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ALX-350-156
Revised 18-Feb-08
Aerophobin-2
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Alkaloids
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ALX-350-156-M001
1 mg
160.00 USD
Product Specification
FORMULA:
C
16
H
19
Br
2
N
5
O
4
MW:
505.2
CAS NUMBER:
87075-23-8
SOURCE/HOST:
Isolated from
Aplysina aerophoba
.
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white amorphous solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Cytotoxic alkaloid. Shows antibiotic properties.
Product Specific Literature References
The bromo-compounds of the true sponge Verongia aerophoba:
G. Cimino, et al.; Tetrahedron Lett.
24
, 3029 (1983)
Antibiotic and cytotoxic activity of brominated compounds from the marine sponge Verongia aerophoba:
R. Teeyapant, et al.; Z. Naturforsch.
48
, 939 (1993)
Abstract
Approaches to the synthesis of some tyrosine-derived marine sponge metabolites: synthesis of verongamine and purealidin N:
T.R. Boehlow, et al.; J.Org. Chem.
66
, 3111 (2001)
Abstract
Two unprecedented dibromotyrosine-derived alkaloids from the Brazilian endemic marine sponge Aplysina caissara:
B.M. Saeki, et al.; J. Nat. Prod.
65
, 796 (2002)
Abstract
Chemical defense of Mediterranean sponges Aplysina cavernicola and Aplysina aerophoba:
C. Thoms, et al.; Z. Naturforsch.
59
, 113 (2004)
Abstract
Further Categories Containing This Product:
Natural Products with Antibiotic Activity
•
Marine Natural Products
ALX-350-256
Revised 07-Oct-08
(+)-Aeroplysinin-1
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Protein Kinase Inhibitors
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ALX-350-256-M001
1 mg
70.00 USD
Product Specification
FORMULA:
C
9
H
9
Br
2
NO
3
MW:
339.0
CAS NUMBER:
28656-91-9
SOURCE/HOST:
Isolated from
Aplysina aerophoba
.
PURITY:
≥97%
APPEARANCE:
Oil.
SOLUBILITY:
Soluble in 100% ethanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Displays cytostatic and cytotoxic activity. Inhibitor of EGFR kinase. Shows antiangiogenic activity.
Product Specific Literature References
Aeroplysinin-1, an antibacterial bromo-compound from the sponge Verongia aerophoba:
E. Fattorusso, et al.; J. Chem. Soc.
1
, 16 (1972)
Abstract
Cytostatic activity of aeroplysinin-1 against lymphoma and epithelioma cells:
M.H. Kreuter, et al.; Z. Naturforsch. [C]
44
, 680 (1989)
Abstract
Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-aeroplysinin-1:
M.H. Kreuter, et al.; Comp. Biochem. Physiol. B
97
, 151 (1990)
Abstract
Production of the cytostatic agent aeroplysinin by the sponge Verongia aerophoba in in vitro culture:
M.H. Kreuter, et al.; Comp. Biochem. Physiol.
101C
, 183 (1992)
Abstract
Antibiotic and cytotoxic activity of brominated compounds from the marine sponge Verongia aerophoba:
R. Teeyapant, et al.; Z. Naturforsch. [C]
48
, 939 (1993)
Abstract
Cytotoxicity and mode of action of aeroplysinin-1 and a related dienonefrom the sponge Aplysina aerophoba:
A. Koulman, et al.; J. Nat. Prod.
59
, 591 (1996)
Abstract
Antiangiogenic activity of aeroplysinin-1, a brominated compound isolated from a marine sponge:
S. Rodriguez-Nieto, et al.; FASEB J.
16
, 261 (2002)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
EGFR Kinase Inhibitors
•
Natural Products with Antibiotic Activity
•
Natural Products for Angiogenesis Research
•
Natural Products - Antitumor Reagents
•
Marine Natural Products
ALX-350-315
Revised 03-Apr-08
Agelasine D
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products with Antibiotic Activity
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ALX-350-315-M001
1 mg
185.00 USD
Product Specification
FORMULA:
C
26
H
40
N
5
MW:
422.6
CAS NUMBER:
92664-80-7
SOURCE/HOST:
Isolated from the sponge
Agelas nakamurai
.
