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Items 8 of 8
ALX-210-957 Revised 23-Apr-08
Polyclonal Antibody to ZBP1 (mouse) (AT132)
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SYNONYMS anti-Z-DNA-binding Protein 1 (mouse) PAb (AT132)
anti-Tumor Stroma And Activated Macrophage Protein DLM-1 (mouse) PAb (AT132)
anti-DAI (mouse) PAb (AT132)
anti-DNA-dependent Activator of IFN-regulatory Factors (mouse) PAb (AT132)
PRODUCT LINE Immunology
PRODUCT CATEGORY Innate Immunity Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-957-C100   100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant mouse ZBP1 (aa 1-411) fused to a N-terminal tag.
SPECIFICITY: Recognizes mouse ZBP1.
APPLICATION: Immunoprecipitation (1:200)
Western blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information

ZBP1  is a cytoplasmic recognition receptor that senses and is activated by DNA from several sources. Upon activation, ZBP1 triggers a type I IFN response through the activation of IRF3 and, probably, IRF7.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response: A. Takaoka, et al.; Nature 448, 501 (2007) Abstract
Related Products
Further Categories Containing This Product:
Interferons & Interferon Receptors Other Products • Polyclonal Antibodies • DNA Regulation / Transcription Other Products
 
 
ALX-210-959 Revised 28-Apr-08
Polyclonal Antibody to ZBP1 (human) (AT133)
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SYNONYMS anti-Z-DNA-binding Protein 1 (human) PAb (AT133)
anti-Tumor Stroma And Activated Macrophage Protein DLM-1 (human) PAb (AT133)
anti-DAI (human) PAb (AT133)
anti-DNA-dependent Activator of IFN-regulatory Factors (human) PAb (AT133)
PRODUCT LINE Immunology
PRODUCT CATEGORY Innate Immunity Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-959-C100   100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human ZBP1 (aa1-429)
SPECIFICITY: Recognizes human ZBP1.
APPLICATION: Immunoprecipitation (1:200)
Western blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information

ZBP1  is a cytoplasmic recognition receptor that senses and is activated by DNA from several sources. Upon activation, ZBP1 triggers a type I IFN response through the activation of IRF3 and, probably, IRF7.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response: A. Takaoka, et al.; Nature 448, 501 (2007) Abstract
Related Products
Further Categories Containing This Product:
Interferons & Interferon Receptors Other Products • Polyclonal Antibodies • DNA Regulation / Transcription Other Products
 
 
ALX-210-964 Revised 24-Nov-08 New product
Polyclonal Antibody to HMGB1 (human) (AT138)
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SYNONYMS anti-High Mobility Group Protein B1 (human) PAb (AT138)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY DNA Regulation / Transcription Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-964-C100   100 µg 380.00 USD Add To Cart
Product Specification
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to 11 aa near the N-terminus of human HMGB1.
SPECIFICITY: Recognizes human HMGB1. Does not cross-react with human HMGB2.
APPLICATION: ELISA
Western blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-804-581 Revised 19-Feb-07
Monoclonal Antibody to RNase L (human) (2E9)
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SYNONYMS anti-RNase L (human) MAb (2E9)
anti-Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-dependent) (human) MAb (2E9)
anti-2-5A-Dependent RNase (human) MAb (2E9)
anti-Ribonuclease 4 (human) MAb (2E9)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY DNA Regulation / Transcription Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-581-C100   100 µg 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 2E9
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY DETAIL: Affinity purified.
FORMULATION: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
IMMUNOGEN: Recombinant human RNase L.
SPECIFICITY: Recognizes human RNase L. Detects a band of ~83kDa by Western blot. Does not cross-react with mouse RNase L.
APPLICATION: ELISA
Western Blot (Alkaline phosphatase/ECL detection)
Immunoprecipitation
Immunocytochemistry
Immunohistochemistry (paraffin sections)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
2-5A-dependent RNase molecules dimerize during activation by 2-5A: B. Dong & R.H. Silverman; J. Biol. Chem. 270, 4133 (1995) Abstract; Full Text
Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis: L. Wang, et al.; Clin. Cancer Res. 1, 1421 (1995) Abstract
Alternative function of a protein kinase homology domain in 2', 5'-oligoadenylate dependent RNase L: B. Dong & R.H. Silverman; Nucleic Acids Res. 27, 439 (1999) Abstract
Germline mutations in the ribonuclease L gene in families showing linkage with HPC1: J. Carpten, et al.; Nat. Genet. 30, 181 (2002) Abstract
An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors: B. Dong, et al.; PNAS 104, 1655 (2007) Abstract; Full Text
General Information
RNase L is an endoribonuclease regulated by 2-5A synthetase (2-5A). It is a 741 aa cytoplasmic and mitochondrial protein in human. RNase L functions in the antiviral and antiproliferative activities of interferons (IFN) and in multiple apoptotic pathways, standing in the first line of the innate cellular defense mechanism induced by the IFN pathway.
In its native state, the N-terminal half of RNase L functions as a repressor of the ribonuclease domain in the C-terminal half. Upon binding with high affinity to 2-5A molecules, the inactive monomeric form of RNase L is induced to dimerize into its catalytically active form.
Since mutations in RNase L relate to an increase incidence of prostate cancer, the activation of RNase L directly or indirectly suppresses prostate tumorigenesis and/or metastasis. The 2-5A/RNase L pathway is implicated in mediating apoptosis in response to viral infections and to several types of external stimuli. The fungal ribonuclease, α-sarcin, the RNA modyfing enzyme, ricin A chain, and UV light each lead to ribotoxic stress responses involving damage to the 3-end of the large ribosomal RNA. These treatments activate c-jun N-terminal kinases (JNKs). JNK activation in response to UV irradiation has been linked to apoptosis through Bax (requires caspase 3 activity, appearance of cytosolic cytochrome C indicating involvement of mitochondria).
General Literature References
Implications for RNase L in prostate cancer biology: R.H. Silverman; Biochemistry 42, 1805 (2003), Review Abstract
Effects of RNase L mutations associated with prostate cancer on apoptosis induced by 2',5'-oligoadenylates: Y. Xiang, et al.; Cancer Res. 63, 6795 (2003) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-865 Revised 13-May-08
Monoclonal Antibody to ZBP1 (Zippy-1)
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SYNONYMS anti-Z-DNA-binding Protein 1 MAb (Zippy-1)
anti-Tumor Stroma And Activated Macrophage Protein DLM-1 MAb (Zippy-1)
anti-DAI MAb (Zippy-1)
anti-DNA-dependent Activator of IFN-regulatory Factors MAb (Zippy-1)
PRODUCT LINE Immunology
PRODUCT CATEGORY Innate Immunity Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-865-C100   100 µg 380.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Zippy-1
ISOTYPE: Mouse IgG2a
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 0.5mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant mouse ZBP1 (aa 1-411)
SPECIFICITY: Recognizes human and mouse ZBP1.
APPLICATION: Immunoprecipitation (1:200)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Interferons & Interferon Receptors Other Products • Monoclonal Antibodies • DNA Regulation / Transcription Other Products
 
