipitation (1-2µg/ml)
Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
Product Specific Literature References
IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis: S.K. Manna, et al.; J. Immunol. 165, 4927 (2000) Abstract; Full Text
KKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development: Y. Cao, et al.; Cell 107, 763 (2001) Abstract
Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway: D. Koul, et al.; J. Biol. Chem. 276, 11402 (2001) Abstract; Full Text
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation: S. Majumdar & B.B. Aggarwal; J. Immunol. 167, 2911 (2001) Abstract; Full Text
Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation: B.S. Miller & E. Zandi; J. Biol. Chem. 276, 36320 (2001) Abstract; Full Text
NEMO trimerizes through its coiled-coil C-terminal domain: F. Agou, et al.; J. Biol. Chem. 277, 17464 (2002) Abstract; Full Text
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways: E. Dejardin, et al.; Immunity 17, 525 (2002) Abstract
Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester: S. Majumdar, et al.; J. Immunol. 168, 2644 (2002) Abstract; Full Text
The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation: C. Makris, et al.; Mol. Cell. Biol. 22, 6573 (2002) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-237 Revised 27-Feb-07
Monoclonal Antibody to IKKβ (human) (10AG2)
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SYNONYMS anti-Inhibitor of Nuclear Factor κ-B Kinase β (human) MAb (10AG2)
anti-IKK2 (human) MAb (10AG2)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY IkB Kinases [IKKs] / Related Products
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ALX-804-237-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 10AG2
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G affinity-purified.
FORMULATION: Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN: Recombinant human IKKβ (inhibitor of NF-κB kinase β; IKK2).
SPECIFICITY: Recognizes human IKKβ. Detects a band of ~87kDa by Western blot.
APPLICATION: Western Blot (2-4µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
Product Images
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Product Specific Literature References
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation: S. Majumdar & B.B. Aggarwal; J. Immunol. 167, 2911 (2001) Abstract; Full Text
Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester: S. Majumdar, et al.; J. Immunol. 168, 2644 (2002) Abstract; Full Text
Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha in transgenic mice expressing keratin K10 in the basal layer of the epidermis: M. Santos, et al.; J. Biol. Chem. 278, 14322 (2003) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-424 Revised 22-May-07
Monoclonal Antibody to IKKγ (human) (46B844)
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SYNONYMS anti-Inhibitor of Nuclear Factor κ-B Kinase γ (human) MAb (46B844)
anti-IKK3 (human) MAb (46B844)
anti-NEMO (human) MAb (46B844)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY IkB Kinases [IKKs] / Related Products
Ordering Information
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ALX-804-424-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 46B844
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN: Recombinant human IKKγ (inhibitor of NF-κB kinase γ; IKK3; NEMO).
SPECIFICITY: Recognizes human IKKγ. Detects a band of ~48kDa by Western blot. Does not cross-react with mouse IKKγ.
APPLICATION: Western Blot (2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
Product Images
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Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-321 Revised 22-Nov-07
Monoclonal Antibody to IKKε (72B587)
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SYNONYMS anti-Inhibitor of Nuclear Factor κ-B Kinase ε MAb (72B587)
anti-IKK-i MAb (72B587)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY IkB Kinases [IKKs] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-321-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: 72B587
ISOTYPE: Mouse IgG2aκ
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G affinity-purified.
FORMULATION: Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 175-188 of human IKKε (inhibitor of NF-κB kinase ε; IKK-i).
SPECIFICITY: Recognizes human, mouse and rat IKKε. Detects a band of ~80kDa by Western blot.
APPLICATION: Western Blot (1-3µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
Product Specific Literature References
Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases: A. Chariot, et al.; J. Biol. Chem. 277, 37029 (2002) Abstract; Full Text
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway: K.A. Fitzgerald, et al.; Nat. Immunol. 4, 491 (2003) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-372 Revised 22-May-08
Monoclonal Antibody to TANK-binding Kinase 1 (108A429)
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SYNONYMS anti-TBK1 MAb (108A429)
anti-NAK MAb (108A429)
anti-NF-κB-activating Kinase MAb (108A429)
anti-T2K MAb (108A429)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY IkB Kinases [IKKs] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-372-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
CLONE: 108A429
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 563-577 (YYQFKKDKAERRLAYC) of human TBK1 (TANK-binding kinase 1).
SPECIFICITY: Recognizes human, mouse, rat, dog and bovine TBK1. Detects a band of ~80kDa by Western blot.
APPLICATION: Western Blot (1-2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
Product Images
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Product Description
TANK-binding Kinase 1 (TBK1) is a member of the IKK family. TANK (TRAF-associated NF-κB activator) interacts with TBK1 and activates NF-κB in a kinase-dependent manner [1].
Product Specific Literature References
[1] NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase: J.L. Pomerantz & D. Baltimore; EMBO J. 18, 6694 (1999) Abstract; Full Text
[2] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway: K.A. Fitzgerald, et al.; Nat. Immunol. 4, 491 (2003) Abstract
[3] Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I: R. Sumpter, Jr., et al.; J. Virol. 79, 2689 (2005) Abstract; Full Text
[4] Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells: P. Osterlund, et al.; J. Virol. 79, 9608 (2005) Abstract
Further Categories Containing This Product:
Antiviral Signalling / Related Products • Monoclonal Antibodies
 
 
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