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Displays broad spectrum of antibacterial activities. Antineoplastic compound. Associated with contractive responses of smooth muscles and inhibition of Na
+
/K
+
-ATPase.
Product Specific Literature References
(+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities:
A. Vik, et al.; J. Nat. Prod.
69
, 381 (2006)
Abstract
Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs:
A. Vik, et al.; Bioorg. Med. Chem.
15
, 4016 (2007)
Abstract
Further Categories Containing This Product:
Na+ / K+-ATPase / Related Products
•
Antibiotics - ATPase Inhibitors
•
Antitumor Agents (Anti-proliferative)
•
Natural Products - Antitumor Reagents
•
Marine Natural Products
ALX-350-329
Revised 21-May-08
Allicin
SYNONYMS
2-Propene-1-sulfinothioic acid S-2-propenyl ester
Diallyl thiosulfinate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antioxidants
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ALX-350-329-M001
1 mg
200.00 USD
ALX-350-329-M005
5 mg
690.00 USD
Product Specification
FORMULA:
C
6
H
10
OS
2
MW:
162.3
CAS NUMBER:
539-86-6
MERCK INDEX:
14:
261
SOURCE/HOST:
Synthetic.
PURITY:
≥98%
APPEARANCE:
Clear to slightly yellow liquid.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Description
Active metabolite of garlic. Exhibits antimicrobial, antioxidant, antiproliferative, chemopreventive, antihyperlipidaemic and antihypertensive effects. Inhibits telomerase activity. Induces apoptosis. Also inhibits inducible nitric oxide synthase (iNOS; NOS II) expression.
Product Specific Literature References
Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica:
S. Ankri, et al.; Antimicrob. Agents Chemother.
41
, 2286 (1997)
Abstract
Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase:
V.M. Dirsch, et al.; Atherosclerosis
139
, 333 (1998)
Abstract
Antimicrobial properties of allicin from garlic:
S. Ankri & D. Mirelman; Microbes Infect.
1
, 125 (1999), Review
Abstract
Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation:
K. Hirsch, et al.; Nutr. Cancer
38
, 245 (2000)
Abstract
The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats:
A. Elkayam, et al.; Am. J. Hypertens.
14
, 377 (2001)
Abstract
Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells:
L. Sun & X. Wang; World J. Gastroenterol.
9
, 1930 (2003)
Abstract
Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells:
S. Oommen, et al.; Eur. J. Pharmacol.
485
, 97 (2004)
Abstract
Antibacterial activity of a new, stable, aqueous extract of allicin against methicillin-resistant Staphylococcus aureus:
R.R. Cutler & P. Wilson; Br. J. Biomed. Sci.
61
, 71 (2004)
Abstract
The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin:
L.J. Macpherson, et al.; Curr. Biol.
15
, 929 (2005)
Abstract
An overview of the antifungal properties of allicin and its breakdown products--the possibility of a safe and effective antifungal prophylactic:
S.R. Davis; Mycoses
48
, 95 (2005), Review
Abstract
Thiolsulfinate allicin from garlic: inspiration for a new antimicrobial agent:
R. Hunter, et al.; Ann. N.Y. Acad. Sci.
1056
, 234 (2005), Review
Abstract
The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide:
L.Y. Chung; J. Med. Food
9
, 205 (2006)
Abstract
Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial:
C.D. Gardner, et al.; Arch. Intern. Med.
167
, 346 (2007)
Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables
•
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
Natural Products - Chemopreventive Agents
•
Antitumor Agents (Anti-proliferative)
•
Natural Products with Antibiotic Activity
•
Natural Products - Nitric Oxide Pathway Modulators
•
Natural Products - Apoptosis Inducers & Inhibitors
•
TRPV1 Agonists and Antagonists / Related Products
ALX-350-162
Revised 11-Aug-08
Altersolanol A
SYNONYMS
As-A 2
NSC 173943
(1
R
-(1α,2β,3β,4α))-1,2,3,4-Tetrahydro-1,2,3,4,5-pentahydroxy-7-methoxy-2-methyl-9,10-anthracenedione
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products with Antibiotic Activity
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ALX-350-162-M001
1 mg
120.00 USD
Product Specification
FORMULA:
C
16
H
16
O
8
MW:
336.3
CAS NUMBER:
22268-16-2
SOURCE/HOST:
Isolated from
Alternaria
sp.