 
ALX-804-866 Revised 05-May-08
Monoclonal Antibody to ZBP1 (mouse) (Zippy-2)
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SYNONYMS anti-Z-DNA-binding Protein 1 (mouse) MAb (Zippy-2)
anti-Tumor Stroma And Activated Macrophage Protein DLM-1 (mouse) MAb (Zippy-2)
anti-DAI (mouse) MAb (Zippy-2)
anti-DNA-dependent Activator of IFN-regulatory Factors (mouse) MAb (Zippy-2)
PRODUCT LINE Immunology
PRODUCT CATEGORY Innate Immunity Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-866-C100   100 µg 380.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: Zippy-2
ISOTYPE: Mouse IgG2a
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant mouse ZBP1 (aa 1-411)
SPECIFICITY: Recognizes mouse ZBP1.
APPLICATION: Immunoprecipitation (1:200)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Interferons & Interferon Receptors Other Products • Monoclonal Antibodies • DNA Regulation / Transcription Other Products • DNA Regulation / Transcription Other Products
 
 
ALX-804-873 Revised 06-Oct-08 New product
Monoclonal Antibody to HMGB1 (human) (Moby-2)
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SYNONYMS anti-High Mobility Group Protein B1 (human) MAb (Moby-2)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY DNA Regulation / Transcription Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-873-C100   100 µg 380.00 USD Add To Cart
Product Specification
CLONE: Moby-2
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human HMGB1.
SPECIFICITY: Recognizes human HMGB1.
APPLICATION: ELISA
Immunoprecipitation (1:200)
Western Blot (1:1‘000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
High mobility group 1 protein (HMGB1) is a chromatin component that is either passively released from necrotic cells or actively secreted in response to angiogenic and inflammatory signals [1]. HMGB1 itself may signal through the receptor for advanced glycation end products (RAGE), and via the Toll-like receptors, TLR2 and TLR4 [2]. HMGB1 functions as a late mediator of immune response. Apoptotic cells also release HMGB1 but in an oxidized form that does not trigger the immune response [3].
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] Pattern recognition receptors in the immune response against dying cells: P. Jeannin, et al.; Curr. Opin. Immunol. 20, 530 (2008) Abstract
[2] Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1): J.R. van Beijnum, et al.; Angiogenesis 11, 91 (2008) Abstract
[3] Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein: H. Kazama, et al.; Immunity 29, 21 (2008) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
APO-54N-043 Revised 27-Nov-08 New product
HMGB1 (human) Detection Set [For ELISA Application]
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SYNONYMS High Mobility Group Protein B1 (human) Detection Set [For ELISA Application]
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY DNA Regulation / Transcription Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
APO-54N-043-KI01   1 Set 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 0.5ng/ml (range 0.78 to 50ng/ml).
QUANTITY: For 5x96 wells.
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION: For the quantitative determination of human HMGB1 from biological fluids (serum and cell culture supernatant).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P09429: HMGB1 (human)
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
ELISA Sets
 
 
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