PURITY:
≥97% (HPLC)
APPEARANCE:
Yellow-orange to brown solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR and MS.
Product Description
Tetrahydroanthraquinone with phytotoxic and antibacterial activity.
Product Specific Literature References
Metabolites of Dactylaria lutea. The structures of dactylariol and the antiprotozoal antibiotic dactylarin:
A.M. Becker, et al.; J. Antibiot. (Tokyo)
31
, 324 (1978)
Abstract
High-performance liquid chromatographic determination of macrosporin, altersolanol A, alterporriol A, B and C in fermentation of Alternaria porri (Ellis) Ciferri:
R. Suemitsu, et al.; J. Chromatogr.
454
, 406 (1988)
Abstract
Mode of phytotoxic action of altersolanols :
H. Haraguchi, et al.; Phytochemistry
43
, 989 (1996)
Biologically active polyketide metabolites from an undetermined fungicolous hyphomycete resembling Cladosporium:
U. Höller, et al.; J. Nat. Prod.
54
, 876 (2002)
Abstract
Secondary metabolite profiling of Alternaria dauci, A. porri, A. solani, and A. tomatophila:
B. Andersen, et al.; Mycol. Res.
112
, 241 (2008)
Abstract
ALX-350-319
Revised 03-Apr-08
Avarol
SYNONYMS
NSC306951
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Chemopreventive Agents
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ALX-350-319-M001
1 mg
185.00 USD
Product Specification
FORMULA:
C
21
H
30
O
2
MW:
314.5
CAS NUMBER:
55303-98-5
SOURCE/HOST:
Isolated from marine sponge
Dysidea avara
.
PURITY:
≥97% (HPLC)
APPEARANCE:
Brown solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Cytostatic agent which has potent antileukemic activity both
in vitro
and
in vivo
(mice). Also displays antibacterial and antifungal activities against a limited range of microorganisms. Inhibits HIV-1 reverse transcriptase.
Product Specific Literature References
Antimicrobial activity of avarol, a sesquiterpenoid hydroquinone from the marine sponge, Dysidea avara:
L. Cariello, et al.; Comp. Biochem. Physiol.
71
, 281 (1982)
Abstract
Antimutagenic activity of the novel antileukemic agents, avarone and avarol:
B. Kurelec, et al.; Mutat. Res.
144
, 63 (1985)
Abstract
Potent antileukemic activity of the novel cytostatic agent avarone and its analogues in vitro and in vivo:
W.E. Muller, et al.; Cancer Res.
45
, 4822 (1985)
Abstract
Inhibition of mitosis by avarol, a natural product isolated from the sponge Dysidea avara:
W.E. Muller, et al.; Basic Appl. Histochem.
29
, 321 (1985)
Abstract
Biphasic and differential effects of the cytostatic agents avarone and avarol on DNA metabolism of human and murine T and B lymphocytes:
W.E. Muller, et al.; Eur. J. Cancer Clin. Oncol.
22
, 473 (1986)
Abstract
Avarol-induced DNA strand breakage in vitro and in Friend erythroleukemia cells:
W.E. Muller, et al.; Cancer Res.
47
, 6565 (1987)
Abstract
Inhibition of replication of the etiologic agent of acquired immune deficiency syndrome (human T-lymphotropic retrovirus/lymphadenopathy-associated virus) by avarol and avarone:
P.S. Sarin, et al.; J. Natl. Cancer Inst.
78
, 663 (1987)
Abstract
Action of the antileukemic and anti-HTLV-III (anti-HIV) agent avarol on the levels of superoxide dismutases and glutathione peroxidase activities in L5178y mouse lymphoma cells:
E. Batke, et al.; Cell Biochem. Funct.
6
, 123 (1988)
Abstract
Induction of gamma-interferon by avarol in human peripheral blood lymphocytes:
R. Voth, et al.; Jpn. J. Cancer Res.
79
, 647 (1988)
Abstract
Suppression of the modulatory effects of the antileukemic and anti-human immunodeficiency virus compound avarol on gene expression by tryptophan:
H.C. Schroder, et al.; Cancer Res.
49
, 2069 (1989)
Abstract
The inhibition of human immunodeficiency virus type 1 reverse transcriptase by avarol and avarone derivatives:
S. Loya and A. Hizi; FEBS Lett.
269
, 131 (1990)
Abstract
;
Full Text
Avarol restores the altered prostaglandin and leukotriene metabolism in monocytes infected with human immunodeficiency virus type 1:
H.C. Schroder, et al.; Virus Res.
21
, 213 (1991)
Abstract
Effect of avarol and avarone on in vitro-induced microsomal lipid peroxidation:
M.A. Belisario, et al.; Toxicology
72
, 221 (1992)
Abstract
Avarol and avarone, two new anti-inflammatory agents of marine origin:
M.L. Ferrandiz, et al.; Eur. J. Pharmacol.
253
, 75 (1994)
Abstract
In vitro effect of avarone and avarol, a quinone/hydroquinone couple of marine origin, on platelet aggregation:
M.A. Belisario, et al.; Pharmacol. Toxicol.
79
, 300 (1996)
Abstract
Application of cell culture for the production of bioactive compounds from sponges: synthesis of avarol by primmorphs from Dysidea avara:
W.E. Muller, et al.; J. Nat. Prod.
63
, 1077 (2000)
Abstract
Potential antipsoriatic avarol derivatives as antioxidants and inhibitors of PGE(2) generation and proliferation in the HaCaT cell line:
M. Amigo, et al.; J. Nat. Prod.
67
, 1459 (2004)
Abstract
Sustainable production of bioactive compounds by sponges--cell culture and gene cluster approach: a review:
W.E. Muller, et al.; Mar. Biotechnol. (NY)
6
, 105 (2004)
Abstract
Reactivity and biological activity of the marine sesquiterpene hydroquinone avarol and related compounds from sponges of the order Dictyoceratida:
D. Sladic & M.J. Gasic; Molecules
11
, 1 (2006)
Abstract
Evaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganisms:
M. Tsoukatou, et al.; Molecules
12
, 1022 (2007)
Abstract
Further Categories Containing This Product:
Natural Products - Immunomodulators
•
Natural Products - Antiviral / anti-HIV Agents
•
Natural Products with Antibiotic Activity
•
Marine Natural Products
•
HIV / AIDS / Related Products
ALX-350-321
Revised 20-Dec-07
Avarone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Chemopreventive Agents
Ordering Information
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ALX-350-321-M001
1 mg
185.00 USD
Product Specification
FORMULA:
C
21
H
28
O
2
MW:
312.5
CAS NUMBER:
55303-99-6
SOURCE/HOST:
Isolated from marine sponge
Dysidea avara
.
PURITY:
≥97% (HPLC)
APPEARANCE:
Brown oil.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Cytostatic agent which has potent antileukemic activity both
in vitro
and
in vivo
(mice). Also displays antibacterial and antifungal activities against a limited range of microorganisms.
Product Specific Literature References
Antimutagenic activity of the novel antileukemic agents, avarone and avarol:
B. Kurelec, et al.; Mutat. Res.
144
, 63 (1985)
Abstract
Potent antileukemic activity of the novel cytostatic agent avarone and its analogues in vitro and in vivo:
W.E. Muller, et al.; Cancer Res.
45
, 4822 (1985)
Abstract
Biphasic and differential effects of the cytostatic agents avarone and avarol on DNA metabolism of human and murine T and B lymphocytes:
W.E. Muller, et al.; Eur. J. Cancer Clin. Oncol.
22
, 473 (1986)
Abstract
Inhibition of replication of the etiologic agent of acquired immune deficiency syndrome (human T-lymphotropic retrovirus/lymphadenopathy-associated virus) by avarol and avarone:
P.S. Sarin, et al.; J. Natl. Cancer Inst.
78
, 663 (1987)
Abstract
Suppression of the modulatory effects of the antileukemic and anti-human immunodeficiency virus compound avarol on gene expression by tryptophan:
H.C. Schroder, et al.; Cancer Res.
49
, 2069 (1989)
Abstract
The inhibition of human immunodeficiency virus type 1 reverse transcriptase by avarol and avarone derivatives:
S. Loya and A. Hizi; FEBS Lett.
269
, 131 (1990)
Abstract
;
Full Text
Effect of avarol and avarone on in vitro-induced microsomal lipid peroxidation:
M.A. Belisario, et al.; Toxicology
72
, 221 (1992)
Abstract
Avarol and avarone, two new anti-inflammatory agents of marine origin:
M.L. Ferrandiz, et al.; Eur. J. Pharmacol.
253
, 75 (1994)
Abstract
In vitro effect of avarone and avarol, a quinone/hydroquinone couple of marine origin, on platelet aggregation:
M.A. Belisario, et al.; Pharmacol. Toxicol.
79
, 300 (1996)
Abstract
Potential antipsoriatic avarol derivatives as antioxidants and inhibitors of PGE(2) generation and proliferation in the HaCaT cell line:
M. Amigo, et al.; J. Nat. Prod.
67
, 1459 (2004)
Abstract
Sustainable production of bioactive compounds by sponges--cell culture and gene cluster approach: a review:
W.E. Muller, et al.; Mar. Biotechnol. (NY)
6
, 105 (2004)
Abstract
Protein covalent modification by biologically active quinones:
D. Sladic, et al.; J. Serb. Chem. Soc.
69
, 901 (2004)
Evaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganisms:
M. Tsoukatou, et al.; Molecules
12
, 1022 (2007)
Abstract
Further Categories Containing This Product:
Natural Products - Antiviral / anti-HIV Agents
•
Natural Products with Antibiotic Activity
•
Natural Products - Immunomodulators
•
Marine Natural Products
•
HIV / AIDS / Related Products
ALX-350-144
Revised 03-Apr-08
Bakuchiol
SYNONYMS
4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
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ALX-350-144-M001
1 mg
170.00 USD
Product Specification
FORMULA:
C
18
H
24
O
MW:
256.4
CAS NUMBER:
10309-37-2
SOURCE/HOST:
Isolated from plant
Psoralea corylifolia
.
PURITY:
≥97% (HPLC)
APPEARANCE:
Yellow to brownish oil.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Inhibitor of protein tyrosine phosphatase 1B (PTB1B). Antioxidant. Inhibitor of mitochondrial lipid peroxidation. Inhibitor of inducible nitric oxide synthase (iNOS; NOS II) expression. DNA polymerase inhibitor. Shows antimicrobial and cytotoxic activity.
Product Specific Literature References
Plant antimutagenic agents, 2. Flavonoids:
M.E. Wall, et al.; J. Nat. Prod.
51
, 1084 (1988)
Abstract
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia:
N.J. Sun, et al.; J. Nat. Prod.
61
, 362 (1998)
Abstract
Inhibition of mitochondrial lipid peroxidation by Bakuchiol, a meroterpene from Psoralea corylifolia:
H. Haraguchi, et al.; Planta Med.
66
, 569 (2000)
Abstract
Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities:
C.N. Backhouse, et al.; J. Ethnopharmacol.
78
, 27 (2001)
Abstract
Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells:
H. Cho, et al.; Planta Med.
67
, 750 (2001)
Abstract
In vitro antimicrobial activities of bakuchiol against oral microorganisms:
H. Katsura, et al.; Antimicrob. Agents Chemother.
45
, 3009 (2001)
Abstract
;
Full Text
Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-kappaB in RAW 264.7 macrophages:
H.O. Pae, et al.; Int. Immunopharmacol.
1
, 1849 (2001)
Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae):
H. Haraguchi, et al.; Phytother. Res.
16
, 539 (2002)
Abstract
The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis:
S.M. Newton, et al.; J. Ethnopharmacol.
79
, 57 (2002)
Abstract
Antioxidant activity of bakuchiol: experimental evidences and theoretical treatments on the possible involvement of the terpenoid chain:
S. Adhikari, et al.; Chem. Res. Toxicol.
16
, 1062 (2003)
Abstract
Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent:
K. Bapat, et al.; Appl. Radiat. Isot.
62
, 389 (2005)
Abstract
In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia:
Y.C. Kim, et al.; Planta Med.
71
, 87 (2005)
Abstract
Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo:
E.J. Park, et al.; Planta Med.
71
, 508 (2005)
Abstract
Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts:
E.J. Park, et al.; Eur. J. Pharmacol.
559
, 115 (2007)
Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
Natural Products - DNA Replication Inhibitors
•
Natural Products - Nitric Oxide Pathway Modulators
•
Natural Products - Topoisomerase Inhibitors
•
Natural Products with Antibiotic Activity
•
Protein Tyrosine Phosphatases Other Products
•
Lipid Peroxidation
•
Natural Products - Antioxidants
ALX-350-094
Revised 24-Jul-08
Berberine . hemisulfate
SYNONYMS
Natural Yellow 18
5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products with Antibiotic Activity
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ALX-350-094-G001
1 g
15.00 USD
Product Specification
FORMULA:
C
20
H
18
NO
4
. 0.5SO
4
MW:
336.4 . 48.0
CAS NUMBER:
633-66-9
MERCK INDEX:
14:
1154
RTECS:
DR9867000
PURITY:
≥98% (TLC)
APPEARANCE:
Off-white to yellow powder.
SOLUBILITY:
50mg/ml soluble in methanol:water 2:1.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
TOXIC.
IDENTITY:
Determined by IR: Identical to standard reference.
Product Description
Alkaloid which exhibits relatively weak antibiotic properties, because of its efflux by multidrug resistance pumps. The antimicrobial action of berberine is potentiated by 5’-methoxyhydnocarpin, a multidrug pump inhibitor. Lowers cholesterol levels through a mechanism different from that of statins. Upregulates the expression of liver low-density lipoprotein receptor (LDLR) resulting in improved clearance of plasma LDL cholesterol through receptor mediated endocytosis. Possesses anti-inflammatory, anti-diabetic and anti-angiogenic effects. Induces apoptosis.
Product Specific Literature References
Berberine sulfate: antimicrobial activity, bioassay, and mode of action:
A.H. Amin, et al.; Can. J. Microbiol.
15
, 1067 (1969)
Abstract
Bacteria lacking a multidrug pump: a sensitive tool for drug discovery:
P.C. Hsieh, et al.; PNAS
95
, 6602 (1998)
Abstract
;
Full Text
Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5’-methoxyhydnocarpin, a multidrug pump inhibitor:
F.R. Stermitz, et al.; PNAS
97
, 1433 (2000)
Abstract
;
Full Text
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins:
W. Kong, et al.; Nat. Med.
10
, 1344 (2004)
Abstract
The anti-inflammatory potential of berberine in vitro and in vivo:
C.L. Kuo, et al.; Cancer Lett.
203
, 127 (2004)
Abstract
Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion:
S.H. Leng, et al.; Acta Pharmacol. Sin.
25
, 496 (2004)
Abstract
Berberine inhibits HIF-1alpha expression via enhanced proteolysis:
S. Lin, et al.; Mol. Pharmacol.
66
, 612 (2004)
Abstract
Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3:
C.C. Lin, et al.; Anticancer Res.
26
, 227 (2006)
Abstract
Berberine acutely inhibits insulin secretion from beta cells through cAMP signaling pathway:
L. Zhou, et al.; Endocrinology (2008)
Abstract
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.:
M.K. Pandey, et al.; Cancer Res.
68
, 5370 (2008)
Abstract
Further Categories Containing This Product:
Natural Products - Chemopreventive Agents
•
Natural Products - Anti-inflammatory Agents
•
Antidiabetic Agents / Related Products
•
Cholesterol & Lipid Transport / Related Products
•
Alkaloids
ALX-380-241
Revised 21-May-08
Blasticidin A
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Antifungal
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-380-241-M001
1 mg
370.00 USD
Product Specification
FORMULA:
C
58
H
107
NO
23
MW:
1186.5 (free acid)
CAS NUMBER:
100513-53-9
RTECS:
EC4897000
SOURCE/HOST:
Isolated from
Streptomyces
sp. MST-AS4079.
PURITY:
